dan

Kitchen Cooking Burns a Real Danger for Kids

Title: Kitchen Cooking Burns a Real Danger for Kids
Category: Health News
Created: 8/19/2016 12:00:00 AM
Last Editorial Review: 8/22/2016 12:00:00 AM




dan

Suicide a Danger for Some Women During Pregnancy: Study

Title: Suicide a Danger for Some Women During Pregnancy: Study
Category: Health News
Created: 8/28/2017 12:00:00 AM
Last Editorial Review: 8/29/2017 12:00:00 AM




dan

As U.S. Kids Take More Meds, Dangerous Drug Mixes Could Rise

Title: As U.S. Kids Take More Meds, Dangerous Drug Mixes Could Rise
Category: Health News
Created: 8/27/2018 12:00:00 AM
Last Editorial Review: 8/27/2018 12:00:00 AM




dan

Your Chocolate Pot 'Edible' Could Hold a Hidden Danger

Title: Your Chocolate Pot 'Edible' Could Hold a Hidden Danger
Category: Health News
Created: 8/25/2019 12:00:00 AM
Last Editorial Review: 8/26/2019 12:00:00 AM




dan

Climate Change Hiking Danger of Flesh-Eating Bacteria Infections

Title: Climate Change Hiking Danger of Flesh-Eating Bacteria Infections
Category: Health News
Created: 8/23/2019 12:00:00 AM
Last Editorial Review: 8/26/2019 12:00:00 AM




dan

Major Study Gives Women More Guidance on Hormone Therapy During Menopause

Title: Major Study Gives Women More Guidance on Hormone Therapy During Menopause
Category: Health News
Created: 8/29/2019 12:00:00 AM
Last Editorial Review: 8/30/2019 12:00:00 AM




dan

Another Study Shows COVID's Danger to Pregnant Women

Title: Another Study Shows COVID's Danger to Pregnant Women
Category: Health News
Created: 8/11/2022 12:00:00 AM
Last Editorial Review: 8/11/2022 12:00:00 AM




dan

Ondansetron (Zofran) vs. Dramamine

Title: Ondansetron (Zofran) vs. Dramamine
Category: Medications
Created: 7/24/2019 12:00:00 AM
Last Editorial Review: 8/2/2022 12:00:00 AM




dan

The deadly dance of alveolar macrophages and influenza virus

Influenza A virus (IAV) is one of the leading causes of respiratory infections. The lack of efficient anti-influenza therapeutics requires a better understanding of how IAV interacts with host cells. Alveolar macrophages are tissue-specific macrophages that play a critical role in lung innate immunity and homeostasis, yet their role during influenza infection remains unclear. First, our review highlights an active IAV replication within alveolar macrophages, despite an abortive viral cycle. Such infection leads to persistent alveolar macrophage inflammation and diminished phagocytic function, alongside direct mitochondrial damage and indirect metabolic shifts in the alveolar micro-environment. We also discuss the "macrophage disappearance reaction", which is a drastic reduction of the alveolar macrophage population observed after influenza infection in mice but debated in humans, with unclear underlying mechanisms. Furthermore, we explore the dual nature of alveolar macrophage responses to IAV infection, questioning whether they are deleterious or protective for the host. While IAV may exploit immuno-evasion strategies and induce alveolar macrophage alteration or depletion, this could potentially reduce excessive inflammation and allow for the replacement of more effective cells. Despite these insights, the pathophysiological role of alveolar macrophages during IAV infection in humans remains understudied, urging further exploration to unravel their precise contributions to disease progression and resolution.




dan

Differential Tissue Abundance of Membrane-Bound Drug Metabolizing Enzymes and Transporter Proteins by Global Proteomics [Special Section on New and Emerging Areas and Technologies in Drug Metabolism and Disposition, Part II]

Protein abundance data of drug-metabolizing enzymes and transporters (DMETs) are useful for scaling in vitro and animal data to humans for accurate prediction and interpretation of drug clearance and toxicity. Targeted DMET proteomics that relies on synthetic stable isotope-labeled surrogate peptides as calibrators is routinely used for the quantification of selected proteins; however, the technique is limited to the quantification of a small number of proteins. Although the global proteomics-based total protein approach (TPA) is emerging as a better alternative for large-scale protein quantification, the conventional TPA does not consider differential sequence coverage by identifying unique peptides across proteins. Here, we optimized the TPA approach by correcting protein abundance data by the sequence coverage, which was applied to quantify 54 DMETs for characterization of 1) differential tissue DMET abundance in the human liver, kidney, and intestine, and 2) interindividual variability of DMET proteins in individual intestinal samples (n = 13). Uridine diphosphate-glucuronosyltransferase 2B7 (UGT2B7), microsomal glutathione S-transferases (MGST1, MGST2, and MGST3) carboxylesterase 2 (CES2), and multidrug resistance-associated protein 2 (MRP2) were expressed in all three tissues, whereas, as expected, four cytochrome P450s (CYP3A4, CYP3A5, CYP2C9, and CYP4F2), UGT1A1, UGT2B17, CES1, flavin-containing monooxygenase 5, MRP3, and P-glycoprotein were present in the liver and intestine. The top three DMET proteins in individual tissues were: CES1>CYP2E1>UGT2B7 (liver), CES2>UGT2B17>CYP3A4 (intestine), and MGST1>UGT1A6>MGST2 (kidney). CYP3A4, CYP3A5, UGT2B17, CES2, and MGST2 showed high interindividual variability in the intestine. These data are relevant for enhancing in vitro to in vivo extrapolation of drug absorption and disposition and can be used to enhance the accuracy of physiologically based pharmacokinetic prediction of systemic and tissue concentration of drugs.

