This brief shows how mainstreaming blue finance hinges on developing a solid regulatory framework that drives investment toward bankable marine-based projects and analyzes how to expand the sector in the People’s Republic of China (PRC).

The earliest evidence of livestock with modified horns has been discovered in ancient Egypt – sheep skulls with horns that point in unnatural directions suggest humans forced them to grow that way

Isotopic analysis of horse teeth from a medieval burial site suggest that the animals were imported to England from Scandinavia or the Alps, perhaps for use in battle or jousting

An arm bone from an ancient human that lived 700,000 years ago on the island of Flores is the smallest ever found from an adult hominin, adding a new piece to the puzzle of Homo floresiensis

The earliest evidence of livestock with modified horns has been discovered in ancient Egypt – sheep skulls with horns that point in unnatural directions suggest humans forced them to grow that way

Title: Need Advice on Medical Pot for Cancer Care? Don't Ask Local Dispensary
Category: Health News
Created: 8/17/2022 12:00:00 AM
Last Editorial Review: 8/18/2022 12:00:00 AM

Title: Nuts Don't Up Risk of Diverticulitis
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Created: 8/27/2008 12:00:00 AM
Last Editorial Review: 8/27/2008 12:00:00 AM

Title: 'Maintain, Don't Gain' May Work Best for Obese Black Women
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Title: Study May Explain Why Some Obese People Don't Get Diabetes
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Last Editorial Review: 8/28/2013 12:00:00 AM

Title: Heart Studies Don't Reflect Real-World Patients, Study Finds
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Title: Donated Livers Not Harmed by Travel Distances, Study Finds
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Title: Girls Lose Friends for Having Sex But Boys Don't, Study Shows
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Title: Weight Loss Fights Liver Condition, No Matter How It's Done
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Title: Most Don't Need 'Bridging' When They Stop Warfarin Temporarily
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Title: Some Newborns Don't Get Heart Defect, Hearing Loss Tests
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Title: Many Parents Don't Tell Doctor About 'Complementary' Therapy Use in Kids
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Title: Blood Pressure Meds Don't Raise Risk of Depression
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Title: Don't Count on Vitamin D to Ease Childhood Asthma
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Title: Don't Forget to Apply Sunscreen Before & After Water Fun
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Title: Alternative Medicine Popular Among Seniors, But Most Don't Tell Their Doctors About It
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Title: Tramadol vs. Hydrocodone
Category: Medications
Created: 4/24/2017 12:00:00 AM
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Title: Organ From Live Donor Best When Child Needs New Kidney
Category: Health News
Created: 8/17/2022 12:00:00 AM
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Aberrant type 2 inflammatory responses are the underlying cause of the pathophysiology of allergic asthma, allergic rhinitis, and other atopic diseases, with an alarming prevalence in relevant parts of the Western world. A bulk of evidence points out the important role of the DP2 receptor in these inflammation processes. A screening of different polyunsaturated fatty acids at a fluorescence resonance energy transfer–based DP2 receptor conformation sensor expressed in human embryonic kidney (HEK) cells revealed an agonistic effect of the prostaglandin (PG)-D₂ precursor arachidonic acid on DP2 receptor activity of about 80% of the effect induced by PGD₂. In a combination of experiments at the conformation sensor and using a bioluminescence resonance energy transfer–based G protein activation sensor expressed together with DP2 receptor wild type in HEK cells, we found that arachidonic acid acts as a direct activator of the DP2 receptor, but not the DP1 receptor, in a concentration range considered physiologically relevant. Pharmacological inhibition of cyclooxygenases and lipoxygenases as well as cytochrome P450 did not lead to a diminished arachidonic acid response on the DP2 receptor, confirming a direct action of arachidonic acid on the receptor.

