4 News24 | SRD R370 grant beneficiaries approved in October still waiting for payment By www.news24.com Published On :: Tuesday Nov 12 2024 20:41:04 Nearly three weeks after they were supposed to be paid, a number of SRD grant beneficiaries who had their applications approved in October are still waiting for their payments. Full Article
4 News24 | Two people arrested over murder of ‘Noem My Skollie’ actor, insurance fraud suspected By www.news24.com Published On :: Tuesday Nov 12 2024 21:31:55 Cape Town police have arrested two suspects in connection with the murder of Noem My Skollie actor David Manuel and his friend, Alfonso Fisher, in Gugulethu last month. Full Article
4 News24 | SA Jewish Board of Deputies approaches Equality Court with social media hate speech complaint By www.news24.com Published On :: Wednesday Nov 13 2024 08:11:04 The Cape South African Jewish Board of Deputies has asked the Equality Court in Cape Town to declare politician Mehmet Vefa Dag's social media posts about about Jewish people hate speech. Full Article
4 News24 | WASTE LAND | Mogale City sewage disaster sees faeces-laden river water testing 100 times above legal limit By www.news24.com Published On :: Tuesday Nov 12 2024 04:45:19 Scientific tests confirm rivers and dams have been poisoned by the raw sewage dumped by the municipality in the Bloubankspruit and Crocodile Rivers, killing aquatic life and destroying businesses and livelihoods. Full Article
4 News24 | Budget constraints force Gauteng education department to delay teacher promotions until April By www.news24.com Published On :: Wednesday Nov 13 2024 06:20:32 The Gauteng education department has postponed the appointment of new office-based staff as well as teachers who applied to be promoted as heads of department, deputy principals and principals until April because of budget constraints. Full Article
4 News24 | Fraser's Phala Phala claims something from a movie, but baseless, says Ramaphosa's lawyer By www.news24.com Published On :: Wednesday Nov 13 2024 08:23:10 President Cyril Ramaphosa's lawyers say former spy boss Arthur Fraser's claims about the Phala Phala break-in are like something from a movie - but are founded on nothing more than baseless speculation. Full Article
4 News24 | Heat attack: 2024 is world's hottest year, and likely to leave South Africans sweating this summer By www.news24.com Published On :: Wednesday Nov 13 2024 04:45:18 The World Meteorological Organisation (WMO) has raised the alarm over climate change, reporting 2024 is the world's hottest year yet. Full Article
4 News24 | Higher education minister clashes with NSFAS head over 'unexplained' suspension of 2 officials By www.news24.com Published On :: Wednesday Nov 13 2024 06:16:50 A formal disciplinary process, or lack thereof, around the suspensions of two high-ranking officials at the National Student Financial Aid Scheme (NSFAS) has pitted Higher Education and Training Minister Nobuhle Pamela Nkabane against NSFAS administrator Freeman Nomvalo. Full Article
4 News24 | Do you have any complaints or feedback about News24's content? Here's how to get in touch By www.news24.com Published On :: Tuesday Oct 08 2024 20:38:59 Any complaints, queries or suggestions about content on News24 may be sent to our public editor George Claassen. Full Article
4 News24 | 'Explainer-in-chief': Rasool aims to amplify SA's voice globally in second stint as ambassador in US By www.news24.com Published On :: Wednesday Nov 13 2024 06:13:33 When Ebrahim Rasool returns to Washington in December as South Africa's ambassador, one of his primary goals is to reposition Pretoria as a "moral superpower" Full Article
4 News24 | Inside Gauteng legislature's shadowy deal with employees accused of fraud during Covid-19 spree By www.news24.com Published On :: Wednesday Nov 13 2024 04:45:15 Gauteng legislature secretary Linda Mwale has signed a sweetheart agreement with Nehawu to let 32 employees accused of defrauding the institution off the hook. Full Article
4 News24 | Senzo Meyiwa murder accused removed from C-Max centre By www.news24.com Published On :: Wednesday Nov 13 2024 07:39:54 It was out of fear for his mental health and to avoid the perpetuation of an ongoing wrong that a judge ordered that one of the five men charged with the murder of soccer star Senzo Meyiwa be removed from solitary confinement. Full Article