SIGNIFICANCE STATEMENT

This study quantified the abundance and compositions of drug-metabolizing enzymes and transporters in pooled human liver, intestine, and kidney microsomes as well as individual intestinal microsomes using an optimized global proteomics approach. The data revealed large intertissue differences in the abundance of these proteins and high intestinal interindividual variability in the levels of cytochrome P450s (e.g., CYP3A4 and CYP3A5), uridine diphosphate-glucuronosyltransferase 2B17, carboxylesterase 2, and microsomal glutathione S-transferase 2. These data are applicable for the prediction of first-pass metabolism and tissue-specific drug clearance.




dan

Healthcare avoidance during the early stages of the COVID-19 pandemic and all-cause mortality: a longitudinal community-based study

BackgroundDuring the COVID-19 pandemic, global trends of reduced healthcare-seeking behaviour were observed. This raises concerns about the consequences of healthcare avoidance for population health.AimTo determine the association between healthcare avoidance during the early stages of the COVID-19 pandemic and all-cause mortality.Design and settingThis was a 32-month follow-up within the population-based Rotterdam Study, after sending a COVID-19 questionnaire at the onset of the pandemic in April 2020 to all communty dwelling participants (n = 6241/8732, response rate 71.5%).MethodCox proportional hazards models assessed the risk of all-cause mortality among respondents who avoided health care because of the COVID-19 pandemic. Mortality status was collected through municipality registries and medical records.ResultsOf 5656 respondents, one-fifth avoided health care because of the COVID-19 pandemic (n = 1143). Compared with non-avoiders, those who avoided health care more often reported symptoms of depression (n = 357, 31.2% versus n = 554, 12.3%) and anxiety (n = 340, 29.7% versus n = 549, 12.2%), and more often rated their health as poor to fair (n = 336, 29.4% versus n = 457, 10.1%) . Those who avoided health care had an increased adjusted risk of all-cause mortality (hazard ratio [HR] 1.30, 95% confidence interval [CI] = 1.01 to 1.67), which remained nearly identical after adjustment for history of any non-communicable disease (HR 1.20, 95% CI = 0.93 to 1.54). However, this association attenuated after additional adjustment for mental and physical self-perceived health factors (HR 0.93, 95% CI = 0.71 to 1.20).ConclusionThis study found an increased risk of all-cause mortality among individuals who avoided health care during COVID-19. These individuals were characterised by poor mental and physical self-perceived health. Therefore, interventions should be targeted to these vulnerable individuals to safeguard their access to primary and specialist care to limit health disparities, inside and beyond healthcare crises.




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Guidance and Resources for Family Medicine Scholarship [Family Medicine Updates]




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[PERSPECTIVES] The Complex Roles of Redox and Antioxidant Biology in Cancer

Redox reactions control fundamental biochemical processes, including energy production, metabolism, respiration, detoxification, and signal transduction. Cancer cells, due to their generally active metabolism for sustained proliferation, produce high levels of reactive oxygen species (ROS) compared to normal cells and are equipped with antioxidant defense systems to counteract the detrimental effects of ROS to maintain redox homeostasis. The KEAP1-NRF2 system plays a major role in sensing and regulating endogenous antioxidant defenses in both normal and cancer cells, creating a bivalent contribution of NRF2 to cancer prevention and therapy. Cancer cells hijack the NRF2-dependent antioxidant program and exploit a very unique metabolism as a trade-off for enhanced antioxidant capacity. This work provides an overview of redox metabolism in cancer cells, highlighting the role of the KEAP1-NRF2 system, selenoproteins, sulfur metabolism, heme/iron metabolism, and antioxidants. Finally, we describe therapeutic approaches that can be leveraged to target redox metabolism in cancer.




