Although immunoglobulin replacement is recognized as effective in children with primary immunodeficiency, pneumococcal infection may occur. There is no available prospective clinical study evaluating levels of protective serospecific antibodies in patients and products.

Protective (0.2 µg/mL) antibody levels for the most frequent pneumococcal serotypes were measured in children treated for primary immunodeficiencies. A linear relationship was demonstrated between peak and trough levels of serospecific antipneumococcal antibodies in patients and infused immunoglobulins. (Read the full article)

Infants who require positive pressure ventilation at birth are considered to be at risk for subsequent compromise and are recommended to receive postresuscitation care. The supportive evidence and details of this care have not been fully investigated.

We investigate the need for postresuscitation care in infants who require positive pressure ventilation at birth, review the aspects of care needed, and explore the important risk factors most predictive of it. (Read the full article)

Background: Intensive care unit (ICU) patients may experience ceftriaxone underexposure but clinical outcomes data are lacking. The objective of this study was to determine the impact of ceftriaxone dosing on clinical outcomes amongst ICU patients without central nervous system (CNS) infection.

Methods: A retrospective study of ICU patients receiving intravenous, empiric ceftriaxone for non-CNS infections was conducted. Patients ≥18 years of age who received ≤2 grams of ceftriaxone daily for ≥72 hours were included and categorized as receiving ceftriaxone 1 gram or 2 grams daily. The primary, composite outcome was treatment failure: inpatient mortality and/or antibiotic escalation due to clinical worsening. Propensity score matching was performed based on the probability of receiving ceftriaxone 2 grams daily. Multivariable logistic regression determined the association between ceftriaxone dose and treatment failure in a propensity-matched cohort.

Results: A total of 212 patients were included in the propensity-matched cohort. The most common diagnoses (83.0%) were pneumonia and urinary tract infection. Treatment failure occurred in 17.0% and 5.7% of patients receiving 1 gram and 2 grams daily, respectively (p=0.0156). Overall inpatient mortality was 8.5%. Ceftriaxone 2 gram dosing was associated with a reduced likelihood of treatment failure (adjusted odds ratio=0.190; 95% confidence interval: 0.059 – 0.607). Other independent predictors of treatment failure included sequential organ failure assessment score (aOR 1.440, 95% CI 1.254 – 1.653) and creatinine clearance at 72 hours from ceftriaxone initiation (aOR 0.980, 95% CI (0.971 – 0.999).

Conclusions: Ceftriaxone 2 grams daily when used as appropriate antimicrobial coverage may be appropriate for ICU patients with lower mortality risk.

NEW CASTLE (July 23, 2018) – A USDA-funded program designed to help food benefits recipients in Delaware increase their earning power and decrease their dependence on state benefits is expanding its services to eligible participants. Delaware WONDER (Work Opportunity Networks to Develop Employment Readiness), a program administered by the Delaware Department of Health and Social […]

Philomène Dias, director of inward investment at Portuguese investment promotion agency Aicep, on how staff and organisation are working through lockdown.

ISLAMABAD: Rector International Islamic University Islamabad Dr Masoom Yasinzai is in the middle of a controversy for allegedly receiving dual salary without the notice and prior approval of Board of...

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ISLAMABAD: Rector International Islamic University Islamabad Dr Masoom Yasinzai is in the middle of a controversy for allegedly receiving dual salary without the notice and prior approval of Board of Governors , Board of Trustees ."I received an honoraria for giving consultancy to a Saudi...

