DeepMind's cofounder and head of applied artificial intelligence, Mustafa Suleyman, has abruptly left the company for an indefinite period

The virtual-based office hours is to connect female founders with early-stage VC investors who will provide business advice and investments

For successful infection of their hosts, pathogenic bacteria recognize host-derived signals that induce the expression of virulence factors in a spatiotemporal manner. The fulminating food-borne pathogen Vibrio vulnificus produces a cytolysin/hemolysin protein encoded by the vvhBA operon, which is a virulence factor preferentially expressed upon exposure to murine blood and macrophages. The Fe-S cluster containing transcriptional regulator IscR activates the vvhBA operon in response to nitrosative stress and iron starvation, during which the cellular IscR protein level increases. Here, electrophoretic mobility shift and DNase I protection assays revealed that IscR directly binds downstream of the vvhBA promoter PvvhBA, which is unusual for a positive regulator. We found that in addition to IscR, the transcriptional regulator HlyU activates vvhBA transcription by directly binding upstream of PvvhBA, whereas the histone-like nucleoid-structuring protein (H-NS) represses vvhBA by extensively binding to both downstream and upstream regions of its promoter. Of note, the binding sites of IscR and HlyU overlapped with those of H-NS. We further substantiated that IscR and HlyU outcompete H-NS for binding to the PvvhBA regulatory region, resulting in the release of H-NS repression and vvhBA induction. We conclude that concurrent antirepression by IscR and HlyU at regions both downstream and upstream of PvvhBA provides V. vulnificus with the means of integrating host-derived signal(s) such as nitrosative stress and iron starvation for precise regulation of vvhBA transcription, thereby enabling successful host infection.

The peroxisome is a subcellular organelle that functions in essential metabolic pathways, including biosynthesis of plasmalogens, fatty acid β-oxidation of very-long-chain fatty acids, and degradation of hydrogen peroxide. Peroxisome biogenesis disorders (PBDs) manifest as severe dysfunction in multiple organs, including the central nervous system (CNS), but the pathogenic mechanisms in PBDs are largely unknown. Because CNS integrity is coordinately established and maintained by neural cell interactions, we here investigated whether cell-cell communication is impaired and responsible for the neurological defects associated with PBDs. Results from a noncontact co-culture system consisting of primary hippocampal neurons with glial cells revealed that a peroxisome-deficient astrocytic cell line secretes increased levels of brain-derived neurotrophic factor (BDNF), resulting in axonal branching of the neurons. Of note, the BDNF expression in astrocytes was not affected by defects in plasmalogen biosynthesis and peroxisomal fatty acid β-oxidation in the astrocytes. Instead, we found that cytosolic reductive states caused by a mislocalized catalase in the peroxisome-deficient cells induce the elevation in BDNF secretion. Our results suggest that peroxisome deficiency dysregulates neuronal axogenesis by causing a cytosolic reductive state in astrocytes. We conclude that astrocytic peroxisomes regulate BDNF expression and thereby support neuronal integrity and function.

Lethal infections by strains of the highly-pathogenic avian influenza virus (HPAIV) H5N1 pose serious threats to both the poultry industry and public health worldwide. A lack of confirmed HPAIV epitopes recognized by cytotoxic T lymphocytes (CTLs) has hindered the utilization of CD8+ T-cell–mediated immunity and has precluded the development of effectively diversified epitope-based vaccination approaches. In particular, an HPAIV H5N1 CTL-recognized epitope based on the peptide MHC-I–β2m (pMHC-I) complex has not yet been designed. Here, screening a collection of selected peptides of several HPAIV strains against a specific pathogen-free pMHC-I (pBF2*1501), we identified a highly-conserved HPAIV H5N1 CTL epitope, named HPAIV–PA123–130. We determined the structure of the BF2*1501–PA123–130 complex at 2.1 Å resolution to elucidate the molecular mechanisms of a preferential presentation of the highly-conserved PA123–130 epitope in the chicken B15 lineage. Conformational characteristics of the PA123–130 epitope with a protruding Tyr-7 residue indicated that this epitope has great potential to be recognized by specific TCRs. Moreover, significantly increased numbers of CD8+ T cells specific for the HPAIV–PA123–130 epitope in peptide-immunized chickens indicated that a repertoire of CD8+ T cells can specifically respond to this epitope. We anticipate that the identification and structural characterization of the PA123–130 epitope reported here could enable further studies of CTL immunity against HPAIV H5N1. Such studies may aid in the development of vaccine development strategies using well-conserved internal viral antigens in chickens.

