secondary Nozzles including secondary passages, drill assemblies including same and associated methods By www.freepatentsonline.com Published On :: Tue, 19 May 2015 08:00:00 EDT Nozzles for drilling tools, such as rotary-type drag bits and roller cone bits, a drilling tool and drilling assembly comprising nozzles, and methods of conveying drilling fluid through a nozzle for use in drilling subterranean formations are provided. A nozzle may include a substantially cylindrical nozzle body having an axis and an inlet port with a primary passage extending therethrough, and at least one secondary passage that diverges from the primary passage at an exit port. Full Article
secondary Apparatus for correcting belt-meandering for secondary battery By www.freepatentsonline.com Published On :: Tue, 25 Nov 2014 08:00:00 EST An apparatus of correcting belt-meandering for a secondary battery is disclosed. In one embodiment, the apparatus includes i) upper and lower rollers configured to receive a base material therebetween, wherein the base material comprises positive and negative electrode materials and an insulating material interposed between the electrode materials and ii) a driver portion configured to rotate the upper and lower rollers such that the base material is transferred in a first direction during the rotation. The apparatus may also include i) a support portion configured to support shafts of the driver portion and the upper and lower rollers and ii) a transverse moving mechanism configured to move the support portion in a second direction substantially perpendicular to the first direction. Full Article
secondary Medication safety enhancement for secondary infusion By www.freepatentsonline.com Published On :: Tue, 26 May 2015 08:00:00 EDT A system and method determine when fluid is not flowing properly from a secondary infusion source during a secondary infusion. The system includes an upstream pressure sensor and a processor programmed to receive signals from the sensor and analyze the signals to determine if secondary fluid flow is proper. The processor samples the output signals from the upstream pressure sensor and analyzes the sampled signals to determine if a pressure rise in the infusion line has occurred when the secondary infusion is initiated. If a pressure rise, indicating that fluid from the secondary container has begun flowing into the infusion line, has not been detected, the processor is programmed to provide a signal indicating that attention should be given to the infusion set up. Full Article
secondary Air proportioning system for secondary air in coke ovens depending on the vault vs. sole temperature ratio By www.freepatentsonline.com Published On :: Tue, 17 Mar 2015 08:00:00 EDT A device for proportioning of secondary combustion air into the secondary air soles of coke oven chamber ovens is shown. The device is formed by a slide gate or a parallelepiped device or by plates moved by means of a thrust bar, the thrust bar being moved longitudinally in parallel to the coke oven chamber wall so that the plates move away from the secondary air apertures and open or close these. The thrust bar is moved by means of a positioning motor, with the power transmission being effected hydraulically or pneumatically. Via suitable measuring parameters, it is thus possible to optimize secondary heating so that heating is provided evenly from all sides, thus achieving an improvement in coke quality. Full Article
secondary NONAQUEOUS ELECTROLYTE SECONDARY BATTERY AND BATTERY PACK By www.freepatentsonline.com Published On :: Thu, 29 Jun 2017 08:00:00 EDT A nonaqueous electrolyte secondary battery of the present invention includes a positive electrode containing olivine-structured Fe or a Mn-containing phosphorus compound as a positive electrode active material; a negative electrode containing a titanium-containing metal oxide capable of inserting and extracting lithium ions as a negative electrode active material; a nonwoven fabric separator, which contains an electrically insulating fiber and is bonded to a surface of at least one of the positive electrode and the negative electrode; and a nonaqueous electrolyte. In a thickness direction of the nonwoven fabric separator, a density of the fiber on a side having contact with the positive electrode is high, and a density of the fiber on a side having contact with the negative electrode is low. Full Article
secondary NONAQUEOUS ELECTROLYTE SECONDARY BATTERY SEPARATOR By www.freepatentsonline.com Published On :: Thu, 29 Jun 2017 08:00:00 EDT The present invention provides a nonaqueous electrolyte secondary battery separator that achieves an excellent rate characteristic by having a tensile creep compliance J satisfying at least one of the following three conditions in a case where stress of 30 MPa is applied for t seconds: (i) when t=300 seconds, J=4.5 GPa−1 to 14.0 GPa−1, (ii) when t=1800 seconds, J=9.0 GPa−1 to 25.0 GPa−1, (iii) when t=600 seconds, J=12.0 GPa−5 to 32.0 GPa−1. Full Article
