This marks the launch of various ventures, including a festival project, a therapeutic space with therapy animals, and a holistic health program for women. 

The following article, The First Wave of Hollyweirdos Leaving America, was first published on The Black Sphere.

Too bad we can't send the FBI to raid the houses of all the dumb ass Leftists who promised to leave if Trump was elected.

Continue reading The First Wave of Hollyweirdos Leaving America ...

(Oct. 6)  Making a political concession speech is a difficult, emotionally fraught task. In Vice President Kamala Harris’ concession remarks Wednesday afternoon, she ably upheld the civic imperatives of the […]

The post My first-ever K. Harris compliment: A decent concession appeared first on Quin Hillyer.

It is also set to be the world's first breach of 1.5C of warming across an entire calendar year.

Uncapped batter Nathan McSweeney will open for Australia in the first of five Tests against India.

Phil Salt powers a superb century to take England to a commanding eight-wicket victory over West Indies in the first T20 in Barbados.

Meet McLaren's first female development driver, Bianca Bustamante, who says she shares her hopes and ambitions to become a professional Formula 1 driver.

Described by some as an "enigma", Mrs Trump is expected to return to her White House duties "on her own terms".

Fans congratulate the Transformers star, who's spoken about a previous pregnancy ending in miscarriage.

With swathes of South Sudan submerged, a whistleblower warns water sources are being polluted by oil.

They are accused of hate speech as rights groups say the law is being used to restrict freedoms.

Our most frequently asked question is, “Is it possible to install a safe on the second floor?” I would say yes. In terms of where your safe will be installed, it is entirely up to you. In theory, it makes sense to store your safe on the second floor of your home. After all, a […]

The post Can You Put A Gun Safe Upstairs? appeared first on Patriot Outdoor News.

Although most states do not require you to securely store your firearms in any particular manner or device, you might want to consider doing so. There are several good reasons to keep any firearms that are not under your direct control locked up securely. It is important to note that some states and cities have […]

The post Do I Need To Have A Safe First To Own Firearms? appeared first on Patriot Outdoor News.

James Barnor, who has photographed the likes of Muhammad Ali, is being honoured in Accra.

A picture of a fox cub has won a prestigious European Wildlife Photographer of the Year award.

What was known as Armistice Day became Remembrance Sunday following the end of World War Two.

President Trump unveiled his long-awaited historic “America First” health care plan Thursday, a series of executive orders aimed at providing Americans affordable, high-quality health care while banning surprise medical billing and affirming to protect those with preexisting conditions. “Today, I will lay out my vision for a healthcare system that puts patients first, families first, […]

The post Trump Unveils America First Healthcare Plan appeared first on Hispolitica.

President Trump and First Lady Melania Trump have tested positive for coronavirus, the president announced on Twitter early Friday morning. “Tonight, @FLOTUS and I tested positive for COVID-19,” Trump tweeted shortly before 1 am Friday. “We will begin our quarantine and recovery process immediately. We will get through this TOGETHER!” Tonight, @FLOTUS and I tested […]

The post President Trump And First Lady Test Positive For COVID appeared first on Hispolitica.

President Trump on Friday shared a pre-recorded video message on Twitter saying he is “doing very well” and thanked Americans for their overwhelming support following his early morning announcement of his COVID-19 diagnosis. pic.twitter.com/B4H105KVSs — Donald J. Trump (@realDonaldTrump) October 2, 2020 “I want to thank everybody for the tremendous support,” Trump said in the […]

The post Trump Tweets First Video Remarks Since Revealing COVID-19 Diagnosis appeared first on Hispolitica.

Kieran McKenna describes Ipswich's 2-1 victory at Tottenham - their first Premier League win in 22 years - as a "massive moment" and validation for the players' hard work.

Southampton defender Taylor Harwood-Bellis says "there was always a pathway" after being handed his first England senior call-up by interim manager Lee Carsley - the pair worked together with England Under-21s.

velocityconf: @tsantero @garethr No, there's just a lot that goes into producing #velocityconf. Plus the chairs are getting ready for Santa Clara + NY! :)

It's a British heritage brand driven by royals, including the late Queen Elizabeth. Now new Jaguars won't be on UK car lots until at least 2026.

The collaboration comes amid skyrocketing demand for Nvidia chips, as companies scramble to secure supplies.

First grade can bring a lot of changes! Even if your child had a great kindergarten year, there can be lots of new routines and expectations for first graders that can feel really different for students (and families). Here’s what you need to know.