Title: Few Sickle Cell Patients Receiving Beneficial Drug, Study Finds
Category: Health News
Created: 4/28/2015 12:00:00 AM
Last Editorial Review: 4/29/2015 12:00:00 AM

The aim of this study was to evaluate the efficacy of ¹⁷⁷Lu-prostate-specific membrane antigen (PSMA)-617 (¹⁷⁷Lu-PSMA) and selective internal radiation therapy (SIRT) for the treatment of liver metastases of castration-resistant prostate cancer. Methods: Safety and survival of patients with metastatic castration-resistant prostate cancer and liver metastases assigned to ¹⁷⁷Lu-PSMA alone (n = 31) or in combination with SIRT (n = 5) were retrospectively analyzed. Additionally, a subgroup (n = 10) was analyzed using morphologic and molecular response criteria. Results: Median estimated survival was 5.7 mo for ¹⁷⁷Lu-PSMA alone and 8.4 mo for combined sequential ¹⁷⁷Lu-PSMA and SIRT. ¹⁷⁷Lu-PSMA achieved discordant therapy responses with both regressive and progressive liver metastases in the same patient (best vs. worst responding metastases per patient: –35% vs. +63% diameter change; P < 0.05). SIRT was superior to ¹⁷⁷Lu-PSMA for the treatment of liver metastases (0% vs. 56% progression). Conclusion: The combination of ¹⁷⁷Lu-PSMA and SIRT is efficient and feasible for the treatment of advanced prostate cancer. ¹⁷⁷Lu-PSMA alone seems to have limited response rates in the treatment of liver metastases.

She accused hit Netflix show of 'betrayal' in first interview since it began

Tottenham legend Jimmy Greaves remains in hospital, "receiving the best possible treatment", as he battles an unspecified illness.

Alan Pardew insists he will not take a bonus from ADO Den Haag after the Dutch outfit avoided relegation from the Eredivisie.

Rugby Australia is prepared to hold crisis talks with a group of disgruntled retired Wallabies captains, who have penned a letter to the governing body claiming the game has "lost its way", while demanding a change in leadership.

Terry Brian Dobbs, an Oklahoma businessman, was sentenced today to 11 years in prison for receiving images of child pornography. Dobbs, 51, was also sentenced to lifetime supervised release following his term in prison by U.S. District Judge Gregory Frizzel, and was ordered to pay an $8,000 fine.

Harris Taubman, of Hyannis, Mass., pleaded guilty today in U.S. District Court in Boston to receiving and possessing child pornography. Taubman, 48, pleaded before U.S. District Judge William G. Young to three counts of receipt of child pornography and one count of possession of child pornography. He was indicted on those charges on Feb. 6, 2008.

Harris Taubman, of Hyannis, Mass., was sentenced today in U.S. District Court in Boston for receiving and possessing child pornography. Taubman, 48, was sentenced to 84 months in prison for three counts of receipt of child pornography and one count of possession of child pornography. He was indicted on those charges on Feb. 6, 2008, and pled guilty on Feb. 11, 2009.

Robert P. Merz, 45, was convicted by a federal jury in Philadelphia today of advertising, transporting, receiving and possessing child pornography.

Joseph McNealy, a former Jackson, Miss., computer systems administrator, was sentenced today to 70 months in prison for receiving and possessing images of child pornography.

Jeffrey Robert Libman, 42, of Fort Lauderdale, Fla., pleaded guilty in Miami today to one count of receiving child pornography.

Robert P. Merz was sentenced to life in prison today for advertising, transporting, receiving and possessing child pornography.

Jeffrey Robert Libman, 42, of Fort Lauderdale, Fla., was sentenced to 87 months in prison today for receiving child pornography.

James White, 46, of Wilmington, Del., was sentenced today to 60 months in prison and five years of supervised release for receiving child pornography.

A former U.S. Army sergeant pleaded guilty today to conspiring to steal U.S. Army equipment related to his work as a non-commissioned officer helping to train Iraqi army personnel in Mosul, Iraq, in 2008.

Patrick W. Boyd, 44, of Gainesville, Fla., was sentenced by U.S. District Judge Matthew F. Kennelly of the Northern District of Illinois.

John Mihalczo, 47, of Homosassa, Fla., was sentenced by U.S. District Judge Matthew F. Kennelly of the Northern District of Illinois.

A former Major in the U.S. Army National Guard who was deployed to Bagram Airfield, Afghanistan, was sentenced to 60 months in prison for receiving bribes from military contractors in exchange for fraudulently verifying the receipt of concrete bunkers and barriers that were never received.

