The Big Questions series features perspectives from the five recipients of the Department of Energy Office of Science's 2019 Distinguished Scientists Fellows Award describing their research and what they plan to do with the award. Ian Foster is the director of Argonne National Laboratory's Data Science and Learning Division.

Hi my angel Day 283 : Damn Each day is worse than the day before. “Time does not heal anything, it just teaches us how to deal with the pain . . .”

We got Storm when he was 13 weeks old as a companion for our Border Collie, Shadow. We decided on a Labrador because they were the opposite of BC's. Storm

You may have seen the news reports this week that German prosecutors have issued an arrest warrant for Dmitry Badin for a massive hack of the German Parliament that made headlines in 2016. The reports about the German arrest warrant all mention that German authorities "believe" that Badin is connected to the Russian GRU and its APT28 hacking group.

The folks over at Bellingcat have done their open source intelligence investigation thing, and provided a ton of evidence to show that Badin almost certainly is part of GRU... including the fact that he registered his 2018 car purchase to the public address of a GRU building. This is not the first time this has happened. A few years back, Bellingcat also connected a bunch of people to the GRU -- including some accused of hacking by the Dutch government -- based on leaked car registration info.

There's much, much more in the Bellingcat report, but the final paragraph really stands out. Bellingcat also found Badin -- again, a hacker who is suspected in multiple massive and consequential hacks, including of email accounts -- didn't seem to be all that careful with his own security:

The most surreal absence of “practice-what-you-breach” among GRU hackers might be visible in their lackadaisical attitude to their own cyber protection. In 2018, a large collection of hacked Russian mail accounts, including user name and passwords, was dumped online. Dmitry Badin’s email — which we figured out from his Skype account, which we in turn obtained from his phone number, which we of course got from his car registration — had been hacked. He had apparently been using the password Badin1990. After this, his email credentials were leaked again as part of a larger hack, where we see that he had changed his password from Badin1990 to the much more secure Badin990.

Yes, the password for at least one of his email accounts... was apparently his own last name and the year he was born. The cobbler's kids go shoeless again.

Pretty sure we’ve all heard Tom Lehrer’s “Lobachevsky,” right? A song about plagiarism where all the bits of melody are...

Recent advancements in Machine Learning (ML) have taught us two main lessons: a large proportion of things that humans do can actually be automated, and that a substantial part of this automation can be done with minimal human supervision. One no longer needs to select features for models to use; in many cases people are … Continue reading Three Paper Thursday: Adversarial Machine Learning, Humans and everything in between →

Automated operators can pay up like anyone – or anything – else

Microsoft has detailed a new form of software licence it offers to non-human users.…

The bartender says “You can’t have that thing in here! Get out!” The guy says “It’s okay, this Alligator is highly trained. Just give me a few seconds and I’ll show you.” The bartender, intrigued, gives him the go-ahead. The man gingerly lifts the alligator up onto a table. By this point, everybody in the […]

The post A Man Walks Into A Bar With An Alligator On A Leash appeared first on Funny & Jokes.

Date: May 8, 2020

As COVID-19 continues to impact communities around the world, people and families everywhere are spending more time at home. In light of this, we’re launching a throwback Doodle series looking back at some of our popular interactive Google Doodle games!

Stay and play at home with today’s featured throwback: 

Our 2010 Doodle game celebrating PAC-MAN!
 

Help stop the spread of COVID-19 by following these steps.  
 

Learn more here about the latest ways we’re responding, and how our products can help people stay connected during this time.

Location: Global

Tags:

The post Reel Review: What’s New with the Shimano Stella SW 2020? appeared first on Ocean Blue Fishing Adventures.

Levodopa-induced dyskinesia (LID) poses a significant health care challenge for Parkinson’s disease (PD) patients. Amantadine is currently the only drug proven to alleviate LID. Although its efficacy in treating LID is widely assumed to be mediated by blockade of N-methyl-D-aspartate (NMDA) glutamate receptors, our experiments demonstrate that at therapeutically relevant concentrations, amantadine preferentially blocks inward-rectifying K+ channel type 2 (Kir2) channels in striatal spiny projection neurons (SPNs) — not NMDA receptors. In so doing, amantadine enhances dendritic integration of excitatory synaptic potentials in SPNs and enhances — not antagonizes — the induction of long-term potentiation (LTP) at excitatory, axospinous synapses. Taken together, our studies suggest that the alleviation of LID in PD patients is mediated by diminishing the disparity in the excitability of direct- and indirect-pathway SPNs in the on state, rather than by disrupting LTP induction. This insight points to a pharmacological approach that could be used to effectively ameliorate LID and improve the quality of life for PD patients.