4 News24 | Wenzeni uGupta? Hlophe asks what crimes Guptas are accused of, disparages Batohi By www.news24.com Published On :: Wednesday Nov 13 2024 08:07:22 The MK Party continued its campaign against accountability for corruption, with its deputy leader, John Hlophe, suggesting National Director of Public Prosecutions Shamila Batohi was "misleading the nation" about the Guptas' extradition. Full Article
4 News24 | WATCH | KZN cops to conduct probe after police assault video goes viral By www.news24.com Published On :: Wednesday Nov 13 2024 08:51:38 KwaZulu-Natal police commissioner Lieutenant General Nhlanhla Mkhwanazi has ordered an "immediate investigation" after a video went viral on social media of a police officer slapping and pulling around a man. Full Article
4 Radar Trends to Watch: August 2024 By www.oreilly.com Published On :: Tue, 06 Aug 2024 10:02:43 +0000 July was a big month for model releases: There are new large models from Mistral and Meta, smaller multilingual models from Mistral and DeepL, another Mistral model that specializes in code generation, and a small version of GPT-4o. The security world saw another software supply chain disaster when CrowdStrike released a bad software update that […] Full Article Radar Trends Signals
4 Radar Trends to Watch: September 2024 By www.oreilly.com Published On :: Tue, 03 Sep 2024 10:00:09 +0000 This month, we’ll give AI a rest. Alex Russell has finished an excellent series of posts titled “Reckoning.” It’s a must-read for web developers. If you want to understand why our networks and laptops are much faster than they were 15 or 20 years ago, but the web is slower, it comes down to one […] Full Article Radar Trends Signals
4 Radar Trends to Watch: October 2024 By www.oreilly.com Published On :: Tue, 01 Oct 2024 09:55:29 +0000 The model release train continues, with Mistral’s multimodal Pixtral 12B, OpenAI’s o1 models, and Roblox’s model for building 3D scenes. We also have another important AI-enabled programming tool: Cursor is an alternative to GitHub Copilot that’s getting rave reviews. Security will never cease to be a problem, but this month seems particularly problematic. The Mirai […] Full Article Radar Trends Signals
4 The State of Security in 2024 By www.oreilly.com Published On :: Tue, 08 Oct 2024 10:05:42 +0000 In August 2024, we asked our customers to tell us about security: their role in security, their certifications, their concerns, and what their companies are doing to address those concerns. We had 1,322 complete responses, of which 419 (32%—roughly one-third) are members of a security team. 903 respondents aren’t on a security team, although 19% […] Full Article Security Deep Dive
4 Radar Trends to Watch: November 2024 By www.oreilly.com Published On :: Tue, 05 Nov 2024 11:04:37 +0000 October had many language model releases. The mid-size models, and even the small models, are catching up to frontier models like GPT-4.5o in performance. But the release that blew us all away wasn’t a language model: It was Claude’s computer use API. Computer use allows you to teach Claude how to use a computer: how […] Full Article Radar Trends Signals
4 "Laptop" with full 4090 GPU weighs 15 pounds By boingboing.net Published On :: Tue, 01 Oct 2024 16:25:57 +0000 There are laptops sold with NVidia's high-end 4090 graphics chip, but it's a power-constrained mobile version appropriate for portable machines. A Chinese-language blogger modded themselves a beast of a machine with a full desktop-class 4090 card. This thing weighs 15 pounds and its battery life is a Borgesian map of nothing (one must plug it in). — Read the rest The post "Laptop" with full 4090 GPU weighs 15 pounds appeared first on Boing Boing. Full Article Post computers gadgets hacks
4 The stunning view from Preikestolen, 604m over Norway's Lysefjorden By boingboing.net Published On :: Wed, 02 Oct 2024 11:40:41 +0000 Preikestolen, Pulpit Rock, is one of Norway's most famous natural landmarks. It's located in Rogaland county, near the town of Forsand. It overlooks the stunning Lysefjorden, a narrow fjord surrounded by steep cliffs. In this video of the 604m Rock, both the stunning beauty and dizzying height of the rock are shown. — Read the rest The post The stunning view from Preikestolen, 604m over Norway's Lysefjorden appeared first on Boing Boing. Full Article Post cliff heights travel
4 Texas man wastes $4k smashing a Taylor Swift "themed" guitar By boingboing.net Published On :: Wed, 02 Oct 2024 16:19:00 +0000 A North Texas man recently spent $4000 on a guitar he believed was signed by Taylor Swift at the Ellis County Wild Game Dinner in Waxahachie, Texas, and then immediately destroyed it with a hammer. Sounds like the guitar was an imposter. — Read the rest The post Texas man wastes $4k smashing a Taylor Swift "themed" guitar appeared first on Boing Boing. Full Article Post guitars maga politics taylor swift texas what a waste of money
