Predicting the spatial configuration of gas molecules in nanopores of shale formations is crucial for fluid flow forecasting and hydrocarbon reserves estimation. The key challenge in these tight formations is that the majority of the pore sizes are less than 50 nm. At this scale, the fluid properties are affected by nanoconfinement effects due to the increased fluid-solid interactions. For instance, gas adsorption to the pore walls could account for up to 85% of the total hydrocarbon volume in a tight reservoir. Although there are analytical solutions that describe this phenomenon for simple geometries, they are not suitable for describing realistic pores, where surface roughness and geometric anisotropy play important roles. To describe these, molecular dynamics (MD) simulations are used since they consider fluid-solid and fluid-fluid interactions at the molecular level. However, MD simulations are computationally expensive, and are not able to simulate scales larger than a few connected nanopores. We present a method for building and training physics-based deep learning surrogate models to carry out fast and accurate predictions of molecular configurations of gas inside nanopores. Since training deep learning models requires extensive databases that are computationally expensive to create, we employ active learning (AL). AL reduces the overhead of creating comprehensive sets of high-fidelity data by determining where the model uncertainty is greatest, and running simulations on the fly to minimize it. The proposed workflow enables nanoconfinement effects to be rigorously considered at the mesoscale where complex connected sets of nanopores control key applications such as hydrocarbon recovery and CO2 sequestration.

When time-dependent partial differential equations (PDEs) are solved numerically in a domain with curved boundary or on a curved surface, mesh error and geometric approximation error caused by the inaccurate location of vertices and other interior grid points, respectively, could be the main source of the inaccuracy and instability of the numerical solutions of PDEs. The role of these geometric errors in deteriorating the stability and particularly the conservation properties are largely unknown, which seems to necessitate very fine meshes especially to remove geometric approximation error. This paper aims to investigate the effect of geometric approximation error by using a high-order mesh with negligible geometric approximation error, even for high order polynomial of order p. To achieve this goal, the high-order mesh generator from CAD geometry called NekMesh is adapted for surface mesh generation in comparison to traditional meshes with non-negligible geometric approximation error. Two types of numerical tests are considered. Firstly, the accuracy of differential operators is compared for various p on a curved element of the sphere. Secondly, by applying the method of moving frames, four different time-dependent PDEs on the sphere are numerically solved to investigate the impact of geometric approximation error on the accuracy and conservation properties of high-order numerical schemes for PDEs on the sphere.

We study the problem of pricing under a Multinomial Logit model where we incorporate network effects over the consumer's decisions. We analyse both cases, when sellers compete or collaborate. In particular, we pay special attention to the overall expected revenue and how the behaviour of the no purchase option is affected under variations of a network effect parameter. Where for example we prove that the market share for the no purchase option, is decreasing in terms of the value of the network effect, meaning that stronger communication among costumers increases the expected amount of sales. We also analyse how the customer's utility is altered when network effects are incorporated into the market, comparing the cases where both competitive and monopolistic prices are displayed. We use tools from stochastic approximation algorithms to prove that the probability of purchasing the available products converges to a unique stationary distribution. We model that the sellers can use this stationary distribution to establish their strategies. Finding that under those settings, a pure Nash Equilibrium represents the pricing strategies in the case of competition, and an optimal (that maximises the total revenue) fixed price characterise the case of collaboration.

The Cannabis Issue During normal times, I-90 Green House is like a destination resort for marijuana lovers.…

Sam Mendes' 1917, which took Best Picture and Best Director awards at the Golden Globes earlier this week, looks like a standard period piece.…

Shape memory and pseudoelastic martensitic behavior is enabled by a structure in which there is provided a crystalline ceramic material that is capable of undergoing a reversible martensitic transformation and forming martensitic domains, during such martensitic transformation, that have an elongated domain length. The ceramic material is configured as a ceramic material structure including a structural feature that is smaller than the elongated domain length of the ceramic material.

