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Immune-enhancing effect of Weizmannia coagulans BCG44 and its supernatant on cyclophosphamide-induced immunosuppressed mice and RAW264.7 cells via the modulation of the gut microbiota

Food Funct., 2024, 15,10679-10697
DOI: 10.1039/D4FO02452D, Paper
Open Access
Yafang Xu, Yi Wang, Tao Song, Xiaxia Li, Haolin Zhou, Oumarou Zafir Chaibou, Bing Wang, Huajun Li
W. coagulans BCG44 and its supernatant possess potential immunomodulatory activity and modulate gut microbiota dysbiosis in CTX-induced immunosuppression.
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Biological effects and mechanisms of dietary chalcones: latest research progress, future research strategies, and challenges

Food Funct., 2024, 15,10582-10599
DOI: 10.1039/D4FO03618B, Review Article
Yun Liang Zhang, Shuang Jiao Sun, Li Zeng
Chalcones are widely distributed in food and have multiple biological activities; there are limitations and drawbacks in the application of dietary chalcones in food; future research strategies and key issues for dietary chalcones.
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Effects of Clostridium butyricum and inulin supplementation on intestinal microbial composition in high-fat diet fed mice

Food Funct., 2024, 15,10870-10884
DOI: 10.1039/D4FO02963A, Paper
Jing Liu, Suhua Zhang, Huachun Weng
Clostridium butyricum and inulin could improve dislipidemia, abnormal glucose tolerance and change intestinal microbial composition in high-fat diet (HFD) mice, increasing Parabacteroides, Bacteroides and Ruminococcaceae and regulating FGF21.
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Novel selenium-enriched Pichia kudriavzevii as a dietary supplement to alleviate dextran sulfate sodium-induced colitis in mice by modulating the gut microbiota and host metabolism

Food Funct., 2024, 15,10698-10716
DOI: 10.1039/D4FO02598A, Paper
Huijuan Wang, Yue Chen, Zhouli Wang, Yahong Yuan, Tianli Yue
Inflammatory bowel disease (IBD) poses persistent challenges due to its chronic and recurrent nature, exacerbated by the unsatisfactory outcomes of the traditional treatment approaches.
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Human breast milk-derived phospholipid DOPE ameliorates intestinal injury associated with NEC by inhibiting ferroptosis

Food Funct., 2024, 15,10811-10822
DOI: 10.1039/D4FO03904A, Paper
Yanjie Chen, Wenjuan Chen, Yu Dai, Xiangyun Yan, Chengyao Jiang, Fan Zhang, Min Zhang, Xiaoshan Hu, Juyi Zhao, Tingyue Wu, Shushu Li, Shuping Han, Xiaohui Chen
Human breast milk-derived dioleoyl phosphatidylethanolamine (DOPE) mitigates intestinal dysfunction in Necrotizing Enterocolitis (NEC) through the suppression of ferroptosis.
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Lacticaseibacillus paracasei 207-27 alters the microbiota–gut–brain axis to improve wearable device-measured sleep duration in healthy adults: a randomized, double-blind, placebo-controlled trial

Food Funct., 2024, 15,10732-10745
DOI: 10.1039/D4FO01684J, Paper
Open Access
Jinxing Li, Jincheng Zhao, Xiaolei Ze, Liang Li, Yapeng Li, Zhimo Zhou, Simou Wu, Wen Jia, Meixun Liu, Yun Li, Xi Shen, Fang He, Ruyue Cheng
Probiotics have been reported to exert beneficial effects on sleep through the gut–brain axis.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Relationships of dietary habits with prostate cancer risk: results from Mendelian randomization analyses and the National Health and Nutrition Examination Survey

Food Funct., 2024, 15,10823-10837
DOI: 10.1039/D4FO03859B, Paper
Zhen Zhou, Jin Xu, Yang Zhao, Yuanjie Niu
Prior investigations identified correlations between dietary habits and the risk of prostate cancer (PCa); however, the causative dynamics are unclear.
The content of this RSS Feed (c) The Royal Society of Chemistry




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High-fat diet promotes type 2 diabetes mellitus by disrupting gut microbial rhythms and short-chain fatty acid synthesis