4 IVT MediaPlatform 4.1 Sets New Standard for Enterprise Video Communications By communicationtransformation.blogspot.com Published On :: Wed, 06 May 2009 20:22:00 +0000 IVT released its latest upgrades to its MediaPlatform software.Click to view the announcement. Full Article
4 Instant Reaction: CPI, August 14, 2024 By www.nar.realtor Published On :: Wed, 14 Aug 2024 13:27:58 +0000 Instant Reaction: CPI, August 14, 2024 Inflation is calmer, thereby setting the Fed Reserve up to start the rate-cutting process in September. By: Lawrence Yun Full Article
4 Fresh Faces, New Perspectives: Diversity Among New REALTORS® in 2024 By www.nar.realtor Published On :: Wed, 14 Aug 2024 17:57:57 +0000 Diversity Among New REALTORS® in 2024 A notable highlight of the findings in the 2024 NAR Member Profile is that new NAR members are more diverse than their experienced counterparts. By: Amethyst Marroquin Full Article
4 Instant Reaction: Mortgage Rates, August 15, 2024 By www.nar.realtor Published On :: Thu, 15 Aug 2024 16:31:08 +0000 Instant Reaction: Mortgage Rates, August 15, 2024 The 30-year fixed mortgage rate from Freddie Mac remained essentially flat at 6.49% this week compared to 6.47% last week. By: Jessica Lautz Mortgages & Home Financing Full Article
4 Instant Reaction: Mortgage Rates, August 29, 2024 By www.nar.realtor Published On :: Thu, 29 Aug 2024 16:30:08 +0000 Instant Reaction: Mortgage Rates, August 29, 2024 The average 30-year fixed mortgage rate from Freddie Mac dropped to 6.35% this week from 6.46% last week. By: Jessica Lautz Mortgages & Home Financing Full Article
4 Instant Reaction: Mortgage Rates, September 5, 2024 By www.nar.realtor Published On :: Thu, 05 Sep 2024 16:37:05 +0000 Instant Reaction: Mortgage Rates, September 5, 2024 The average 30-year fixed mortgage rate from Freddie Mac remained unchanged at 6.35% this week from last week. By: Jessica Lautz Mortgages & Home Financing Full Article
4 Instant Reaction: Jobs, September 6, 2024 By www.nar.realtor Published On :: Fri, 06 Sep 2024 13:27:31 +0000 Instant Reaction: Jobs, September 6, 2024 The softening job figures suggest that the Federal Reserve will cut interest rates in mid-September. By: Lawrence Yun Full Article
4 Amazing: Trump Moved 48 States Toward the Republican Party By conservativefiringline.com Published On :: Sun, 10 Nov 2024 16:15:37 +0000 The following article, Amazing: Trump Moved 48 States Toward the Republican Party, was first published on Conservative Firing Line. When the 2024 election dust settled early on Wednesday morning, it became clear that Donald Trump didn’t just win the election, he trounced Kamala Harris. It was so bad for the Democrats that nearly every state moved to the right. The GOP hasn’t seen so many votes move their way since Ronald Reagan in 1980. … Continue reading Amazing: Trump Moved 48 States Toward the Republican Party ... Full Article Politics democrats Harris Republican Trump voters
4 Forty-Seven Percent Of Harris Voters Believe Trump Will Not Be A Legitimate President; 54 Percent Want To Leave The Country By conservativefiringline.com Published On :: Wed, 13 Nov 2024 01:15:35 +0000 The following article, Forty-Seven Percent Of Harris Voters Believe Trump Will Not Be A Legitimate President; 54 Percent Want To Leave The Country, was first published on Conservative Firing Line. I really wish that everyone would just calm down. Emotions always run high immediately after an election, but what we are witnessing this time around is truly frightening. We live at a time when people feel free to express their deepest, darkest emotions on social media, and right now “freak out video” after “freak out … Continue reading Forty-Seven Percent Of Harris Voters Believe Trump Will Not Be A Legitimate President; 54 Percent Want To Leave The Country ... Full Article Opinion Politics country Harris leave liberals Trump voters