A method includes determining a read threshold voltage corresponding to a group of storage elements in a non-volatile memory that includes a three-dimensional (3D) memory of a data storage device. The method also includes determining an error metric corresponding to data read from the group of storage elements using the read threshold voltage. The method includes comparing the read threshold voltage and the error metric to one or more criteria corresponding to a corrupting event.

The invention relates to polymers that can be obtained by polymerizing the monomers (A), (B), and (D), and optionally (C), where (A) is a monomer of formula (I), wherein A stands for C2 to C4 alkylene, B stands for a C2 to C4 alkylene different from A, R stands for hydrogen or methyl, m stands for a number from 1 to 500, n stands for a number from 1 to 500, (B) is an ethylenically unsaturated monomer that contains at least one carboxylic acid function, (C) is optionally a further ethylenically unsaturated monomer different from (A) and (B), (D) is a monomer of formula (II), wherein D stands for C2 to C4 alkylene, E stands for a C2 to C4 alkylene group different from D, F stands for a C2 to C4 alkylene group different from E, R stands for hydrogen or methyl, o stands for a number from 1 to 500, p stands for a number from 1 to 500, q stands for a number from 1 to 500, and wherein the weight fraction of the monomers is 35 to 99% for the macromonomer (A), 0.5 to 45% for the monomer (B), 0 to 20% for the monomer (C), and 1 to 20% for the monomer (D), and to the use of said polymers as defoamers for inorganic solid suspensions.

A device and method for accurately characterizing tissue impedance employs multiple electrodes at a plurality of separation distances to cancel the effects of front end loading leakage currents and electrode polarization to improve the accuracy of sensitive impedance measurements used to identify cancerous tissues. These measurements may be automated over a range of frequencies.

In a method for simulating temperature and electrical characteristics within an circuit, a temperature of at least one volume within the circuit as a function of a resistance within the at least one volume is repeatedly calculated and the resistance as a function of the temperature is repeatedly calculated until the temperature is within a predetermined tolerance of a previous temperature result and until the resistance is within a predetermined tolerance of a previous resistance result. Once the temperature is within a predetermined tolerance of the previous temperature result and the resistance is within a predetermined tolerance of the previous resistance, then an output indicative of the temperature is generated.

The embodiments relate to modeling resistance in a multi-fin multi-gate field effect transistor (MUGFET). In these embodiments, a design for a multi-fin MUGFET comprises a gate structure with a horizontal portion traversing multiple semiconductor fins and comprising a plurality of first resistive elements connected in series, with vertical portions adjacent to opposing sides of the semiconductor fins and comprising second resistive elements connected in parallel by the horizontal portion, and with contact(s) comprising third resistive element(s). The total gate resistance is determined based on resistance contributions from the first resistive elements, the second resistive elements and the third resistive element(s), particularly, where each resistive contribution is based on a resistance value of the resistive element, a first fraction of current from the semiconductor fins entering the resistive element and a second fraction of the current from the semiconductor fins exiting the resistive element.

Disclosed are polysulfone-based materials that can be used as active and/or passive components in various electronic, optical, and optoelectronic devices, particularly, metal-oxide-semiconductor field-effect transistors. For example, various metal-oxide-semiconductor field-effect transistors can include a dielectric layer and/or a passivation layer prepared from such polysulfone-based materials and exhibit good device performance.

One or more temporal stimulation parameters of vagus nerve stimulation (VNS) are selected to substantially modulate one or more target physiological functions without substantially modulating one or more non-target physiological functions. In one embodiment, a stimulation duty cycle is selected such that VNS is delivered to the cervical vagus nerve trunk to modulate a cardiovascular function without causing laryngeal muscle contractions.

A combination trimming/flame treatment end effector adapted for mounting to the end of a robotic arm. A trimming blade extends from a main body portion of the end effector for performing a trimming operation. The trimming blade may be mounted in an exchangeable cartridge to facilitate blade changing. Also extending from the main body portion is a flame treatment element for performing a flame treatment operation. The flame treatment element generally comprises a torch or burner. Because both the trimming blade and the flame treatment element are part of the same end effector, the robot simply manipulates the end effector such that the desired one of the trimming blade or the flame treatment element is properly positioned for use. As such, a tooling change can be avoided. While not restricted thereto, it is contemplated that an end effector of the present invention may be used to process vehicle bumper fascias.