secondary SECONDARY BATTERY By www.freepatentsonline.com Published On :: Thu, 29 Jun 2017 08:00:00 EDT A secondary battery includes a case composed of a metal containing aluminum as a main component, a stacked electrode assembly arranged in the case, a negative electrode current collector electrically connecting negative electrodes of the stacked electrode assembly to a negative electrode terminal, a positive electrode current collector electrically connecting positive electrodes of the stacked electrode assembly to a positive electrode terminal, a first metal plate arranged between the case and the stacked electrode assembly, and a spacer arranged between the case and the first metal plate, the spacer being composed of an insulating material. The positive electrodes are electrically connected to the case or a second metal plate arranged on the first metal plate with an insulating member provided between the first metal plate and the insulating member. The negative electrode current collector is in contact with the first metal plate to establish electrical connection between the negative electrode current collector and the first metal plate. Full Article
secondary SECONDARY BATTERY By www.freepatentsonline.com Published On :: Thu, 29 Jun 2017 08:00:00 EDT A secondary battery is disclosed. In one aspect, the secondary battery includes a case accommodating an electrode assembly, a cap plate sealing an opening of the case, an electrode terminal electrically connected to the electrode assembly and disposed over the cap, and an insulating member provided between the cap plate and the electrode terminal and configured to insulate the electrode terminal from the cap plate. The battery also includes a connection tab disposed over the electrode terminal, and a safety device having a portion positioned under the connection tab and electrically connected to the electrode terminal via the connection tab. The safety device has at least one of electric conductivity and thermal conductivity greater than that of the connection tab, and at least a part of the safety device is seated on the insulating member. Full Article
secondary POSITIVE ELECTRODE ACTIVE MATERIAL FOR LITHIUM SECONDARY BATTERIES, POSITIVE ELECTRODE FOR LITHIUM SECONDARY BATTERIES, AND LITHIUM SECONDARY BATTERY By www.freepatentsonline.com Published On :: Thu, 29 Jun 2017 08:00:00 EDT The object of the present invention is to provide a positive electrode active material usable for a lithium ion battery capable of high charge/discharge cycle performance and high discharge capacity. The positive electrode active material for a lithium secondary battery has a layered structure and comprises at least nickel, cobalt and manganese. Further, the positive electrode active material satisfies requirements (1) to (3) below: (1) a primary particle size of 0.1 μm to 1 μm, and a 50% cumulative particle size D50 of 1 μm to 10 μm, (2) a ratio (D90/D10) of volume-based 90% cumulative particle size D50 to volume-based 10% cumulative particle size D10 of 2 to 6, and (3) a lithium carbonate content in a residual alkali on particle surfaces of 0.1% by mass to 0.8% by mass as measured by neutralization titration. Full Article
secondary POSITIVE ELECTRODE FOR NONAQUEOUS ELECTROLYTE SECONDARY BATTERY AND NONAQUEOUS ELECTROLYTE SECONDARY BATTERY By www.freepatentsonline.com Published On :: Thu, 29 Jun 2017 08:00:00 EDT The positive electrode as an embodiment includes a positive electrode current collector mainly composed of aluminum, a positive electrode mixture layer containing a lithium-containing transition metal oxide and disposed above the positive electrode current collector, and a protective layer disposed between the positive electrode current collector and the positive electrode mixture layer. The protective layer contains inorganic particles, an electro-conductive material, and a binding material; is mainly composed of the inorganic particles; and is disposed on the positive electrode current collector to cover the positive electrode current collector in approximately the entire area where the positive electrode mixture layer is disposed and at least a part of the exposed portion of the positive electrode current collector where the positive electrode mixture layer is not disposed on the surface of the positive electrode current collector. Full Article
secondary POSITIVE ELECTRODE ACTIVE MATERIAL FOR SODIUM SECONDARY BATTERY, AND METHOD FOR PREPARING SAME By www.freepatentsonline.com Published On :: Thu, 29 Jun 2017 08:00:00 EDT The present invention relates to a positive electrode active material for a sodium secondary battery, and a method for preparing the same. The positive electrode active material for the sodium secondary battery according to the present invention is structurally more stable by replacing a part of the transition metal with Li, and accordingly, the thermal stability and life characteristics of the sodium battery including the positive electrode active material are greatly improved. Full Article
secondary CARBON MATERIAL, METHOD FOR PRODUCING CARBON MATERIAL, AND NON-AQUEOUS SECONDARY BATTERY USING CARBON MATERIAL By www.freepatentsonline.com Published On :: Thu, 29 Jun 2017 08:00:00 EDT A carbon material for a non-aqueous secondary battery containing a graphite capable of occluding and releasing lithium ions, and having a cumulative pore volume at pore diameters in a range of 0.01 μm to 1 μm of 0.08 mL/g or more, a roundness, as determined by flow-type particle image analysis, of 0.88 or greater, and a pore diameter to particle diameter ratio (PD/d50 (%)) of 1.8 or less, the ratio being given by equation (1A): PD/d50 (%)=mode pore diameter (PD) in a pore diameter range of 0.01 μm to 1 μm in a pore distribution determined by mercury intrusion/volume-based average particle diameter (d50)×100 is provided. Full Article