Clinical reports suggest that the most effective strategies for managing opioid use disorder comprise a comprehensive treatment program of both pharmacological and nonpharmacological approaches. However, the conditions under which these combinations are most effective are not well characterized. This study examined whether the presence of an alternative reinforcer could alter the efficacy of Food and Drug Administration–approved opioid antagonist or agonist medications, as well as the nonopioid flumazenil, in decreasing oxycodone choice self-administration in nonhuman primates. Adult squirrel monkeys (n = 7; four females) responded under concurrent second-order fixed-ratio (FR)-3(FR5:S);TO45s schedules of reinforcement for intravenous oxycodone (0.1 mg/kg) or saline on one lever and 30% sweetened condensed milk or water on the other. Doses of naltrexone (0.00032–1.0 mg/kg), nalbuphine (0.32–10 mg/kg), buprenorphine (0.0032–0.032 mg/kg), methadone (0.32–1.0 mg/kg), or flumazenil (1–3.2 mg/kg) were administered intramuscularly prior to oxycodone self-administration sessions that occurred with either milk or water as the alternative. Naltrexone, a μ-opioid receptor antagonist, was >30-fold more potent when milk was available compared with water and abolished oxycodone intake (injections/session) while concomitantly increasing milk deliveries at the highest dose tested. Pretreatment with the low-efficacy μ-agonist nalbuphine was most effective in the presence of milk compared with water, decreasing oxycodone preference to <50% of control values. The higher efficacy μ-agonists, methadone and buprenorphine, and the benzodiazepine antagonist flumazenil did not appreciably alter the reinforcing potency of oxycodone under either condition. These results suggest that antagonist medications used in combination with alternative reinforcers may be an effective strategy to curtail opioid abuse–related behaviors.

That anyone could witness or directly experience the increasingly frequent and intense heat domes, droughts, floods and record high temperatures and claim we don’t have a problem is insanity!

The post Don’t buy-in to climate science denialism appeared first on rabble.ca.

BILL Shorten believes Labor can still win next Saturday’s election despite new opinion polling predicting his party will struggle.

Join Anna Marie, Chris, Josh, and Kelley this week, as things get a little weirder than usual. A sticky soda fracas kicks off the show. Meanwhile, Kelley runs the news section for the first time, which is good since Chris stomps off after discovering this is definitely the worst timeline of them all. And don't forget, #JRPGJuly continues for one more week!

The post RPG Cast – Episode 551: “I Don’t Want the Moe Future” appeared first on RPGamer.

It's Extra Life 2020. Chris is dying in Hades. Anna Marie thinks orange is pretty sus. Kelley can't let go of Laharl. Josh is back on the Trails. And Alex is outta here to pursue his new racing career.

The post RPG Cast – Episode 562: “Don’t Disgaea Shame Me” appeared first on RPGamer.

Alex looks so good he must be rendered. Robert rickrolls all the things. Kelley is our Neptunian Angel. Chris is getting ready to Rise, but first he must Ryza.

The post RPG Cast – Episode 578: “Sorry, I Just Don’t Care” appeared first on RPGamer.

It’s a tiny cast with just Chris, Anna Marie, and Kelley. PS5 blood money is being thrown around, while Kelley curses the asthma tax. Chris is simulating his real life job in a game that simulates his job. Anna Marie re-discovers she doesn’t like SMT. And everyone agrees cutscenes need both pause and skip options.

The post RPG Cast – Episode 592: “First World Donut Problems” appeared first on RPGamer.

Kelley's cat tosses a coin to The Witcher. Chris finds out there's just too many pigs. And Josh goes to Reddit, but all he finds is a meme.

The post RPG Cast – Episode 595: “I’m With the PS5, I Don’t Like Your Range Extender” appeared first on RPGamer.

Sonic makes Kelley violent so goes on a chili dog fueled rampage. Josh wants a break cause it's been a slow week. Chris plays the market board stocks and loses his freedom.

The post RPG Cast – Episode 626: “Don’t Anger the SRW Fans” appeared first on RPGamer.

Kelley enters the phlegm dimension. Chris thinks he's an Elden Lord. Josh summons another cat. You, unfortunately, went to E3 programming camp and are now a slave for EA. Sorry.