Robert Rosenbeck, 49, was sentenced by U.S. District Judge Denise J. Casper in Boston.

The former vice president of a construction company doing work in Afghanistan was arrested today on allegations of accepting tens of thousands of dollars in gratuities from subcontractors during his employment in Afghanistan.

Two former employees at the Marine Corps Logistics Base Albany (MCLB-Albany) have pleaded guilty to receiving bribes related to a scheme to funnel freight hauling business to a local transportation company resulting in the loss of millions of dollars to the United States government.

Kenny E. Toy, 54, the former Afloat Programs Manager at the United States Navy Military Sealift Command, was sentenced today to serve 96 months in prison for receiving bribes

A former project manager of a U.S. construction company working on U.S. government contracts in Afghanistan who solicited a $60,000 kickback from an Afghan subcontractor pleaded guilty today in federal court in Tucson, Arizona

Dr Aluvihare

Time to Talk CINV™ Video

"I mean, Congress went out of its way to carve out businesses that have more than 500 employees but are restaurants, chain restaurants," ex-TARP watchdog Neil Barofsky told CNBC.

Time is running out if you're receiving SSI or VA benefits and want to make sure your children under 17 are included in your stimulus payments. You have just until tomorrow to report your information to the IRS. But beware: Some people have already complained that their checks fall short.

Share price of Biocon rose up to 3.22% to Rs 360.9 against previous close of Rs 349.65 on BSE

Fallon Sherrock said it was 'incredible' to have her latest PDC World Darts Championship win tweeted about by Billie Jean King.

Cologne have ramped up checks following the three positive tests, a development that will alert the Premier League as they monitor how Germany are attempting to resume football.

The Strictly Come Dancing star, 35, explained at a special International Women's Day event that she was subjected to racist trolls throughout her stint on the 2019 edition of the show.

Jeff Bezos's cell phone was hacked in May 2018 after he was sent a malicious video filed from the personal phone number of Saudi Crown Prince Mohammed bin Salman, it is claimed.

She asked for charitable donations in lieu of gifts this year as she rings in her 46th birthday in lockdown. Yet Victoria revealed her daughter Harper couldn't resist getting her a little gift.

Coronation Street star Kym Marsh was forced off Twitter on Monday after receiving a barrage of 'hate' over her coronavirus questions.

An influencer and OnlyFans creator, known as Billie Beever to her fans, posted an emotional TikTok video last week.In the video, she said she could no longer pay her bills after losing subscribers amid the pandemic and economic downturn."I've got nothing else going for me," the creator said in the clip, which has racked up 15,000 views. Since posting the video, she has received intense backlash from online trolls who have told her to get "a real job."The content creator, and several online supporters, have pushed back against her critics, saying that sex work is, indeed, real work — requiring planning, marketing, and physical labor. Visit Insider's homepage for more stories.Billie Beever, an influencer in Australia who has monetized her online presence by posting adult content on OnlyFans,

An indie road trip romance that has stood out of the crowd as a weird and wonderful film that has set tongues wagging

MARTIN KEOWN: Twenty-five years ago today, me and my Arsenal team-mates were caught up in a storm at Anfield as Robbie Fowler - just 19 at the time - scored three times in four minutes.

Wright-Phillips and Ashley Cole were subjected to monkey noises and insults during England's 1-0 defeat inside the Bernabeu, which saw the FA lodge a complaint to FIFA over the incident.

Who knew Hailey Bieber was part of the Beyhive? The 22-year-old model wore head-to-toe Ivy Park, Beyonce's athleisure collaboration with Adidas, while on her way to a dance studio Wednesday.

Food blogger and fashion influencer Karylle Banez took to Instagram to complain about the disappointing service she allegedly receiving while dining at Leigh Street Wine Room in Adelaide.

Tiger King's Doc Antle revealed on Monday that he sleeps with an AK-47 gun following various death threats. Doc Antle rose to fame on the recent Netflix show, Tiger King.