Does JavaScript use UCS-2 or UTF-16 encoding? Since I couldn’t find a definitive answer to this question anywhere, I decided to look into it. The answer depends on what you’re referring to: the JavaScript engine, or JavaScript at the language level.

Did you know var π = Math.PI; is syntactically valid JavaScript? I thought this was pretty cool, so I decided to look into which Unicode glyphs are allowed in JavaScript variable names, or identifiers as the ECMAScript specification calls them.

Fun fact: var foo = { H̹̙̦̮͉̩̗̗ͧ̇̏̊̾Eͨ͆͒̆ͮ̃͏̷̮̣̫̤̣Cͯ̂͐͏̨̛͔̦̟͈̻O̜͎͍͙͚̬̝̣̽ͮ͐͗̀ͤ̍̀͢M̴̡̲̭͍͇̼̟̯̦̉̒͠Ḛ̛̙̞̪̗ͥͤͩ̾͑̔͐ͅṮ̴̷̷̗̼͍̿̿̓̽͐H̙̙̔̄͜: 42 }; is valid JavaScript. It may not be immediately obvious, but the real surprise here is that the Cthulhu-esque property name is not surrounded by quotes. Intrigued by this, and having written about the similar topic of JavaScript identifiers before, I decided to look into valid property names in JavaScript. When do they need to be quoted? When can the quotes be omitted? And in which cases can dot notation be used instead of bracket notation to get or set a property based on its name?

Looking for a list of all reserved words in JavaScript? You’ve come to the right place. I recently needed such a list myself, but ended up comparing the reserved keywords in all ECMAScript versions as well. The result is listed below, for future reference.

The way JavaScript handles Unicode is… surprising, to say the least. This write-up explains the pain points associated with Unicode in JavaScript, provides solutions for common problems, and explains how the ECMAScript 6 standard improves the situation.

ES2015 updates the grammar for identifiers. This affects a number of things, but most importantly, identifiers can be used as variable names, and identifier names are valid unquoted property names. This post describes the observable changes compared to the old ES5 behavior.

ES2018 adds support for Unicode property escapes of the form p{…} and P{…} to JavaScript regular expressions. This article explains what Unicode property escapes are, how they work, and why they’re useful.

This article describes some key fundamentals that are common to all JavaScript engines — and not just V8, the engine the authors work on. As a JavaScript developer, having a deeper understanding of how JavaScript engines work helps you reason about the performance characteristics of your code.

This article explains JavaScript engine optimization pipeline trade-offs, and describes how engines such as V8 speed up accesses to prototype properties. As a JavaScript developer, having a deeper understanding of how JavaScript engines work helps you reason about the performance characteristics of your code.

The globalThis proposal introduces a unified mechanism to access the so-called “global object” a.k.a. “the global” in any JavaScript environment. It sounds like a simple thing to polyfill, but it turns out it’s pretty hard to get right.

Mines Director assures timely support to complete construction of colonies

Even as the district administration is busy taking steps to set up an institutional quarantine centre at Devaraj Urs hostel at Navalur between Hubball

400 students in UK avail coupons

The Trento Alpine Rescue service said the body of one man was found late Saturday on the Folgaria plateau after an avalanche separated him from his dog.

Most of the 698 Indians, of whom 440 are from Kerala, were stranded in the island country after they lost their jobs

Passengers showing Covid-19 symptoms are being disembarked first, followed by others in small groups, district-wise, says a Cochin Port Trust official

This is the Indian Navy's first massive evacuation exercise from foreign soil during the COVID-19 lockdown.

The fossil teeth of a 15- to 18-million-year-old three-toed browsing horse, Anchitherium clarencei, were recently discovered by scientists from the Smithsonian Tropical Research Institute and the […]

The post Fossil teeth of 15-million-year-old browsing horse found in Panama Canal excavations. appeared first on Smithsonian Insider.

The National Aeronautics and Space Administration has made available to the public a new online collection of images that capture the excitement of planetary exploration and the journey to understand the origin and evolution of the solar system.

The post Stunning high-resolution NASA images available online for public exhibits appeared first on Smithsonian Insider.