Food Funct., 2024, 15,10838-10852
DOI: 10.1039/D4FO02957G, Paper
Yangrui Wang, Fenfen Yan, Qingxue Chen, Fei Liu, Baofeng Xu, Yuanyuan Liu, Guicheng Huo, Jinsheng Xu, Bailiang Li, Song Wang
A schematic diagram of a high-fat diet promotes type 2 diabetes mellitus by disrupting gut microbial rhythms and short-chain fatty acid synthesis.
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Dietary supplementation with novel selenium-enriched Pichia kudriavzevii regulates gut microbiota and host metabolism in mice

Food Funct., 2024, 15,10896-10912
DOI: 10.1039/D4FO03633F, Paper
Huijuan Wang, Dan Shi, Yue Chen, Zhouli Wang, Yahong Yuan, Tianli Yue
Insufficient selenium intake can lead to serious health problems.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Exploring the potential of sorghum with reference to its bioactivite, physicochemical properties and potential health benefits

Food Funct., 2024, Accepted Manuscript
DOI: 10.1039/D4FO04128C, Review Article
Sakshi Singh, Mehvish Habib, David J McClements, Khalid Bashir, Shumaila Jan, Kulsum Jan
Sorghum is a resilient and adaptable cereal grain recognized for its rich nutritional profile. It is a valuable source of dietary fiber (around 6%), protein (9-13%), and essential minerals such...
The content of this RSS Feed (c) The Royal Society of Chemistry




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Dietary Lactobacillus johnsonii-derived extracellular vesicles ameliorate acute colitis by regulating gut microbiota and maintaining intestinal barrier homeostasis

Food Funct., 2024, Accepted Manuscript
DOI: 10.1039/D4FO04194A, Paper
Zhiguo Li, Mengyu Li, Xuexun Fang, Dahai Yu, Xin Hu
Inflammatory bowel disease (IBD) is a chronic gastrointestinal disease with intricate pathogenesis, and clinical treatment is still not ideal. The imbalance of gut microbiota is associated with IBD progression. Various...
The content of this RSS Feed (c) The Royal Society of Chemistry




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Inhibitory effect of tea flower polysaccharides on oxidative stress and microglial oxidative damage in aging mice by regulating gut microbiota

Food Funct., 2024, Advance Article
DOI: 10.1039/D4FO03484H, Paper
Yidan Cai, Siyu Liu, Xing Ge, Lu Cheng, Xin Zhang
Tea flower polysaccharides (TFPS) can improve the disorder of gut microbiota, alleviate oxidative damage to glial cells, alleviate neuroinflammation, and play a role in delaying aging.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Summer–autumn tea promotes adipocyte browning and thermogenesis in association with gut microbiota regulation in high-fat diet-fed mice

Food Funct., 2024, Advance Article
DOI: 10.1039/D4FO03826F, Paper
Chengcheng Yang, Luyao Liu, Yao Du, Lu Zhao, Lu Liu, Xingbin Yang, Yan Zhao
This study revealed for the first time the anti-obesity effect of summer–autumn tea aqueous extract (SATE) and its underlying mechanism.
To cite this article before page numbers are assigned, use the DOI form of citation above.
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Gastroprotective effects of Pediococcus acidilactici GKA4 and Lactobacillus brevis GKL93 against ethanol-induced gastric ulcers via regulation of the immune response and gut microbiota in mice

Food Funct., 2024, Advance Article
DOI: 10.1039/D4FO04106B, Paper
Yun-En Huang, Sheng-Yi Chen, Tsung-Ju Li, You-Shan Tsai, Chin-Chu Chen, Gow-Chin Yen
Pediococcus acidilactici GKA4 and Lactobacillus brevis GKL93 exert gastroprotective effects against ethanol-induced gastric ulcers through multiple mechanisms.
To cite this article before page numbers are assigned, use the DOI form of citation above.
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Anti-obesity and other health benefits of bioprocessed black rice bran in combination with green tea extract in 3T3-L1 preadipocyte cells and in mice on a high-fat diet

