A train in India on Friday plowed through a group of migrant workers who fell asleep on the tracks after walking back home from a coronavirus lockdown, killing 15, the Railways Ministry said. Early this week the government started running trains to carry stranded workers to their home states.

Amanda Avona
May 29, 2019; 39:4323-4331
Systems/Circuits

Hepatocyte growth factor (HGF) is a multifunctional protein that signals through the MET receptor. HGF stimulates cell proliferation, cell dispersion, neuronal survival, and wound healing. In the inner ear, levels of HGF must be fine-tuned for normal hearing. In mice, a deficiency of HGF expression limited to the auditory system, or an overexpression of HGF, causes neurosensory deafness. In humans, noncoding variants in HGF are associated with nonsyndromic deafness DFNB39. However, the mechanism by which these noncoding variants causes deafness was unknown. Here, we reveal the cause of this deafness using a mouse model engineered with a noncoding intronic 10 bp deletion (del10) in Hgf. Male and female mice homozygous for del10 exhibit moderate-to-profound hearing loss at 4 weeks of age as measured by tone burst auditory brainstem responses. The wild type (WT) 80 mV endocochlear potential was significantly reduced in homozygous del10 mice compared with WT littermates. In normal cochlea, endocochlear potentials are dependent on ion homeostasis mediated by the stria vascularis (SV). Previous studies showed that developmental incorporation of neural crest cells into the SV depends on signaling from HGF/MET. We show by immunohistochemistry that, in del10 homozygotes, neural crest cells fail to infiltrate the developing SV intermediate layer. Phenotyping and RNAseq analyses reveal no other significant abnormalities in other tissues. We conclude that, in the inner ear, the noncoding del10 mutation in Hgf leads to developmental defects of the SV and consequently dysfunctional ion homeostasis and a reduction in the EP, recapitulating human DFNB39 nonsyndromic deafness.

SIGNIFICANCE STATEMENT Hereditary deafness is a common, clinically and genetically heterogeneous neurosensory disorder. Previously, we reported that human deafness DFNB39 is associated with noncoding variants in the 3'UTR of a short isoform of HGF encoding hepatocyte growth factor. For normal hearing, HGF levels must be fine-tuned as an excess or deficiency of HGF cause deafness in mouse. Using a Hgf mutant mouse with a small 10 bp deletion recapitulating a human DFNB39 noncoding variant, we demonstrate that neural crest cells fail to migrate into the stria vascularis intermediate layer, resulting in a significantly reduced endocochlear potential, the driving force for sound transduction by inner ear hair cells. HGF-associated deafness is a neurocristopathy but, unlike many other neurocristopathies, it is not syndromic.

Migration has always existed. It has been a means to reunite with family, to find better jobs, to have a new experience or to start a better life. In 2015, the number of people migrating was up to 1 out of every 7 people in the world.   When it is a choice, migration can be a good way to spread [...]

Bank of Italy Working Papers by Eleonora Porreca and Alfonso Rosolia

Central Bank of Chile Working Papers by Benjamín García and Juan Guerra-Salas

In the everyday relationships of life, an OM worker finds God working to make His name known.

While President Donald Trump signed executive orders this week that could have widespread impact on immigrant communities, many in K-12 education await word on his decision on Deferred Action for Childhood Arrivals.

Education Week's top English-language learner stories on 2019 explored who's teaching the nation's English-learners and the struggles those educators encounter on the job, how the Trump administration's immigration policies affected students and their families and examined why more schools in the Un

Treatment of adolescent migraine remains a significant unmet medical need. In adults, the combination of sumatriptan and naproxen sodium has demonstrated superior efficacy, with similar tolerability, to its components in the acute treatment of migraine.

This study constitutes the first large-scale, placebo-controlled evidence for the acute relief of adolescent migraine pain and associated symptoms with an oral medication. (Read the full article)

Childhood headache is a common medical condition and can negatively impact a child’s social and academic life in several ways. Early and accurate diagnoses of headache syndromes, including migraine, are essential to appropriate treatment and outcome for affected youth.

The Diagnostic Interview of Headache Syndromes–Child Version is a new tool for the assessment of pediatric migraine that can enhance the standardization of collection of diagnostic criteria in both clinical and community settings, leading to better recognition and treatment of this condition. (Read the full article)

Parents in disadvantaged households are less likely to book share with their children during early childhood. These children are more likely to enter school with delays in emergent literacy and language skills, apparent as early as the age of 3.