The post RPG Cast – Episode 632: “I’m Done Dating Weapons” appeared first on RPGamer.

Kelley is creeped out by grown men in diapers. Josh can't name a kaiju that isn't Godzilla or Mothra. And Chris gets an Elden Pacifier since he's never happy.

The post RPG Cast – Episode 647: “Stellar Eve for When You Don’t Feel Fresh” appeared first on RPGamer.

In this week's show, we discover Drakthyr are OP, but Chris is not. Anna Marie is on the fun patrol, and she's handing out citations. And Kelley is hungry for ham sandwiches thanks to Pokémon.

The post RPG Cast – Episode 659: “Don’t Give Adol a Ship” appeared first on RPGamer.

Kelley builds a fan mod alternate LEGO Sonic build. Josh learns not to read the wiki...any wiki. Matt digs through Infinity's trash to find out when the money ran out. Chris is watching the anime...but it's not good either.

The post RPG Cast – Episode 733: “You Don’t Have to Go Home but You Can’t Fish Here” appeared first on RPGamer.

Nintendo today hosted a Super Nintendo World Direct livestream that featured Shigeru Miyamoto giving a deep dive look into the Donkey Kong Country-themed land.

The new land will feature a family roller coaster, called Mine-Cart Madness, congas you can hit to a rhythm, letters that can found throughout the land that can be scanned on the new Donkey Kong Power-Up Band, character meet and greets, and new food options.

Donkey Kong Country will open at Universal Studios Japan on December 11, 2024, and will also be a part of Super Nintendo World at Epic Universe in Florida when the theme park opens in May 2025.

View the Direct below:

A life-long and avid gamer, William D'Angelo was first introduced to VGChartz in 2007. After years of supporting the site, he was brought on in 2010 as a junior analyst, working his way up to lead analyst in 2012 and taking over the hardware estimates in 2017. He has expanded his involvement in the gaming community by producing content on his own YouTube channel and Twitch channel. You can contact the author on Twitter @TrunksWD.

Full Article - https://www.vgchartz.com/article/463038/super-nintendo-world-direct-dives-into-the-donkey-kong-country-themed-land/

Disaster was averted at a Kentucky hospital when an ostensibly deceased organ donor began “thrashing” around in the operating theater, a preservationist tells NPR.

“He was moving around,” Natasha Miller recalled of the patient, whom NPR identified as Anthony Thomas “TJ” Hoover II. “He was crying visibly.”

The two surgeons assigned to the transplant naturally refused to go through with the procedure, which was reportedly scheduled to take place at Baptist Health Richmond Hospital in October 2021. But when her colleague called Kentucky Organ Donor Affiliates, which coordinated the harvest, Miller said the supervisor told them they “were going to do the case” and needed to “find another doctor.”

Read more at The Daily Beast.

Senate Minority Leader Mitch McConnell called his party’s presidential nominee, Donald Trump, a “stupid,” “ill-tempered,” and “despicable human being,” according to his own records.

McConnell made the withering assessments in a series of private “personal oral histories” that he gave to Michael Tackett, the deputy Washington bureau chief of the Associated Press, who has a forthcoming biography about the Kentucky senator called The Price of Power. The AP conveniently reported the book’s juicy details.

McConnell’s remarks were made after the 2020 election that Trump lost, and the senator was apparently elated to see the backside of the former president, musing, “it’s not just the Democrats who are counting the days” until he leaves office.

Read more at The Daily Beast.

Donald Trump pulled out of another mainstream interview Thursday–this time nixing a sit-down with NBC News.

The interview, CNN reported, would be in Philadelphia with NBC News' senior business correspondent, Christine Romans. CNN’s Brian Stelter said one source suggested that it had only been “postponed.”

It was the second time in a week that he had canceled a scheduled appearance outside the conservative news sphere, CNN’s Reliable Sources reported Thursday. He had canceled an in-studio appearance on the CNBC flagship show, Squawk Box, which was due on Friday.