Texts classified according to guided reading levels (GRL) are ubiquitous in U.S. beginning reading classrooms. This study examined features of texts across three grade bands (kindergarten, early first grade, final first grade) and the 10 GRLs within these bands. The 510 texts came from three programs with different functions in beginning reading instruction: core, intervention, and content areas.

Iif you're a new owner or just bought your first travel trailer, these are the must-have travel trailer accessories that may not have occurred to you.

The post Travel Trailer Accessories You Absolutely Need (Read This BEFORE Your First Trip) appeared first on Vagabondish.

What Is "Demure and Mindful" to Real Estate?

Websites are Blocking the Wrong AI Scrapers (Because AI Companies Keep Making New Ones) – 404 Media *** I had a call the other day with the Dean of a top-five school of public health, and in between furiously scribbling notes (yes, I still take notes), it struck me that here in the United States … Continue reading "Consume First, Deal with the Shit Later"

Team Biden thought it was a clever work-around to open up the border without looking like they were opening the border. Texas took the cheat to court.

The post AMNESTY: Texas & American First Legal Score BIG Win Against Open Border Policy appeared first on Clash Daily.

Just because you’re paranoid, it doesn’t mean you’re wrong. And for any supporters of President-elect Donald Trump who feel that they’ve been unfairly targeted by the government, but were summarily […]

The post Fired FEMA Worker Reveals Discrimination Against Trump Supporters Was Even Worse Than First Reported appeared first on The Western Journal.

With some of its infrastructure decaying and no premier division club using it, the somewhat abandoned Dobsonville Stadium offered the perfect setting for Sage Stephens to take his first steps as a Bafana Bafana player at the ripe age of 33.

Labour Party Conference – International affairs networking brunch 24 September 2024 — 11:00AM TO 12:00PM Anonymous (not verified) 16 September 2024 Labour – Grace 1 Suite, Hilton Hotel, Liverpool

Hosted by Sir Simon Fraser, Chairman of Chatham House.

This event is taking place at the Hilton Hotel, Grace 1 Suite, Liverpool.

You are warmly invited to join us for an exclusive networking brunch at the 2024 Labour Party Conference.

Sir Simon Fraser, Chairman of Chatham House, and Olivia O’Sullivan, Director of Chatham House’s UK in the World Programme, will deliver opening remarks, followed by an interactive networking session where you will have the chance to engage with a wide range of stakeholders. Join us to connect with key senior parliamentary, corporate and media attendees at the Labour Party Conference.

This event will be taking place outside of the secure zone.

Reflections at 100: Women in international affairs Audio MVieira 19 December 2022

How have women contributed to international relations?

The last episode of Reflections at 100, marking the centenary of International Affairs, looks at women’s contributions to international thought.

Isabel and Krisztina speak to Dr Katharina Rietzler about women’s contributions to the journal and international relations, especially in the UK. Then, Krisztina speaks to Professor Barbara Savage about Black women’s contributions to international relations in the US. To wrap up this episode, Leah de Haan sheds light on Chatham House’s Equality, Diversity and Inclusion (EDI) initiative and Jo Hills shares their thoughts about putting together the archive collections.   

Reflections at 100 is a mini-series accompanying the journal’s centenary Archive Collections. The collections bring together articles from our archive which speak to the past, present and future of current affairs issues. In each podcast episode, we speak to contributors from a specific collection and explore what the research tells us about policy-making today. 

Explore the Archive Collection freely until the end of December 2022, including Katharina’s introduction: 100 years of women in International Affairs.

International Affairs was started at Chatham House in 1922 to communicate research to members who could not attend in person. Over the last 100 years it has transformed into a journal that publishes academically rigorous and policy relevant research. It is published for Chatham House by Oxford University Press. Read the latest issue here. 

Saturday Club introduces young people to international affairs News release jon.wallace 24 February 2022

Clubs will help 13-16 year-olds learn more about the forces that are shaping the world and discover how young people can influence the future.

National Saturday Club and Chatham House are delighted to announce the launch of the Society&Change Saturday Club. This new programme creates opportunities for UK 13–16-year-olds to develop a global mindset and build awareness of trends that will shape the world in the coming decades.

Three pilot Society&Change Clubs will be hosted by the University of Sussex, Manchester Metropolitan University, and the University of Huddersfield. Chatham House will provide speakers and generate ideas for the clubs.