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Column: Why reporting from South Sudan is so difficult — and critically needed

Simona Foltyn walks down a mountain slope shortly after crossing into South Sudan. Photo by Jason Patinkin

In August, fellow reporter Jason Patinkin and I crossed on foot from northern Uganda into rebel-held South Sudan. Over the course of four days, we walked more than 40 miles through the bush, escorted by rebel soldiers, to shed light on one of the world’s most underreported conflicts.

Reporting on South Sudan’s war, which began in 2013, has always been a challenge due to the risk and logistical hurdles associated with accessing remote areas where fighting takes place. But over the past year, covering the war and its humanitarian fallout has become particularly difficult. Since the beginning of this year, South Sudan’s government has banned at least 20 foreign journalists in an apparent effort to silence reporters who had a track record of critically reporting on the government.

The war has had a devastating impact on South Sudanese communities, but much of it has remained out of the limelight of international media.

This systematic crackdown on the foreign press (South Sudanese journalists have long risked imprisonment and death for doing their work) coincided with two important developments. In November 2016, the United Nations warned that the violence being committed against civilians in the southern region of Equatoria risked spiraling into genocide. Then, in February, the UN declared a man-made famine, warning that 100,000 people were at risk of starving to death as a result of civil war.

Journalists seeking to cover these events were left with two equally unsavory options: self-censorship or a risky trip to rebel-held parts of the country. Only a handful of journalists have attempted the latter since fighting escalated in July last year. For us, this was our second embed with the rebels this year.

Martin Abucha (second from right) rests with his troops in rebel-held South Sudan. Photo by Jason Patinkin

We set off from a town in northern Uganda at five in the morning, bouncing along a bumpy dirt track towards the South Sudan border. Crammed into our four-wheel drive were rebel commander Martin Abucha, a dual American and South Sudanese citizen who we planned to profile for our PBS NewsHour Weekend segment, a couple of guides, and several duffle bags stuffed with our tents, sleeping bags, emergency medical kits and provisions to last us four days.

Just as the sun began to rise above a distant range of hills that we aimed to cross later that day, our car came to a halt in front of a stream. Because of the rainy reason, it carried more water than usual. It was time to disembark and start walking, or “footing,” as South Sudanese tend to call it.

We took off our shoes and waded through the stream’s chilly waters. This was the first of a many rivers we’d have to cross along the way, either on foot or in small flimsy canoes dug out from tree trunks. Each time, we dreaded the idea of falling in with our camera gear.

The first part of our journey in northern Uganda felt very much like a hike through a national park. Passing beautiful landscapes and idyllic farming villages, one could almost forget we were headed into a war zone — but we were about to get a reality check.

We had just crossed into South Sudan when out of nowhere, two dozen armed men popped out of the tall grass and surrounded us at gunpoint.

“Stop! Who are you and where are you going?” a soldier called out in Juba Arabic from his hideout no more than 20 yards away, pointing his AK47 at us. Another one next to him had a rocket-propelled grenade propped on his shoulder, also unequivocally aiming it in our direction.

Instinctively, we threw our hands in the air and exchanged a baffled glance. Had we accidentally bumped into government soldiers? Or perhaps we had come onto the “wrong” rebels? Abucha’s group, called the Sudan People’s Liberation Army In Opposition, is the biggest but not the only armed group in Equatoria, an area rife with rival militia and bandits who exploit the security vacuum left by war.

To our relief, and only after Abucha answered a series of questions, this routine security check quickly gave way to a warm welcome. The platoon would be our escort for the next four days as we trekked to their base and to Loa, Abucha’s hometown.

Keeping up with the rebels was no easy task. Given the country’s pervasive lack of basic infrastructure, South Sudanese grow up walking for dozens of miles just to go about their daily lives. For sedentary Westerners, keeping the target pace of “two meters per second” (around five miles an hour) proved challenging amid 90-degree temperatures, all while filming and plowing our way through dense, itchy elephant grass.

The upside of the cumbersome terrain was that it kept us safe. During our four-day trip, we didn’t cross a single road, instead walking along a dizzying network of narrow bush paths the rebels seemed to know like the backs of their hands. An unwanted encounter with government troops, who tended to stick to roads and move around in vehicles as opposed to on foot, was highly unlikely.

The closest we got to government-controlled area was a visit to Loa, located just two kilometers away from a main road frequently patrolled by government soldiers. We couldn’t stay long, but the hour we spent on the ground offered us a glimpse into what villages must look like in many parts of Equatoria: burned mud huts, looted schools and clinics, fallow fields and – most strikingly – no civilians.

The war has had a devastating impact on South Sudanese communities like the one in Loa, but much of it has remained out of the limelight of international media. Our four-day venture into rebel-held South Sudan offered us a rare opportunity to report ground truths, and we are thankful for that.

The post Column: Why reporting from South Sudan is so difficult — and critically needed appeared first on PBS NewsHour.