A device and method for adjusting the magnetic strength of a magnetic end effector for lift systems is described. The magnetic end effector is capable of lifting discriminate payloads by selectively varying the strength of the magnetic forces output by the magnetic end effector. An actuator can be operatively coupled to the variable strength magnet end effector, wherein the actuator is selectively actuatable to control the adjustment of the variable strength magnet. The actuator may also be configured to maintain the variable strength magnet at a desired magnetic force output strength once achieved for any given amount of time.

A rotary cutting tool, such as a milling cutter (10) includes a central hub (12), a cutting rim (14) and a plurality of spokes (22) connecting the central hub (12) to the cutting rim (14). Each spoke (22) is separated by an opening (32) and polygonal in cross-sectional shape formed by two side walls (22a, 22b), two front walls (22c, 22d) and a rear wall (22e). One of the side walls (22a) of each spoke (22) is formed at a pitch angle (42) with respect to a central axis (11) of the cutting tool (10) that is sufficient to cause lift of chips through the opening (32), thereby providing effective chip evacuation during a material removal operation.

The invention discloses a novel method of controlling the open circuit potential (OCP) of a medical implant by coupling it with small amounts of metals having a lower OCP than the implant. Coupling of Mg to less than 1% of the surface area of a titanium implant is shown to induce cathodic polarization of the titanium that inhibits cell proliferation at the surface of the implant. Mg—Ti coupling in medical devices promises to attenuate or eliminate potential complications of surgery such as peri-implantitis and bacterial infections at the site of implantation.

A method of controlling an operation of a robotically-controlled surgical instrument can include receiving a first input signal at a controller indicative of a user's readiness to actuate the surgical instrument to perform a surgical procedure, outputting an output signal from the controller to provide feedback to the user in response to the received first input signal, receiving a second input signal at the controller confirming the user's readiness to actuate the surgical instrument, outputting an actuation signal from the controller in response to receiving the second input signal, and actuating the surgical instrument to perform the surgical procedure based on the actuation signal.

Whether the growth hormone (GH)/Insulin-like growth factor 1(IGF-I) axis exerts cardioprotective effects remains controversial; and the underlying mechanism(s) for such actions are unclear. Here we tested the hypothesis that growth-hormone releasing hormone (GHRH) directly activates cellular reparative mechanisms within the injured heart, in a GH/IGF-I independent fashion. Following experimental myocardial infarction (MI), rats were randomly assigned to receive, during a 4 week period, either placebo (n=14), rat recombinant GH (rrGH, n=8) or JI-38 (n=8; 50 μg/Kg/day), a potent GHRH-agonist. JI-38 did not elevate serum levels of GH or IGF-I, but markedly attenuated the degree of cardiac functional decline and remodeling after injury. In contrast, GH administration markedly elevated body weight, heart weight, circulating GH and IGF-I, but did not offset the decline in cardiac structure and function. Whereas, both JI-38 and GH augmented levels of cardiac precursor cell proliferation, only JI-38 increased anti-apoptotic gene expression. The receptor for GHRH was detectable on myocytes supporting direct activation of cardiac signal transduction. Collectively, these findings demonstrate that within the heart GHRH-agonists can activate cardiac repair following MI, suggesting the existence of a potential signaling pathway based on GHRH in the heart. The phenotypic profile of the response to a potent GHRH agonist has therapeutic implications.

The present invention provides polymerization processes utilizing an ansa-metallocene catalyst system for the production of olefin polymers. Polymers produced from the polymerization processes have properties that vary based upon the presence or the absence of hydrogen and/or comonomer in the polymerization process.