BACKGROUND Mirabegron is a β3-adrenergic receptor (β3-AR) agonist approved only for the treatment of overactive bladder. Encouraging preclinical results suggest that β3-AR agonists could also improve obesity-related metabolic disease by increasing brown adipose tissue (BAT) thermogenesis, white adipose tissue (WAT) lipolysis, and insulin sensitivity.METHODS We treated 14 healthy women of diverse ethnicities (27.5 ± 1.1 years of age, BMI of 25.4 ± 1.2 kg/m2) with 100 mg mirabegron (Myrbetriq extended-release tablet, Astellas Pharma) for 4 weeks in an open-label study. The primary endpoint was the change in BAT metabolic activity as measured by [18F]-2-fluoro-d-2-deoxy-d-glucose (18F-FDG) PET/CT. Secondary endpoints included resting energy expenditure (REE), plasma metabolites, and glucose and insulin metabolism as assessed by a frequently sampled intravenous glucose tolerance test.RESULTS Chronic mirabegron therapy increased BAT metabolic activity. Whole-body REE was higher, without changes in body weight or composition. Additionally, there were elevations in plasma levels of the beneficial lipoprotein biomarkers HDL and ApoA1, as well as total bile acids. Adiponectin, a WAT-derived hormone that has antidiabetic and antiinflammatory capabilities, increased with acute treatment and was 35% higher upon completion of the study. Finally, an intravenous glucose tolerance test revealed higher insulin sensitivity, glucose effectiveness, and insulin secretion.CONCLUSION These findings indicate that human BAT metabolic activity can be increased after chronic pharmacological stimulation with mirabegron and support the investigation of β3-AR agonists as a treatment for metabolic disease.TRIAL REGISTRATION Clinicaltrials.gov NCT03049462.FUNDING This work was supported by grants from the Intramural Research Program of the NIDDK, NIH (DK075112, DK075116, DK071013, and DK071014).

BACKGROUND The live attenuated BPZE1 vaccine candidate induces protection against B. pertussis and prevents nasal colonization in animal models. Here we report on the responses in humans receiving a single intranasal administration of BPZE1.METHODS We performed multiple assays to dissect the immune responses induced in humans (n = 12) receiving BPZE1, with particular emphasis on the magnitude and characteristics of the antibody responses. Such responses were benchmarked to adolescents (n = 12) receiving the complete vaccination program of the currently used acellular pertussis vaccine (aPV). Using immunoproteomics analysis, potentially novel immunogenic B. pertussis antigens were identified.RESULTS All BPZE1 vaccinees showed robust B. pertussis–specific antibody responses with regard to significant increase in 1 or more of the following parameters: IgG, IgA, and memory B cells to B. pertussis antigens. BPZE1–specific T cells showed a Th1 phenotype, and the IgG exclusively consisted of IgG1 and IgG3. In contrast, all aPV vaccines showed a Th2-biased response. Immunoproteomics profiling revealed that BPZE1 elicited broader and different antibody specificities to B. pertussis antigens as compared with the aPV that primarily induced antibodies to the vaccine antigens. Moreover, BPZE1 was superior at inducing opsonizing antibodies that stimulated ROS production in neutrophils and enhanced bactericidal function, which was in line with the finding that antibodies against adenylate cyclase toxin were only elicited by BPZE1.CONCLUSION The breadth of the antibodies, the Th1-type cellular response, and killing mechanisms elicited by BPZE1 may hold prospects of improving vaccine efficacy and protection against B. pertussis transmission.TRIAL REGISTRATION ClinicalTrials.gov NCT02453048, NCT00870350.FUNDING ILiAD Biotechnologies, Swedish Research Council (Vetenskapsrådet), Swedish Heart-Lung Foundation.

BACKGROUND Beige adipose tissue is associated with improved glucose homeostasis in mice. Adipose tissue contains β3-adrenergic receptors (β3-ARs), and this study was intended to determine whether the treatment of obese, insulin-resistant humans with the β3-AR agonist mirabegron, which stimulates beige adipose formation in subcutaneous white adipose tissue (SC WAT), would induce other beneficial changes in fat and muscle and improve metabolic homeostasis.METHODS Before and after β3-AR agonist treatment, oral glucose tolerance tests and euglycemic clamps were performed, and histochemical analysis and gene expression profiling were performed on fat and muscle biopsies. PET-CT scans quantified brown adipose tissue volume and activity, and we conducted in vitro studies with primary cultures of differentiated human adipocytes and muscle.RESULTS The clinical effects of mirabegron treatment included improved oral glucose tolerance (P < 0.01), reduced hemoglobin A1c levels (P = 0.01), and improved insulin sensitivity (P = 0.03) and β cell function (P = 0.01). In SC WAT, mirabegron treatment stimulated lipolysis, reduced fibrotic gene expression, and increased alternatively activated macrophages. Subjects with the most SC WAT beiging showed the greatest improvement in β cell function. In skeletal muscle, mirabegron reduced triglycerides, increased the expression of PPARγ coactivator 1 α (PGC1A) (P < 0.05), and increased type I fibers (P < 0.01). Conditioned media from adipocytes treated with mirabegron stimulated muscle fiber PGC1A expression in vitro (P < 0.001).CONCLUSION Mirabegron treatment substantially improved multiple measures of glucose homeostasis in obese, insulin-resistant humans. Since β cells and skeletal muscle do not express β3-ARs, these data suggest that the beiging of SC WAT by mirabegron reduces adipose tissue dysfunction, which enhances muscle oxidative capacity and improves β cell function.TRIAL REGISTRATION Clinicaltrials.gov NCT02919176.FUNDING NIH: DK112282, P30GM127211, DK 71349, and Clinical and Translational science Awards (CTSA) grant UL1TR001998.