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South Sudan civil war causes Africa’s worst refugee crisis

Watch Video | Listen to the Audio

The United Nations says South Sudan’s four-year-old civil war has left half of the nation’s population — 6 million people — in need of humanitarian aid. The conflict began when South Sudan’s army split between factions loyal to President Salva Kiir and former Vice President Riek Machar. The two men mobilized their respective tribes, the Dinka and the Nuer. The war has caused what is now one of the world’s worst refugee crises.

SIMONA FOLTYN: Civil war is emptying huge swaths of South Sudan. The violence has uprooted four million people, including two million who’ve fled to neighboring countries. In the last year, more than a million South Sudanese have poured into northern Uganda alone, crossing makeshift bridges like this one to flee fighting, hunger, and brutal attacks on civilians.

SEME LUPAI, REFUGEE: They started fighting very, very severely. So that made us to escape with our properties to this side.

SIMONA FOLTYN: When Seme Lupai’s family went to one of the refugee camps, initially, he stayed behind to look after the family’s most precious commodity — their cattle. He hid for a year to escape the violence. The refugees carry whatever they can salvage — mattresses, pots, clothes, notebooks — remnants of once peaceful lives turned upside down. At checkpoints, Ugandan soldiers search their belongings for weapons, before the refugees proceed to reception centers. After entering Uganda, the refugees sign in at small waystations. For many, it’s the first night spent in safety after walking for days to escape fighting. Levi Arike fled with his wife and four children.

LEVI ARIKE, REFUGEE: When the gunshots started, we laid under a tree with the whole family, because there was nowhere else to hide. We waited for the fighting to stop, and then we got up and started walking to Uganda.

SIMONA FOLTYN: Uganda now shoulders most of the burden of Africa’s biggest refugee crisis, managing a constellation of camps which require food, water, healthcare, and policing. At Imvepi Camp, now home to more than 120,000 South Sudanese, new arrivals receive vaccinations, hot meals, and basic items such as soap and plastic tarps to build a house. The government also gives each refugee family a small plot of land, about a twentieth of an acre, where they can build a tent shelter and grow crops to eat or sell. But the land often proves too rocky for farming.

SIMONA FOLTYN, IMVEPI REFUGEE CAMP, NORTHERN UGANDA: After completing the registration process, the new arrivals will receive their plot, to start a new life as refugees in Uganda. While they are safe here, there are many challenges ahead, not least processing the trauma of what they experienced back home.

This woman, who we’ll call “Agnes,” agreed to tell us about her harrowing experience. She says four government soldiers from President Salva Kiir’s Dinka tribe stopped her as she was fleeing South Sudan and raped her right in front of her family.

AGNES (translated to English): When they started raping me, they told me not to raise alarm, otherwise they would shoot me. Still when I’m sleeping, I’m dreaming of the Dinka, that they are coming to rape me again.

SIMONA FOLTYN: How often do you have those dreams?

AGNES: Daily, every time I lie down, those dreams come.

SIMONA FOLTYN: A recent Human Rights Watch report on South Sudan found “…a clear pattern of government forces unlawfully targeting civilians for killings, rapes, torture…and destruction of property..” The victims are from ethnic groups suspected to support the rebels.

AGNES: They are doing it, because they know very well that those soldiers are our brothers. So they do it to punish them..

SIMONA FOLTYN: Although the rebels, known as the Sudan People’s Liberation Army In Opposition, purport to protect local communities, there are also reports of their fighters assaulting civilians near the Ugandan border. Josephine Yanya told us she didn’t feel safe in the presence of either side’s soldiers. Her family and neighbors fled their village after government soldiers killed her uncle.

They hid in the mountains only to find themselves under attack again, this time by opposition fighters from the Nuer tribe loyal to former vice president Riek Machar. Yanya says ethnic Nuer soldiers from the SPLA-IO rebel group raped a member of her group and stole her father’s’ cattle.

JOSEPHINE YANYA (translated to English): Before we were thinking that the rebels would protect us, but if they are lacking food, they just come and take things by force.

SIMONA FOLTYN: With nowhere left to hide, Yanya fled to Uganda with her son.
But instead of finding a place to rebuild their lives, they are in limbo. And aid groups don’t have enough food to distribute.

JOSEPHINE YANYA (translated to English):We are getting small food rations. I know it won’t be enough even for one month.

SIMONA FOLTYN: According to the United Nations, the international community has given less than a-third of the $1.4 billion dollars needed for the refugee response in South Sudan’s neighboring countries. These refugees foresee more hardship and have no idea when they might return home.

JOSEPHINE YANYA (translated to English): I’m always praying for peace in South Sudan, and until then, I’ll just stay here.

The post South Sudan civil war causes Africa’s worst refugee crisis appeared first on PBS NewsHour.




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The battle for Mosul is over, but this hidden ISIS danger could lurk for years

Watch Video | Listen to the Audio

HARI SREENIVASAN: But first: The de facto capital of the Islamic State, Raqqa, in Syria fell yesterday to U.S.-backed forces.

