(University of Illinois at Urbana-Champaign, News Bureau) University of Illinois classics professor Clara Bosak-Schroeder writes about how the ancient Greeks thought about natural resources and how it is relevant to responding to climate change today.

This week host Matt Egan is rejoined by Macworld.co.uk acting editor David Price to chat about Apple's latest Macbook announcements. Then online editor at ComputerworldUK Christina Mercer jumps in to give a break down of Google's fight with the EU over antitrust infringements (13:00). Finally, ex-dating app user Scott Carey, online editor at Techworld.com gives a state of the union on dating apps, from Tinder to Bumble to Happn, if they are good for society and which one is set to corner the market (27:00).  

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Inflammation contributes to ventricular remodeling after myocardial ischemia, but its role in nonischemic heart failure is poorly understood. Local tissue inflammation is difficult to assess serially during pathogenesis. Although ¹⁸F-FDG accumulates in inflammatory leukocytes and thus may identify inflammation in the myocardial microenvironment, it remains unclear whether this imaging technique can isolate diffuse leukocytes in pressure-overload heart failure. We aimed to evaluate whether inflammation with ¹⁸F-FDG can be serially imaged in the early stages of pressure-overload–induced heart failure and to compare the time course with functional impairment assessed by cardiac MRI. Methods: C57Bl6/N mice underwent transverse aortic constriction (TAC) (n = 22), sham surgery (n = 12), or coronary ligation as an inflammation-positive control (n = 5). MRI assessed ventricular geometry and contractile function at 2 and 8 d after TAC. Immunostaining identified the extent of inflammatory leukocyte infiltration early in pressure overload. ¹⁸F-FDG PET scans were acquired at 3 and 7 d after TAC, under ketamine-xylazine anesthesia to suppress cardiomyocyte glucose uptake. Results: Pressure overload evoked rapid left ventricular dilation compared with sham (end-systolic volume, day 2: 40.6 ± 10.2 μL vs. 23.8 ± 1.7 μL, P < 0.001). Contractile function was similarly impaired (ejection fraction, day 2: 40.9% ± 9.7% vs. 59.2% ± 4.4%, P < 0.001). The severity of contractile impairment was proportional to histology-defined myocardial macrophage density on day 8 (r = –0.669, P = 0.010). PET imaging identified significantly higher left ventricular ¹⁸F-FDG accumulation in TAC mice than in sham mice on day 3 (10.5 ± 4.1 percentage injected dose [%ID]/g vs. 3.8 ± 0.9 %ID/g, P < 0.001) and on day 7 (7.8 ± 3.7 %ID/g vs. 3.0 ± 0.8 %ID/g, P = 0.006), though the efficiency of cardiomyocyte suppression was variable among TAC mice. The ¹⁸F-FDG signal correlated with ejection fraction (r = –0.75, P = 0.01) and ventricular volume (r = 0.75, P < 0.01). Western immunoblotting demonstrated a 60% elevation of myocardial glucose transporter 4 expression in the left ventricle at 8 d after TAC, indicating altered glucose metabolism. Conclusion: TAC induces rapid changes in left ventricular geometry and contractile function, with a parallel modest infiltration of inflammatory macrophages. Metabolic remodeling overshadows inflammatory leukocyte signal using ¹⁸F-FDG PET imaging. More selective inflammatory tracers are requisite to identify the diffuse local inflammation in pressure overload.

TODAY Study Group
Jun 1, 2013; 36:1758-1764
TODAY Study

TODAY Study Group
Jun 1, 2013; 36:1735-1741
TODAY Study

TODAY Study Group
Jun 1, 2013; 36:1749-1757
TODAY Study

The Commission on Dental Accreditation announced April 3 that it directed all CODA-accredited dental programs to submit a report by May 15 on their use of distance learning, enhanced activities and other educational modalities in response to the COVID-19 pandemic.