Material removal tool (100), such as for forming surfaces of valve seats, includes an integral or separable reduced diameter circumferential insert housing (106) including a plurality of inserts (120) bonded thereto. The plurality of inserts (120) include cutting surfaces (122) at different axial and radial positions relative to the axis (112) of the material removal tool (100). Cutting surfaces (122) at different axial and radial positions are arranged at different angles to the axis (112), and at least one cutting surface (122) on at least one insert is at an angle of about 45 degrees relative to the axis (112). Cutting surfaces (122) can be located on one insert-type or different insert-types and can have different combinations of cutting surfaces (122). When arranged circumferentially on the insert housing (106), a N-effective material removal tool (100) is formed. Methods of machining using the N-effective material removal tool (100) is also disclosed.

According to one aspect of the present disclosure, a surgical instrument is disclosed. The instrument includes a handle portion, a body portion extending distally from the handle portion and defining a first longitudinal axis and a loading unit. The loading unit includes a tool assembly, the loading adapted to be coupled to the body portion. The instrument also includes a sensor tube movably positioned within the body portion, the sensor tube adapted to engage the loading unit and a load switch coupled to a microcontroller. The load switch is adapted to be actuated by the sensor tube when the sensor tube is engaged by the loading unit being inserted into the body portion.

The subject invention pertains to matrix metalloproteinase (MMP) inhibitors that exhibit an IC50 of below 10−4M against MMP and have substantially no activity against non-MMP metalloproteinase-related events. The MMP inhibitors of the invention have reduced side-effects, especially with respect to joint pain.

An AF unit of a lens holder driving device includes a lens holder, a focusing coil, a permanent magnet having a plurality of permanent magnet pieces having first surfaces opposed to the focusing coil, a magnet holder holding the permanent magnet, and first and second leaf springs supporting the lens holder in a direction of an optical axis shiftably. An image stabilizer portion includes a fixed portion disposed near the second leaf spring, a supporting member swingably supporting the AF unit with respect to the fixed portion, an image stabilizer coil having a plurality of image stabilizer coil portions disposed so as to oppose to second surfaces of the plurality of permanent magnet pieces that are perpendicular to the first surfaces, and a plurality of Hall elements. Each Hall element is disposed at a position where the image stabilizer coil portion is separated into a plurality of coil parts.

Devices and methods are provided for reducing matrix effects in protein precipitated bioanalytical samples comprising: a support, and a sorbent associated with the support capable of binding matrix interfering agents present in the bioanalytical sample, wherein the device further comprises filtering means for removing precipitated protein particles. The filtering means is a size exclusion filter or a polymeric or inorganic monolith having a maximum pore size less than or equal to the diameter of the particles to be removed from the sample, and can be integral with the sorbent or associated with the sorbent. The sorbent is characterized by sufficient selectivity between the matrix interfering agents and analytes of interest to provide retention of the matrix interfering agents while providing elution of the analytes of interest (e.g., a reversed phase or a polar modified reversed phase). Typical devices incorporating these features include luer syringe filters, individual filter cartridges, multiwell plates, pipette tips, or inline columns for multiple or single use.

Described herein are techniques for assembling a polynucleotide encoding a transcription activator-like effector nucleases (TALEN). The techniques ligate and digest necessary modules for a TALEN assembly in one reactor or system. Methods and Kits for generating a TALEN are also described.

Textured surface for increasing Leidenfrost temperature. The texture comprises of surface features over multiple length scales—from micro to nanoscale—wherein the features at each length scale have a size, aspect ratio, and spacing selected to increase the Leidenfrost temperature. The structure includes an array of microscale structures disposed on the surface, the structure having size, aspect ratio and spacing selected to increase Leidenfrost temperature. The microscale structures may also include nanoscale structures on their surface to create a hierarchical structure. The structures result in an increased Leidenfrost temperature.

A method of complementing a spoken text. The method including receiving text data representative of a natural language text, receiving effect control data including at least one effect control record, each effect control record being associated with a respective location in the natural language text, receiving a stream of audio data, analyzing the stream of audio data for natural language utterances that correlate with the natural language text at a respective one of the locations, and outputting, in response to a determination by the analyzing that a natural language utterance in the stream of audio data correlates with a respective one of the locations, at least one effect control signal based on the effect control record associated with the respective location.