It’s release day for my new MM romance! My last release was Christmas 2018, so I’m very excited to finally have a new book for you. When I was in Australia earlier this year, I got hooked on Bondi Rescue, and this (completely fictional!) romance between a trainee and an older, very closeted lifeguard was born. […]

You can grab four steamy and sweet MM holiday romances in one box set for a major discount! This new collection is only $6.99 or you can borrow it in KU. I’m also very excited that these novellas are available in print for the first time! ???? Buy the ebook box set exclusively at Amazon […]

“Looking for a fun and sweet holiday romance with dual POV, some heat, a humorous caper, and a wonderful HEA ending? Look no further!” ~ Gay Book Reviews Fa-la-la-la-la! My new holiday romance is now available to buy or borrow in KU! You’ve got fake boyfriends, bisexual exploration, found family, a single dad in desperate need […]

My figure skating romance has a new (old) title! Misha and Dev’s story was originally two novellas published through Loose Id called Cold War and Holding the Edge. I later combined them into one volume to give you more bang for your buck. To avoid confusion, I called the book The Winning Edge. However, Cold War is frankly just a much better […]

Apple today announced that it will begin reopening its retail stores in Germany on May 11, nearly two months after they were closed due to the global health crisis.


In a statement shared with German website Macerkopf, Apple said the stores will initially be focusing on Genius Bar service and support. Enhanced health and safety measures will be implemented, such as body temperature checks prior to entry, limits on how many customers can be in the store at once, social distancing, and reduced hours of operation.

Apple operates 15 retail stores in Germany and will be posting specific hours of operation for each location on its website.

Apple closed all of its retail stores outside of the Greater China region in mid-March. The company has since started to reopen some locations, including in South Korea, Austria, and Australia. All locations in the United States remain closed.

Erowid Exp104849

Erowid Exp113948

Cornel West and Tavis Smiley criticize President Barack Obama for being to the right of even President Richard Nixon. Continue reading →

A year ago this month the U.S. Department of Justice announced that the banking giant JPMorgan Chase would avoid criminal charges by agreeing to pay $13 billion to settle claims that it had routinely overstated the quality of mortgages it … Continue reading →

we know how politics works in the United States. Whoever—whatever political party gets into government is going to merge with the bureaucracy pretty damn fast. It will be in a position where it has some levers in its hand. And so, as a result, corporate lobbyists will move in to help control those levers. So it doesn’t make much difference in the end. What does make a difference is political accountability, a general deterrence set to stop political organizations behaving in a corrupt manner. Continue reading →

"And you know, we have to stop looking beyond this election cycle and see that this corporate driven ideology, you know, this commodification of the culture, this constant extracting of blood from us as citizens to pay what in essence were private debts of the banks which engaged in casino capitalism, has political consequences. History has taught us that. And Hillary Clinton is only going to further that process." Continue reading →

Donald Trump sold out his supporters and the 99% by selecting Wall Streeters and war mongers for his top cabinet positions. Continue reading →

MARTY FRIEDMAN сообщил о том, что долгожданная документальная лента о нём — "Spacefox" (первоначально называвшаяся "Hebi Metal San"), режиссёром которой является Jeremy Frindel, выйдет в следующем году:

«Я закончил документалку, она в работе, нужно всё смонтировать и добавить кое-какие съёмки. Мы думали о том, чтобы добавить фрагменты с моего выступления на Tokyo Marathon, но этого не случилось по понятным причинам.

Документальные фильмы могут порой занимать огромное количество времени. Но я видел основу, и всё довольно весело. И надеюсь, что она будет выпущена в следующем году. Но как знать — пока никакой конкретной даты нет. Но материал я видел, и видел черновой монтаж. И надеюсь, что после того, как будет добавлено кое-что новое, мы сделаем и яркий финал. Но это же не закончившаяся история, так что чем заканчивать? Но думаю, что всё будет выпущено в следующем году». #Marty_Friedman #MartyFriedman #HardRock #Hard_Rock #SymphonicRock #Symphonic_Rock #InstrumentalMetal #Instrumental_Metal #HeavyMetal #Heavy_Metal #IndustrialMetal #Industrial_Metal

The indie cinema chain is going digital.