Food Funct., 2024, Accepted Manuscript
DOI: 10.1039/D4FO03210A, Paper
Ki Sun Kwon, Eun Seok Lee, Kyung Hee Lee, Woon Sang Hwang, Wha Young Lee, Jae Jung Kim, Jeanman Kim, Sang-Jong Lee, Sung Phil Kim, Mendel Friedman
Black rice bran, a waste product from the commercial milling of black rice that removes the bran and germ and leaves the starchy endosperm, contains bioactive anthocyanin, phenolic, and phytosteroid...
The content of this RSS Feed (c) The Royal Society of Chemistry




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Interaction of oat bran and exercise training improved exercise adaptability via alleviating oxidative stress and promoting energy homeostasis

Food Funct., 2024, Advance Article
DOI: 10.1039/D4FO03374D, Paper
Rui Dong, Hamad Rafique, Qianwen Niu, Xin Zeng, Maria Cristina Messia, Li Yuan, Lin Shi, Liang Zou, Lu Li, Xinzhong Hu
Interaction of oat bran (OB) diet and moderate intensity exercise training (MlET) reinforced the positive effect on skeletal muscle function.
To cite this article before page numbers are assigned, use the DOI form of citation above.
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Aspartate restrains thermogenesis by inhibiting the AMPK pathway in adipose tissues

Food Funct., 2024, Advance Article
DOI: 10.1039/D4FO03614J, Paper
Shengjun Dong, Mengxin Jiang, Qinglei Sun, Junqing Xu, Lei Zhang, Lei Han, Yan-na Li, Zhengtong Zhou, Yingjiang Xu
We evaluated the potential effects of aspartate on brown adipose tissue function.
To cite this article before page numbers are assigned, use the DOI form of citation above.
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Brassica rapa L. crude polysaccharide meditated synbiotic fermented whey beverage ameliorates hypobaric and hypoxia induced intestinal damage

Food Funct., 2024, Accepted Manuscript
DOI: 10.1039/D4FO04667F, Paper
Yuanlin Niu, Tingting Zhao, Zhenjiang Liu, Diantong Li, Dongxu Wen, Bin Li, Xiaodan Huang
Hypobaric hypoxia causes oxidative stress and inflammatory responses and disrupts the gut microbiome and metabolome. In this study, we developed a synbiotic fermented whey beverage, combining kefir and Brassica rapa...
The content of this RSS Feed (c) The Royal Society of Chemistry




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Bioactive compounds regulate appetite through the melanocortin system: a review

Food Funct., 2024, Advance Article
DOI: 10.1039/D4FO04024D, Review Article
Yujia Niu, Wancong Yu, Xiaohong Kou, Shuqi Wu, Mengyi Liu, Chenlong Chen, Jiaxin Ji, Ying Shao, Zhaohui Xue
The melanocortin system is regulated by long-term and short-term regulatory hormones and nutrients. Bioactive compounds influence appetite through multiple pathways: central nervous system, peripheral hormones, and intestinal microbiota.
To cite this article before page numbers are assigned, use the DOI form of citation above.
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A probiotic multi-strain mixture combined with hydroxyectoine improves intestinal barrier function by alleviating inflammation in lipopolysaccharide stimulated differentiated Caco-2 cells

Food Funct., 2024, Advance Article
DOI: 10.1039/D4FO03130J, Paper
Azza Dabous, Antonietta Stellavato, Donatella Cimini, Valentina Vassallo, Maria D'Agostino, Chiara Schiraldi
Freeze-dried formula containing three probiotic strains and hydroxyectoine reduces LPS-induced inflammation in Caco-2 cells, assessed via RT-PCR, western blot, ELISA, and immunofluorescence for tight junction integrity.
To cite this article before page numbers are assigned, use the DOI form of citation above.
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Goat milk derived small extracellular vesicles ameliorate LPS-induced intestinal epithelial barrier dysfunction, oxidative stress, and apoptosis by inhibiting the MAPK signaling pathway

Food Funct., 2024, Advance Article
DOI: 10.1039/D4FO04067H, Paper
Feng Gao, Xin Zhang, Zhiming Xu, Kang Zhang, Fusheng Quan
Intestinal injury is often accompanied by epithelial barrier dysfunction, oxidative stress, and apoptosis.
To cite this article before page numbers are assigned, use the DOI form of citation above.
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Investigation of the hypoglycemic bioactive components of Phyllanthi Fructus through biological assessment combined with ultrafiltration affinity mass spectrometry