Photo-field-effect transistor devices and associated methods are disclosed in which a photogate, consisting of a quantum dot sensitizing layer, transfers photoelectrons to a semiconductor channel across a charge-separating (type-II) heterointerface, producing a sustained primary and secondary flow of carriers between source and drain electrodes. The light-absorbing photogate thus modulates the flow of current along the channel, forming a photo-field effect transistor.

A differential circuit with a function to compensate unevenness observed in the differential gain thereof is disclosed. The differential circuit provides a low-pass filter in one of the paired transistors not receiving the input signal in addition to another low-pass filter that provides an average of output signals as a reference level of the differential circuit. The cut-off frequency of the filter is preferably set to be equal to the transition frequency at which the self-heating effect explicitly influences the trans-conductance of the transistor.

A thermal desalination system adapted to produce distilled water from feed water which may be sea water, based on a forward feed evaporator made up of a main water feed line, a vapor feed line, a distilled water main line and any number of effect groups. The effect groups include any number of effects which in turn include vapor inlets, water inflow lines, concentrate outflow lines that drain into a common concentrate drainage line, a vapor and water outlet in fluid communication with the distilled water main line, and heat transfer means that condense part of an inlet vapor to produce the distilled water.

An evaporative desalination device includes a multi stage vapor generator that generates vapor by passing a hot water supply pipe successively through a plurality of vapor generators to evaporate sea water inside thereof, a multi effect vapor generator that uses vapor in the respective vapor generators as heat source and forms a plurality of evaporator groups which can adjust a number of evaporators disposed inside the respective evaporator groups and produce fresh water according to amounts of supplied vapor to evaporate sea water in the evaporator groups on an outer circumference surface of an evaporation tube by heat of vapor flowing in the evaporation tube, and a discharge unit that condenses vapor in the multi effect generator by sea water to discharge fresh water in liquid state, and returns and supplies portions of discharged sea water to the multi stage vapor generator and the multi effect evaporator.

Solid state light emitting devices include multiple LED components providing adjustable melatonin suppression effects. Multiple LED components may be operated simultaneously according to different operating modes according to which their combined output provides the same or similar chromaticity, but provides melatonin suppressing effects that differ by at least a predetermined threshold amount between the different operating modes. Switching between operating modes may be triggered by user input elements, timers/clocks, or sensors (e.g., photosensors). Chromaticity of combined output of multiple LED components may also be adjusted, together with providing adjustable melatonin suppression effects at each selected combined output chromaticity.

This disclosure generally relates to high-volume and cost-effective methods for producing non-spherical metal particles, particularly methods for producing metal cubes having rounded edges. The metal cubes having rounded edges are useful as ballistic shot in shotshell loads for hunting, where the particle shape imparted by the disclosed process packs to a higher density than spherical shot in the same volume.

An electroluminescent arrangement is described. This electroluminescent arrangement comprises the following functional layers: (a) rear electrode as layer A;(b) dielectric layer as layer B;(c) electroluminescent layer as layer C; and(d) cover electrode as layer D.

The invention provides compositions and methods for treating leukemia, for example, acute myeloid leukemia (AML) and B-cell acute lymphoid leukemia (B-ALL). The invention also relates to at least one chimeric antigen receptor (CAR) specific to CD123, vectors comprising the same, and recombinant T cells comprising the CD123 CAR. The invention also includes methods of administering a genetically modified T cell expressing a CAR that comprises a CD123 binding domain. The invention also includes methods of bone marrow ablation for use in treatments necessitating bone marrow reconditioning or transplant.

A vessel includes a hull and a deck, a substantially cylindrical rotor having a peripheral wall rotatable with respect to the deck around a longitudinal center line, the rotor being at a lower end connected to the deck and including an upper end plate, the rotor being mounted on the deck in such a manner that in an operational state the rotor is substantially vertically oriented and in an inoperational state the upper end plate is situated in the vicinity of the deck, the end plate extending transversely to the longitudinal center line, wherein the end plate is provided with movable edge segments that in the operational state of the rotor extend radially outwardly from the peripheral wall to an extended position and in the inoperational state of the rotor are moved to a retracted position that is situated closer to the peripheral wall than the extended position.