The post Studio Coffee Run 5/8/20: Alamo On Demand brings new and old films to your home theater appeared first on The Beat.

Plus more ways to support comics creators and new authors launching their books worldwide while social distancing!

The post Social Distancing Roundup: JOHN WICK Livestream, Neil Gaiman reads CORALINE, and an X-MEN ’92 watchalong appeared first on The Beat.

Real heroes deserve their own comics/Los héroes reales merecen sus propios comics

The post Heroes always come home in David Rubín’s free COVID-19 SUPERMAN story (version en español incluída) appeared first on The Beat.

Now that’s a name I haven’t heard in a long time…

The post Heads up: TEMUERA MORRISON will be THE MANDALORIAN’s Boba Fett appeared first on The Beat.

As the 2015 Atlantic hurricane season gets underway, communities in severe weather-prone regions are anxiously tracking pending storms and working to create effective disaster response plans. IBM, through its strategic alliance with The Weather Company and its global B2B division WSI, today announced a new emergency management solution that features sophisticated analytics and the use of real-time weather data to help communities predict and plan for natural disasters far more accurately and deploy the right resources in advance.

ISS, ISS A/S, a leading global provider of facility services, has signed a commercial agreement with IBM to use the power of Watson IoT to transform the management of over 25,000 buildings around the world.

IBM and Stone Ridge Technology today announced a performance milestone in reservoir simulation designed to help improve efficiency and lower the cost of production. Working with NVIDIA, the companies shattered previous published results using one-tenth the power and 1/100th of the space. The news demonstrates the ability of NVIDIA GPUs to simulate one billion cell models in a fraction of the published time, while delivering 10x the performance and efficiency than legacy CPU codes.

IBM today announced that according to results from International Data Corporation (IDC) Worldwide Quarterly Server Tracker®(June, 2017) IBM has achieved market growth by 3x compared with the total Linux server market which grew at +6 percent. The improved performance are the result of success across IBM Power Systems including IBM’s OpenPOWER LC servers and IBM Power Systems running SAP HANA as well as the OpenPOWER-Ready servers developed through the OpenPOWER Foundation.

IBM today announced two significant milestones in making the on-premises IBM Cloud Object Storage System much more accessible for customers with new compliance-enabled vaults and concentrated dispersal mode capabilities.

IBM Security today announced it has been positioned by Gartner, Inc. as a Leader for the sixth consecutive year in the Magic Quadrant for Enterprise Mobility Management Suites1 for its ability to execute and completeness of vision.

IBM and West Virginia University’s Center for Disability Inclusion (CDI) today announced they are developing a first generation mobile workplace accommodation case management app to help U.S. businesses create inclusive workplaces for employees with disabilities.

IBM today announced that Vissensa, a UK-based managed service provider (MSP), has taken delivery of the IBM Enterprise Cloud System, which will help the company offer new and improved cloud services to its customers.

MAP Health Management and IBM Watson Health today announced a partnership that aims to address the pervasive problem of relapse among Americans suffering from Substance Use Disorder, a chronic disease. MAP will integrate Watson cognitive technologies into the MAP Recovery Network Platform to enhance the platform’s existing capabilities around patient risk models. In doing so, it is anticipated that behavioral health and substance abuse treatment providers that use the MAP platform will be better able to predict and prevent incidence of relapse nationwide.

IBM today announced that Joanne Wright, Vice President, IBM Watson Supply Chain and Jeanette Barlow, Vice President of Offering Management and Strategy for IBM Watson Supply Chain will be participating in the “Industry Value Chain Exchange Series,” part of the Gartner Supply Chain Management Executive Conference. The conference takes place from May 23-25 in Phoenix, Arizona.

IBM today announced that for the seventh consecutive year, Gartner, Inc. has named IBM as a leader in the April 2017 Gartner Magic Quadrant for Multichannel Campaign Management.

[Image: Der Wanderer über dem Nebelmeer by Caspar David Friedrich (c. 1818).] It would be interesting to look at locations of the American popular imagination, as seen in movies and TV, mapped against regional tax breaks for the film industry. There was a brief span of time, for example, when rural Pennsylvania stood in for … Continue reading "Tax Incentives and the Human Imagination"

[Image: An otherwise unrelated photo of fire-fighting foam, via Wikipedia.] There are at least two classes of materials that have always interested me: synthetic materials designed to be so resistant and indestructible that they verge on a kind of supernatural longevity, and engineered biomaterials, such as enzymes or microbes, designed to consume exactly these sorts … Continue reading "Fables of the Permanent and Insatiable"