Patricia Tappatá, integrante de la Misión Internacional Independiente de determinación de hechos sobre la República Bolivariana Venezuela de la ONU, conversó sobre la alerta sobre fase de reactivación de la violenta represión en ese país.

The spread of COVID19 put a lot of extra work on emergency doctors, due to increased visits as a result of respiratory failure and other consequences caused by the infection. .

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Modernisation of a warehouse can increase performance and service life. Edward Hutchison, Managing Director of BITO Storage Systems asks: have you considered retrofitting existing pallet racking?

In This Episode Erin and Weer’d discuss: Gov. Maura Healey signing the emergency preamble to the new Massachusetts gun law, and its details are insane; SCOTUS hearing a case on “Ghost Guns” in Garland v. VanDerStok; 2023’s FBI Crime Statistics,  and … Continue reading →

RetroStyle Games, a company specializing in game development and visual design, congratulates Space Age Games on Supercell's acquisition of the remaining 38% of their shares, making Space Ape Games fully owned by Supercell.... Tagged as:

Systematic review produced by the EPPI-Centre in 2015.This systematic review aimed to evaluate the effect of HAART and ARV monotherapy on liver disease progression and liver-related mortality in individuals co-infected with HIV and hepatitis C, including in patients with haemophilia.

The Usenix LISA conference is no more. After 35 years, I have a lot of good (and some not good) memories of the conference. It was a big part of my career and I'm sad to see it go. However I'm proud of what LISA accomplished.

I wrote my personal reflections on the conference in a new article published on the Usenix website. Warning: this article includes some over-sharing.

Read it here: LISA made LISA obsolete (That's a compliment!)

Abstract

After training as a gastroenterologist in the UK the author became interested in lipidology while he was a research fellow in the USA and switched careers after returning home. Together with Nick Myant he introduced the use of plasma exchange to treat FH homozygotes and undertook non-steady state studies of LDL kinetics, which showed that the fractional catabolic rate of LDL remained constant irrespective of pool size. Subsequent steady-state turnover studies showed that FH homozygotes had an almost complete lack of receptor-mediated LDL catabolism, providing in vivo confirmation of the Nobel Prize-winning discovery by Goldstein and Brown that LDL receptor dysfunction was the cause of FH. Further investigation of metabolic defects in FH revealed that a significant proportion of LDL in homozygotes and heterozygotes was produced directly via a VLDL-independent pathway.

Management of heterozygous FH has been greatly facilitated by statins and PCSK9 inhibitors but remains dependent upon lipoprotein apheresis in homozygotes. In a recent analysis of a large cohort treated with a combination of lipid-lowering measures survival was markedly enhanced in homozygotes in the lowest quartile of on-treatment serum cholesterol. Emerging therapies could further improve the prognosis of homozygous FH whereas in heterozygotes the current need is better detection.

This analysis aimed to identify clinical factors associated with positivity on repeat ⁶⁸Ga-PSMA-11 PET/CT after a negative scan in patients with recurrent prostate cancer (PCa) under observation. Methods: This single-center, retrospective analysis included patients who underwent at least 2 ⁶⁸Ga-PSMA-11 PET/CT scans (PET1 and PET2) at UCLA between October 2016 and June 2021 for recurrent PCa with negative PET1 and no PCa-related treatments between the 2 scans. Using Prostate Cancer Molecular Imaging Standardized Evaluation criteria to define negative and positive scans, the final cohort was divided into PET2-negative (PET2-Neg) and PET2-positive (PET2-Pos). The same PET1 was used twice in the more than 2 PET cases with inclusion criteria fulfilled. Patient characteristics and clinical parameters were compared between the 2 cohorts using Mann–Whitney U test and Fisher exact test. Areas under the curve (AUCs) of the receiver operating characteristic and the Youden index were computed to determine the discrimination ability of statistically significant factors and specific cut points that maximized sensitivity and specificity, respectively. Results: The final analysis included 83 sets of 2 PET/CT scans from 70 patients. Thirty-nine of 83 (47%) sets were PET2-Neg, and 44 of 83 (53%) sets were PET2-Pos. Prostate-specific antigen (PSA) increased from PET1 to PET2 for all 83 (100%) sets of scans. Median PSA at PET1 was 0.4 ng/mL (interquartile range, 0.2–1.0) and at PET2 was 1.6 ng/mL (interquartile range, 0.9–3.8). We found higher serum PSA at PET2 (median, 1.8 vs. 1.1 ng/mL; P = 0.015), absolute PSA difference (median, 1.4 vs. 0.7 ng/mL; P = 0.006), percentage of PSA change (median, +270.4% vs. +150.0%: P = 0.031), and median PSA velocity (0.044 vs. 0.017 ng/mL/wk, P = 0.002) and shorter PSA doubling time (DT; median, 5.1 vs. 8.3 mo; P = 0.006) in the PET2-Pos cohort than in the PET2-Neg cohort. Receiver operating characteristic curves showed cutoffs for PSA at PET2 of 4.80 ng/mL (sensitivity, 34%; specificity, 92%; AUC, 0.66), absolute PSA difference of 0.95 ng/mL (sensitivity, 62%; specificity, 71%; AUC, 0.68), percentage of PSA change of a positive 289.50% (sensitivity, 48%; specificity, 82%; AUC, 0.64), PSA velocity of 0.033 ng/mL/wk (sensitivity, 57%; specificity, 80%; AUC, 0.70), and PSA DT of 7.91 mo (sensitivity, 71%; specificity, 62%; AUC, 0.67). Conclusion: Patients with recurrent PCa under observation after a negative ⁶⁸Ga-PSMA-11 PET/CT scan with markedly elevated serum PSA levels and shorter PSA DT are more likely to have positive findings on repeat ⁶⁸Ga-PSMA-11 PET/CT.