This study examines the effect of parental immigrant status as a predictor of reading and sharing books with children. This research disentangles immigrant status from other variables thought to explain disparities in familial practices related to emergent literacy. (Read the full article)

Migraine headaches are a common presenting complaint in emergency departments. Abortive treatment in this setting is not well studied, leading to considerable variation in treatment. The relationship between acute medications and emergency department revisits has not been studied.

Eighty-five percent of children with migraine are successfully discharged from the emergency department; only 1 in 18 children require a return visit. Prochlorperazine is associated with less revisits than metoclopramide, and diphenhydramine use is associated with increased risk of return visits. (Read the full article)

The new Trump administration rule regarding immigrants' use of federal benefits could have an indirect but significant impact on schools, education advocates warn.

Even the best intentioned educators often harbor blind spots, write Re-Imagining Migration's Adam Strom and Veronica Boix Mansilla.

In the wake of anti-immigrant violence, we must help make sure that all students feel welcomed, writes Susana Cordova.

La imagen de Camerún como una isla de paz en medio de una región tumultuosa terminó en 2013, cuando la violencia de Boko Haram cruzó la frontera nigeriana. Este grupo está afiliado al llamado Estado Islámico o Daesh, e incluso se rebautizó como Estado Islámico de África Occidental a principios de este año. Pero la forma brutal de yihadismo africano que representa difícilmente se explica por el auge del Estado Islámico en Irak y Siria. De hecho, es en parte una consecuencia del cambiante panorama religioso africano, que afecta y no poco a Camerún.

Aspergillus niger, the third species responsible for invasive aspergillosis has been considered as a homogeneous species until DNA-based identification uncovered many cryptic species. These species have been recently reclassified into the Aspergillus section Nigri. However little is yet known among the section Nigri about the species distribution and the antifungal susceptibility pattern of each cryptic species. A total of 112 clinical isolates collected from 5 teaching hospitals in France and phenotypically identified as A. niger were analyzed. Identification to the species level was carried out by nucleotide sequence analysis. The Minimum Inhibitory Concentrations (MICs) of itraconazole, voriconazole, posaconazole, isavuconazole and amphotericin B were determined by both the EUCAST and gradient concentration strips methods. Aspergillus tubingensis (n=51, 45.5%) and A. welwitschiae (n=50, 44.6%) were the most common species while A. niger accounted for only 6.3% (n=7). The MICs of azoles drugs were higher for A. tubingensis than for A. welwitschiae. The MIC of amphotericin B was 2 mg/L or less for all isolates. Importantly, MICs determined by EUCAST showed no correlation with those determined by gradient concentration strips methods, these latter being lower than the former (Spearman's rank correlation tests ranging - depending on the antifungal agent - from 0.01 to 0.25; p>0.4). In conclusion, A. niger should be considered as a minority species in the section Nigri. The differences in MICs between species for different azoles underline the importance of accurate identification. Significant divergences in the determination of MIC between EUCAST and gradient concentration strips methods require further investigation.

Education Week's top English-language learner stories on 2019 explored who's teaching the nation's English-learners and the struggles those educators encounter on the job, how the Trump administration's immigration policies affected students and their families and examined why more schools in the Un

Shoba Sivaprasad Wadhia, Samuel Weiss Faculty Scholar and Clinical Professor of Law at Penn State Law in University Park, has written a chapter on immigration law in a new legal textbook covering issues surrounding the current global COVID-19 pandemic, published by Columbia Law School.

Atlético ended Real Madrid's four-game UEFA Super Cup winning streak in Tallinn, and maintained their 100% record in the competition.

OM worker Lynn, along with teammates, ministers to immigrant women in France.

OM’s Xenos team in Heilbronn ministers to immigrants in a holistic way by proclaiming the gospel and supporting them in their physical and emotional needs.

A member of OM Germany's Xenos team experiences the joy of seeing immigrants reach other immigrants.

OM workers Elsbeth and Josef* are seeing vibrant communities of Jesus followers among least reached immigrants in Germany.