However, the largest city the militants once held was Mosul in Iraq. They were ousted from it in July after a brutal 10-month-long fight that killed thousands.

Now a new major task: finding and destroying the ISIS mines, booby-traps and bombs that litter the city.

Special correspondent Marcia Biggs reports from Iraq.

MARCIA BIGGS, Special Correspondent: It was once a center of learning for over 6,000 students of technology, agriculture, and medicine.

Today, Mosul Technical Institute’s classrooms are burnt to the ground, laboratories reduced to rubble, and books charred and shredded. It’s one of the city’s five universities ravaged by the Islamic State and the battle to oust it.

Now that the battle is over, a new danger looms, the trail of land mines and booby-traps left by ISIS.

So this is the wire, and this is where it was buried.

CHRISTIAN, Team Leader, Janus Global Operations: Yes, they would cut the asphalt, and then they lay the wire in and put the main charge here.

MARCIA BIGGS: We spent the day with Christian, a team leader from Janus Global, a security and risk management firm hired by the U.S. government to sweep and clear major areas of unexploded ordnance and mines.

He’s not allowed to show his face or use his last name, for security reasons.

CHRISTIAN: There’s actually two more on that road before we get to the target building that have to be excavated and/or rendered safe.

MARCIA BIGGS: So, the first building you have to clear, you have got to get rid of the IEDs on the road to that building?

CHRISTIAN: Yes.

MARCIA BIGGS: It’s a long process.

CHRISTIAN: It is, but that’s what makes it interesting.

MARCIA BIGGS: The United States has sunk $30 million this year into clearing former ISIS territories all over Northern Iraq. Under this program, Janus has already cleared 727 buildings, removing 3,000 IEDs, which they say ISIS was producing on assembly lines at an industrial scale.

But State Department officials and experts say the number of unexploded ordnance in Mosul itself is unprecedented.

What’s your first line of attack, in terms of trying to clear Mosul?

CHRISTIAN: Our priority is more the community, rather than the individual, you know, infrastructure. You have got schools, power, sewer, water, so that the area can accept people back into it. And then, once this stabilization phase is over, we can move into the individual homes, so that they can be safer.

MARCIA BIGGS: Clearing Mosul is a process that they say could take years, even decades. So Janus is training local Iraqis to do the job, sending them out as a front-line search team, then investigating and removing any suspicious items themselves.

CHRISTIAN: We’re not going to be here the whole time, so when we — it’s our time to leave, they will have the capacity built from us, and the mentoring we have done, so that they can do it on their own.

MARCIA BIGGS: How are they doing?

CHRISTIAN: They’re — a lot of them are very apt to learn. They’re quick. They’re smart.

MARCIA BIGGS: Fawzi al Nabdi is the team leader for the Iraqi local partner. He’s cleared mines all over Iraq for the last six years.

CHRISTIAN: What you got?

FAWZI AL NABDI, Team Leader, Al Fahad Company (through interpreter): We are ready for this, because it’s my job and I love it. The Americans are here to complete our work and to help us. They have greater experience than we do. If we find any mines, we have to stop and they will investigate it and make a plan to remove it.

MARCIA BIGGS: But he says Mosul is the biggest project he has ever seen, and we’re told it could take at least a month to just get the campus cleared of mines. Only then can they start cleaning it up, so that students can resume classes, this itself a huge task.

ISIS fighters closed the university back in 2014, and used it as a military base. As coalition forces pounded ISIS targets, this seat of higher learning became a battleground.

Ghassan Alubaidy is the institute’s dean.

GHASSAN ALUBAIDY, Dean, Mosul Technical Institute (through interpreter): ISIS used our university to manufacture mines and bombs. For this reason, it was the target of airstrikes in the beginning. They struck the institute nine times, and they struck our workshops, too. Now we can’t use them.

MARCIA BIGGS: The former commander of coalition forces in Iraq, Lieutenant General Stephen Townsend, recently listed 81 locations where bombs were dropped, but had not yet exploded.

Facilities used to make weapons were often on the list of high-value targets for the coalition. So now those places are twice as likely to contain dangerous items.

So, this was once a workshop for electrical engineering students. You can still see the lab tables here. It was hit by an airstrike in 2015. Afterwards, members of the university staff found bomb-making instructions among the rubble. This was likely an ISIS bomb-making factory, and judging by the crater, a high-value target.

Despite the damage, Dean Alubaidy says he will hold classes this fall in alternate buildings, until the campus is ready. He’s expecting registration to be in the thousands, students who lost three years of education during the fighting and don’t want to lose another one.