A scientist from the Smithsonian Tropical Research Institute uses a pick to dislodge the fossil skull of an extinct toothed whale from sediments on the […]

The post Fossil skull of an extinct toothed whale excavated from Panamanian sediments appeared first on Smithsonian Insider.

What Google is attempting for books, the University of California, Berkeley, plans to do for the world's vertebrate specimens: store them in "the cloud."

The post New “cloud-based” storage initiative to make vertebrate research collections available worldwide appeared first on Smithsonian Insider.

The discovery of two new extinct camel species by scientists from the University of Florida and the Smithsonian is casting new light on the history of the tropics, a region containing more than half the world's biodiversity and some of its most important ecosystems.

The post Two new species of extinct camels discovered in Panama Canal excavations appeared first on Smithsonian Insider.

“Ignition Sequence,” 1968, Vincent Cavallaro, oil on canvas. The power of the ignition and launch sequence of a NASA rocket is portrayed in an abstract […]

The post “Ignition Sequence,” by Vincent Cavallaro appeared first on Smithsonian Insider.

Kepler-78b is a planet that shouldn’t exist. This scorching lava world circles its star every eight and a half hours at a distance of less […]

The post Mystery lava world baffles astronomers appeared first on Smithsonian Insider.

Seven fossil teeth exposed by the Panama Canal expansion project are the first evidence of a monkey on the North American continent before the Isthmus […]

The post First North American Monkey Fossils Found in Panama Canal Excavation appeared first on Smithsonian Insider.

Eric Peterman, Mindaugas Valius, and Rytis Prekeris

During mitotic cell division, the actomyosin cytoskeleton undergoes several dynamic changes that play key roles in progression through mitosis. While the regulators of cytokinetic ring formation and contraction are well-established, proteins that regulate cortical stability during anaphase and telophase have been understudied. Here, we describe a role for CLIC4 in regulating actin and actin-regulators at the cortex and cytokinetic cleavage furrow during cytokinesis. We first describe CLIC4 as a new component of the cytokinetic cleavage furrow that is required for successful completion of mitotic cell division. We also demonstrate that CLIC4 regulates the remodeling of sub-plasma membrane actomyosin network within the furrow by recruiting MST4 kinase and regulating ezrin phosphorylation. This work identifies and characterizes new molecular players involved in regulating cortex stiffness and blebbing during late stages of cytokinetic furrowing.

Miniature camels and horses, a rhinoceros and a giant bear-dog are among fossils unearthed in the recent excavations of the Panama Canal expansion project. These […]

The post First five years of Panama Canal excavations reveal fossil finds appeared first on Smithsonian Insider.

Scientists from the Smithsonian and the University of Rhode Island have found unsuspected linkages between the oxidation state of iron in volcanic rocks and variations […]

The post Scientists uncover relationship between lavas erupting on sea floor and deep-carbon cycle appeared first on Smithsonian Insider.

As of today all PDF versions of books published by the National Academies Press will be downloadable to anyone free of charge. This includes a current catalog of more than 4,000 books plus future reports produced by the Press.

A new publication from the U.S. National Academies of Sciences, Engineering, and Medicine, provides a brief summary of presentations and discussions at the Second International Summit on Human Genome Editing, held in Hong Kong on Nov. 27-29, 2018.

The Gulf Research Program (GRP) of the National Academies of Sciences, Engineering, and Medicine today announced a new funding opportunity to provide up to $2.5 million in grants to foster innovative approaches that support its ongoing efforts to improve understanding and prediction of the Gulf of Mexico Loop Current System (LCS).

The Gulf Research Program (GRP) of the National Academies of Sciences, Engineering, and Medicine today announced a new funding opportunity under its Healthy Ecosystems Initiative.

A new report from the National Academies of Sciences, Engineering, and Medicine – which reviews a separate report by a federally funded laboratory that examines options for treating low-activity radioactive waste at the Hanford Nuclear Reservation -- is available for public comment until Oct. 31.