4 Instapaper 4: Deciding to Read By www.43folders.com Published On :: Mon, 17 Oct 2011 19:37:45 +0000 Introducing Instapaper 4.0 for iPad and iPhone The lede here is that my pal, Marco, has just released the stellar new 4.0 version of his Instapaper suite. This is fantastic news, and–as if you needed one more of Marco’s beta testers to say so–I do sincerely hope you’ll mark the occasion (and support his hard work) by purchasing the Instapaper iOS app(s). I promise you’ll be treating yourself to a massive update to an already excellent product. Now, it’s fortunate and appropriate that you’ll be hearing this advice at length from a lot of people this week. Because, if it’s not already obvious, Marco’s little app (and its associated services) enjoys a rabid fanbase of sundry paragraph cultists who are as eager as I am to spread the word; and, yes, we do want you to join the Reading Nerd cult. But, I also want to mark the occasion by adding a few thoughts on exactly what Instapaper has done, and continues to do, for me. (As you may already know, I’m a big Marco fan.) Thing is, I want to tell you how Marco has made a magical machine for people who have decided to read. Long-Time Fan For years, Instapaper has been one of the best made, most used, and most beloved apps in my iOS ecosystem. It’s always lived on my iPhone’s home page, and, as you can surmise, that’s because I use Instapaper a lot. Like, a lot a lot. Specifically, I use Instapaper a lot because it helps me do four things extremely well. Four things that work together to make my life a little better. In that typically annoying mixed order I can’t seem to stop doing, here goes. 2. Deciding WHEN to read Second, and most obviously, I use Instapaper maybe five to ten times a day to catch up on my reading. Which is great. This is what Instapaper is actually for, right? You read stuff. Long articles, smaller features, short books, big piles of documentation, and really just anything that I would like to read…later. More saliently, these are things that I have decided to read. This decision part’s important, but more on that in a couple minutes. But, how does all this “stuff” I’ve decided to read get in to Instapaper? 1. Deciding WHAT to read See, this is the really important first part. Because as much as I use Instapaper for all manner of reading, its use as an ephemeral destination for mostly ephemeral content wouldn’t be nearly so useful if I didn’t have so many ways to collect all that stuff. So, that flexibility in collecting material is where I end up using some form of Instapaper dozens of times each day. Examples? I have a bookmarklet for adding items to Instapaper in 4 browsers on 7 devices. I have (and use the hell out of) the “Send to Instapaper” services that are built in to everything from Google Reader to Reeder to Flipboard to Instacast to Tweetbot to Zite to you name it. I can automate in or out of Instapaper with If This Then That, I can email items directly to Instapaper–hell, I can even just copy a URL from iOS Safari, and paste it directly into the motherscratching Instapaper app. Suffice it to say, there are many ways to get “stuff” into Instapaper. E.g.: But, that banner dump only tells part of the story. Yes, a big part of this is about ubiquity and ease-of-use. But, the practical result is that all those little entrees to Instapaper are available to me everywhere I might need them, and they each represent a single little click that silently adds an item of “stuff” to my Instapaper pile. Each button is one more simple opportunity for me to decide to read. 3. Deciding WHERE to read Now, the third part of this magic is less immediately obvious, not least because the reading experience of the Instapaper iOS apps is, for my own purposes, perfect. But, there’s more. Because, all that support for getting stuff into Instapaper is mirrored by an endless number of ways to get stuff back out. To, in fact, read. That thing I decided to read is now everywhere. However I ended up deciding to read something, seconds after that *click*, the real magic starts happening, and–through whatever inscrutable black art and transmogrification is happening inside the fearsome celestial engine Marco has made–that decision to read is expressed in the most elegant of results and in a startlingly broad variety of convenient places. It’s readable on a website; it’s readable on an iPhone, and 2 iPads; it’s readable on a Kindle 3; it’s readable on the crazy number of apps and services that display Instapaper items. And, it’s even preserved for posterity in my private Pinboard archive. So, for practical purposes, this stuff that I’ve decided to read can now go whooshing through a network of customized tubes, and gently land practically anywhere that well-formed bits may reside. 