The sufficiency of Scripture is a doctrinal hill to die on, even if it doesn’t seem like a contested battleground today. But God’s people need to understand that while biblical sufficiency itself is not often assaulted overtly, it is often implicitly in the crosshairs. So what are these subtle attacks, and how should Christians respond to them?

Donald Trump has not donned one. Emmanuel Macron boasted a small French flag on his. Slovakia’s president made a fashion statement by sporting a fuchsia-coloured one to match her outfit.As the world starts emerging from coronavirus lockdowns, political leaders are being closely scrutinised over their choice to wear a mask – or not – with many people questioning the seemingly mixed messages about the value of face coverings as infection barriers.Many Western governments counselled against face…

The EU’s “Green Recovery” could reward high polluters. Good data is crucial to prevent this ǀ View

PARIS: Donald Trump has not donned one. Emmanuel Macron boasted a small French flag on his. Slovakia´s president made a fashion statement by sporting a fuchsia-coloured one to match her outfit.As the world starts emerging from coronavirus lockdowns, political leaders are being closely...

Asia’s economies have generally maintained sound macroeconomic policies that can help the region withstand this latest challenge and emerge even stronger.

SAMRH71 Using ICC and ECC for Efficient Memory Scrubbing

STAMFORD, CT – May 5, 2016 – Today, HARMAN International Industries, Incorporated (NYSE:HAR), the premier connected technologies company for automotive, consumer and enterprise markets, announced it will showcase the industry’s first  developer-ready ...

HARMAN Hacks TechCrunch Disrupt NY As one of the year’s premier tech events, TechCrunch Disrupt NY continues to attract the industry’s top innovators, startups and developers – this year was no exception. Today, developers can personalize everything...

STAMFORD, CT – September 14, 2016 –HARMAN International Industries, Incorporated (NYSE:HAR), the premier connected technologies company for automotive, consumer and enterprise markets, announced it will showcase additional sensor functionality for the...

Ever since the breakup of the supercontinent Pangaea, sea water has been flowing deep into the planet, causing sea levels to fall over millions of years

Julia Ebner infiltrated the hidden forums that extremists use. Her experiences lay bare how they hijack social media and video games to spread hate – and how to beat them

Many people feel intimidated by the prospect of making pastry, says Sam Wong, but a little understanding can go a long way to successfully making this beautiful rhubarb tart

A fresh look at the world’s oldest religious texts suggests ancient Egyptians saw the sky as a water-filled iron container from which chunks fell to Earth as meteorites

Julia Ebner infiltrated the hidden forums that extremists use. Her experiences lay bare how they hijack social media and video games to spread hate – and how to beat them

The Pine Island glacier has three tipping points that could lead to the collapse of the entire West Antarctic ice sheet, potentially raising sea levels by 3 metres over centuries

The UK government has set a new target of recruiting an army of 18,000 coronavirus contact tracers by the middle of May, to be in place for the launch of the NHS contact tracing app

A fresh look at the world’s oldest religious texts suggests ancient Egyptians saw the sky as a water-filled iron container from which chunks fell to Earth as meteorites

Title: Measles Case Leads to Quarantine of Cruise Ship in St. Lucia
Category: Health News
Created: 5/2/2019 12:00:00 AM
Last Editorial Review: 5/2/2019 12:00:00 AM

HIV-1 persists in cellular reservoirs that can reignite viremia if antiretroviral therapy (ART) is interrupted. Therefore, insight into the nature of those reservoirs may be revealed from the composition of recrudescing viremia following treatment cessation. A minor population of macrophage-tropic (M-tropic) viruses was identified in a library of recombinant viruses...

Cellular starvation is typically a consequence of tissue injury that disrupts the local blood supply but can also occur where cell populations outgrow the local vasculature, as observed in solid tumors. Cells react to nutrient deprivation by adapting their metabolism, or, if starvation is prolonged, it can result in cell...

Cep57 has been characterized as a component of a pericentriolar complex containing Cep63 and Cep152. Interestingly, Cep63 and Cep152 self-assemble into a pericentriolar cylindrical architecture, and this event is critical for the orderly recruitment of Plk4, a key regulator of centriole duplication. However, the way in which Cep57 interacts with the Cep63-Cep152 complex and contributes to the structure and function of Cep63-Cep152 self-assembly remains unknown. We demonstrate that Cep57 interacts with Cep63 through N-terminal motifs and associates with Cep152 via Cep63. Three-dimensional structured illumination microscopy (3D-SIM) analyses suggested that the Cep57-Cep63-Cep152 complex is concentrically arranged around a centriole in a Cep57-in and Cep152-out manner. Cep57 mutant cells defective in Cep63 binding exhibited improper Cep63 and Cep152 localization and impaired Sas6 recruitment for procentriole assembly, proving the significance of the Cep57-Cep63 interaction. Intriguingly, Cep63 fused to a microtubule (MT)-binding domain of Cep57 functioned in concert with Cep152 to assemble around stabilized MTs in vitro. Thus, Cep57 plays a key role in architecting the Cep63-Cep152 assembly around centriolar MTs and promoting centriole biogenesis. This study may offer a platform to investigate how the organization and function of the pericentriolar architecture are altered by disease-associated mutations found in the Cep57-Cep63-Cep152 complex.