GHASSAN ALUBAIDY (through interpreter): On our Facebook pages, we found a great number of students posting that they were full of encouragement to come back. For us, it was unbelievable. We couldn’t imagine it, to see how many students wanted to start again, how they were dreaming of the first day of classes, when they could sit in front of teachers again and start to live their lives again.

MARCIA BIGGS: Next door, Mosul University has already started classes. Students even volunteered to help in the cleanup.

But across the river, West Mosul was the site of ISIS’ last stand and bore the brunt of the battle. It’s densely packed Old City, with its flattened buildings, is a challenge for mine-sweeping.

FAWZI AL-NABDI (through interpreter): Most of the homes here were full of mines. And just here in front of us, a man with two kids came back to his home, and when he opened the door, the bomb killed him and his kids.

MARCIA BIGGS: Ahmed Younes fled back in early July with only the clothes on his back. Residents have been virtually banned from returning to his neighborhood on the outskirts of the Old City, but Ahmed said he got special permission, in order to retrieve some personal items.

AHMED YOUNES, Local Resident (through interpreter): We came on our own. We got permission to come, but they are not responsible if anything happens to us.

MARCIA BIGGS: Right now, there is no plan to begin clearing the Old City or even to determine how many mines there are. It is still out of bounds to anyone but the Iraqi security forces.

So the Janus team is focusing on progress in the rest of the city, building by building, bomb by bomb.

CHRISTIAN: Whoever made this device had a set goal. And to allow him to win, people get hurt. So you kind of compete against him to be better than him to take it out before it can do any harm.

MARCIA BIGGS: So, you feel like you’re winning the battle against ISIS?

CHRISTIAN: Yes, one IED at a time.

MARCIA BIGGS: For the PBS NewsHour, I’m Marcia Biggs in Mosul, Iraq.

HARI SREENIVASAN: Tune in later.

Frontline’s latest film, “Mosul,” was on the ground filming the fight as it unfolded street by street and house by house. That’s tonight on PBS.

The post The battle for Mosul is over, but this hidden ISIS danger could lurk for years appeared first on PBS NewsHour.




dan

Stormy Daniels Says Trump Is Trying to Silence Her Again

Phillip Faraone/Getty Images

It appears Donald Trump is once again attempting to silence Stormy Daniels, despite his recent convictions in that category.

MSNBC’s Rachel Maddow reports that Trump’s lawyers tried to “get another hush money deal” with the adult film star, to keep her from making any “public or private statements related to any alleged past interactions” with the former president. In exchange for her written agreement, Trump’s team reportedly offered to adjust the debt she owes Trump for the unsuccessful defamation case her lawyer brought against him in 2018.

Daniels still needs to pay “hundreds of thousands of dollars” in legal fees, Maddow explained, and in hammering out the exact amount, Trump’s lawyers allegedly offered to “pretend” she owed their client “less than they actually believed” she did. Whereas they first estimated Daniels’ debt at $650,000, Maddow reported, they said they would settle her tab for $620,000, if she promised not to make any “defamatory or disparaging statements about him, his business, and/or any affiliates, or his suitability as a candidate for president.” They then adjusted the fee, asking $635,000 if she refused to sign a non-disclosure agreement. Daniels reportedly turned them down, paying $627,500 and declining to sign the NDA.

Read more at The Daily Beast.




dan

Liam Payne 911 Caller Said One Direction Star’s Life Could Be in Danger Minutes Before Death

Ian West/PA Images via Getty

A hotel worker called 911 to request urgent assistance before musician Liam Payne fell to his death from the third floor of the building in Buenos Aires on Wednesday.

The 31-year-old British singer and former member of the boy band One Direction died after he “jumped from the balcony of his room,” Buenos Aires Security Ministry Communications Director Pablo Policicchio told the Associated Press. He added that police had been called to the Casa Sur Hotel in the Argentine capital after receiving an emergency call shortly after 5 p.m. local time about an “aggressive man who could be under the influence of drugs or alcohol.”

A transcript of a 911 call published by the BBC shows a worker at the hotel telling the operator that they have “a guest who is high on drugs and who is trashing the room” and the staff therefore “need someone to come.”

Read more at The Daily Beast.




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Ex-DWP insider reveals essential tips for PIP and Attendance Allowance claims



A DWP employee who has been working in the welfare system for 42 years has shared some key advice for new claims for the likes of PIP and Attendance Allowance




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Video Friday: Disney Robot Dance



Video Friday is your weekly selection of awesome robotics videos, collected by your friends at IEEE Spectrum robotics. We also post a weekly calendar of upcoming robotics events for the next few months. Please send us your events for inclusion.

ICRA@40: 23–26 September 2024, ROTTERDAM, NETHERLANDS
IROS 2024: 14–18 October 2024, ABU DHABI, UAE
ICSR 2024: 23–26 October 2024, ODENSE, DENMARK
Cybathlon 2024: 25–27 October 2024, ZURICH

Enjoy today’s videos!