4. Just…Deciding to Read I know most of you know these things. I know you’re familiar with the many “Features and Benefits” of Instapaper. And, I even know that most of you reading this are probably already using Instapaper–perhaps even to read this very article. So, the point here is not simply that Instapaper is flexible, idiot-proof, and sanity-savingly redundant. Although it is all those things and many more. The point is that my life always gets better when I decide to read things–and then actually read those things I decided to read. This is not a trivial point. We’re all busy, and we’re all bombarded with 10,000 potential calls on our attention every day. Some days, we handle that better than others. Some days, we don’t handle it all. All I know, is that, throughout my life, deciding to read has made that life better. It made my life better at 7 with Henry Huggins. It made my life better at 16 with Slaughterhouse-Five. It made my life better at 20 with Absalom, Absalom!. And, it made my life way better at 25 with A Confederacy of Dunces (cf.). And, now, for the past few years–following over a decade during which I read way more href tags than actual prose paragraphs–my life has gotten better, in part, due to Instapaper. I’ve finally gotten my hands around this “too much stuff” issue, at least insofar as it relates to words of theoretical interest. Now, I know where it goes. It goes into Instapaper. Because, now? Yeah. Twenty-some years after a college career sucking down over 1,000 pages a week, I am finally returning to reading a lot more. Because, I am deciding to read a lot more. Instapaper means there’s no excuse for not reading a lot more. Period. How about you? What Are YOU Deciding? When you’re in line at the ATM or the professional sporting event, what do you do? If you’re like a lot of people, you hit your mobile device like a pigeon on a goddamned pellet. Then, you decide what happens. You can decide to throw birds at pigs. You can decide to check in on which strangers are pretending to like you today. You may even decide to see what you would look like if you were really fat. Thing is, you could also decide to read. Just for a couple minutes. Maybe more. Maybe less. Who knows. It’s your decision. A Nudge Towards “Better” But, if you have followed the circuitous skeins of yarn comprising this little sweater you’ve been reading, it comes down to this: If you’ve decided that you want to read, Marco’s app will really help you. He’s removed any phony barriers you’ve built about “not having time” or “not having it with you” or “not knowing where to put it.” There are no excuses, apart from the superficial animated ones you’ve constructed out of cartoon birds. As for me? In the last week alone, I decided to read a lot of things in Instapaper. A small sampling: I decided to read about an American family’s educational experiment in Russia. I decided to read about what Heidegger means by Being-in-the-World. I decided to read about why toasters are so bad. I decided to read about responsive web design. I decided to read about why Charlie Kaufman wrote Being John Malkovich. I decided to read about how Open Data could make San Francisco Public Transportation better. I decided to read about how John Siracusa remembers Steve Jobs. I decided, and then I read. I read, and I read. So, thanks, Marco. You’ve made my life better by making it easier to decide to read. Then, you made it way easier to do the actual reading. And, to you–the kind readers-of-prose-paragraphs who were inexplicably patient enough to decide to read this long article–please consider supporting Marco’s work. Please get an account at Instapaper and, if you have an iOS dingus, please do buy the Instapaper app. In addition to having exquisite taste in app icons and a lovely speaking voice, Marco’s just a very good human. And, good humans more than deserve our support. Buy Instapaper 4.0 by Marco Arment. ”Instapaper 4: Deciding to Read” was written by Merlin Mann for 43Folders.com and was originally posted on October 17, 2011. Except as noted, it's ©2010 Merlin Mann and licensed for reuse under CC BY-NC-ND 3.0. "Why a footer?" Full Article Decision-Making Instapaper Marco Arment reading
4 AK Monthly Recap: August 2024 By www.adventurouskate.com Published On :: Mon, 09 Sep 2024 12:43:05 +0000 Remember back when turning 40 was about being over the hill? Back when I was a kid, I remember that 40th birthday parties were about those black OVER THE HILL balloons, and joke “you’re old now” gifts like canes with a blowhorn attached to them. That seems to have been phased out with the Boomer […] The post AK Monthly Recap: August 2024 appeared first on Adventurous Kate. Full Article Blog