secondary LITHIUM ION SECONDARY BATTERY By www.freepatentsonline.com Published On :: Thu, 29 Jun 2017 08:00:00 EDT A lithium ion secondary battery including: a positive electrode including a positive electrode active material capable of intercalating and deintercalating a lithium ion; a negative electrode including a negative electrode active material capable of intercalating and deintercalating a lithium ion; and a non-aqueous electrolytic solution, wherein the positive electrode active material includes a Mn-based spinel-type composite oxide and an additional active material, and the content of the Mn-based spinel-type composite oxide based on the whole of the positive electrode active material is 60% by mass or less, and the negative electrode active material includes a first graphite particle containing natural graphite and a second graphite particle containing artificial graphite, and the content of the second graphite particle based on the sum total of the first graphite particle and the second graphite particle is in the range of 1 to 30% by mass. Full Article
secondary POSITIVE ELECTRODE ACTIVE MATERIAL FOR NONAQUEOUS ELECTROLYTE SECONDARY BATTERIES, PRODUCTION METHOD THEREOF, AND NONAQUEOUS ELECTROLYTE SECONDARY BATTERY INCLUDING SAID MATERIAL By www.freepatentsonline.com Published On :: Thu, 29 Jun 2017 08:00:00 EDT Provided is a positive electrode active material that can be used to fabricate a nonaqueous electrolyte secondary battery having excellent output characteristics not only in an environment at normal temperature but also in all temperature environments from extremely low to high temperatures. A positive electrode active material for nonaqueous electrolyte secondary batteries, the positive electrode active material includes a boron compound and lithium-nickel-cobalt-manganese composite oxide of general formula (1) having a layered hexagonal crystal structure. The lithium-nickel-cobalt-manganese composite oxide includes secondary particles composed of agglomerated primary particles. The boron compound is present on at least part of the surface of the primary particles, and contains lithium. Li1+sNixCoyMnzMotMwO2 (1) Full Article
secondary GARNET MATERIALS FOR LI SECONDARY BATTERIES AND METHODS OF MAKING AND USING GARNET MATERIALS By www.freepatentsonline.com Published On :: Thu, 29 Jun 2017 08:00:00 EDT Set forth herein are garnet material compositions, e.g., lithium-stuffed garnets and lithium-stuffed garnets doped with alumina, which are suitable for use as electrolytes and catholytes in solid state battery applications. Also set forth herein are lithium-stuffed garnet thin films having fine grains therein. Disclosed herein are novel and inventive methods of making and using lithium-stuffed garnets as catholytes, electrolytes and/or anolytes for all solid state lithium rechargeable batteries. Also disclosed herein are novel electrochemical devices which incorporate these garnet catholytes, electrolytes and/or anolytes. Also set forth herein are methods for preparing novel structures, including dense thin ( Full Article
secondary NON-AQUEOUS ELECTROLYTE SECONDARY CELL By www.freepatentsonline.com Published On :: Thu, 29 Jun 2017 08:00:00 EDT A non-aqueous electrolyte secondary cell includes: a positive electrode including a positive electrode active material which contains as a primary component, a lithium composite oxide in which the rate of nickel to the total number of moles of metal elements other than lithium is 50 percent by mole or more; a negative electrode; and a non-aqueous electrolyte. The non-aqueous electrolyte contains lithium bis(fluorosulfonyl)amide and a fluorinated chain carboxylic acid ester represented by the following formula, R1 and R2 each represent H, F, or CH3-xFx (x represents 1, 2, or 3) and may be equivalent to or different from each other. R3 represents an alkyl group having 1 to 3 carbon atoms and may contain F. Full Article
secondary ELECTROLYTE SOLUTION COMPRISING SULFUR DIOXIDE-BASED IONIC LIQUID ELECTROLYTE, AND SODIUM-SULFUR DIOXIDE SECONDARY BATTERY HAVING SAME By www.freepatentsonline.com Published On :: Thu, 29 Jun 2017 08:00:00 EDT The described technology relates to an electrolyte solution comprising a sulfur dioxide-based ionic liquid electrolyte, and a sodium-sulfur dioxide (Na—SO2) secondary battery having same, one purpose of the described technology being to enhance the storage characteristics of sulfur dioxide gas in an electrolyte solution. The sodium-sulfur dioxide secondary battery includes a negative electrode which is formed from an inorganic material and which contains sodium. The battery also includes a positive electrode which is formed from a carbon material and a sulfur dioxide-based inorganic electrolyte solution. Here, the electrolyte solution contains a sulfur dioxide-based ionic liquid electrolyte prepared by injecting SO2 gas in an ionic liquid. Full Article
secondary LITHIUM SECONDARY BATTERY By www.freepatentsonline.com Published On :: Thu, 29 Jun 2017 08:00:00 EDT A lithium secondary battery includes: a negative electrode, a positive electrode, and an electrolyte disposed between the negative electrode and the positive electrode, wherein the negative electrode includes a silicon composite including silicon, a silicon oxide of the formula SiOx wherein 0 Full Article
secondary LITHIUM SECONDARY BATTERY By www.freepatentsonline.com Published On :: Thu, 29 Jun 2017 08:00:00 EDT A lithium secondary battery includes a case, a jelly roll housed in the case, the jelly roll including a plurality of electrode plates and a separation film disposed between the plurality of electrode plates, and a heat conduction plate disposed on both sides of the jelly roll and housed in the case together with the jelly roll. Full Article