I think it’s time for us all to admit that some of the most interesting bipedal and humanoid research is being done by Disney.

[ Research Paper from ETH Zurich and Disney Research]

Over the past few months, Unitree G1 robot has been upgraded into a mass production version, with stronger performance, ultimate appearance, and being more in line with mass production requirements.

[ Unitree ]

This robot is from Kinisi Robotics, which was founded by Brennand Pierce, who also founded Bear Robotics. You can’t really tell from this video, but check out the website because the reach this robot has is bonkers.

Kinisi Robotics is on a mission to democratize access to advanced robotics with our latest innovation—a low-cost, dual-arm robot designed for warehouses, factories, and supermarkets. What sets our robot apart is its integration of LLM technology, enabling it to learn from demonstrations and perform complex tasks with minimal setup. Leveraging Brennand’s extensive experience in scaling robotic solutions, we’re able to produce this robot for under $20k, making it a game-changer in the industry.

[ Kinisi Robotics ]

Thanks Bren!

Finally, something that Atlas does that I am also physically capable of doing. In theory.

Okay, never mind. I don’t have those hips.

[ Boston Dynamics ]

Researchers in the Department of Mechanical Engineering at Carnegie Mellon University have created the first legged robot of its size to run, turn, push loads, and climb miniature stairs.

They say it can “run,” but I’m skeptical that there’s a flight phase unless someone sneezes nearby.

[ Carnegie Mellon University ]

The lights are cool and all, but it’s the pulsing soft skin that’s squigging me out.

[ Paper, Robotics Reports Vol.2 ]

Roofing is a difficult and dangerous enough job that it would be great if robots could take it over. It’ll be a challenge though.

[ Renovate Robotics ] via [ TechCrunch ]

Kento Kawaharazuka from JSK Robotics Laboratory at the University of Tokyo wrote in to share this paper, just accepted at RA-L, which (among other things) shows a robot using its flexible hands to identify objects through random finger motion.

[ Paper accepted by IEEE Robotics and Automation Letters ]

Thanks Kento!

It’s one thing to make robots that are reliable, and it’s another to make robots that are reliable and repairable by the end user. I don’t think iRobot gets enough credit for this.

[ iRobot ]

I like competitions where they say, “just relax and forget about the competition and show us what you can do.”

[ MBZIRC Maritime Grand Challenge ]

I kid you not, this used to be my job.

[ RoboHike ]




dan

How E. coli infections wreak havoc on the body, causing dangerous disease — particularly in kids

Certain strains of E. coli are capable of causing severe disease, by rapidly spreading through the human digestive system, wreaking havoc throughout the bloodstream, and eventually damaging the delicate kidneys. That's the situation right now during a large outbreak in Alberta, with hundreds of children now affected.




dan

Is just reading that sketchy scammer’s email dangerous or do I have to click on a link to get in trouble?

Tech expert Kurt “CyberGuy" Knutsson says opening emails is safe, but risks arise from interacting with links, attachments or HTML content.



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dan

Jordan Nobbs Column: England Have Impressed So Far But Must Be Wary of Tough Japan Challenge

Arsenal and England midfielder Jordan Nobbs will be a columnist for 90min & BBC Sport pundit at the Women's World Cup in France this summer, as Phil Neville's Lionesses' look to secure a maiden World Cup triumph. Two wins from our first two games is obviously what we were all hoping for. The first game of a World Cup, or any other major tournament, is never going to be one where you're playing at your absolute best. But the 2-1 win over was Scotland was great given the pre-match hype, the..





dan

Media portrayals peddle a dangerous fiction about substance misuse

Narratives around addiction often reduce it to a series of poor choices, lack of values and weakness. This has real-world consequences, warns Anna Wolfe




dan

Snoring isn't just a nuisance, it's dangerous. Why can't we treat it?

Snoring is often viewed as harmless, at least to the snorer, but we are now uncovering its potentially serious effects on cardiovascular health. And finding ways to stop is surprisingly challenging




dan

Fired FEMA employee says instructions to skip Trump homes were part of ‘colossal avoidance’ policy

A FEMA supervisor fired for instructing subordinates to skip over houses with Trump signs says her actions were consistent with agency guidance and were not isolated to her team alone.



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dan

Allies providing Sudan's warring parties with weapons are 'enabling the slaughter,' UN official says




dan

How Scientists’ Tender Loving Care Could Save This Endangered Penguin Species

From fish smoothies to oral antibiotics, researchers are taking matters into their own hands in a radical effort to save New Zealand’s yellow-eyed penguins




dan

Can Fungi Save This Endangered Hawaiian Tree?