Food Funct., 2024, Accepted Manuscript
DOI: 10.1039/D4FO04198D, Paper
Yifan Zhang, Qiang Yu, Peng Tan, Shimin Tian, Jun-zhi Lin, Mengqi Li, Li Han, Haozhou Huang, Ding-kun Zhang
Phyllanthi Fructus (PF) is a tropical fruit with the potential to effectively reduce postprandial blood glucose, making it highly promising for the development of functional foods. However, the lack of...
The content of this RSS Feed (c) The Royal Society of Chemistry




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Galacto-oligosaccharides regulates intestinal mucosal sialylation to counteract antibiotic-induced mucin dysbiosis

Food Funct., 2024, Accepted Manuscript
DOI: 10.1039/D4FO04626A, Paper
Laipeng Xu, Xuan Li, Shuibing Han, Chunlong Mu, Wei-Yun Zhu
Intestinal mucin offers a physical barrier to maintain host-commensal homeostasis. Glycosylation is essential for appropriate function of mucin. Galacto-oligosaccharides (GOS) have been used as a prebiotic with proved intestinal benefits,...
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Influence of dairy matrix on the prebiotic effects of inulin related to gut metabolic activity and bone health

Food Funct., 2024, 15,11129-11140
DOI: 10.1039/D4FO01635A, Paper
Xiaorui Zhao, Weiwei He, Louise M. A. Jakobsen, Farhad M. Panah, Banny Silva Barbosa Correia, Dennis Sandris Nielsen, Axel K. Hansen, Hanne Christine Bertram
This study investigated if the prebiotic efficacy of inulin depends on the dairy matrix used as vehicle.
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Lactobacillus plantarum 69-2 combined with α-lactalbumin hydrolysate alleviates DSS-induced ulcerative colitis through the TLR4/NF-κB inflammatory pathway and the gut microbiota in mice

Food Funct., 2024, 15,10987-11004
DOI: 10.1039/D4FO02975E, Paper
Yue Ma, Chuanbing Hu, Jing Zhang, Cong Xu, Lizhi Ma, Yunhe Chang, Muhammad Altaf Hussain, Jiage Ma, Juncai Hou, Zhanmei Jiang
Ulcerative colitis (UC), an inflammatory bowel disease, seriously affects people's quality of life.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Lacticaseibacillus plantarum postbiotics prepared by the combined technique of pasteurization and ultrasound: effective measures to alleviate obesity based on the SCFAs-GPR41/GPR43 signaling pathway

Food Funct., 2024, 15,11005-11019
DOI: 10.1039/D4FO03591G, Paper
Chao Miao, Linge Wang, Huabing Wang, Yu Shen, Chaoxin Man, Wei Zhang, Yu Zhang, Qianyu Zhao, Yujun Jiang
Postbiotics prepared by ultrasound and pasteurization are used for the alleviation of obesity.
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Dynamic changes in the gel properties, microbial community, and volatile flavor profile of Spanish mackerel (Scomberomorus niphonius) sausages inoculated with Lactiplantibacillus plantarum CY1-2

Food Funct., 2024, 15,11060-11071
DOI: 10.1039/D4FO03841J, Paper
Xinran Lv, Wenyu Wu, Shuilin Liu, Lili Ding, Anqi Ren, Le An, Fengling Bai, Jianrong Li, Xuepeng Li, Shumin Yi
This study aimed to examine the dynamic changes in the gel properties, microbial diversity, and volatile flavor compounds (VFCs) of Spanish mackerel sausages inoculated with Lactiplantibacillus plantarum CY1-2 during fermentation.
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Solid-state fermentation of green lentils by Lactiplantibacillus plantarum leads to formation of distinct peptides that are absorbable and enhances DPP-IV inhibitory activity in an intestinal Caco-2 cell model

Food Funct., 2024, 15,11220-11235
DOI: 10.1039/D4FO03326D, Paper
Elisa Di Stefano, Nico Hüttmann, Pieter Dekker, Monic M. M. Tomassen, Teresa Oliviero, Vincenzo Fogliano, Chibuike C. Udenigwe
In vitro gastrointestinal digestion, brush border enzyme activity, and microbial fermentation with Lactiplantibacillus plantarum influenced the peptidome of green lentils and peptide transport across the intestinal Caco-2 cell monolayer.
The content of this RSS Feed (c) The Royal Society of Chemistry