secondary Seal with primary and secondary sealing lobes for use in roll-up door applications By www.freepatentsonline.com Published On :: Tue, 19 May 2015 08:00:00 EDT A roll-up door seal that may be monolithically formed from a single material of uniform density. The seal is sized and adapted to assemble to a standard roll-up door frame without a separate or dedicated frame structure. The seal provides redundant sealing surfaces, positioned to cooperate with both the door and door frame, which ensure an effective and durable fluid tight seal between the cargo space enclosed by the roll-up door and the ambient environment. The seal may be produced by extrusion from a flexible, weather resistant material such as EPDM, thereby providing a low cost solution for sealing roll-up doors having industry standard door frame constructions. The seal is firmly engageable with the door frame, such that the seal may be installed with little or no secondary fixation. Full Article
secondary METHOD OF MANUFACTURING LITHIUM-ION SECONDARY BATTERY ELECTRODE SHEET By www.freepatentsonline.com Published On :: Thu, 22 Jun 2017 08:00:00 EDT A method of manufacturing a lithium-ion secondary battery electrode sheet disclosed herein includes the step of preparing powder 220 of granulated particles. In this step, the powder (220) of granulated particles (240) including active material particles (241) and a hinder (242) is prepared. The powder (220) is deposited on a strip-shaped collector foil (201) that is being conveyed. Then, the powder (220) is removed from widthwise center portions (202) and (203) of the collector foil (201), and a squeegee (106) is brought into contact with the powder (220) remaining on the opposite sides of the center portions (202) and (203) of the collector foil (201), thus adjusting the thickness of the powder (220). Subsequently, the powder (220) remaining on the opposite sides of the center portions (202) and (203) of the collector foil (201) is pressed. Full Article
secondary SILICON-BASED ACTIVE MATERIAL FOR LITHIUM SECONDARY BATTERY AND PREPARATION METHOD THEREOF By www.freepatentsonline.com Published On :: Thu, 29 Jun 2017 08:00:00 EDT Disclosed is a silicon-based anode active material for a lithium secondary battery. The silicon-based anode active material imparts high capacity and high power to the lithium secondary battery, can be used for a long time, and has good thermal stability. Also disclosed is a method for preparing the silicon-based anode active material. The method includes (A) binding metal oxide particles to the entire surface of silicon particles or portions thereof to form a silicon-metal oxide composite, (B) coating the surface of the silicon-metal oxide composite with a polymeric material to form a silicon-metal oxide-polymeric material composite, and (C) heat treating the silicon-metal oxide-polymeric material composite under an inert gas atmosphere to convert the coated polymeric material layer into a carbon coating layer. Full Article
secondary The amphipathic helix in the exchangeable apolipoproteins: a review of secondary structure and function By feedproxy.google.com Published On :: 1992-02-01 JP SegrestFeb 1, 1992; 33:141-166Reviews Full Article
secondary Secondary Hyperparathyroidism and Chronic Kidney Disease By spectrum.diabetesjournals.org Published On :: 2008-01-01 Sarah TomaselloJan 1, 2008; 21:19-25Articles Full Article
secondary Revamp of Committee on Self-financing Post-secondary Education announced By www.info.gov.hk Published On :: Tue, 22 Oct 2019 15:15:22 Full Article
secondary New notification arrangements on Secondary One discretionary places and distribution of school choice documents for Central Allocation By www.info.gov.hk Published On :: Tue, 24 Mar 2020 15:51:38 Full Article
secondary Loan repayment by self-financing post-secondary institutions under Start-up Loan Scheme, non-profit-making international schools and student loan repayers to be deferred for two years By www.info.gov.hk Published On :: Mon, 20 Apr 2020 22:18:19 Full Article
secondary Wellbeing - some advice for telehealth in secondary care By feeds.bmj.com Published On :: Thu, 16 Apr 2020 18:30:00 +0000 We’ve published info on Telehealth in primary care - and have been overwhelmed by the response from GPs who are finding it useful. But it’s not only primary care that is dramatically shifting to remote care - routine hospital care is moving online too, so we’ve asked Rowena McCash - GP and out of hours triage trainer joins us to give some tips... Full Article
secondary Immigrant-Origin Adults without Postsecondary Credentials: A 50-State Profile By www.migrationpolicy.org Published On :: Wed, 20 Mar 2019 11:51:29 -0400 With immigrants and their U.S.-born children poised to be the main source of labor-force growth, these adults are an important target for efforts to build the skills of the U.S. workforce to meet the knowledge-based economy of tomorrow. This fact sheet and state data snapshots explore the characteristics of adults without an academic degree or professional credential, by immigrant generation, race/ethnicity, and more. Full Article
secondary Have your say on the Highway 404 Employment Corridor Secondary Plan By www.eastgwillimbury.ca Published On :: Mon, 27 Apr 2020 22:16:01 GMT Full Article
