A slimmed down Maikel Franco and a bulked up Scott Kingery will compete for playing time at third base this season.

Preclinical data have shown that ¹⁶¹Tb-labeled peptides targeting the somatostatin receptor are therapeutically more effective for peptide receptor radionuclide therapy than are their ¹⁷⁷Lu-labeled counterparts. To further substantiate this enhanced therapeutic effect, we performed cellular dosimetry to quantify the absorbed dose to the cell nucleus and compared dose–response curves to evaluate differences in relative biological effectiveness in vitro. Methods: CA20948 cell survival was assessed after treatment with [¹⁶¹Tb]Tb- and [¹⁷⁷Lu]Lu-DOTATATE (agonist) and with [¹⁶¹Tb]Tb- and [¹⁷⁷Lu]Lu-DOTA-LM3 (antagonist) via a clonogenic assay. Cell binding, internalization, and dissociation assays were performed up to 7 d to acquire time-integrated activity coefficients. Separate S values for each type of particle emission (Auger/internal conversion [IC] electrons and β^– particles) were computed via Monte Carlo simulations, while considering spheric cells. Once the absorbed dose to the cell nucleus was calculated, survival curves were fitted to the appropriate linear or linear-quadratic model and corresponding relative biological effectiveness was evaluated. Results: Although the radiopeptide uptake was independent of the radionuclide, [¹⁶¹Tb]Tb-DOTATATE and [¹⁶¹Tb]Tb-DOTA-LM3 delivered a 3.6 and 3.8 times higher dose to the nucleus, respectively, than their ¹⁷⁷Lu-labeled counterparts on saturated receptor binding. This increased nucleus-absorbed dose was mainly due to the additional emission of IC and not Auger electrons by ¹⁶¹Tb. When activity concentrations were considered, both [¹⁶¹Tb]Tb-DOTATATE and [¹⁶¹Tb]Tb-DOTA-LM3 showed a lower survival fraction than did labeling with ¹⁷⁷Lu. When the absorbed dose to the nucleus was considered, no significant difference could be observed between the dose–response curves for [¹⁶¹Tb]Tb- and [¹⁷⁷Lu]Lu-DOTATATE. [¹⁶¹Tb]Tb-DOTA-LM3 showed a linear-quadratic dose response, whereas [¹⁶¹Tb]Tb-DOTATATE showed only a linear dose response within the observed dose range, suggesting additional cell membrane damage by Auger electrons. Conclusion: The IC, rather than Auger, electrons emitted by ¹⁶¹Tb resulted in a higher absorbed dose to the cell nucleus and lower clonogenic survival for [¹⁶¹Tb]Tb-DOTATATE and [¹⁶¹Tb]Tb-DOTA-LM3 than for the ¹⁷⁷Lu-labeled analogs. In contrast, [¹⁶¹Tb]Tb-DOTATATE showed no higher dose response than [¹⁷⁷Lu]Lu-DOTATATE, whereas for [¹⁶¹Tb]Tb-DOTA-LM3 an additional quadratic response was observed. Because of this quadratic response, potentially caused by cell membrane damage, [¹⁶¹Tb]Tb-DOTA-LM3 is a more effective radiopeptide than [¹⁶¹Tb]Tb-DOTATATE for labeling with ¹⁶¹Tb.

