Dan Deming, KKM Financial

Dan Deming, KKM Financial

Dan Deming, KKM Financial

Dan Deming, KKM Financial

Dan Deming, KKM Financial

Dan Deming, KKM Financial

Dan Deming, KKM Financial

Dan Deming, KKM Financial

Dan Deming, KKM Financial

Calgarians who contributed to peacekeeping missions around the world reflected on the country's contributions to this work, highlighting the country's mission in Cyprus, which started 60 years ago.

After Canada Post workers gave a 72-hour notice to strike early Tuesday, some Calgary business owners are worried about what this means for holiday season sales. 

Charlottetown-born curler Brett Gallant says competing in the Olympics will be a dream come true for him and his fiancée, Jocelyn Peterman, even if COVID-19 protocols will make it difficult for them to see each other.

Curling Canada, with the assistance of Own the Podium and the Canadian Olympic Committee, announced Rachel Homan and John Morris as the mixed doubles team for Canada competing at the Beijing Olympics.

Now that all of Canada's Olympic curling teams are finally set, CBC Sports' daily newsletter takes a look at the three tournaments.

Newly announced mixed doubles duo Rachel Homan and John Morris, skips Jennifer Jones and Brad Gushue, and broadcasters Mike Harris, Joanne Courtney and Bruce Rainnie all break down a busy week in curling news.

A researcher may have many reasons for wanting to establish new laboratory colonies from field-collected mosquitoes. In particular, the ability to study the diversity found within and among natural populations in a controlled laboratory environment opens up a wide range of possibilities for understanding how and why burdens of vector-borne disease vary over space and time. However, field-collected mosquitoes are often more difficult to work with than established laboratory strains, and considerable logistical challenges are involved in safely transporting field-collected mosquitoes into the laboratory. Here, we provide advice for researchers working with Aedes aegypti, Anopheles gambiae, and Culex pipiens, as well as notes on other closely related species. We provide guidance on each stage of the life cycle and highlight the life stages for which it is easiest to initiate new laboratory colonies for each species. In accompanying protocols, we provide methods detailing Ae. aegypti egg collection and hatching as well as how to transport larvae and pupae from the field.

The establishment of neural connectivity is a major part of neural development. The central nervous system (CNS) midline is the most characterized axon guidance choice point, and work in Drosophila has played a pivotal role in understanding the molecular mechanisms responsible. Axons respond to attractive cues such as Netrin via the Frazzled receptor, and repulsive cues such as Slit via Robo receptors. Both signals are expressed at the CNS midline, affect pioneer axons, and have dramatic effects on the axon scaffold as a whole. Here, we focus on previous research analyzing classic mutants in the Slit/Robo pathway, which can readily be detected with a dissecting microscope. We also discuss analyzing these mutants in a teaching lab situation. The combination of sophisticated genetics and reliable axonal markers in Drosophila allows phenotypic analysis to be performed at the single-cell level. The elaborate architecture of neurons is very sensitive to disruption by genetic mutations, allowing the effects of novel mutations to be easily detected and assessed.

CRISPR–Cas9 has revolutionized gene editing for traditional and nontraditional model organisms alike. This tool has opened the door to new mechanistic studies of basic mosquito biology as well as the development of novel vector control strategies based on CRISPR–Cas9, including gene drives that spread genetic elements in the population. Although the promise of the specificity, flexibility, and ease of deployment CRISPR is real, its implementation still requires empirical optimization for each new species of interest, as well as to each genomic target within a given species. Here, we provide an overview of designing and testing single-guide RNAs for the use of CRISPR-based gene editing tools.

Flagship Data Management Solution Introduces‘Item-Centric’ PDM and New BOM Functionality

Leading elevator components supplier implements 550 licenses of the SolidWorks PDM solution

World Cup Champion Noelle Pikus-Pace Turns To Local Metal Shop – And Her Husband – For Innovative New Sled

Ramac Analyzes Design With SolidWorks SustainabilityXpress, Finds Alternatives That Consume Fewer Resources

Intuitive Software Fosters Rapid Engagement with Engineering Challenges

SolidWorks 3D CAD Software Helps Enable Launch of SideEyes, a Potentially Life-Saving Infrared Alert System

University

Company cites ease of use, localized languages, and data management capabilities in software

Power of One project's goal is perfecting solar technology for tomorrow's hybrid cars as high oil prices peak interest in alternative vehicles

Andergauge and National Oilwell are the latest of more than 300 petroleum industry companies to streamline product development and delivery

M G Bennett & Associates designs machine to help test U.K. 's oldest major suspension bridge

Industry leader's innovations further streamline design engineering, including mainstream validation and simple evolution from 2D to 3D

Lithuania's JSC Vilniaus Vingis tackles design challenges of time to market, precision, and complexity with SolidWorks software

MatWeb's new export engine pipes data from its 47,000 material information sheetsdirectly into SolidWorks and COSMOSWorks

Global design firm cuts development time and costs in half

Besser Company has significantly compressed its mold design cycle

SolidWorks' dominance in Mexican industry prompts purchase of 300 seats at leading academic institution

World's largest supplier of food weighing machines to automate custom product configuration with 3D CAD software

Extensive automation of time-consuming tasks gives designers fast, accurate tools for testing their ideas

Manufacturing leader quantifies savings in multiple phases of development process

World's largest annual 3D CAD event will feature special guest Steve Wozniak this year

Gasabo 3D Design, Ltd. to help companies around the world streamline product development, cut costs, reuse design data

Analyzing packing case design with COSMOS and modifying in SOLIDWORKS yields light, strong container that reduces manufacturers' shipping costs

Japanese university teaches mechanical engineering using SOLIDWORKS 3D CAD and COSMOS design analysis software

'Breakaway link' is key feature in new, safer utility connector

DraftSight Delivers Collaborative Services and Unprecedented Ability to Create, Edit, Share, and Manage DWG Files

SOLIDWORKS CAD and Simulation are Key Links in Goal to Cut Up to 90 percent from Design and Construction Time

SOLIDWORKS Helps Companies Automate Documentation, Analysis, and Data Management for Compliance

Previous CEO, Jeff Ray, Promoted to Dassault Systèmes Executive Team

Re-Design a Greener Airport Chair