4 AK Monthly Recap: September 2024 By www.adventurouskate.com Published On :: Tue, 08 Oct 2024 12:03:47 +0000 Ah, September — one of the most beautiful months of the year, and one of the best months to travel. I definitely put this month to good use. This was a busy September for me, beginning with my getaway to South Moravia in the Czech Republic, with a 12-day trip to the Basque Country and […] The post AK Monthly Recap: September 2024 appeared first on Adventurous Kate. Full Article Monthly Recap
4 AK Monthly Recap: October 2024 By www.adventurouskate.com Published On :: Mon, 04 Nov 2024 17:16:56 +0000 This was the month of my big, far-flung solo trip of 2024 — my trip to Nepal, Bhutan, and Qatar! It was an incredible trip to three new-to-me countries, and I’m excited to share it with you all. Let’s take a look at the month! Destinations Visited Highlights A fun trip to Bohemian Switzerland and […] The post AK Monthly Recap: October 2024 appeared first on Adventurous Kate. Full Article Monthly Recap
4 Former BLM Chapter Co-Founder Switches To Trump In ’24 … What Changed His Mind? By clashdaily.com Published On :: Tue, 05 Nov 2024 10:10:35 +0000 Mark Fisher was co-founder of the Rhode Island chapter of BLM. He voted for Joe Biden in 2020. Does he have buyers remorse? Yeah, you could say so. His viral video is causing a stir... but there's more to that story. The post Former BLM Chapter Co-Founder Switches To Trump In ’24 … What Changed His Mind? appeared first on Clash Daily. Full Article Videos
4 YIKES: Kamala’s Failed Campaign Finished DEEP In Debt — Here’s The 411 By clashdaily.com Published On :: Thu, 07 Nov 2024 09:47:09 +0000 It was just a couple of weeks ago that the media was bragging about Kamala's HUGE fundraising haul. The post YIKES: Kamala’s Failed Campaign Finished DEEP In Debt — Here’s The 411 appeared first on Clash Daily. Full Article News Clash
4 Why Democrats Lost the 2024 Elections By clashdaily.com Published On :: Fri, 08 Nov 2024 03:00:04 +0000 If Democrat politicians want our votes in the future then it would be nice if they said they were sorry for what they have done in the past. We don’t have far to look. Let’s see at why they lost and how they can win. The post Why Democrats Lost the 2024 Elections appeared first on Clash Daily. Full Article Opinion
4 Election 2024: the Aftermath By clashdaily.com Published On :: Mon, 11 Nov 2024 09:00:16 +0000 And in the aftermath of the election, a series of events have taken place, which are as follows: The post Election 2024: the Aftermath appeared first on Clash Daily. Full Article Opinion
4 A.F. Branco Cartoons Etc 10/16/24 By comicallyincorrect.com Published On :: Wed, 16 Oct 2024 12:30:42 +0000 A.F. Branco and Joe Dan Gorman discuss Tony’s recent toons and related issues, along with some videos and a few.. Full Article Political Cartoons Videos
4 A.F. Branco Cartoons Etc 10/23/24 By comicallyincorrect.com Published On :: Wed, 23 Oct 2024 08:27:40 +0000 A.F. Branco and Joe Dan Gorman discuss Tony’s recent toons and related issues like the 2024 election, along with some.. Full Article Political Cartoons Videos
4 A.F. Branco Cartoons Etc. 11/06/24 By comicallyincorrect.com Published On :: Wed, 06 Nov 2024 09:00:05 +0000 A.F. Branco and Joe Dan Gorman discuss The debate, Tony’s toons and related issues, along with some videos and some.. Full Article Political Cartoons Videos
4 How to waste half a day by not reading RFC 1034 By signalvnoise.com Published On :: Fri, 30 Oct 2020 20:59:44 +0000 HEY uses a branch deploy system that I’ve written about here on SvN and talked about frequently on Twitter. Plenty of other companies have implemented their own version of branch deploys (typically under a different name), but this was my own implementation, so I’m proud of it. First, a primer on how it works: Developer… keep reading Full Article Tech
4 Newsroom: US mortgage debt to surpass $14 trillion in 2022 By www.emarketer.com Published On :: Wed, 12 Jan 2022 04:01:00 GMT January 12, 2022 (New York, NY) – The total value of residential mortgage debt in the US will continue to experience solid growth into 2022 and 2023. In our inaugural […] Full Article
4 Newsroom: 34 Million US Adults Own Cryptocurrency By www.emarketer.com Published On :: Wed, 20 Apr 2022 04:01:00 GMT 3.6 million will pay with crypto in US; payment value to spike 70% in 2022   April 20, 2022 (New York, NY) – Cryptocurrency usage will continue its meteoric rise, […] Full Article