This analysis aimed to identify clinical factors associated with positivity on repeat ⁶⁸Ga-PSMA-11 PET/CT after a negative scan in patients with recurrent prostate cancer (PCa) under observation. Methods: This single-center, retrospective analysis included patients who underwent at least 2 ⁶⁸Ga-PSMA-11 PET/CT scans (PET1 and PET2) at UCLA between October 2016 and June 2021 for recurrent PCa with negative PET1 and no PCa-related treatments between the 2 scans. Using Prostate Cancer Molecular Imaging Standardized Evaluation criteria to define negative and positive scans, the final cohort was divided into PET2-negative (PET2-Neg) and PET2-positive (PET2-Pos). The same PET1 was used twice in the more than 2 PET cases with inclusion criteria fulfilled. Patient characteristics and clinical parameters were compared between the 2 cohorts using Mann–Whitney U test and Fisher exact test. Areas under the curve (AUCs) of the receiver operating characteristic and the Youden index were computed to determine the discrimination ability of statistically significant factors and specific cut points that maximized sensitivity and specificity, respectively. Results: The final analysis included 83 sets of 2 PET/CT scans from 70 patients. Thirty-nine of 83 (47%) sets were PET2-Neg, and 44 of 83 (53%) sets were PET2-Pos. Prostate-specific antigen (PSA) increased from PET1 to PET2 for all 83 (100%) sets of scans. Median PSA at PET1 was 0.4 ng/mL (interquartile range, 0.2–1.0) and at PET2 was 1.6 ng/mL (interquartile range, 0.9–3.8). We found higher serum PSA at PET2 (median, 1.8 vs. 1.1 ng/mL; P = 0.015), absolute PSA difference (median, 1.4 vs. 0.7 ng/mL; P = 0.006), percentage of PSA change (median, +270.4% vs. +150.0%: P = 0.031), and median PSA velocity (0.044 vs. 0.017 ng/mL/wk, P = 0.002) and shorter PSA doubling time (DT; median, 5.1 vs. 8.3 mo; P = 0.006) in the PET2-Pos cohort than in the PET2-Neg cohort. Receiver operating characteristic curves showed cutoffs for PSA at PET2 of 4.80 ng/mL (sensitivity, 34%; specificity, 92%; AUC, 0.66), absolute PSA difference of 0.95 ng/mL (sensitivity, 62%; specificity, 71%; AUC, 0.68), percentage of PSA change of a positive 289.50% (sensitivity, 48%; specificity, 82%; AUC, 0.64), PSA velocity of 0.033 ng/mL/wk (sensitivity, 57%; specificity, 80%; AUC, 0.70), and PSA DT of 7.91 mo (sensitivity, 71%; specificity, 62%; AUC, 0.67). Conclusion: Patients with recurrent PCa under observation after a negative ⁶⁸Ga-PSMA-11 PET/CT scan with markedly elevated serum PSA levels and shorter PSA DT are more likely to have positive findings on repeat ⁶⁸Ga-PSMA-11 PET/CT.

About 1,100 workers will be laid off indefinitely in January from the Jeep Gladiator plant in Toledo, Ohio, Stellantis officials announced Wednesday.

As Nissan on Thursday reported a roughly half-billion- dollar revenue drop in 2024, the Japanese automaker said it will cut 9,000 jobs and reduce manufacturing capacity by 20%.

Mattel has apologized after inadvertently directing customers of its new line of Wicked dolls to a pornographic website, stating it is taking action to remove the misprinted toys' packaging.

Oct. 16, 2024 — Xsight Labs, a leading fabless semiconductor company providing end-to-end connectivity solutions for next-generation hyperscale, edge, and AI data center networks, has announced the tape-out of the […]

The post Xsight Labs Launches E1 SoC Built on TSMC’s 5nm Tech for AI Workloads appeared first on HPCwire.

LONDON and TORONTO, Sept. 30, 2024 — Alphawave Semi, a global leader in high-speed connectivity and compute silicon for the world’s technology infrastructure, has unveiled the availability of the industry’s […]

The post Alphawave Semi and TSMC Collaborate on 3nm UCIe Die-to-Die Subsystem for AI and HPC appeared first on HPCwire.

In AI, time is money. Top AI players are spending billions to create computing infrastructures to satisfy that need for speed. However, these companies are bottlenecked by computing constraints at […]

The post Ayar Labs CEO: Optical Chiplets Coming to SOCs Soon appeared first on HPCwire.

Mattel has apologized after inadvertently directing customers of its new line of Wicked dolls to a pornographic website, stating it is taking action to remove the misprinted toys' packaging.

ATLANTA, Nov. 12, 2024 — Sylabs, in collaboration with Sandia National Laboratories, will host a Birds of a Feather (BoF) session at SC24 titled Integrating Confidential Computing into High-Performance Cloud Workflows. […]

The post Sylabs Highlights Confidential Computing in HPC at SC24 BoF Session appeared first on HPCwire.

Nov. 8, 2024 — Barcelona Supercomputing Center‘s Innostroke project aims to transform the prevention and monitoring of stroke, one of the leading causes of death and disability worldwide, through artificial […]

The post BSC Develops AI Model to Predict Stroke Risk Using Mobile Devices appeared first on HPCwire.

Country music star Blake Shelton and writer-producer Taylor Sheridan are working on a new reality competition series for CBS called "The Road."

North Dakota lawmakers fended off an effort to ensure that the state's new standards, and any tests that might be used with them, won't mirror the common core.

Maryland may be a model for how states should approach educating students for the workforce of the future, according to a new policy brief.

At least four Kentucky school districts were forced to close last Thursday as hundreds of teachers called in sick to continue protesting what they believe to be anti-public education proposals in the state legislature.

The demand for substitute teacher positions is outpacing the supply, and the quality of those applying is a concern in many places.

There could be an 8.4 percent reduction in the U.S. teaching corps, and some states could see reductions as large as 20 percent, according to a new analysis by the Learning Policy Institute.