One simple game is proving to be a surprising hero in the fight against PTSD.

The Delaware Division of Social Services is issuing retroactive emergency food assistance benefits under the Pandemic Electronic Benefit Transfer (P-EBT) program for School Year 2022-2023 and Summer 2023 to Delaware households with eligible children. Eligible households began receiving P-EBT benefits beginning in August. Benefits from Fall 2022 (September-December 2022) are available on EBT cards as […]

Every day, there are tens of thousands of domain names registered across the globe – often as a key first step in creating a unique online presence. Making that experience possible for Verisign-operated top-level domains (TLDs) like .com and .net is a powerful and flexible technology platform first introduced 25 years ago. Thanks to the […]

The post The Verisign Shared Registration System: A 25-Year Retrospective appeared first on Verisign Blog.

Title: What Therapeutic Options Are Available for Treating an Antiretroviral Naive Patient?
Category: Diseases and Conditions
Created: 6/16/2022 12:00:00 AM
Last Editorial Review: 6/16/2022 12:00:00 AM

Retrotransposable elements (RTEs) are common mobile genetic elements comprising ~42% of the human genome. RTEs play critical roles in gene regulation and function, but how they are specifically involved in complex diseases is largely unknown. Here, we investigate the cellular heterogeneity of RTEs using 12 single-cell transcriptome profiles covering three neurodegenerative diseases, Alzheimer's disease (AD), Parkinson's disease, and multiple sclerosis. We identify cell type marker RTEs in neurons, astrocytes, oligodendrocytes, and oligodendrocyte precursor cells that are related to these diseases. The differential expression analysis reveals the landscape of dysregulated RTE expression, especially L1s, in excitatory neurons of multiple neurodegenerative diseases. Machine learning algorithms for predicting cell disease stage using a combination of RTE and gene expression features suggests dynamic regulation of RTEs in AD. Furthermore, we construct a single-cell atlas of retrotransposable elements in neurodegenerative disease (scARE) using these data sets and features. scARE has six feature analysis modules to explore RTE dynamics in a user-defined condition. To our knowledge, scARE represents the first systematic investigation of RTE dynamics at the single-cell level within the context of neurodegenerative diseases.

ABSTRACTBackground: This analysis aimed to evaluate the effectiveness of eliciting sexual partners from HIV-positive clients using the elicitation box model (where an HIV-positive index can report sexual contacts on paper and insert in a box for a health care provider to contact at a later time) compared to the conventional model (in which a health care provider elicits sexual contacts directly from clients) in Akwa Ibom, Southern Nigeria.Methods: Between March 2021 and April 2022, data were collected from index testing registers at 4 health facilities with a high volume of HIV clients currently on treatment in 4 local government areas in Akwa Ibom State. Primary outcome analyzed was the elicitation ratio (number of partners elicited per HIV-index offered index testing services). Secondary outcomes were the index testing acceptance (index HIV-positive clients accepted index testing service), testing coverage (partners tested for HIV from a list of partners elicited from HIV-index accepted index testing services), testing yield (index partners identified HIV positive from index partners HIV-tested), and linkage rate (index partners identified HIV positive and linked to antiretroviral therapy).Results: Of the total 2,705 index clients offered index testing services, 91.9% accepted, with 2,043 and 439 indexes opting for conventional elicitation and elicitation box models, respectively. A total of 3,796 sexual contacts were elicited: 2,546 using the conventional model (elicitation ratio=1:1) and 1,250 using the elicitation box model (elicitation ratio=1:3). Testing coverage was significantly higher in the conventional compared to the elicitation box model (P<.001). However, there was no significant difference in the testing yield (P=.81) and linkage rate using the conventional compared to elicitation box models (P=.13).Conclusion: The implementation of the elicitation box model resulted in an increase in partner elicitation compared to the conventional model. Increasing the testing coverage by implementing the elicitation box model should be considered.