The Commission on Dental Accreditation announced April 3 that it will reschedule all postponed and remaining site visits this year, including regular/reaccreditation and special focused site visits, to 2021 in response to the COVID-19 pandemic.

This Migration Policy Institute Europe webinar examines possible scenarios for how social, economic, and technological trends could affect jobs, labor market policy, education and social policies, and migrant integration. Speakers also explored the potential of coding schools for refugees to help alleviate skills shortages and provide a pathway to work.

This policy brief traces the successes and failures of the 1986 Immigration Reform and Control Act, which represented the first and most comprehensive legislation to take on the issue of illegal immigration to the United States. The brief makes the case that IRCA's major flaws were rooted in statutory design more than regulatory challenges and implementation by the administrative agencies.

For years, economists have taught their students a simple maxim: As employers hunt for workers, they want to get the best talent at the lowest price.

What do the war in Iraq, your Christmas shopping and this week's Thanksgiving dinner have in common?

So simple and so sensational. Lots of cultures have a version of this but I love Fijian food.. Fijians are so full of happiness and it crosses over to their cuisine.

170g/6oz self-raising wholemeal flour 170g/6oz plain flour 1/2 tsp salt 1/2 tsp bicarbonate of soda 290ml/1/2 pint buttermilk

What’s going on in the world of sex research today? What are some of the biggest controversies and challenges? I recently sat down with a few of my colleagues to discuss these and other interesting questions. In the video below, I chat with Drs. Zhana Vrangalova (New York University), Diana Fleischman (University of Portsmouth), and Geoffrey Miller (University of New Mexico).

Rhode Island may become the first state to adopt the Next Generation Science Standards. The state board will vote later today.

Mass media -- Political aspects -- United States.

Common good.

Argentorati : Sumtibus Amandi Koenig, 1786-1787.

Paris : V. Masson, 1867.

Alessandro Casa, José E. Chacón, Giovanna Menardi.

Source: Electronic Journal of Statistics, Volume 14, Number 1, 835--856.

Abstract:
Density-based clustering relies on the idea of linking groups to some specific features of the probability distribution underlying the data. The reference to a true, yet unknown, population structure allows framing the clustering problem in a standard inferential setting, where the concept of ideal population clustering is defined as the partition induced by the true density function. The nonparametric formulation of this approach, known as modal clustering, draws a correspondence between the groups and the domains of attraction of the density modes. Operationally, a nonparametric density estimate is required and a proper selection of the amount of smoothing, governing the shape of the density and hence possibly the modal structure, is crucial to identify the final partition. In this work, we address the issue of density estimation for modal clustering from an asymptotic perspective. A natural and easy to interpret metric to measure the distance between density-based partitions is discussed, its asymptotic approximation explored, and employed to study the problem of bandwidth selection for nonparametric modal clustering.

This paper studies the nonparametric modal regression problem systematically from a statistical learning viewpoint. Originally motivated by pursuing a theoretical understanding of the maximum correntropy criterion based regression (MCCR), our study reveals that MCCR with a tending-to-zero scale parameter is essentially modal regression. We show that the nonparametric modal regression problem can be approached via the classical empirical risk minimization. Some efforts are then made to develop a framework for analyzing and implementing modal regression. For instance, the modal regression function is described, the modal regression risk is defined explicitly and its Bayes rule is characterized; for the sake of computational tractability, the surrogate modal regression risk, which is termed as the generalization risk in our study, is introduced. On the theoretical side, the excess modal regression risk, the excess generalization risk, the function estimation error, and the relations among the above three quantities are studied rigorously. It turns out that under mild conditions, function estimation consistency and convergence may be pursued in modal regression as in vanilla regression protocols such as mean regression, median regression, and quantile regression. On the practical side, the implementation issues of modal regression including the computational algorithm and the selection of the tuning parameters are discussed. Numerical validations on modal regression are also conducted to verify our findings.

Francisco Cribari-Neto, Rodney V. Fonseca.

