The U.S. Forest Service's Pacific Northwest Research Station today released a new report that outlines a climate adaptation strategy for yellow-cedar in Alaska.

A conservation and management strategy for yellow-cedar in Alaska is presented in the context of climate change.

NASHVILLE based BIG YELLOW DOG MUSIC (BYD) has signed CLARE DUNN to its publishing and label roster. DUNN's new single, “Safe Haven,” is available now via the label and is the … more

Perchlorate-free flare compositions are disclosed which, when burned, produce yellow smoke and flames. Methods of producing the compositions are also disclosed.

The New Orleans-born author spoke with Eleanor Wachtel about generational love and the power of place.

Smiles and tears from country friends reunited.

Australian hockey star Adam Imer will be pulling on the green-and-yellow of Brazil this August and is heading to the Olympic Games where his biggest challenge will be taking on the Aussies.

Hi AllWell with the weather being so beautiful at the minute we decided to go to the Yellow River yesterday. It's only 20 km north of the city. So we hopped onto a bus which was stuffed to the gills seriously the driver could only just shut the doors

The Beatles will stream a rare sing-along version of the animated film "Yellow Submarine" for free on YouTube, encouraging users to stay home amid coronavirus.

KATE MIDDLETON wore a yellow dress with a tree-inspired pattern on This Morning today. The 38-year-old mum of three spoke about her new project.

Mayor Jon Pike confirmed southwest Utah communities want a "yellow level," which would have lesser restrictions for the public.

Officials had asked Governor Gary Herbert to lower the threat level in southwest Utah. He did not.

The St. George mayor said the region could be moving to "yellow" as soon as Friday night.

Southern Utah's latest appeal to move from orange to yellow may be in jeopardy because of the high transmission rate of COVID-19 in the region.

Once again, Indiana government officials are pushing plans to increase logging in state forests.

Há meio século, Thomas Brock descobriu uma bactéria capaz de sobreviver a altas temperaturas; saiba como essa descoberta cruza com o combate à pandemia do novo coronavírus.

The Amateur Traveler talks to Erik Smith (who was a guest on Travel to America’s National Parks - Amateur Traveler Episode 121) about Yellowstone and Grand Teton National Parks. We talk about all the different geothermal highlights of the park including Old Faithful, other geysers, thermal pools, etc. We also talk about wildlife, hiking, camping, floating down the Snake river, the grand canyon of the yellowstone, the grandeur of the Tetons (and the strange original of the name Teton).

(University of Barcelona) The yellow-legged gull has a high ability to adapt to human activities and benefit from these as a food resource during all year. This is stated in a scientific article published in the journal Ecology and Evolution whose first author is the researcher Francisco Ramírez, from the Faculty of Biology and the Biodiversity Research Institute (IRBio) of the University of Barcelona.

Researchers studying yellow warbler responses to the parasitic cowbird realized that red-winged blackbirds were eavesdropping on the calls and reacting to them, too.

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Westminster : printed by F. Hayden, [1839]

Researchers found that almost half of the mountain lions they tested showed signs of plague infection

Yellowknife RCMP confirmed the death of the missing 22-year-old woman on Friday and charged 27-year-old Devon Larabie in connection with her death.

From bikes to vinyl records to a remote controlled airplane, Yellowknifers looking to get rid of or find second-hand treasures have a new place to look.

Rural educator Frank Cyr had the vision and pull to force the nation to standardize the color of the ubiquitous vehicle

Where are they from? Why are they there? Crates full of steel-toe boots showed up at the Yellowknife dump last week. Now they're almost gone.

Title: Yellow Fever Outbreak: Is the U.S. at Risk?
Category: Health News
Created: 4/29/2016 12:00:00 AM
Last Editorial Review: 4/29/2016 12:00:00 AM

Title: U.S. Moves to Avert Shortage of Yellow Fever Vaccine
Category: Health News
Created: 4/28/2017 12:00:00 AM
Last Editorial Review: 5/1/2017 12:00:00 AM

ABSTRACT

Recent outbreaks of yellow fever virus (YFV) in West Africa and Brazil resulted in rapid depletion of global vaccine emergency stockpiles and raised concerns about being unprepared against future YFV epidemics. Here we report that a live attenuated virus similar to the Japanese encephalitis virus (JEV) vaccine JE-CVax/Imojev that consists of YFV-17D vaccine from which the structural (prM/E) genes have been replaced with those of the JEV SA14-14-2 vaccine strain confers full protection in mice against lethal YFV challenge. In contrast to the YFV-17D-mediated protection against YFV, this protection is not mediated by neutralizing antibodies but correlates with YFV-specific nonneutralizing antibodies and T cell responses against cell-associated YFV NS1 and other YFV nonstructural (NS) proteins. Our findings reveal the potential of YFV NS proteins to mediate protection and demonstrate that chimeric flavivirus vaccines, such as Imojev, could confer protection against two flaviviruses. This dual protection may have implications for the possible off-label use of JE-CVax in case of emergency and vaccine shortage during YFV outbreaks. In addition, populations in Asia that have been vaccinated with Imojev may already be protected against YFV should outbreaks ever occur on that continent, as several countries/regions in the Asia-Pacific are vulnerable to international spread of the YFV.