Read more at The Daily Beast.

Putting aside my natural annoyance at Metal Gear Solid Delta: Snake Eater for almost beating out the Twarhammer series in the headline real estate wars, I am more than a little excited to play. Some days, you simply must feast on a tree frog, and while we still don’t have a solid release date, that day doesn’t feel too far away. Good news for stealth fans, and perhaps gooder news for a dozen strapline writers sweating profusely, soiling themselves in anticipation of using “kept you waiting, huh?”.

Until then, I at least have a steady drip feed of new information to keep me sated, the latest of which is the substantial hint that there'll be some new dialogue in the game, as per the video below. Alongside that, the previously pseudonymous Suzetta Miñet - who was credited with voicing EVA in MGS3 and Peace Walker - has revealed herself to be Jodi Benson, the voice of Ariel in Disney’s The Little Mermaid. Cheers for the spot, Automaton West.

Read more

When I was a competitive long-distance runner at school, breath control was paramount. We were never really taught this, mind. It was an art you picked up through practice: how to breathe before the race, saturating your blood with O2 without dizzying yourself; when to permit the shorter, emergency breaths and when to apply restraint; when to deepen your inhales and charge yourself up for an attack on a hill.

And then, how to organise your body around your breath, straightening your posture to expand your lungs without tipping back too far and squandering muscle power; how to breath in time with your stride and the movement of your shoulders, so as to firm up your momentum and shave a miraculous-feeling minute off your finishing time. All this, plus various daft psychological war gambits of my own devising. When overtaking or being overtaken, I used to seal my lips shut on that side and breath through the other corner of my mouth, to make it look like I was hardly out of breath at all.

Read more

Watch Video | Listen to the Audio

JUDY WOODRUFF: It’s been almost a month since Hurricane Maria destroyed much of Puerto Rico and killed at least 48 people. The island and its residents are still coming to grips with the scale of the devastation.

William Brangham brings us the latest.

WILLIAM BRANGHAM: Many Puerto Ricans are still in the dark, without electrical power. Hundreds of thousands still have no access to running water, and the rebuilding of the countless damaged homes, roads and facilities is just beginning.

The Associated Press reported yesterday that almost half the sewage treatment plants on the island are still out of service, increasing the risk of contamination and disease.

I’m joined now by David Begnaud. He’s a correspondent from CBS News who’s been doing some very strong reporting there from since when the storm hit, and is just back from his latest trip to the island.

David, welcome to the NewsHour.

I wonder. We saw many of your reports and others of people still three weeks out from the storm who are still drinking from streams and creeks. You heard — I mentioned this AP report about fears of contamination.

Can you just tell us what is going on there? How are people getting water now?

DAVID BEGNAUD, CBS News: Well, let me tell you this.

The governor of Puerto Rico said this morning that he’s aware of those reports and that they’re looking into it. What’s concerning, William, is that three weeks after the storm and at least a week after the allegations first surfaced that people might be trying to drink from toxic wells at what’s known as Superfund sites, the governor of Puerto Rico is still saying, we’re looking into it and telling people to stay out of rivers where sewage may be spilling into the river.

And, he said, we want them to stay away from the coastal areas.

How are people doing? They’re still desperate to get water. No one seems to be able to figure out how to get enough water to every single person on that island who needs it. And as long as people need water, it’s still an emergency phase.

Nearly four weeks later, no one seems to be able to move from the emergency to the recovery.

WILLIAM BRANGHAM: So, people who are — we see them drinking out of these PVC pipes that they have kind of rigged and sort of poked into the side of a creek.

People are just drinking that water straight, without purification, without boiling it; is that right?

DAVID BEGNAUD: Absolutely.

Look, they have got the PVC pipes tapped into the mountains so that it’s coming out of the stream that way. And they literally are — I saw a woman walk up to a potable water tank that the military had brought in, and she had a Clorox bottle.

And I said, “Ma’am, you’re putting drinkable water in a Clorox bottle?”