BackgroundLong-term health conditions are major challenges for care systems. Social prescribing link workers have been introduced via primary care networks (PCNs) across England since 2019 to address the wider determinants of health by connecting individuals to activities, groups, or services within their local community.AimTo assess whether the rollout of social prescribing link workers was in areas with the highest need.Design and settingA retrospective study of social prescribing link workers in England from 2019 to 2023.MethodWorkforce, population, survey, and area-level data at the PCN-level from April 2020 to October 2023 were combined. Population need before the rollout of link workers was measured using reported lack of support from local services in the 2019 General Practice Patient Survey. To assess if rollout reflected need, linear regression was used to relate provision of link workers (measured by full-time equivalent [FTE] per 10 000 patients) in each quarter to population need for support.ResultsPopulations in urban, more deprived areas and with higher proportions of people from minority ethnic groups had the highest reported lack of support. Geographically these were in the North West and London. Initially, there was no association between need and provision; then from July 2022, this became negative and significant. By October 2023, a 10-percentage point higher need for support was associated with a 0.035 (95% confidence interval = −0.634 to −0.066) lower FTE per 10 000 patients.ConclusionRollout of link workers has not been sufficiently targeted at areas with the highest need. Future deployments should be targeted at those areas.

Beginning today, Apple will have released one new Apple Vision Pro game, one App Store Great, and upgrading an App …

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Le corps ligoté en état de décomposition retrouvé le 30 octobre dans l’un des parcs les plus achalandés de Montréal est celui de Kevin Mirshahi.

Florence et Marianne seront finalement au concert de leur idole, vendredi, à Toronto, mais elles ont eu toute une frousse.

Une ancienne boîte de poulet St-Hubert, retrouvée par hasard dans l’entretoit d’un chalet, a été remise à la famille Martin en échange d'un don.

A new study conducted by researchers reveals a possible answer to the mystery of why infected people can't get rid of HIV altogether. In HIV patients,

The renowned filmmaker started life as an artist before moving to filmmaking

[Auckland, New Zealand] : Libertas Academica

CSS offers an array of tools that, when used correctly, can improve the visual experience on your website. In this tutorial, we’ll explore a straightforward way to design a retro text effect with pure CSS. The approach, while not overly …

Karnataka jobs Bill should be scrapped

Mining companies slapped with unfair burden

King took to her Instagram story while she was missing her Black Summer co-stars. The Netflix series was renewed for a second season in November, but production has been halted amid COVID-19.

Archives, Room Use Only - HE7797.W53 W46 1901

Policies and programmes providing technological solutions to improve household energy efficiency alone may be insufficient to actually reduce overall household energy consumption, finds new research. The research examined home renovators’ motivations, behaviours and use of green technologies. Overall, reduced energy consumption was often undermined by other considerations, such as installation and maintenance costs, aesthetic considerations and daily routines or social concerns.

Why Volkswagen should bring back the Microbus.

Environmentally-friendly practices aren't just for new buildings anymore. Their existing – and, in some cases, elderly – counterparts are catching on, too.

The company's New York headquarters is now equipped with energy-saving LED lighting.

After the nation's largest deep energy retrofit, the Castle Square Apartments in Boston's South End achieves LEED Platinum status.

France's most visited house of worship, the Notre Dame Cathedral, just seriously slashed its energy bills with the addition of 400 LED lamps.

Adam finally gets his chance to shine in the (non-damaging) spotlight with 7,000 energy-saving LEDs set to undo the dim atmospherics of the Sistine Chapel.

Shelterbus is a retrofitted coach bus that serves as a mobile emergency shelter for the homeless in Toronto.

Some people believe that Mercury retrograde means you should be cautious in many aspects of your life, but what do the astrologists say?