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CoQ10 bioaccessibility and Caco-2 cell uptake improved with novel medium chain triglyceride encapsulation

Food Funct., 2024, 15,10981-10986
DOI: 10.1039/D4FO02844A, Communication
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Ziqi Li, Rachel E. Kopec
Coenzyme Q10 (CoQ10), a key component of the electron transport chain, is better micellarized and absorbed by intestinal cells following novel encapsulation with MCTs + phospholipid.
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Human milk oligosaccharides and milk fat globule membrane reduce allergic reactions in mice through the modulation of gut microbiota and metabolic functions

Food Funct., 2024, 15,11252-11265
DOI: 10.1039/D4FO03851G, Paper
Xinzhang Chen, Shengjun Yang, Zhengtao Guo, Bailiang Li, Zhongjiang Wang, Lianzhou Jiang
Human milk oligosaccharides (HMOs) and the milk fat globule membrane (MFGM) represent novel treatments for cow's milk allergy (CMA).
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Techno-functional, antioxidant, and amino acid characterization of hydrolyzed bioactive peptides from coconut (Cocos nucifera L.) meal protein

Food Funct., 2024, 15,11266-11279
DOI: 10.1039/D4FO02741H, Paper
Roshanak Zolqadri, Zahra Akbarbaglu, Khashayar Sarabandi, Seyed Hadi Peighambardoust, Seid Mahdi Jafari, Amin Mousavi Khaneghah
In this study, the techno-functional characteristics and nutritional value of coconut meal protein (CMP) and the obtained polypeptides by alcalase (H-Alc), trypsin (H-Try), pancreatin (H-Pan), and pepsin (H-pep) were investigated.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Development of Pickering water-in-oil emulsions using a dual stabilization of candelilla wax and acylated EGCG derivatives to enhance the survival of probiotics (Lactobacillus plantarum) powder

Food Funct., 2024, 15,11141-11157
DOI: 10.1039/D4FO01342E, Paper
Zhaojuan Shi, Jun Wu, Xingting Wang, Tongqiao Nie, Qingmei Zeng, Chuanxun Yuan, Risheng Jin
Candelilla wax reinforced the stability of Pickering W/O emulsions with a three-dimensional crystal network. The oil phase volume fraction of the emulsions showed dramatic differences in protecting probiotic viability from environmental stresses.
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Ellagic acid ameliorates alcohol-induced cognitive and social dysfunction through the gut microbiota-mediated CCL21-CCR7 axis

Food Funct., 2024, 15,11186-11205
DOI: 10.1039/D4FO03985H, Paper
Hongbo Zhang, Min Luo, Yinuo Li, Lu Liu, Ji Bian, Lan Gong, Caian He, Lin Han, Min Wang
EA enhanced the abundance of beneficial bacteria as well as their derived metabolites, thereby inhibiting chronic alcohol-induced neuroinflammation via regulation of the gut microbiota-mediated CCL21-CCR7 axis, ultimately ameliorating AICSD.
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The co-fermentation of whole-grain black barley and quinoa improves murine cognitive impairment induced by a high-fat diet via altering gut microbial ecology and suppressing neuroinflammation

Food Funct., 2024, Advance Article
DOI: 10.1039/D4FO02704C, Paper
Fenfen Wei, Huibin Jiang, Chuang Zhu, Lingyue Zhong, Zihan Lin, Yan Wu, Lihua Song
A high-fat diet (HFD) is associated with various adverse health outcomes, including cognitive impairment and an elevated risk of neurodegenerative conditions.
To cite this article before page numbers are assigned, use the DOI form of citation above.
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Advances in plant-derived extracellular vesicles: isolation, composition, and biological functions

Food Funct., 2024, Advance Article
DOI: 10.1039/D4FO04321A, Review Article
Yao-Bo Zeng, Xun Deng, Li-Sha Shen, Yong Yang, Xing Zhou, Lianbao Ye, Sibao Chen, Da-Jian Yang, Guo-Qing Chen
Plant-derived extracellular vesicles (PDEVs) are nanoscale vesicles released from plant cells into the extracellular space.
To cite this article before page numbers are assigned, use the DOI form of citation above.
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Corn cob and corn silk-based ingredients exhibit bioaccessible and antioxidant phenolic compounds displaying anti-inflammatory effects in vitro