VOLUME 294 (2019) PAGES 2555–2568Due to publisher error, “150 l/mm” was changed to “150 liters/mm” in the second paragraph of the “Vibrational spectroscopy of samples” section under “Experimental Procedures.” The correct phrase should be “150 l/mm.”

The C-type lectin receptors (CLRs) form a family of pattern recognition receptors that recognize numerous pathogens, such as bacteria and fungi, and trigger innate immune responses. The extracellular carbohydrate-recognition domain (CRD) of CLRs forms a globular structure that can coordinate a Ca2+ ion, allowing receptor interactions with sugar-containing ligands. Although well-conserved, the CRD fold can also display differences that directly affect the specificity of the receptors for their ligands. Here, we report crystal structures at 1.8–2.3 Å resolutions of the CRD of murine dendritic cell-immunoactivating receptor (DCAR, or Clec4b1), the CLR that binds phosphoglycolipids such as acylated phosphatidyl-myo-inositol mannosides (AcPIMs) of mycobacteria. Using mutagenesis analysis, we identified critical residues, Ala136 and Gln198, on the surface surrounding the ligand-binding site of DCAR, as well as an atypical Ca2+-binding motif (Glu-Pro-Ser/EPS168–170). By chemically synthesizing a water-soluble ligand analog, inositol-monophosphate dimannose (IPM2), we confirmed the direct interaction of DCAR with the polar moiety of AcPIMs by biolayer interferometry and co-crystallization approaches. We also observed a hydrophobic groove extending from the ligand-binding site that is in a suitable position to interact with the lipid portion of whole AcPIMs. These results suggest that the hydroxyl group-binding ability and hydrophobic groove of DCAR mediate its specific binding to pathogen-derived phosphoglycolipids such as mycobacterial AcPIMs.

(Michigan Medicine - University of Michigan) They know it's addictive. They know it's linked to dangerous lung diseases. And they know it delivers more nicotine than the cigarettes it's supposed to replace. But the social aspects of vaping drives young people to use Juul and other e-cigarettes, according to nearly two-thirds of teens and young adults in a new study. Less than 5% say the availability of fruity flavors drives use of e-cigarettes by members of their generation, and only 10% say addiction does.

(University of Houston) A University of Houston biomedical researcher is developing a new device to treat babies with blood disorders, because current technology is designed for adults. The ability to perform lifesaving leukapheresis safely and effectively in these most vulnerable pediatric patients will significantly increase their access to highly effective cell-based therapies.

(University of Illinois at Urbana-Champaign, News Bureau) University of Illinois classics professor Clara Bosak-Schroeder writes about how the ancient Greeks thought about natural resources and how it is relevant to responding to climate change today.

(Carnegie Mellon University) A new study developed a model of regulation in which the probability of a stricter standard being enacted increased with the proportion of firms in an industry that could meet the standard. The study found that regulations that consider the proportion of firms that can meet the new standard can motivate the development of a new green technology more effectively than regulations that do not consider this factor.

(St. Jude Children's Research Hospital) Funding will help expand collaboration across engineering and physical sciences to expand tools for studying pediatric diseases.

(The Institute of Medical Science, The University of Tokyo) Understanding the principles of cancer evolution is important in designing a therapeutic strategy. A research group at The Institute of Medical Science, The University of Tokyo (IMSUT) announced a new simulation model that describes various modes of cancer evolution in a unified manner.

(Carnegie Mellon University) A new study sought to determine how the impact of recommender systems (also called recommenders) is affected by factors such as product type, attributes, and other sources of information about products on retailers' websites. The study found that recommenders increased the number of consumer views of product pages as well as the number of products consumers consider, but that the increase was moderated by product attributes and review ratings.