secondary Streaming of Repeated Noise in Primary and Secondary Fields of Auditory Cortex By www.jneurosci.org Published On :: 2020-05-06T09:30:22-07:00 Statistical regularities in natural sounds facilitate the perceptual segregation of auditory sources, or streams. Repetition is one cue that drives stream segregation in humans, but the neural basis of this perceptual phenomenon remains unknown. We demonstrated a similar perceptual ability in animals by training ferrets of both sexes to detect a stream of repeating noise samples (foreground) embedded in a stream of random samples (background). During passive listening, we recorded neural activity in primary auditory cortex (A1) and secondary auditory cortex (posterior ectosylvian gyrus, PEG). We used two context-dependent encoding models to test for evidence of streaming of the repeating stimulus. The first was based on average evoked activity per noise sample and the second on the spectro-temporal receptive field. Both approaches tested whether differences in neural responses to repeating versus random stimuli were better modeled by scaling the response to both streams equally (global gain) or by separately scaling the response to the foreground versus background stream (stream-specific gain). Consistent with previous observations of adaptation, we found an overall reduction in global gain when the stimulus began to repeat. However, when we measured stream-specific changes in gain, responses to the foreground were enhanced relative to the background. This enhancement was stronger in PEG than A1. In A1, enhancement was strongest in units with low sparseness (i.e., broad sensory tuning) and with tuning selective for the repeated sample. Enhancement of responses to the foreground relative to the background provides evidence for stream segregation that emerges in A1 and is refined in PEG. SIGNIFICANCE STATEMENT To interact with the world successfully, the brain must parse behaviorally important information from a complex sensory environment. Complex mixtures of sounds often arrive at the ears simultaneously or in close succession, yet they are effortlessly segregated into distinct perceptual sources. This process breaks down in hearing-impaired individuals and speech recognition devices. By identifying the underlying neural mechanisms that facilitate perceptual segregation, we can develop strategies for ameliorating hearing loss and improving speech recognition technology in the presence of background noise. Here, we present evidence to support a hierarchical process, present in primary auditory cortex and refined in secondary auditory cortex, in which sound repetition facilitates segregation. Full Article
secondary Primary and Secondary Prevention of Youth Suicide By pediatrics.aappublications.org Published On :: 2020-05-01T01:00:26-07:00 Youth suicide is a national and global public health crisis. Pediatricians can use primary and secondary prevention strategies to intervene with youth before or after the onset of suicidal behaviors. Universal suicide risk screening programs can be used to identify youth in medical settings who may otherwise pass through the health care setting with undetected suicide risk. Pediatricians are uniquely positioned to help foster resilience in their young patients and equip families of at-risk youth with safety plans and lethal means safety counseling. Pediatricians on the frontlines of this critical public health crisis require education and training in detecting suicide risk, managing those who screen positive, and connecting their patients to much needed mental health interventions and treatments. Evidence-based suicide risk screening and assessment tools, paired with interventions, are feasible and potentially life-saving in the medical setting. Full Article
secondary Nebraska Expands Anti-Hazing Law to Cover Primary and Secondary Schools By feedproxy.google.com Published On :: Fri, 01 Apr 2016 00:00:00 +0000 Nebraska Gov. Pete Ricketts signed a bill into law Wednesday that expands the state's anti-hazing regulations to elementary, middle, and high schools rather than just post-secondary institutions. Full Article Lawandcourts
secondary Postsecondary Education and Employment Among Youth With an Autism Spectrum Disorder By pediatrics.aappublications.org Published On :: 2012-05-14T00:07:37-07:00 Previous research has identified low rates of employment and postsecondary education for youth with autism, but generalizability has been limited by small samples.Using national data, the authors of this study found that youth with autism are at high risk for no postsecondary education or employment, especially in the first 2 years after high school. Findings highlight the need for improved transition planning. (Read the full article) Full Article
secondary Secondary Sexual Characteristics in Boys: Data From the Pediatric Research in Office Settings Network By pediatrics.aappublications.org Published On :: 2012-10-20T00:05:41-07:00 Recent investigations of pubertal onset in US girls suggest earlier maturation. The situation for US boys is unknown, and existing investigations are outdated and lack information on a key physical marker of male puberty: testicular enlargement.US boys appear to be developing secondary sexual characteristics and achieving testicular enlargement 6 months to 2 years earlier than commonly used norms, with African American boys entering Tanner stages 2 to 4 earlier than white or Hispanic boys. (Read the full article) Full Article
secondary Secondary Sexual Characteristics and Menses in Young Girls Seen in Office Practice: A Study from the Pediatric Research in Office Settings Network By pediatrics.aappublications.org Published On :: 1997-04-01 Marcia E. Herman-GiddensApr 1, 1997; 99:505-512ARTICLES Full Article