Source: Streetwise Reports   04/27/2020

Avadel Pharmaceuticals Plc (AVDL:NASDAQ) today announced "positive topline data from its pivotal Phase 3 REST-ON trial assessing the safety and efficacy of FT218, an investigational, once-nightly formulation of sodium oxybate for the treatment of excessive daytime sleepiness and cataplexy in patients with narcolepsy." The firm pointed out that it met all three of the co-primary efficacy endpoints in the study for each of three dosage levels which it claims demonstrates "highly significant, clinically meaningful improvements on the Maintenance of Wakefulness Test, Clinical Global Impression-Improvement and mean weekly cataplexy attacks."

The company's Chief Medical Officer Jordan Dubow, M.D., commented, "We are excited to see these positive topline data from the REST-ON study, where all three dose levels of once-nightly FT218 demonstrated a statistically significant and clinically meaningful improvement on the measures of the two prominent symptoms of narcolepsy, as well as an improvement in overall functioning compared to placebo...Once-nightly FT218 delivered a clinically meaningful response within three weeks of treatment initiation, which was sustained through each treatment period...We think once-nightly FT218, if approved, has the potential to be a meaningful contributor to patient care."

Avadel Pharma's CEO Greg Divis remarked, "The successful outcome of the REST-ON study strengthens our belief that, if approved, once-nightly FT218 has the potential to be a significant advancement for patients in the estimated $1.7 billion twice-nightly sodium oxybate market. Our proprietary market research with physicians and patients informs us that there is a strong interest in a once-nightly sodium oxybate formulation. We look forward to sharing the results from the REST-ON study with the FDA and progressing toward a potential approval that would allow us to bring this important treatment to the patients who need it most. If approved, FT218 would be the first once-nightly therapy to address both excessive daytime sleepiness and cataplexy in patients with narcolepsy."

The REST-ON study is a double-blind, randomized, placebo-controlled Phase 3 trial to assess the efficacy and safety of once-nightly FT218, a formulation of sodium oxybate using Avadel's proprietary Micropump technology for extended-release oral suspension in the treatment of excessive daytime sleepiness and cataplexy in patients suffering from narcolepsy. The company stated that 212 patients were enrolled in the study and result "showed that the 9 g dose of once-nightly FT218 demonstrated a highly significant and clinically meaningful improvement compared to placebo across all three co-primary endpoints."

The company advised that FT218 has been granted Orphan Drug Designation from the U.S. FDA for the treatment of narcolepsy. The firm added that the designation was granted on basis that FT218 may be clinically superior to a formulation of sodium oxybate that is already approved by the FDA for the same indication.

Avadel Pharmaceuticals is biopharmaceutical company headquartered in Dublin, Ireland. The company's primary focus is on the development and potential FDA approval for FT218, which just completed its Phase 3 REST-ON clinical trial for the treatment of narcolepsy patients suffering from excessive daytime sleepiness and cataplexy. The firm also develops and markets sterile injectable drugs for use in hospital settings.

Avadel started off the day with a market capitalization of around $456.2 million with approximately 46.4 million shares outstanding and a short interest of about 14.00%. AVDL shares opened more than 34% higher today at $13.30 (+$3.37, +34.28%) over Friday's $9.83 closing price and reached a new 52-week high price this morning of $13.49. The stock has traded today between $11.90 and $13.49 per share and is currently trading at $12.27 (+$2.44 +24.82%).

Disclosure:
1) Stephen Hytha compiled this article for Streetwise Reports LLC and provides services to Streetwise Reports as an independent contractor. He or members of his household own securities of the following companies mentioned in the article: None. He or members of his household are paid by the following companies mentioned in this article: None.
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( Companies Mentioned: AVDL:NASDAQ, )

Current knowledge on the availability of mineral resources is explored in a recent study, which focuses on phosphorus as a key example. Static measures of availability, such as the consumption-to-production ratio, are useful as early warning signals, the researchers suggest, but more dynamic indicators that consider technological development and population change are needed to better inform policy.

Current knowledge on the availability of mineral resources is explored in a recent study, which focuses on phosphorus as a key example. Static measures of availability, such as the consumption-to-production ratio, are useful as early warning signals, the researchers suggest, but more dynamic indicators that consider technological development and population change are needed to better inform policy.

Millions of years ago, Africa's savannas were covered with thick, ancient forests, which disappeared and turned into the grassy ecosystems that they are today.

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