4 Newsroom: Buy Now Pay Later Transactions Will Surpass $100 billion by 2024 By www.emarketer.com Published On :: Wed, 22 Jun 2022 04:01:00 GMT June 22, 2022 (New York, NY) – Will Apple’s entry into the buy now, pay later (BNPL) space upend the already competitive industry? That’s the question many are trying to […] Full Article
4 The endosomal trafficking regulator LITAF controls the cardiac Nav1.5 channel via the ubiquitin ligase NEDD4-2 [Computational Biology] By www.jbc.org Published On :: 2020-12-25T00:06:30-08:00 The QT interval is a recording of cardiac electrical activity. Previous genome-wide association studies identified genetic variants that modify the QT interval upstream of LITAF (lipopolysaccharide-induced tumor necrosis factor-α factor), a protein encoding a regulator of endosomal trafficking. However, it was not clear how LITAF might impact cardiac excitation. We investigated the effect of LITAF on the voltage-gated sodium channel Nav1.5, which is critical for cardiac depolarization. We show that overexpressed LITAF resulted in a significant increase in the density of Nav1.5-generated voltage-gated sodium current INa and Nav1.5 surface protein levels in rabbit cardiomyocytes and in HEK cells stably expressing Nav1.5. Proximity ligation assays showed co-localization of endogenous LITAF and Nav1.5 in cardiomyocytes, whereas co-immunoprecipitations confirmed they are in the same complex when overexpressed in HEK cells. In vitro data suggest that LITAF interacts with the ubiquitin ligase NEDD4-2, a regulator of Nav1.5. LITAF overexpression down-regulated NEDD4-2 in cardiomyocytes and HEK cells. In HEK cells, LITAF increased ubiquitination and proteasomal degradation of co-expressed NEDD4-2 and significantly blunted the negative effect of NEDD4-2 on INa. We conclude that LITAF controls cardiac excitability by promoting degradation of NEDD4-2, which is essential for removal of surface Nav1.5. LITAF-knockout zebrafish showed increased variation in and a nonsignificant 15% prolongation of action potential duration. Computer simulations using a rabbit-cardiomyocyte model demonstrated that changes in Ca2+ and Na+ homeostasis are responsible for the surprisingly modest action potential duration shortening. These computational data thus corroborate findings from several genome-wide association studies that associated LITAF with QT interval variation. Full Article
4 Sustainability Accelerator Summer Drinks 2024 By www.chathamhouse.org Published On :: Mon, 19 Aug 2024 09:17:13 +0000 Sustainability Accelerator Summer Drinks 2024 6 September 2024 — 5:30PM TO 7:30PM Anonymous (not verified) 19 August 2024 Chatham House Join us for the Sustainability Accelerator’s annual summer drinks reception. This event brings together a diverse group of thinkers and changemakers from our network, as well as our collaboration partners, to reflect on our successes over the past year and give an opportunity to meet new people.The reception will follow the Sustainability Accelerator’s annual UnConference, but is a separate event. Unless you have received confirmation of your place at UnConference, you must register for the summer drinks reception via this webpage to secure your place. Full Article
4 The 2024 US Election: Global Consequences By www.chathamhouse.org Published On :: Tue, 17 Sep 2024 14:32:14 +0000 The 2024 US Election: Global Consequences 26 September 2024 — 5:30PM TO 6:45PM Anonymous (not verified) 17 September 2024 Online This webinar explores what is at stake for US policy in key regions around the globe. In the lead up to the 2024 US presidential election, Chatham House experts discuss:What is at stake for US policy towards China, Europe, and Latin America and what challenges will confront the next US president?Can the US lead when its partners and allies are continually dissatisfied by the new turn in its trade and economic policy?What are the core humanitarian challenges and how can they be addressed? Full Article
4 Looking ahead to the 2024 US Presidential Election By www.chathamhouse.org Published On :: Mon, 23 Sep 2024 18:07:13 +0000 Looking ahead to the 2024 US Presidential Election 2 October 2024 — 6:00PM TO 7:00PM Anonymous (not verified) 23 September 2024 Chatham House and Online This panel explores the state of the US presidential election following the vice presidential debate. With only weeks to go, this panel looks at the state of the 2024 US presidential election.Harris and Trump are campaigning to drive up voter enthusiasm and bring undecided voters to their side.What are the key issues shaping voter’s preferences and how may this impact voter turnout? What can we expect in the weeks ahead? Full Article