Students whose teachers viewed their parents as less engaged in their schooling had lower grade point averages and were less likely to be recommended for advanced courses, according to a new study.

Program will explore what life would be like for a two-month crossing of the Atlantic Ocean from Europe to the New World.

Bihar Water Minister Sanjay Kumar Jha hitout at the Delhi government after it claimed reimbursement over train fares paid for return of migrants stranded in the national capital amid the coronavirus...

They had started their journey on foot from Maharashtra hoping to reach Madhya Pradesh, but it was their bodies that reached their home districts of Shahdol and Umaria by special trains on Saturday...

The West Bengal government on Saturday refuted the allegations of non-cooperation by Union Home Minister Amit Shah and said that it has facilitated the return of around 6,000 migrants stranded outside...

While nearly eight lakh migrant workers stranded in Haryana have registered themselves on a government portal to return to their native states, over 1.5 lakh of them have applied on the same portal...

Over 1 lakh migrant workers from Uttar Pradesh stranded in different parts of the country following the coronavirus-induced lockdown will return to the state by Saturday night on 114 trains, a senior...

The West Bengal government has agreed to allow eight trains to bring migrants home from four states, the Railway Ministry tweeted today. It said Bengal had until now allowed only two "Shramik"...

NEW CASTLE (Oct. 23, 2018) – Department of Health and Social Services (DHSS) Secretary Dr. Kara Odom Walker, a board-certified family physician, is reassuring Delawareans that a proposed change to the public charge rule by the U.S. Department of Homeland Security does not affect current eligibility for health care and social services in Delaware, and […]

Based on the recent data released by the Australian Bureau of Statistics immigration is an important contributor towards population growth in Australia.The StatisticsLast year the growth in Australian population was 1.6 percent and by the year end its…

The NSW Government has issued an update with the following information:The Home Affairs Department recently announced that the Subclass 491 Skilled Work Regional visa will replace the present 489 visa in Nov 2019.The visa in the new subclass will have…

The minister accountable for maintaining Australia's population levels is watching to Canada for motivation to shift more immigrants to regional areas. Alan Tudge aspires to follow Canada's success in providing provinces a more prominent role…

To ensure safety, passengers would be screened by the sending states and only those found asymptomatic would be allowed to travel. Sending state governments will have to bring these persons in batches that can be accommodated in the train to the designated railway station in sanitised buses following social distancing norms and other precautions.

The English language abilities of an applicant are likely to get a rank based on proficiency in the new British visa regime that is getting finalized by UK after it makes an exit from the EU.UK Immigration and Need for an Evaluation The authorities…

Britain will soon accept immigrants only when they possess the right skills. An immigration system based on points is common to Canada, Australia, and New Zealand and in the immediate future, it appears that Britain will join them. The election results…

There has been a 63 percent rise in the number of student visas allotted to Indians to study in the UK in the past one year, data published by UK's Office for National Statistics (O.N.S) reveals. Report Says Tremendous Growth in Student Visas from…

Every department has aims and objectives, and the numbers are the focus of the Immigration Department in the UK. There is an opportunity to make this system fair but the focus needs to be away from strict control of borders. Boris Johnson, the PM has…

There is an issue in the world for stopping uncontrolled immigration of nonwhite, as it adversely affects the world.Boris Johnson the UK Prime Minister has made a campaign promise to make an onslaught on migration to control and check it. There is a…

PM Boris Johnson is set to change the plan about the minimum £30,000 earning the threshold for migrants who aim to enter the UK after the exit of Britain from the EU.The Reasons Behind the DecisionThe proposal appears to not fit in with his plan to…

The Japanese policy makers are looking to frame a policy for bringing foreign workers to counter the rapidly growing – aging population, without naming it as an actual immigration policy. Japanese Conservatives give high importance to the cultural…

Google CEO Sunder Pichai and three other people of Indian origin are in the list of 42 US nationals to be honored with the United States "Great Immigrants: The Pride of America" award. The three other prominent personalities are Hari Sreenivasan,…

Things aren’t great between Hong Kong Beijing, and scared residents are moving to a safer Taiwan, Hong Kong’s neighbor. Hong Kong has been under China’s rule for almost two decades now and is a major financial hub for the Asian country. According…

Read Full Article at RT.com

Read Full Article at RT.com