Dalton Buysse, Anna-Katharina Pfitzner, Matt West, Aurelien Roux, and Greg Odorizzi

The ESCRT-III protein complex executes reverse-topology membrane scission. The scission mechanism is unclear but is linked to remodeling of ESCRT-III complexes at the membrane surface. At endosomes, ESCRT-III mediates the budding of intralumenal vesicles (ILVs). In Saccharomyces cerevisiae, ESCRT-III activity at endosomes is regulated through an unknown mechanism by Doa4, an ubiquitin hydrolase that deubiquitylates transmembrane proteins sorted into ILVs. We report that the non-catalytic N-terminus of Doa4 binds Snf7, the predominant ESCRT-III subunit. Through this interaction, Doa4 overexpression alters Snf7 assembly status and inhibits ILV membrane scission. In vitro, the Doa4 N-terminus inhibits association of Snf7 with Vps2, which functions with Vps24 to arrest Snf7 polymerization and remodel Snf7 polymer structure. In vivo, Doa4 overexpression inhibits Snf7 interaction with Vps2 and also with the ATPase Vps4, which is recruited by Vps2 and Vps24 to remodel ESCRT-III complexes by catalyzing subunit turnover. Our data suggest a mechanism by which the deubiquitylation machinery regulates ILV biogenesis by interfering with ESCRT-III remodeling.

Background and objectives

The effects of active case finding (ACF) models that mobilise community networks for early identification and treatment of tuberculosis (TB) remain unknown. We investigated and compared the effect of community-based ACF using a seed-and-recruit model with one-off roving ACF and passive case finding (PCF) on the time to treatment initiation and identification of bacteriologically confirmed TB.

Interactions between platelets, leukocytes and the vessel wall provide alternative pathological routes of thrombo-inflammatory leukocyte recruitment. We found that when platelets were activated by a range of agonists in whole blood, they shed platelet-derived extracellular vesicles which rapidly and preferentially bound to blood monocytes compared to other leukocytes. Platelet-derived extracellular vesicle binding to monocytes was initiated by P-selectin-dependent adhesion and was stabilised by binding of phosphatidylserine. These interactions resulted in the progressive transfer of the platelet adhesion receptor GPIbα to monocytes. GPIbα^+-monocytes tethered and rolled on immobilised von Willebrand Factor or were recruited and activated on endothelial cells treated with TGF-β1 to induce the expression of von Willebrand Factor. In both models monocyte adhesion was ablated by a function-blocking antibody against GPIbα. Monocytes could also bind platelet-derived extracellular vesicle in mouse blood in vitro and in vivo. Intratracheal instillations of diesel nanoparticles, to model chronic pulmonary inflammation, induced accumulation of GPIbα on circulating monocytes. In intravital experiments, GPIbα⁺-monocytes adhered to the microcirculation of the TGF-β1-stimulated cremaster muscle, while in the ApoE^–/– model of atherosclerosis, GPIbα⁺-monocytes adhered to the carotid arteries. In trauma patients, monocytes bore platelet markers within 1 hour of injury, the levels of which correlated with severity of trauma and resulted in monocyte clearance from the circulation. Thus, we have defined a novel thrombo-inflammatory pathway in which platelet-derived extracellular vesicles transfer a platelet adhesion receptor to monocytes, allowing their recruitment in large and small blood vessels, and which is likely to be pathogenic.

We spoke with industry experts to identify what’s preventing developers from fully going green – and it all boils down to lack of finances.

Julia Ebner infiltrated the hidden forums that extremists use. Her experiences lay bare how they hijack social media and video games to spread hate – and how to beat them

In addition to being a hotbed for pandemics, the cruise industry is an ethical and ecological abomination.

Scientists are speculating as to how the two creatures managed to become preserved in such an unusual way.

No going out to buy ingredients you don't already have, though. Crumpets are treats.

Chris punches stuff. Anna Marie whips girls. Alice does a sick dunk. And Jonathan Rainbows your Six. Now where’s that pizza?

Justice in case of 25-year-old black male delayed amid COVID-19 response. Apparently in Georgia bowling and tattooing are more essential.

The UK government has set a new target of recruiting an army of 18,000 coronavirus contact tracers by the middle of May, to be in place for the launch of the NHS contact tracing app

One sounds far more promising than the other

Miley Cyrus doesn't get a reply from all the celebrities she messages.

According to NASA administrator Jim Bridenstine, NASA will be working...

The post Tom Cruise To Collaborate With NASA On First Film Shot In Space appeared first on Man's World India.

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BELLE PLAINE, Kan. (AP) - Kansas harvester Mike Keimig is growing increasingly anxious about whether the foreign seasonal workers he needs to run his nine combines and drive his grain trucks will arrive in time for the start of the winter wheat harvest, which is just weeks away.

His regular ...

With a discovery that could rewrite the immunology textbooks, an international group of scientists have identified a new type of antigen-presenting immune cell.

Action star Tom Cruise is working on a movie shot in outer space, the National Aeronautics and Space Administration said on Tuesday.

The Government is facing calls from cross-party MPs to urgently recall of parliament in "virtual" form so that their coronavirus response can be properly scrutinised.

Read our live coronavirus updates HERE

South Korea's Joint Chiefs of Staff said the projectiles – presumed to be cruise missiles – were fired from the North's eastern Kangwon province on Tuesday morning.

Coronavirus: the symptoms Read our LIVE updates on coronavirus here

You can donate here virginmoneygiving.com/fund/FoodforLondonNOW

Design and technology teachers have made more than 200,000 pieces of protective equipment for frontline NHS workers, new figures reveal.

Coronavirus warning messages from celebrities including Jamie Redknapp are being broadcast from cars driving around the streets of east London to get people to respect the lockdown.

A distressing video of an unidentified woman boxing her German Shepherd dog has sparked outrage on social media and prompted an investigation into alleged animal cruelty.