Food Funct., 2024, Accepted Manuscript
DOI: 10.1039/D4FO02968B, Paper
Yessica Rubí Hernández-García, Ivan Luzardo-Ocampo, Gaytán-Martínez Marcela, G. Loarca-Pina, Estela Vázquez Barrios, Rocio Campos-Vega
The poor disposal and lack of corncob (CC) and cornsilk (CS) utilization generate environmental problems. This research aimed to develop CC and CS-based ingredients (1:1, 1:2, and 2:1 mixtures), evaluate...
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Human Milk Metals and Metalloids Shape Infant Microbiota

Food Funct., 2024, Accepted Manuscript
DOI: 10.1039/D4FO01929F, Paper
Open Access
Eduard Flores Ventura, Manuel Bernabeu, Belén Callejón Leblic, Raúl Cabrera-Rubio, Laxmi Yeruva, Javier Estañ-Capell, Cecilia Martínez-Costa, Tamara García-Barrera, Maria Carmen Collado
Background: The profile of metal (loid)s in human milk is essential for infant growth and development, yet its impact on the development of the infant microbiota remains unclear. Elements such...
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A novel method for exploration and prediction of the bioactive target of rice bran-derived peptide (KF-8) by integrating computational methods and experiments

Food Funct., 2024, Advance Article
DOI: 10.1039/D4FO02493A, Paper
Rui Liang, Fangliang Song, Ying Liang, Yanpeng Fang, Jianqiang Wang, Yajuan Chen, Zhongxu Chen, Xiaorong Tan, Jie Dong
The diagram of the strategy to explore peptide targets based on model predictions and experiments.
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Oral administration of cranberry-derived exosomes attenuates murine premature ovarian failure in association with changes in the specific gut microbiota and diminution in ovarian granulosa cell PANoptosis

Food Funct., 2024, Advance Article
DOI: 10.1039/D4FO03468F, Paper
Open Access
Zeyu Cui, Te Liu, Yichao Wen, Weihao Li, Jianghong Xu, Yingjuan Chen, Danping Chen, Ying Zhu
We confirmed that oral administration of cranberry-derived exosomes attenuated murine POF by modulating the gut microbiota and decreasing ovarian granulosa cell PANoptosis.
To cite this article before page numbers are assigned, use the DOI form of citation above.
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Big gender shift in our workforce

Latest PLFS data show a heartening increase in female employment. What needs to be addressed now is the quality of jobs




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Implications of RBI’s securities buyback

It serves in smoothening out debt redemption of the government, and with it keeping the fiscal deficit and interest rates in check




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Editorial. BRICS’ financial ambitions cannot be wished away

BRICS countries have expressed the need for developing a platform where central bank digital currencies can be linked. This will reduce intermediation costs




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Biomass needs greater push in energy mix

Biomass power is neglected vis-a-vis green energy sources such as solar, green hydrogen




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Effects of SEBI outsourcing arbitration

The arbitrators who were previously assigned arbitration work are now being assigned conciliation work as well, albeit with a lower fee




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Corporate ‘assurance’ on sustainability needed

Sustainability-assured statements ensure risks not captured by financial statements are properly disclosed and evaluated




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When hobbies can be all-consuming

There must be lots of other top-class minds who were devoted to their hobbies but who never let them distract them as completely as Bibek Debroy did



  • From the Viewsroom

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Big Girls Don't Cry Review

Big Girls Don't Cry is too solemn to be fun and too timid to be truly bold, feels Deepa Gahlot.




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Women Of My Billion Review

Women Of My Billion is stark and disturbing, but at the end of it Srishti Bakshi is still able to say, 'My India is not beyond repair', observes Deepa Gahlot.




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Dedh Bigha Zameen Review

Pratik Gandhi once again proves that he is an actor who can bring any character to life with his dedication to his craft and instinctive understanding of what the role requires, observes Deepa Gahlot.




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Punjab Minister says state to meet 20 per cent fuel demand through biofuels by 2035