IMPORTANCE Efficient and safe vaccines against yellow fever (e.g., YFV-17D) that provide long-lasting protection by rapidly inducing neutralizing antibody responses exist. However, the vaccine supply cannot cope with an increasing demand posed by urban outbreaks in recent years. Here we report that JE-CVax/Imojev, a YFV-17D-based chimeric Japanese encephalitis vaccine, also efficiently protects against YFV infection in mice. In case of shortage of the YFV vaccine during yellow fever outbreaks, (off-label) use of JE-CVax/Imojev may be considered. Moreover, wider use of JE-CVax/Imojev in Asia may lower the risk of the much-feared YFV spillover to the continent. More generally, chimeric vaccines that combine surface antigens and replication machineries of two distinct flaviviruses may be considered dual vaccines for the latter pathogen without induction of surface-specific antibodies. Following this rationale, novel flavivirus vaccines that do not hold a risk for antibody-dependent enhancement (ADE) of infection (inherent to current dengue vaccines and dengue vaccine candidates) could be designed.

ABSTRACT

While the basic mechanisms of flavivirus entry and fusion are understood, little is known about the postfusion events that precede RNA replication, such as nucleocapsid disassembly. We describe here a sensitive, conditionally replication-defective yellow fever virus (YFV) entry reporter, YFVSK/Nluc, to quantitively monitor the translation of incoming, virus particle-delivered genomes. We validated that YFVSK/Nluc gene expression can be neutralized by YFV-specific antisera and requires known flavivirus entry pathways and cellular factors, including clathrin- and dynamin-mediated endocytosis, endosomal acidification, YFV E glycoprotein-mediated fusion, and cellular LY6E and RPLP1 expression. The initial round of YFV translation was shown to require cellular ubiquitylation, consistent with recent findings that dengue virus capsid protein must be ubiquitylated in order for nucleocapsid uncoating to occur. Importantly, translation of incoming YFV genomes also required valosin-containing protein (VCP)/p97, a cellular ATPase that unfolds and extracts ubiquitylated client proteins from large complexes. RNA transfection and washout experiments showed that VCP/p97 functions at a postfusion, pretranslation step in YFV entry. Finally, VCP/p97 activity was required by other flaviviruses in mammalian cells and by YFV in mosquito cells. Together, these data support a critical role for VCP/p97 in the disassembly of incoming flavivirus nucleocapsids during a postfusion step in virus entry.

IMPORTANCE Flaviviruses are an important group of RNA viruses that cause significant human disease. The mechanisms by which flavivirus nucleocapsids are disassembled during virus entry remain unclear. Here, we used a yellow fever virus entry reporter, which expresses a sensitive reporter enzyme but does not replicate, to show that nucleocapsid disassembly requires the cellular protein-disaggregating enzyme valosin-containing protein, also known as p97.

Objective

To determine whether live-attenuated yellow fever vaccine (YFV) was associated with MS relapse, we evaluated the clinical courses of 23 patients in the year before and the year after immunization at the university hospital of Geneva, Switzerland.

body fluidsCSF

Researchers have found the weird exoplanet WASP-79b, nearly 800 light-years from Earth, does not have a blue sky as our planet does. Instead, its skies are yellow.

Remember the Yellow Pages Association? They represent the folks who print phone books. They've fought some efforts by cities to ban phone book distribution, and

Vibrant tones liven up this redesign of a 1920s apartment in Stockholm, Sweden.

Urine for a surprise as Alex Wilson concludes that urine collection beats composting. I was, because they are not mutually exclusive.

Can you bear to look at these intimate and frightening photos of grizzly bears.

Former star or ABC’s The Bachelorette Ali Fedotowsky and [ yellow tail ], America’s go-to holiday wine, team up to Spread Holiday Cheer in New York City to kick-off [yellow tail ] wine’s 12 Days of Giveaways. Starting Tuesday, Dec. 8, 2015, people can visit Facebook.com/yellowtail to find out more ways to win exciting prizes.

Samantha sports head-to-toe yellow see-through dress at the Zine Cine Awards Telugu

TALK OF THE TOWN: Three months after splitting from The Crown actor Matt Smith, Lily James nipped to a florist near her home in Primrose Hill, North London, to buy a large yellow bouquet,

The 42-year-old fashion designer showed off a pair of unreleased bright yellow Yeezy boots while heading to his office in Calabasas, California on Tuesday morning.

The couple were pictured leaving the Bluebird restaurant in London's Chelsea on Wednesday evening, following a romantic date night.