And she said, “It’s all I have got.”

Now, that was a good scenario. The other scenarios are people right now who are drinking from streams and creeks and rivers who have no water filters, who have nothing, right? They’re just taking this water.

Now, listen, the government got a million water-purifying tablets within the last week. It took almost three weeks to get those. Now there’s a large push to bring in water filters.

I have got to tell you, most of the water filters I’m seeing brought in are coming from the private sector, and civilian samaritans who are getting 1,000 or more from the mainland and flying them over to Puerto Rico and personally hand-delivering them.

WILLIAM BRANGHAM: That’s really incredible.

Medical facilities were another big — just a huge devastation on the island. I know you have been doing a lot of reporting on the USS Comfort.

DAVID BEGNAUD: Yes.

WILLIAM BRANGHAM: This is the huge Naval hospital that is now just offshore Puerto Rico.

But I understand it hasn’t been fully utilized. Can you tell us what your reporting has found there?

DAVID BEGNAUD: The two men running the ship told us that nearly 87 percent of the ship is empty. Sounds alarming, right? They have 200 beds, and 87 percent are empty.

Now, here’s what they said: We stand ready for whatever the government wants to do. We are waiting to be told by the government.

So, I went to the governor, and said exactly what’s happening. And he said: “Look, I’m not satisfied with what the protocol was from the beginning.”

He said, initially, they were prioritizing only the most critically ill patients go to the Comfort. And he said there was a layered process that was complicating things.

So, the governor, Ricardo Rossello, said: “I started to take out some of those layers, and I, said, listen, take people on the ship who may not be critically ill, but need good medical care and can’t get it at the hospital, where the lights are flickering and the A.C. is not running.”

That’s what the governor said.

Within a matter of hours, I got a tweet from a third-year medical student who said: “Let me tell you what a nightmare it has been to reach the Comfort.”

He said: “We have got a pediatric patient who desperately needs to get off this island, either to a hospital on the mainland or to the Comfort.”

And he said: “I went through Google and the local newspaper to find the number. I couldn’t find it.”

Now, here is how things work. Within about 30 minutes of that tweet going out and that medical student’s story being posted, the governor’s spokesperson responded with numbers that should be able to help.

The bottom line here, William, is that asking relentless questions and the good work of journalism is what’s making a difference there. It’s no one person. There’s no heroic work that’s being done by any journalist, other than people who are going back to the same officials and asking some of the same questions, relentlessly seeking the right answer that will make a difference.

WILLIAM BRANGHAM: One of the other pieces of reporting that you did that was very early in the story was this backlog of supplies trapped in container ships on the ports in Puerto Rico.

I understand some of that — some of those supplies are now moving. Can you tell us, are they getting to where they need to be throughout the island?

DAVID BEGNAUD: So, the shipping containers you’re talking about, about 3,000 sitting in the Port of San Juan, have been moved out, not all of them, but a majority of them.

And they were intended for grocery stores around the island. Right? So, those were private companies that had brought in these shipping containers, paid for the supplies, but couldn’t move them because their truck drivers were either at home, because the home had been destroyed, or the road was impassable.

More and more supplies are getting out. But let me tell you, the grocery stores around the island, they have a lot of nonperishables, Pringles, candy, cookies, all on the shelf.

But when you go to the meat section, it’s nearly 75 percent empty at the stores we have been to, the produce section 90 percent empty. And finding bottled water there is almost like playing a game.

WILLIAM BRANGHAM: David Begnaud, CBS News, thank you so much for your reporting. Thanks for your time.

DAVID BEGNAUD: You bet.

The post Puerto Ricans still don’t have reliable drinking water, and fears of contamination are rising appeared first on PBS NewsHour.

The books, TV, games and more that New Scientist staff have enjoyed this week

Plans to create an interactive AI model of the legendary code breaker Alan Turing are reckless and problematic, says Matthew Sparkes

Emma Raducanu struck a deal to return to one of her favourite tournaments.