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The rumoured iPhone 17 Air may not be as thin as Apple hoped it would be

Manufacturing means Apple may not be able to make the iPhone as thin as it wants to. #iphone17air #apple #iphone



  • Reads from WWW

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Lenovo updates its Thinkpad notebooks with local pricing and availability details

Do any of these new Lenovo AI-powered notebooks make you want to spend your dollars? #lenovo #copilot+ #ai




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Elon Musk joining Trump's team would not impact EU Commission's X probes

Elon Musk joining Trump's team would not impact EU Commission's X probes




not

One Touch is Not Enough

In this video I would like to talk about the Managed Services sales cycle.

Source: One Touch is Not Enough - Technibble.com



  • MSP Marketing Strategy

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Your MSP is Not Making Enough Offers

Boost your MSP revenue by making more offers! Learn how consistent selling, even through soft offers, can help you grow your business without the discomfort

Source: Your MSP is Not Making Enough Offers - Technibble.com



  • MSP Content Marketing
  • MSP Marketing Strategy

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How We Will Really Find E.T. — Not with a Message, But with a Molecule

The grand discovery of alien life is likely to come in the form of frustratingly subtle chemical clues.




not

The Latest News out of the Arctic Is Mixed — and That's Not Good

The extent of Arctic sea ice may not look as dire right now as in some recent years, but beneath the surface (literally and figuratively), there’s still plenty reason for concern.




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Magnesium May Reduce Risk of Dementia — But It’s Not That Simple

Magnesium-rich foods may help lower dementia risk and boost brain health, but experts agree a well rounded diet is your best bet.




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While Not as Cute as Dogs, Giant Rats Are Excellent at Sniffing Out Illicit Goods

Rodents could be used to find illicit goods at airports and harbors in places where dogs can’t easily access.




not

Cringing at That Old Facebook Post? You’re Not the Only One

There are several reasons to feel this way, and a few ways to cope with the feeling.




not

Not in solitude

Location: Special Collections Hevelin Collection- PS3513.A575N6 1961




not

Congress debates women and the draft, but not war and the draft

"Firestorm erupts over requiring women to sign up for military draft", reads the headline on a story today on TheHill.com.

Unfortunately, that firestorm amounts mostly to an exchange of sound bites and social-media posts, not a real debate, much less a hearing with independent witnesses, in either the House or Senate. It focuses on the proposal included in the Senate version of the annual National Defense [sic] Authorization Act (NDAA) to expand registration with the Selective Service System to include young women as well as young men, rather than on what may be a more significant proposal in the House version of the same bill to try to make draft registration automatic by basing the list of potential draftees on information aggregated from other Federal records rather than provided by registrants themselves -- denying potential draftees the chance to indicate their opposition to being drafted, and to obstruct the mobilization for total war, by opting out of draft registration.

Most importantly, the current "debate" ignores both the profound and quite possibly insolvable practical problems with trying to compile a registry of potential draftees from other existing Federal databases, and the more fundamental issue with any contingency planning or preparation for a draft: the way that, even when a draft is not active, the perceived availability of a draft as a fallback emboldens warmakers to embark on wars that people wouldn't volunteer to fight.




not

The Rediscovery of Synchronous Reluctance and Ferrite Permanent Magnet Motors Tutorial Course Notes

Location: Electronic Resource- 




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Regenerative Medicine - from Protocol to Patient 3. Tissue Engineering, Biomaterials and Nanotechnology

Location: Electronic Resource- 




not

Top notch developer - Tel Aviv

Technical requirements
Great flash / flex developer.
The ideal candidate will have knowledge of open source frameworks such as PureMVC and Robotlegs with good understanding of the Drupal CMS .

Personal
Someone passionate willing to live an entrepreneurial venture and make it big.

Opportunity
Grow very quickly with the company as VP R&D + chunk of equity.

About us
Sparkeo is focusing on educational video monetization and inventing knowledge as a monetization model for the web. Sparkeo develops a player focused on creating a learning experience fused with interactivity and social features in the field of online video (in-video payment solution + interactive feature). It is an award winning web startup (Innovate 2010, TWS 2010, and Techcrunch Europa) and Seedcamp winner.

Send CV and cover letter to contact@Sparkeo.com.