(Northumbria University ) Researchers from Northumbria University have been awarded £1.2m to help advance our understanding of the Sun and its impact on the planets within our solar system.

(Aarhus University) An international team of researchers has put together a new image of Neanderthals based on the genes Neanderthals left in the DNA of modern humans when they had children with them about 50,000 years ago. The researchers found the new information by trawling the genomes of more than 27,000 Icelanders. Among other things, they discovered that Neanderthal children had older mothers and younger fathers than the Homo-Sapien children in Africa did at the time.

(American Chemical Society) When a dead body is found, one of the first things a forensic pathologist tries to do is estimate the time of death. There are several ways to do this, including measuring body temperature or observing insect activity, but these methods don't always work for corpses found in water. Now, researchers are reporting a mouse study in ACS' Journal of Proteome Research showing that certain proteins in bones could be used for this determination.

The streets of Chicago may be largely empty as residents hunker down from coronavirus but some of the city's most deprived neighborhoods are still echoing to the sound of deadly gunfire and raucous partying. While significant falls in crime have been one of the few positive side effects of lockdowns in much of the United States and elsewhere, they have barely made a dent in the homicide rate in Chicago, a city that has long recorded the most murders in the country. Chicago police say 56 murders were committed in April despite statewide stay-at-home orders -- only a fraction lower than the 61 for the same month in 2019 -- while last weekend, the first of the new month, four people were killed and 46 others shot and wounded.

The U.S. Navy is in “rough waters” and suffering from leadership failures, the diplomat tapped to be the next Navy secretary told a Senate committee Thursday. Kenneth J. Braithwaite, the ambassador to Norway and a retired Navy rear admiral, faced repeated questions about recent crises that have rocked the service, including the firing of an aircraft carrier captain who urged faster action to fight a coronavirus outbreak on his ship and the subsequent resignation of the acting secretary who fired him. Braithwaite said that Navy culture has been tarnished and trust in the service's leaders has broken down.

SAVANNAH—Gregory and Travis McMichael have been arrested and charged with murder and aggravated assault in connection with the February killing of Ahmaud Arbery, the Georgia Bureau of Investigation announced Thursday. According to police, the white father and son, 64 and 34, chased Arbery, a 25-year-old black man, after he ran by Travis McMichael’s home in the Satilla Shores neighborhood of Brunswick on Feb. 23. He was unarmed and jogging at the time. “This is a start towards victory,” Thea Brooks, Arbery’s aunt, told The Daily Beast on Thursday. “This only the beginning though, but this is what we were all hoping for.”The McMichaels said they believed Arbery was a burglar responsible for a series of break-ins in their neighborhood and that they pursued him in their pickup truck while armed with a shotgun and a .357 magnum. The GBI alleges the McMichaels confronted Arbery, and that Travis shot him. A local prosecutor previously indicated a third man, William Bryan, took part in the chase and filmed the incident.‘It’s Murder’: This Shooting of an Unarmed Black Man Is Roiling GeorgiaAt least two shots hit the 25-year-old, the Glynn County Coroner’s Office told The Daily Beast last week.Video that Brooks said depicted her nephew’s death elicited a furious reaction nationwide, and residents of the area protested the initial failure to prosecute a case on Tuesday.“It’s murder. It’s heartbreaking to even look at. The whole city has seen it,” Brooks told The Daily Beast after the video was released this week.The Georgia NAACP echoed her words in a Thursday response to the McMichaels’ arrest: “The murderers of Ahmaud Arbery have been arrested.”Gregory McMichael, a former cop and investigator with a local prosecutor’s office, previously told The Daily Beast he “never would have gone after someone for their color.” He also said the “closest version of the truth” about the incident was captured in a letter effectively clearing him and his son that was written by a prosecutor who recused himself from the case, George Barnhill. McMichael also admitted he had no direct evidence that Arbery was a thief. “But he’s the guy who’s there without permission,” he said from behind the closed front door of his son’s home.The owner of an unfinished home just down the street from Travis McMichael's home, Larry English, told The Daily Beast earlier this week that he had surveillance footage that appeared to show Arbery stopping to look at the foundation of his still-under-construction home. While Gregory McMichael claimed to police that Arbery had been caught on surveillance video, it was not immediately clear what video he was referring to. English told The Daily Beast he had no knowledge of the McMichaels seeing his surveillance footage. McMichael’s ties to law enforcement helped fuel a haze of suspicion around the killing from the beginning. Barnhill was one of two area prosecutors who looked into the incident before recusing themselves. A third prosecutor—District Attorney Tom Durden—sought a GBI probe ahead of the arrests this week.Read more at The Daily Beast.Got a tip? Send it to The Daily Beast hereGet our top stories in your inbox every day. Sign up now!Daily Beast Membership: Beast Inside goes deeper on the stories that matter to you. Learn more.