A vessel includes a hull, a propeller for propulsion of the vessel and at least one rotatable cylinder which in its operational state is vertically mounted on the vessel, the cylinder having a rigid outer surface, a motor drive for rotating the cylinder around a longitudinal axis and a displacement member for displacing the cylinder to an inoperational position, wherein the motor drive is situated inside the cylinder.

A process obtains an aged or faded effect on garments made of protein fibers such as wool, cashmere and silk. Granules of inert materials, which are particularly light in order not to damage very fine fibers, are introduced into a tumbler. The garments were previously treated with a chemical product commonly referred to as “dye retardant” for inhibiting dyeing of the fabric. The tumbler is pre-arranged so that the chemical product does not migrate through holes or openings. Raw confectioned garments that are to be treated, such as jerseys or outerwear, are introduced into the tumbler. The garments are extracted from the tumbler at the end of migration of the chemical product for inhibiting dyeing of the outer surface of the garments by the granules and steamed in an autoclave to fix the chemical process of the product for inhibiting dyeing of the outer surface of the garments. The garments are then dyed with a specific selection of dyes that must be defined each time according to the desired result.

A vibration isolator with a pneumatic spring that is effective only in vertical direction, the pneumatic spring including a working space in which a vertically effective actuator is disposed.

Methods, burner, apparatuses, and systems are provided for controlling a velocity of a jet of gas exiting a burner when the gas is heated or not and at a corresponding second higher temperature or lower first temperature. Through the use of a temperature-sensitive magnetic valve, the flow of a gas can be redirected to maintain velocity of the gas as delivered to a combustion chamber based on the temperature of the gas. The temperature-sensitive magnetic valve can redirect flow of the gas based on the magnetic state of a ferromagnetic material. The state of the temperature-sensitive magnetic valve changes based on the temperature of the gas to maintain the velocity of the gas delivered through an outlet of the burner to the combustion chamber. Thus, heated gases and standard temperature gases can be delivered at approximately equal velocities thus maintaining flame size and shape.

An apparatus that includes two separate reservoirs wherein the first reservoir is molded into the body of the larger artificial body of water and filled using a standard pump from the main body of water. From the larger body of water, the water is then moved upward through the apparatus through the manual opening of a valve assembly. Once the valve assembly is opened, the water moves through the valve assembly and through a grate and into a second reservoir. From this second reservoir, the water is pulled by the force gravity over the spillway into the main body of water, creating a clean, sheer waterfall effect.

In some embodiments, a field effect transistor structure includes a first semiconductor structure and a gate structure. The first semiconductor structure includes a channel region, and a source region and a drain region. The source region and the drain region are formed on opposite ends of the channel region, respectively. The gate structure includes a central region and footing regions. The central region is formed over the first semiconductor structure. The footing regions are formed on opposite sides of the central region and along where the central region is adjacent to the first semiconductor structure.

A method for controlling the effective heat transfer from a storage unit (1). During gas release from storage material (3) in the storage unit the storage material is heated by a heater (2). During re-saturation of the storage material (3) with gas the heater is off. Controlling of the effective heat transfer from the storage unit (1) is performed, during gas release, by ceasing convection of a convection gas and, during re-saturation, by performing or enabling convection of a convection gas to cool the storage unit (1).

A system and method provides a piezoelectric stack arrangement for reduced driving voltage while maintaining a driving level for active piezoelectric materials. A stack arrangement of d36 shear mode single crystals of both air X-cut and Y-cut ±1:45° (±20°) arrangement are bonded with discrete conductive pillars to form a shear crystal stack. The bonding area between the neighboring crystal parts is minimized. The bonding pillars are positioned at less than a total surface are of the single crystal forming the stack. The stack fabrication is facilitated with a precision assembly system, where crystal parts are placed to desired locations on an assembly fixture for alignment following the preset operation steps. With the reduced clamping effect from bonding due to lower surface coverage of the discrete conductive pillars, such a piezoelectric d36 shear crystal stack exhibits a reduced driving voltage while maintaining a driving level and substantial and surprisingly improved performance.