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Tū kasī nīstī kih bargardī : majmūʻah-i shiʻr = You are not the one who returns

Location: Main Library- PK6562.16.A73T8 2014




not

Immunotherapy and Biomarkers in Neurodegenerative Disorders

Location: Electronic Resource- 




not

Nanotheranostics for personalized medicine

Location: Engineering Library- RS122.2.N36 2016




not

Structural DNA nanotechnology

Location: Engineering Library- TP248.25.N35S77 2015




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ASSYRIANS NOT SYRIANS

ASSYRIANS NOT SYRIANS



  • The New York Times



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WikiLeaks: 2010-02-08: 10VATICAN23: Vatican: Iran is not Res...

WikiLeaks: 2010-02-08: 10VATICAN23: Vatican: Iran is not Respecting Human Rights




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I Remember and Demand. Recognise! Do not Keep Silent!

I Remember and Demand. Recognise! Do not Keep Silent!



  • Assyrian Government Network

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Wincanton and Co-op join forces for another five-years

Wincanton, a supply chain partner for UK business, has been awarded a five-year contract extension by convenience retailer, Co-op, building on over three decades of successful collaboration between the two companies. 




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Giant 'God of Darkness' Asteroid May Not Escape Earth Unscathed




not

Genocide Recognition by Itself Is Not Enough

Genocide Recognition by Itself Is Not Enough



  • Armenian
  • Assyrian and Hellenic Genocide News

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Speaki - Voice Notifications

Description: 

Features:
+ Smart - trying and learning to read only the relevant text from your notification. + Selection - select which apps would you like Speaki to read aloud. + Speak Output - protect your privacy and control when Speaki should read. + Read content - read aloud full notification content (beside title and summary). + Caller ID - speak caller ID on incoming call. (For Android 8.1 and below) + Stop - stop Speaki from reading by shaking your device, double pressing the power key or by pressing the stop/play button on your headset. + No interruption during phone calls.
+ Quick...

Free Or Paid: 

Free

Category: 




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CRISPR Immune Cells Not Only Survive, They Thrive After Infusion Into Cancer Patients

CRISPR Immune Cells Not Only Survive, They Thrive After Infusion Into Cancer Patients

In the first-ever (sanctioned) investigational use of multiple edits to the human genome, a study found that cells edited in three specific ways and then removed from patients and brought back into the lab setting were able to kill cancer months after their original manufacturing and infusion.

This is the first U.S. clinical trial to test the gene editing approach in humans, and the publication of this new data today follows on the initial report last year that researchers were able to use CRISPR/Cas9 technology to successfully edit three cancer patients' immune cells. The ongoing study is a cooperative between Tmunity Therapeutics, the Parker Institute for Cancer Immunotherapy, and the University of Pennsylvania. 

Patients on this trial were treated by Edward A. Stadtmauer, MD, section chief of Hematologic Malignancies at Penn, co-lead author on the study. The approach in this study is closely related to CAR T cell therapy, in which patient immune cells are engineered to fight cancer, but it has some key differences. Just like CAR T, researchers in this study began by collecting a patient's T cells from blood. However, instead of arming these cells with a receptor against a protein such as CD19, the team first used CRISPR/Cas9 editing to remove three genes. The first two edits removed a T cell's natural receptors so they can be reprogrammed to express a synthetic T cell receptor, allowing these cells to seek out and destroy tumors. The third edit removed PD-1, a natural checkpoint that sometimes blocks T cells from doing their job. 

Once the three genes are knocked out, a fourth genetic modification was accomplished using a lentivirus to insert the cancer-specific synthetic T cell receptor, which tells the edited T cells to target an antigen called NY-ESO-1. Previously published data show these cells typically survive for less than a week, but this new analysis shows the edited cells used in this study persisted, with the longest follow up at nine months. 

Several months after the infusion, researchers drew more blood and isolated the CRISPR-edited cells for study. When brought back into the lab setting, the cells were still able to kill tumors. 

The CRISPR-edited T cells used in this study are not active on their own like CAR T cells. Instead, they require the cooperation of a molecule known as HLA-A*02:01, which is only expressed in a subset of patients. This means that patients had to be screened ahead of time to make sure they were a match for the approach. Participants who met the requirements received other clinically-indicated therapy as needed while they waited for their cells to be manufactured. Once that process was completed, all three patients received the gene-edited cells in a single infusion after a short course of chemotherapy. Analysis of blood samples revealed that all three participants had the CRISPR-edited T cells take root and thrive in the patients. While none responded to the therapy, there were no treatment-related serious adverse events. 