A heated school board election in the fast-changing Atlanta suburbs pits Black Lives Matter vs. the “Suburban Lifestyle Dream.”

U.S. Secretary of Education Betsy DeVos will hold a workforce event at a South Carolina drug manufacturer that employs hundreds of cash-strapped teachers in second jobs.

Nephron Pharmaceuticals, a drug manufacturing company in West Columbia, S.C., recently hired 650 current and retired teachers through a new program designed to provide educators with additional income.

The study found that youth in rural New Hampshire have poor perceptions of job opportunities in the area, and are more likely to be depressed or abuse substances than other rural youth.

Confusion reigns when it comes to finding and reporting data on school-related coronavirus infections. That's a problem for school leaders weighing shutdowns.

There was some dramatic movement in the second College Football Playoff rankings. Here's who got slighted.

A union lobbyist who worked just one day as a substitute teacher is entitled to a pension worth potentially tens of thousands of dollars annually, the Illinois supreme court has ruled.

Confusion reigns when it comes to finding and reporting data on school-related coronavirus infections. That's a problem for school leaders weighing shutdowns.

Nora D. Volkow
Dec 1, 2001; 21:9414-9418
Behavioral

A new exhibition co-presented by the National Portrait Gallery and the Archives of American Art explores the seminal artist’s work

Today we celebrate the cultural heritage, health benefits and economic importance of tea.

Rome – The newly released Annual Report for 2020, 2021 and 2022 raises the visibility of the Organization's Resource Partners, including FAO Members, international financial institutions (IFIs), United Nations entities, [...]

The PSS Technical Cooperation Programme (TCP) team is excited to announce the launch of its newly designed webpages. The webpage has a fresh look [...]

Social protection and decent jobs are cornerstones of agrifood systems transformation, but they require strong political commitment

The cheetah cubs will be named after the fastest male and female American Olympic athletes in the 100-meter dash at the London Olympics.

The Ouija board might seem like a simple game that sparks spooky childhood memories, but have you ever pondered its mysterious history? Even more importantly, does it actually…work? Uncover the fascinating truth behind the game and its unusual origins. ___ A little more information: In the late 19th century, Americans were captivated by Spiritualism, the belief that the dead could communicate with the living. Charles Kennard saw the commercial potential in this trend, leading to the creation of the Ouija board. Yet, the backstory behind its invention, its rules, and even its name are all wrapped up in uncertainty. One thing is certain: the more turbulent the times, the more popular the game became – particularly during World War II and the social upheaval of the late 1960s. Ultimately, the allure of the Ouija board lies in its ability to tap into human imagination and curiosity. Whether regarded as a nostalgic artifact or a mystical tool, the Ouija board is here to stay. #OuijaBoard #Ouija #history #Smithsonianmagazine Subscribe: https://www.youtube.com/@SmithsonianMagazine Read more about the history of the Ouija Board here: https://www.smithsonianmag.com/history/the-strange-and-mysterious-history-of-the-ouija-board-5860627/ Did you know that US Navy Officers rely on a system called the “ouija board” to track the movement of airplanes on a carrier? Learn more here: https://www.smithsonianmag.com/air-space-magazine/how-things-work-the-ouija-board-10048217/ For more videos from Smithsonian Magazine: https://www.smithsonianmag.com/videos/ Get More Smithsonian Magazine: Official Site: https://www.smithsonianmag.com/ Facebook: https://www.facebook.com/smithsonianmagazine/ X: https://x.com/smithsonianmag Instagram: https://www.instagram.com/SmithsonianMagazine/ Digital Editorial Director: Brian Wolly Director of Programming: Nicki Marko Manager of Programming: Michelle Mehrtens Scriptwriter: Dan Wolf Video Editor: Adam Benavides

Researchers analyzed tiny fossils embedded in the limestone to determine the age and origins of the grave maker, which marked the final resting place of a prominent Jamestown colonist

New research traces the genetic underpinnings of the enzyme amylase, which helps humans digest starches and sugars

The Pinecrest Queensway and Somerset West health centres are aiming to get a slice of $370 million of provincial funding to operate centres focused on addictions recovery and links to supportive housing.

Details remain scarce surrounding the death of a Canada Border Services Agency (CBSA) officer at the Ambassador Bridge on Saturday. The border authority and union said an employee died by suicide while on the job on the Windsor, Ont., side of the border. 

R&D ‘Sandbox’ Previews Some Potential Capabilities for 3D CAD Software

3D CAD Software’s Superior Data Translation Capabilities Support Growth of Tech Publishing and Engineering Services