secondary RBI continues secondary market OMO purchases in third week of April By www.financialexpress.com Published On :: 2020-04-29T00:01:00+05:30 Although there is no concrete proof, experts believe a large chunk of this is likely to be T-Bill purchases by the RBI from the secondary market. Full Article Economy
secondary US lifts the Cuba secondary sanctions waiver By www.eversheds.com Published On :: 2019-05-10 The United States (“US”) Government announced on 17 April 2019 that it would not renew a waiver to Title III of the US Helms-Burton Act 1996 (“Title III”) that had effectively prevented former owners of property confiscated f... Full Article
secondary Secondary osteon structural heterogeneity between the cranial and caudal cortices of the proximal humerus in white-tailed deer [RESEARCH ARTICLE] By jeb.biologists.org Published On :: 2020-05-04T02:24:22-07:00 Jack Nguyen and Meir M. BarakCortical bone remodeling is an ongoing process triggered by microdamage, where osteoclasts resorb existing bone and osteoblasts deposit new bone in the form of secondary osteons (Haversian systems). Previous studies revealed regional variance in Haversian systems structure and possibly material, between opposite cortices of the same bone. As bone mechanical properties depend on tissue structure and material, it is predicted that bone mechanical properties will vary in accordance with structural and material regional heterogeneity. To test this hypothesis, we analyzed the structure, mineral content and compressive stiffness of secondary bone from the cranial and caudal cortices of the white-tailed deer proximal humerus. We found significantly larger Haversian systems and canals in the cranial cortex but no significant difference in mineral content between the two cortices. Accordingly, we found no difference in compressive stiffness between the two cortices and thus our working hypothesis was rejected. Seeing that the deer humerus is curved and thus likely subjected to bending during habitual locomotion, we expect that similar to other curved long bones, the cranial cortex of the deer humerus is likely subjected primarily to tensile strains and the caudal cortex is likely subject primarily to compressive strains. Consequently, our results suggest that strain magnitude (larger in compression) and sign (compression vs. tension) affect differently the osteoclasts and osteoblasts in the BMU. Our results further suggest that osteoclasts are inhibited in regions of high compressive strains (creating smaller Haversian systems) while osteoblasts’ osteoid deposition and mineralization is not affected by strain magnitude and sign. Full Article
secondary Renal, Cardiovascular, and Safety Outcomes of Canagliflozin by Baseline Kidney Function: A Secondary Analysis of the CREDENCE Randomized Trial By jasn.asnjournals.org Published On :: 2020-04-30T10:00:30-07:00 Background Canagliflozin reduced renal and cardiovascular events in people with type 2 diabetes in the CREDENCE trial. We assessed efficacy and safety of canagliflozin by initial estimated glomerular filtration rate (eGFR). Methods CREDENCE randomly assigned 4401 participants with an eGFR of 30 to <90 ml/min per 1.73 m2 and substantial albuminuria to canagliflozin 100 mg or placebo. We used Cox proportional hazards regression to analyze effects on renal and cardiovascular efficacy and safety outcomes within screening eGFR subgroups (30 to <45, 45 to <60, and 60 to <90 ml/min per 1.73 m2) and linear mixed effects models to analyze the effects on eGFR slope. Results At screening, 1313 (30%), 1279 (29%), and 1809 (41%) participants had an eGFR of 30 to <45, 45 to <60, and 60 to <90 ml/min per 1.73 m2, respectively. The relative benefits of canagliflozin for renal and cardiovascular outcomes appeared consistent among eGFR subgroups (all P interaction >0.11). Subgroups with lower eGFRs, who were at greater risk, exhibited larger absolute benefits for renal outcomes. Canagliflozin’s lack of effect on serious adverse events, amputations, and fractures appeared consistent among eGFR subgroups. In all subgroups, canagliflozin use led to an acute eGFR drop followed by relative stabilization of eGFR loss. Among those with an eGFR of 30 to <45 ml/min per 1.73 m2, canagliflozin led to an initial drop of 2.03 ml/min per 1.73 m2. Thereafter, decline in eGFR was slower in the canagliflozin versus placebo group (–1.72 versus –4.33 ml/min per 1.73 m2; between-group difference 2.61 ml/min per 1.73 m2). Conclusions Canagliflozin safely reduced the risk of renal and cardiovascular events, with consistent results across eGFR subgroups, including the subgroup initiating treatment with an eGFR of 30 to <45 ml/min per 1.73 m2. Absolute benefits for renal outcomes were greatest in subgroups with lower eGFR. Clinical Trial registry name and registration number Evaluation of the Effects of Canagliflozin on Renal and Cardiovascular Outcomes in Participants With Diabetic Nephropathy (CREDENCE), NCT02065791. Full Article