CRISPR technology has not previously been tested in humans in the U.S. so the research team had to move through a comprehensive and rigorous series of institutional and federal regulatory approval steps, including approval by the National Institutes of Health's Recombinant DNA Research Advisory Committee and review by the U.S. Food and Drug Administration, as well as Penn's institutional review board and institutional biosafety committee. The entire process required more than two years.

 Researchers say these new data will open the door to later stage studies to investigate and extend this approach to a broader field beyond cancer, several of which are already planned at Penn.

sb admin Thu, 02/06/2020 - 14:52
Categories




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Coronavirus Is Not Passed From Mother to Child Late In Pregnancy

Coronavirus Is Not Passed From Mother to Child Late In Pregnancy

After a newborn (born to a mother infected with the 2019 novel coronavirus disease (COVID-19) testing positive for COVID-19 infection within 36 hours of birth, there were concerns about whether the virus could be contracted in the womb. A new study finds that COVID-19 does not pass to the child while in the womb. The women in the small study were from Wuhan, China, in the third trimester of pregnancy and had pneumonia caused by COVID-19. However, it only included women who were late in their pregnancy and gave birth by caesarean section. 

There were two cases of fetal distress but all nine pregnancies resulted in live births. That symptoms from COVID-19 infection in pregnant women were similar to those reported in non-pregnant adults, and no women in the study developed severe pneumonia or died.

All mothers in the study were aged between 26-40 years. None of them had underlying health conditions, but one developed gestational hypertension from week 27 of her pregnancy, and another developed pre-eclampsia at week 31. Both patients’ conditions were stable during pregnancy. The nine women in the study had typical symptoms of COVID-19 infection, and were given oxygen support and antibiotics. Six of the women were also given antiviral therapy. In the study, the medical records of nine pregnant women who had pneumonia caused by COVID-19 infection were retrospectively reviewed. Infection was lab-confirmed for all women in the study, and the authors studied the nine women’s symptoms.

(A) Patient 1: left-sided patchy consolidation and multiple bilateral ground-glass opacities. (B) Patient 2: subpleural patchy consolidation in the right lung and slightly infiltrated shadows around left bronchus. (C) Patient 3: bilateral multiple ground-glass opacities, prominent on the left. (D) Patient 4: left-sided patchy ground-glass opacity. (E) Patient 5: multiple ground-glass opacities bilaterally. (F) Patient 6: bilateral clear lung fields with no obvious ground-glass opacities. (G) Patient 7: right-sided subpleural patchy consolidation. (H) Patient 8: multiple bilateral ground-glass opacities, prominent on the right. (I) Patient 9: multiple bilateral ground-glass opacities.


In addition, samples of amniotic fluid, cord blood, neonatal throat swabs and breast milk were taken for six of the nine cases [2] and tested for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Importantly, the samples of amniotic fluid, cord blood, and neonatal throat swabs were collected in the operating room at the time of birth to guarantee that samples were not contaminated and best represented intrauterine conditions. All nine pregnancies resulted in live births, and there were no cases of neonatal asphyxia. Four women had pregnancy complications (two had fetal distress and two had premature rupture of membrane), and four women had preterm labor which was not related to their infection and occurred after 36 gestational weeks. Two of the prematurely born newborns had a low birth weight.

The authors note that their findings are similar to observations of the severe acute respiratory syndrome (SARS) virus in pregnant women, where there was no evidence of the virus being passed from mother to child during pregnancy or birth. The findings are based on a limited number of cases, over a short period of time, and the effects of mothers being infected with the virus during the first or second trimester of pregnancy and the subsequent outcomes for their offspring are still unclear, as well as whether the virus can be passed from mother to child during vaginal birth.

Dr Jie Qiao (who was not involved in the study) of Peking University Third Hospital, China,compares the effects of the virus to those of SARS, and says: “Previous studies have shown that SARS during pregnancy is associated with a high incidence of adverse maternal and neonatal complications, such as spontaneous miscarriage, preterm delivery, intrauterine growth restriction, application of endotracheal intubation, admission to the intensive care unit, renal failure, and disseminated intravascular coagulopathy. However, pregnant women with COVID-19 infection in the present study had fewer adverse maternal and neonatal complications and outcomes than would be anticipated for those with SARS-CoV-1 infection. Although a small number of cases was analysed and the findings should be interpreted with caution, the findings are mostly consistent with the clinical analysis done by Zhu and colleagues of ten neonates born to mothers with COVID-19 pneumonia."

sb admin Wed, 02/12/2020 - 13:03
Categories




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Two LAPD officers injured when patrol car hit by another vehicle

Two Los Angeles Police Department officers were injured early Sunday morning in South L.A. when their vehicle overturned after being struck by a car.