National Saturday Club gives 13–16-year-olds across the country the opportunity to study subjects they love at their local university, college or cultural institution, for free.

Society&Change Club members will be introduced to a wide range of careers including policy making and diplomacy, advocacy, media and journalism, international trade and business, and the international development and humanitarian sector.

Weekly classes will be led by led by professional tutors from the host institutions. Club members will also take part in masterclasses with industry professionals, as well as an end of year summer show and graduation ceremonies.

Lucy Kennedy, Chief Executive of the Saturday Club Trust said:

‘We are delighted to be partnering with Chatham House to launch the Society&Change Saturday Club, the sixth subject within the National Saturday Club programme. Over the past 12 years, working nationally with 13–16-year-olds, we have seen that young people are eager to share their hopes and ideas for the future and address the issues the world faces.

‘We hope this new Saturday Club will empower them to shape their own futures and will bring the urgent voice of young people to international debate.’

Rose Abdollahzadeh, Managing Director for Research Partnerships at Chatham House said:

‘We are really excited about the potential for this partnership to encourage young people across the UK to explore their role in the world. The National Saturday Club network will also give Chatham House opportunities to harness the energy, ideas and passion of young people towards positive change.

‘By introducing Club members to contemporary debates on global issues and a range of professions in foreign policy and international relations, our hope is that some Club members will choose to follow a career path into this sector.’

Learn more about the Society&Change Saturday Club.

Lawford Hatcher
Proc. Amer. Math. Soc. 152 (), 5191-5205.
Abstract, references and article information

Yu. L. Ershov
St. Petersburg Math. J. 35 (), 461-465.
Abstract, references and article information

30 September 2020

Qin Zhang
Nov 17, 2020; 0:RA120.002325v1-mcp.RA120.002325
Research

Insulin receptor substrate 2 (IRS2) is an essential adaptor that mediates signaling downstream of the insulin receptor and other receptor tyrosine kinases. Transduction through IRS2-dependent pathways is important for coordinating metabolic homeostasis, and dysregulation of IRS2 causes systemic insulin signaling defects. Despite the importance of maintaining proper IRS2 abundance, little is known about what factors mediate its protein stability. We conducted an unbiased proteomic screen to uncover novel substrates of the Anaphase Promoting Complex/Cyclosome (APC/C), a ubiquitin ligase that controls the abundance of key cell cycle regulators. We found that IRS2 levels are regulated by APC/C activity and that IRS2 is a direct APC/C target in G₁. Consistent with the APC/C's role in degrading cell cycle regulators, quantitative proteomic analysis of IRS2-null cells revealed a deficiency in proteins involved in cell cycle progression. We further show that cells lacking IRS2 display a weakened spindle assembly checkpoint in cells treated with microtubule inhibitors. Together, these findings reveal a new pathway for IRS2 turnover and indicate that IRS2 is a component of the cell cycle control system in addition to acting as an essential metabolic regulator.

Hirschsprung disease (HSCR) is a heterogeneous group of neurocristopathy characterized by the absence of the enteric ganglia along a variable length of the intestine. Genetic defects play a major role in the pathogenesis of HSCR while family studies of pathogenic variants in all the known genes (loci) only demonstrate incomplete penetrance and variable expressivity for unknown reasons. Here, we applied large-scale, quantitative proteomics of human colon tissues from 21 patients using iTRAQ method followed by bioinformatics analysis. Selected findings were confirmed by parallel reaction monitoring (PRM) verification. At last the interesting differentially expressed proteins were confirmed by western blot. A total of 5341 proteins in human colon tissues were identified. Among them, 664 proteins with >1.2-fold difference were identified in 6 groups: groups A1 and A2 pooled protein from the ganglionic and aganglionic colon of male, long-segment HSCR patients (L-HSCR, n=7); groups B1 and B2 pooled protein from the ganglionic and aganglionic colon of male, short-segment HSCR patients (S-HSCR, n=7); and groups C1 and C2 pooled protein from the ganglionic and aganglionic colon of female, S-HSCR patients (n=7). Based on these analyses, 49 proteins from 5 pathways were selected for PRM verification, including ribosome, endocytosis, spliceosome, oxidative phosphorylation and cell adhesion. The downregulation of three neuron projection development genes ARF4, KIF5B and RAB8A in the aganglionic part of the colon were verified in 15 paired colon samples using WB. The findings of this study will shed new light on the pathogenesis of HSCR and facilitate the development of therapeutic targets.