secondary Intravenous Iron Dosing and Infection Risk in Patients on Hemodialysis: A Prespecified Secondary Analysis of the PIVOTAL Trial By jasn.asnjournals.org Published On :: 2020-04-30T10:00:30-07:00 Background Experimental and observational studies have raised concerns that giving intravenous (IV) iron to patients, such as individuals receiving maintenance hemodialysis, might increase the risk of infections. The Proactive IV Iron Therapy in Haemodialysis Patients (PIVOTAL) trial randomized 2141 patients undergoing maintenance hemodialysis for ESKD to a high-dose or a low-dose IV iron regimen, with a primary composite outcome of all-cause death, heart attack, stroke, or hospitalization for heart failure. Comparison of infection rates between the two groups was a prespecified secondary analysis. Methods Secondary end points included any infection, hospitalization for infection, and death from infection; we calculated cumulative event rates for these end points. We also interrogated the interaction between iron dose and vascular access (fistula versus catheter). Results We found no significant difference between the high-dose IV iron group compared with the lose-dose group in event rates for all infections (46.5% versus 45.5%, respectively, which represented incidences of 63.3 versus 69.4 per 100 patient years, respectively); rates of hospitalization for infection (29.6% versus 29.3%, respectively) also did not differ. We did find a significant association between risk of a first cardiovascular event and any infection in the previous 30 days. Compared with patients undergoing dialysis with an arteriovenous fistula, those doing so via a catheter had a higher incidence of having any infection, hospitalization for infection, or fatal infection, but IV iron dosing had no effect on these outcomes. Conclusions The high-dose and low-dose IV iron groups exhibited identical infection rates. Risk of a first cardiovascular event strongly associated with a recent infection. Full Article
secondary Shared decision making about blood tests: secondary analysis of video-recorded primary care consultations By bjgp.org Published On :: 2020-04-30T16:04:41-07:00 BackgroundAwareness of the importance of shared decision making (SDM) is widespread; however, little research has focused on discussions surrounding investigations, despite increasing laboratory testing in primary care.AimTo explore the discussion of blood tests in routine primary care consultations.Design and settingA secondary analysis of 50 video-recorded routine primary care consultations, linked surveys, and records data (all from the One in a Million [OiaM] archive). The consultations were taken by 22 GPs across 12 practices.MethodA coding scheme was developed, using qualitative content analysis, to explore discussion of blood tests in transcripts of recorded consultations. Codes focused on instigating testing, the extent of SDM, and how results were explained. Survey data were used to compare patients’ pre-visit expectations with consultation content. Medical records were reviewed to compare tests discussed with those ordered.ResultsIn 36 out of 50 consultations that discussed ordering blood tests, 11 patients (31%) hinted that they wanted a blood test; however, none asked explicitly. Only four patients (11%) were offered alternative options. In 29 cases (81%) the GP gave some explanation of the indication, but only in six cases (17%) were the limitations of testing explained. Only 10 out of 31 patients (32%) were informed about all blood tests ordered. Of the 23 out of 50 consultations in which results were conveyed, the GP gave no explanation of the results in six cases (26%). Thirteen patients (57%) were only informed of an assessment of the results (for example, ‘normal’), rather than the actual results.ConclusionA lack of information dissemination and SDM exists around ordering tests and conveying results. Promoting SDM could reduce unnecessary testing and improve patient-centred care. Full Article
secondary Design of the {beta}3-Adrenergic Agonist Treatment in Chronic Pulmonary Hypertension Secondary to Heart Failure Trial By www.basictranslational.onlinejacc.org Published On :: 2020-04-27T11:00:20-07:00 Combined pre-and post-capillary hypertension (CpcPH) is a relatively common complication of heart failure (HF) associated with a poor prognosis. Currently, there is no specific therapy approved for this entity. Recently, treatment with beta-3 adrenergic receptor (β3AR) agonists was able to improve pulmonary hemodynamics and right ventricular (RV) performance in a translational, large animal model of chronic PH. The authors present the design of a phase II randomized clinical trial that tests the benefits of mirabegron (a clinically available β3AR agonist) in patients with CpcPH due to HF. The effect of β3AR treatment will be evaluated on pulmonary hemodynamics, as well as clinical, biochemical, and advanced cardiac imaging parameters. (Beta3 Agonist Treatment in Chronic Pulmonary Hypertension Secondary to Heart Failure [SPHERE-HF]; NCT02775539) Full Article
secondary The Road Map to post-secondary success in Greater Seattle By webfeeds.brookings.edu Published On :: Wed, 24 Feb 2016 13:45:00 -0500 Think of Seattle’s workforce and you may imagine overworked tech employees at Amazon, Microsoft software developers, or Boeing engineers. But the region’s workforce’s story is more complicated. Alongside the highly skilled workers driving the region’s strong growth since the Great Recession is an increasingly diverse youth population in South Seattle and its surrounding South King County suburbs often disconnected from the region’s trademark innovation economy. As a result, the region faces a skills challenge as only one-quarter of the roughly one-half of King County adults who hold a bachelor’s degree are Washington natives. This limits both individual opportunity and long-term regional competitiveness: 67 percent of jobs in the state will demand postsecondary education within two years, according to an estimate from Georgetown University, but only 28 percent of students in South Seattle and the South King County suburbs receive a postsecondary credential by their mid-20s. These challenges aren’t unique. Many regions are grappling