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Photo of Fauci not wearing mask or social distancing earns him stern tongue lashing on social media

Radio host Mark Levin and others on Twitter slammed White House coronavirus task force member Dr. Anthony Fauci over a photo of him sitting next to two other people at a baseball game with his face uncovered.




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Scarlett Johansson also thinks OpenAI's new voice sounds like her. She's not happy about it

Johansson, who portrayed the voice of a computer program in 'Her,' was not behind OpenAI's 'Sky' voice assistant. Another actor provided the voice, OpenAI said.




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Careful not to stifle innovation, Newsom hesitates on major tech bills

The governor said he seeks to balance his desire to preserve California's role as the vanguard of technology against his job to shield society from potential harm.




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L.A. Times, Washington Post see subscription cancellations over not endorsing in presidential race

The Washington Post has lost about 8% of its readers and the L.A. Times 1.8%. But some argue to stay with the newspapers for their roles in reality checking Donald Trump.




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Redskins OTA May 30: Notes and observations

1. Here’s an update on Robert Griffin III. Know what’s not in here? Anything about wedding registries, injury controversies or any issues that have to be worked out with the coach. You’re welcome.




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Redskins OTAs, June 6: Notes and observations

1. Robert Griffin III says “without a doubt” the start of training camp is a realistic goal for his return. He did walk with a slight limp at one point Thursday.




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Redskins minicamp June 11: Notes and observations

…Quarterback Robert Griffin III was closer to running all-out sprints Tuesday, but the big test remains over the next month when he adds cutting to his rehab.




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Redskins minicamp June 12: Notes and observations

…The Redskins signed receiver Donte Stallworth, as expected after a good two-day showing by the veteran wideout. The question is, can Stallworth make the final roster? It depends on how many receivers they keep, but the first four appear set: Pierre Garcon, Josh Morgan, Leonard Hankerson and Santana Moss. Aldrick Robinson’s speed, and the couple big plays he made last season, make him the leader at the fifth receiver spot. But Stallworth would provide insurance if one of the starters got hurt. The only drawback is that he does not play special teams. So it could be that, even if he makes the roster, he’d be inactive until a health issue arises.




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Are "Flesh-Eating" Bacteria Causing Infections in Florida? Not Exactly, Experts Clarify

Following recent hurricanes, reports of "flesh-eating" bacteria in Florida have emerged, but these bacteria, which exist year-round, don't actually consume flesh.



  • News
  • News & Opinion

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Nothing compares to Yu Darvish

The Angels took pitcher C.J. Wilson and outfielder Josh Hamilton from the Texas Rangers each of the last two winters. But those poachings don't seem to have hurt their A.L. West rivals. Instead, Texas was off to a 14-7 start entering play on Thursday and has already swiped four of six games from Los Angeles this season.




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So long, but not for long

In the fall of 2006, The Washington Examiner launched the Yeas & Nays column to cover the world of people, power and politics. In those almost seven years, the print column has entertained hundreds of thousands on their daily Metro commutes. Now, with the print edition gone after Friday, Yeas & Nays will have a new home. The column is moving to our sister site, Red Alert Politics, and will resume covering politics and pop culture on July 1.




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Another taste of heartbreak for Capitals in Game 7 loss to Rangers

Capitals get crushed in decisive Game 7




not

Another year and still no answers for Capitals

Players can't explain latest loss in playoffs





not

Spokane rental units are required to be registered, but not everyone knows that; now they might have to pay the fee

Whether you agree with it or not, Spokane's rental registry is law…




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The Zags are set for another season competing at the very top of college basketball

Forget rebuilding and reloading…




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Gonzaga notches a critical win versus Kentucky in Spokane Arena

After a tough loss at Texas, the Zags bounced back in a big way On Sunday evening, all eyes in college basketball were on Spokane Arena, where a battle between “new blood” Gonzaga and the bluest of blue bloods Kentucky went down. A fervent fanbase stoked on by two-plus decades of increasing success, against a team that has been at the top of the sport since time immemorial…




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Spokane home values just officially skyrocketed, and not everyone is happy about it

When property assessments were mailed to Spokane County homeowners earlier this month, the average home was valued a whopping 31 percent higher than the year before…



  • News/Local News

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Award Season: Notable Design

We're always searching out interesting and noteworthy projects at H&H, and we're happy to report that two buildings we've featured have recently been honored with awards…



  • Health & Home/Lifestyle