Source: Brazilian Journal of Probability and Statistics, Volume 33, Number 2, 329--355.

Abstract:
The log-linear Birnbaum–Saunders model has been widely used in empirical applications. We introduce an extension of this model based on a recently proposed version of the Birnbaum–Saunders distribution which is more flexible than the standard Birnbaum–Saunders law since its density may assume both unimodal and bimodal shapes. We show how to perform point estimation, interval estimation and hypothesis testing inferences on the parameters that index the regression model we propose. We also present a number of diagnostic tools, such as residual analysis, local influence, generalized leverage, generalized Cook’s distance and model misspecification tests. We investigate the usefulness of model selection criteria and the accuracy of prediction intervals for the proposed model. Results of Monte Carlo simulations are presented. Finally, we also present and discuss an empirical application.

In this paper we propose a bimodal gamma distribution using a quadratic transformation based on the alpha-skew-normal model. We discuss several properties of this distribution such as mean, variance, moments, hazard rate and entropy measures. Further, we propose a new regression model with censored data based on the bimodal gamma distribution. This regression model can be very useful to the analysis of real data and could give more realistic fits than other special regression models. Monte Carlo simulations were performed to check the bias in the maximum likelihood estimation. The proposed models are applied to two real data sets found in literature.

Jose Ameijeiras-Alonso, Akli Benali, Rosa M. Crujeiras, Alberto Rodríguez-Casal, José M. C. Pereira.

Source: The Annals of Applied Statistics, Volume 13, Number 4, 2120--2139.

Abstract:
Understanding the role of vegetation fires in the Earth system is an important environmental problem. Although fire occurrence is influenced by natural factors, human activity related to land use and management has altered the temporal patterns of fire in several regions of the world. Hence, for a better insight into fires regimes it is of special interest to analyze where human activity has altered fire seasonality. For doing so, multimodality tests are a useful tool for determining the number of annual fire peaks. The periodicity of fires and their complex distributional features motivate the use of nonparametric circular statistics. The unsatisfactory performance of previous circular nonparametric proposals for testing multimodality justifies the introduction of a new approach, considering an adapted version of the excess mass statistic, jointly with a bootstrap calibration algorithm. A systematic application of the test on the Russia–Kazakhstan area is presented in order to determine how many fire peaks can be identified in this region. A False Discovery Rate correction, accounting for the spatial dependence of the data, is also required.

The capacity to process information in conceptual form is a fundamental aspect of human cognition, yet little is known about how this type of information is encoded in the brain. Although the role of sensory and motor cortical areas has been a focus of recent debate, neuroimaging studies of concept representation consistently implicate a network of heteromodal areas that seem to support concept retrieval in general rather than knowledge related to any particular sensory-motor content. We used predictive machine learning on fMRI data to investigate the hypothesis that cortical areas in this "general semantic network" (GSN) encode multimodal information derived from basic sensory-motor processes, possibly functioning as convergence–divergence zones for distributed concept representation. An encoding model based on five conceptual attributes directly related to sensory-motor experience (sound, color, shape, manipulability, and visual motion) was used to predict brain activation patterns associated with individual lexical concepts in a semantic decision task. When the analysis was restricted to voxels in the GSN, the model was able to identify the activation patterns corresponding to individual concrete concepts significantly above chance. In contrast, a model based on five perceptual attributes of the word form performed at chance level. This pattern was reversed when the analysis was restricted to areas involved in the perceptual analysis of written word forms. These results indicate that heteromodal areas involved in semantic processing encode information about the relative importance of different sensory-motor attributes of concepts, possibly by storing particular combinations of sensory and motor features.

SIGNIFICANCE STATEMENT The present study used a predictive encoding model of word semantics to decode conceptual information from neural activity in heteromodal cortical areas. The model is based on five sensory-motor attributes of word meaning (color, shape, sound, visual motion, and manipulability) and encodes the relative importance of each attribute to the meaning of a word. This is the first demonstration that heteromodal areas involved in semantic processing can discriminate between different concepts based on sensory-motor information alone. This finding indicates that the brain represents concepts as multimodal combinations of sensory and motor representations.