Russia's GRU military intelligence service appears to have got hold of many emails from Chancellor Angela Merkel's constituency office in a 2015 hack attack on Germany's parliament, Der Spiegel magazine reported on Friday, without citing its sources. A spokesman for the German government had no immediate comment. Der Spiegel said federal criminal police and the federal cyber agency had been able to partially reconstruct the attack and found that two email inboxes from Merkel's office had been targeted.

As part of the College's move to remote learning, 143 first-year students are taking a series of virtual field courses to investigate biodiversity.

(American Geriatrics Society) The American Geriatrics Society (AGS) annually honors researchers, clinicians, educators, and emerging health professionals who have made outstanding contributions to high-quality, person-centered care for older people. This year's award recipients include more than 20 leaders representing the breadth of disciplines championing care for us all as we age.

(Kessler Foundation) Andrew Houtenville, Ph.D., research director of the University of New Hampshire's Institute on Disability: 'Unlike the Great Recession and the Great Depression, many workers in the COVID Recession may be 'on temporary layoff' (aka furloughed) and may be recalled, rather than losing their jobs completely. To further investigate this issue, we plan to release a Special nTIDE Report on May 15.'

(American Geriatrics Society) The American Geriatrics Society (AGS) today announced that Ellen Flaherty, PhD, APRN, AGSF, an assistant professor at the Dartmouth Geisel School of Medicine and director of the Dartmouth Centers for Health & Aging, will deliver the society's prestigious Henderson State-of-the-Art Lecture. Dr. Flaherty will deliver her talk, Leveraging the Potential of Interprofessional Teams in Primary Care Practice, at the AGS 2021 Annual Scientific Meeting (#AGS21) in Chicago, Ill. (May 12-15, 2021).

(American Association for the Advancement of Science) While an effective vaccine for the SARS-CoV-2 virus is likely many months away, development could be accelerated by conducting controlled human infection (CHI) studies -- which are increasingly being considered by the scientific community due to the urgent need.

Chester B. Good
Oct 1, 2002; 15:
Articles

Stephen F. Quevedo
Oct 1, 2001; 14:
Feature Articles

Ruban Dhaliwal
Feb 1, 2014; 27:9-20
Research to Practice

Emmy Suhl
Oct 1, 2006; 19:234-240
Articles

Russell E. Glasgow
Apr 1, 2001; 14:
Feature Articles

Last month, Prime Minister Andrew Holness announced the establishment of an Economic Recovery Task Force, chaired by Finance Minister Dr Nigel Clarke. The multisectoral task force, which is mandated to oversee Jamaica's economic recovery from...

Having to witness your child go off to bed without a meal is not the most pleasing experience for a parent. However, this is the reality of Viviene Francis, who was laid off from her job as a bartender. Francis, who is a single mother, told THE...

Professor Tano Santos, Professor Ray Horton, and Dean Emeritus Glenn Hubbard discuss the impact of the pandemic on American and international political economies.

13 April 2018

Invitation Only Research Event

Event participants

Harriet Moynihan, Associate Fellow, International Law Programme, Chatham House
Dr Champa Patel, Head, Asia-Pacific Programme, Chatham House
Chair: Rod Wye, Associate Fellow, Asia-Pacific Programme, Chatham House

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