The invention relates to an electronic musical instrument system (1) for influencing the sound of an electric musical instrument having a housing (2) that has signal ports (14, 18) and a power supply port (15). In order to simplify the individual combination of different audio effects, the housing (2) contains control electronics (6) that have associated slots (4a-4f) for effects modules (19), wherein the slots (4a-4f) are arranged in the housing (2) and each slot (4a-4f) has a multipin connection (5a-5f) for connection to a plug-in effects module (19). The invention additionally relates to a corresponding effects module (19).

An acoustic effect impartment apparatus for use in a piano including a plurality of keys, a plurality of strings provided in corresponding relation to the keys and a plurality of hammers each responsive to an operation of any one of the keys to strike the string corresponding to the key. The acoustic effect impartment apparatus comprising at least one elongate member disposed near at least one of the plurality of strings. The elongate member movable by means of a first actuator between a retracted configuration in which the elongate member is disengaged away from the at least one of the plurality of strings and an imparted configuration wherein the elongate member is imparted against the at least one of the plurality of strings, and the first actuator can be actuated by a piano player such that the elongate member is imparted against the at least one of the plurality of strings as said piano player strikes a key associated therewith.

Systems and methods for effecting posture of a subject who is to be positioned on a support surface having an inclinable portion such that the subject's thorax is inclinable relative to the subject's legs, are provided. An example system includes a detachedly coupleable thoracic harness having at least an inner surface and an outer surface. The inner surface being contoured to fit over shoulders of the subject. The outer surface having a fastening surface that releasable attaches to a corresponding fastening surface disposed on the inclinable portion of the support surface.

The disclosed apparatus cools a drinking liquid utilizing the Peltier effect, and optionally includes a system of gasification for gasifying the drinking liquid, once cooled. The cooling system in turn includes: a first cooling circuit, in which an operating fluid circulates, associated with a hot side of a Peltier cell; and a second cooling circuit, in which the drinking liquid circulates, associated with a cold side of the Peltier cell. The Peltier cell is integrated in a cooling unit exhibiting a special sandwich structure which integrates, as well as the Peltier cell, a first and a second heat exchanger, apt respectively to exchange directly the heat between the operating fluid which circulates in the first cooling circuit and the hot side of the Peltier cell and between the drinking liquid which circulates in the second cooling circuit and the cold side of the Peltier cell to cool the drinking liquid.

In this month's edition of AppleVis Unleashed, Thomas Domville, Randy Rusnak, and Mike Malarsie discuss recent Apple news and other topics of interest. Topics featured in this podcast include:

• Apple Announces WWDC 2019 Kicks Off June 3
• Apple Announces New 10.5-inch iPad Air and iPad mini with A12 Bionic chip and Apple Pencil Support
• Apple's 2019 iMac gets some fresh chips, including an eight-core CPU
• Apple Launches Second Generation AirPods; with "Hey Siri" Support, Wireless Charging Case, and Latency Improvements
• Apple Launches 'Apple News+' Subscription Service for $9.99/Month
• Apple Card: Release date, cash back rewards and sign up bonus info
• Apple Announces Original Content Streaming Service, Apple TV+
• Apple introduces Apple Arcade
• Apple releases iOS 12.2 with Apple News Plus and support for new AirPods
• Apple is rolling out these 40 new features and changes in iOS 12.2 for iPhone & iPad
• Apple Music launches on Amazon Fire TV, coming to Echo for UK users soon
• Google Duplex for iPhone coming in a few weeks
• Latest Seeing AI app lets blind and low-vision users explore photos by touch, adds iPad support
• A Warm Welcome to the Newest Specialized Help Partner: Google
• Chirp for Twitter has been updated with the FlickType Keyboard for Apple Watch
• Tip: How to make a call on speakerphone with Siri on iPhone and iPad
• Tip: How to Enable Reader View in Safari Automatically on iPhone or iPad

You can contact the Unleashed Team with feedback or questions at unleashed@applevis.com