[London] : Cleanair, Campaña para un Medio Ambiente Libre de Humo, [198-?]

Jared W. Young
Mar 4, 2009; 29:2663-2665
Journal Club

Fatma Deniz
Sep 25, 2019; 39:7722-7736
BehavioralSystemsCognitive

Mar del Plata, Argentina :: Crew work alongside a pastor who has plans to improve children's futures.

Smithsonian folklorist James Deutsch says the fast spread of stories and memes are cultural expressions that build cohesion and support

Distant notes |India Today Insight  India Today

Hobbies during quarantine: How they can help us in a pandemic  Today.com

Ralph Goodale says building water diversion conduits in Lake Diefenbaker could help grow Saskatchewan's economy and environment but it comes with a $3 billion price tag.

Here's a look at what's happening in our area on Thursday, May 7.

Here's a look at what's happening in our area on Friday, May 8.

The post 3DEXPERIENCE World – Building tomorrow today with our Education Community appeared first on SOLIDWORKS Education Blog.

Bank of Italy Working Papers by Concetta Rondinelli and Roberta Zizza

In what are the lowest prices we've seen on Mid 2019 15-inch MacBook Pros, Amazon-owned Woot has refurbished units discounted to as low as $1,579.99, with savings of up to $950 off. These units are refurbished by Apple, but come with a 1-year Woot warranty.

Such was the truth God gave the Artslink, Dancelink and Bill Drake Band teams for Baja, Hungary, from 10-17 July 2011. The results were eternal.

Soda bread is a quick and simple treat to make. I think most of you will have all of these ingredients in your cupboards right now. Soda bread is traditionally made with bicarbonate soda instead of yeast. Here I have added honey and oats for a slight flavour difference.

Concern of the risk of malignancy from ionizing radiation has prompted many to advocate for judicious use of computed tomography (CT) and as low as necessary radiation doses administered per scan. Recent analysis has shown a decline in CT utilization.

We identified decreases in CT utilization between 2004 and 2012 for the 10 most common diagnostic groups receiving CT. Decreases were typically associated with increases in alternate imaging modalities. We provide a possible reason for the decrease in CT utilization. (Read the full article)

Target is offering a buy two, get one free deal on hundreds of Star Wars items, including toys, clothing, bedding, and more.

Source: theweek.com - Saturday, May 09, 2020
1. The Labor Department on Friday said that 20.5 million jobs were lost in April, and the unemployment rate climbed to 14.7 percent. The staggering report showed that a decade of job gains were wiped out in just one month. The report also notes that if it included workers classified as furloughed or temporarily laid off, "the overall unemployment rate would have been almost 5 percentage points higher than reported." The Labor Department's March report showed the unemployment rate climbing to 4.4 percent, from 3.5 percent in February. Weekly data previously showed that more than 33 million Americans have filed initial jobless claims over the course of seven weeks, a number that's equivalent to about 21 percent of the labor force. The ADP National Employment Report also said earlier this week that 20.2 million private sector jobs were lost from March to April. President Trump, who was live on Fox & Friends the moment the report was released, described the unemployment numbers as "fully expected" and "no surprise." [ U.S. Bureau of Labor Statistics , The Washington Post ] 2. The Office of Special Counsel is recommending that ousted vaccine official Dr. Rick Bright be reinstated while it investigates his case, his lawyers announced Friday. Bright, while leading coronavirus vaccine development, was recently removed from his position as the director of the Department of Health and Human Services' Biomedical Advanced Research and Devel

You won't want to miss these great deals.

Given that GoDaddy's GoCentral Online Store is an add-on service to its web hosting product, you'll find its features a little more limited than much of the competition. But if you're a GoDaddy customer, then it's a great way to start quickly.