with rising diversity’s impact on the labor force, and thinking about how educational programs and outreach need to adapt to reach diverse populations in an era of constrained resources and growing suburban poverty. But Greater Seattle has an advantage over many communities: a committed group of cross-sector leaders working together as part of the Road Map Project and its ambitious goal “to double the number of students in South King County and South Seattle who are on track to graduate from college or earn a career credential by 2020 and to close racial/ethnic opportunity gaps.” In the six years since it started, Road Map has tackled the region’s educational disparities in many ways: connecting students to scholarships, boosting parental involvement, and attracting a $40 million federal Race to the Top grant for the region’s school districts. Its approach follows the collective impact model, which emphasizes setting shared goals and coordinating resources and activities to magnify the impact beyond that of isolated interventions. With four years left to meet its goal, Road Map released a report last month analyzing student success at the area’s community and technical colleges. This unique effort—marrying data from Road Map-area high schools with area community and technical colleges—produced a finely-grained view of 2011 high school graduates’ progress toward completion, tracking key criteria such as attaining college-readiness in math and completing 30 or more credits in the first year of college. Community and technical colleges are critical institutions in the region—nearly one-third of 2011 Road Map-area high school graduates were direct enrollees—but the report found that only slightly more than one-third of those students successfully completed a degree or transferred to a four-year institution within three years. And outcomes for blacks, Latinos, and, in many cases, Native Americans, consistently trail those of whites and Asians. In response, the Road Map report recommends a series of strategies aimed at attacking the problem from multiple directions, including working with high schools to boost college readiness, helping institutions improve their ability to deliver on student completion, adopting new culturally responsive strategies, and pushing for increased funding for both the institutions and student scholarships. Filling these gaps and meeting the 2020 goal will be difficult. A different Road Map Project report highlights an improving high school graduation rate, but lagging enrollment of graduates directly into college. Nevertheless, the region’s collaborative approach of working across institutions and jurisdictions continues to hold great promise. As more regions confront similar demographic challenges and seek new solutions for boosting skills and opportunity, Greater Seattle offers a compelling case study in how to move beyond one-off collaborations and initiatives to achieve real systems change. Authors Rachel BarkerAlan Berube Image Source: © JASON REDMOND / Reuters Full Article
secondary How early colleges can make us rethink the separation of high school and postsecondary systems By webfeeds.brookings.edu Published On :: Wed, 15 Apr 2020 16:06:01 +0000 The COVID-19 pandemic has caused a historic spike in unemployment insurance claims, and there is growing consensus that the economy is headed for a potentially deep and protracted recession. In the past, postsecondary credentials or degrees have helped mitigate the impact of an economic downturn. Of all new jobs created after the Great Recession, 99%… Full Article
secondary Greening Secondary School Education with the Institute of International Education By www.treehugger.com Published On :: Sun, 14 Dec 2008 21:40:58 -0500 Though I delved into Toyota's reasons for annually executing their singular teaching program in the Galapagos, I amazingly failed to touch on the Full Article Science
secondary Help build an eco-friendly secondary school in Kenya By www.treehugger.com Published On :: Tue, 15 Oct 2019 14:36:22 -0400 A young Toronto-based woman is working to build a school in the Kenyan village near where she grew up. Full Article Living
secondary Amgen Foundation Announces New $4 Million Commitment to Bring Hands-On Biotechnology Labs to Secondary School Students - The Amgen Biotech Experience in the classroom By feedproxy.google.com Published On :: 22 Oct 2015 08:55:00 EDT The Amgen Biotech Experience empowers teachers to bring biotechnology into their classrooms to spark students’ love of science and features a hands-on curriculum that introduces students to the excitement of scientific discovery. Full Article Biotechnology Education Healthcare Hospitals Medical Pharmaceuticals Medical Equipment Broadcast Feed Announcements Corporate Social Responsibility MultiVu Video
secondary OECD: Postsecondary education key to maintaining global standing of U.S. workforce By www.oecd.org Published On :: Wed, 10 Jul 2013 14:00:00 GMT The United States should improve postsecondary career and technical training provisions to help students transition smoothly into education programs and the labor market, according to a new OECD report published today. Full Article
secondary Prince George and Princess Charlotte's London prep school to open secondary next door By www.dailymail.co.uk Published On :: Wed, 04 Mar 2020 13:09:51 GMT Artist's impressions of Thomas's Battersea Square, set to open next to Thomas's Battersea, currently attended by George, six, and Charlotte, four, show a state-of-the-art educational facility. Full Article