By inoculating greenhouse na’u seedlings with mycorrhizal fungi, researchers hope to boost survival odds when the plants are returned to the wild





dan

Daniel Khalife pleads guilty to escaping Wandsworth prison last year

The former soldier Daniel Khalife has changed his plea to guilty and admitted escaping from Wandsworth prison.




dan

Dry weather in New York and New Jersey leads to a rash of dangerous wildfires

Wildfires have been raging in New York and New Jersey. People in some areas have been asked to prepare for possible evacuations.




dan

Vikrant Massey says Hindus, Muslims not in danger in India: ‘Everything is going fine’

The actor, who stars in the upcoming film ‘The Sabarmati Report’, based on the 2002 Godhra train burning incident, emphasised his secular credentials while saying that his perspective on the state of the nation has shifted in the last ten years




dan

Le Carnet de Karine: Sylvain Croteau combat la violence dans le sport

Amoureux du sport, Sylvain Croteau a décidé de consacrer sa carrière, depuis 10 ans, à prévenir et à contrer la violence et les abus dans ce monde.




dan

Kim Kardashian debuts Princess Diana pendant

Billionaire and social media mogul Kim Kardashian finally wore the Princess Diana-owned pendant she bought last year. She debuted the amethyst and diamond cross, purchased in January 2023 for £163,800 (roughly $265,000 Cdn), at the LACMA Art+Film Gala in Los Angeles on Saturday. 




dan

27 000$ dérobés à Hydro-Québec: un avocat de Laval a volé de l’électricité pendant 14 ans

Un avocat de Laval épinglé pour son compteur d’Hydro-Québec trafiqué qui lui a fait économiser près de 27 000$ d’électricité devra payer une amende.




dan

«Ce n’est pas légal»: des enfants sélectionnés selon l’ethnie ou la religion dans des garderies

La sélection d’enfants selon des critères ethniques ou religieux pour l’admission dans des CPE du grand Montréal n’est pas légale.




dan

Influenceur en cryptomonnaie enlevé dans le Vieux-Montréal: le corps décomposé de Kevin Mirshahi retrouvé

Le corps ligoté en état de décomposition retrouvé le 30 octobre dans l’un des parcs les plus achalandés de Montréal est celui de Kevin Mirshahi.




dan

«C’était absolument nécessaire»: Laurence Jalbert a tout arrêté pendant deux mois pour guérir de la COVID

Laurence Jalbert a dû tout arrêter pendant deux mois




dan

Lock-out dans les ports: Ottawa n’aurait pas été assez «proactif», selon un expert

Ottawa aurait laissé trop de liberté aux syndicats, en leur donnant «carte blanche» pour déclencher des grèves dans les ports du pays.




dan

La CAQ prend les Ukrainiens en otages dans sa guerre contre Ottawa

Dans ses guéguerres avec Ottawa, le gouvernement de la CAQ ne recule devant aucune bassesse pour marquer des points.




dan

Procès pour triple meurtre à Brossard: incursion dans une scène de crime sanglante et chaotique pour le jury

Le jury au procès du père accusé d’avoir décimé sa famille a eu droit à une véritable incursion dans la scène de crime.




dan

Une ancienne boîte St-Hubert des années 70 retrouvée dans l’entretoit d’un chalet près de Stoneham et remise à la famille Martin en échange d'un don de 1000$

Une ancienne boîte de poulet St-Hubert, retrouvée par hasard dans l’entretoit d’un chalet, a été remise à la famille Martin en échange d'un don.




dan

Enlevée par ses frères dans un resto: «Elle criait d’appeler le 911»

Une ado qui aurait été enlevée de force par ses propres frères était en panique et criait d’appeler le 911, selon un témoin appelé au procès.




dan

PRIMEUR | Le PQ a choisi sa candidate pour la partielle dans Terrebonne

Le Parti Québécois misera sur sa présidente, Catherine Gentilcore, pour tenter de ravir la circonscription de Terrebonne à la CAQ.




dan

CSIS had concerns about Abdelrazik's motives ahead of trip to Sudan, investigator testifies

Canada's intelligence agency amassed a sizable file on Abousfian Abdelrazik's suspected terrorism ties in the early 2000s, although the validity of that intelligence was called into question during the Montreal man's Federal Court case.




dan

Karol G s’excuse pour des paroles jugées offensantes dans son nouveau single

La vedette colombienne du reggaeton Karol G s’est excusée pour des paroles de son nouveau single «+57» jugées offensantes.




dan

Guylaine Tanguay tiendra la vedette de la mouture québécoise de la comédie musicale «Ménopause»: «J’ai besoin de me mettre en danger»

Elle tiendra la vedette de l’adaptation québécoise du succès mondial Ménopause aux côtés de Claudine Mercier, Catherine Sénart et Geneviève Charest.




dan

10 bons choix à intégrer dans la boîte à lunch des enfants

Ces produits se démarquent par leurs valeurs nutritives, surpassant celles d’options similaires.