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FAP and PSMA Expression by Immunohistochemistry and PET Imaging in Castration-Resistant Prostate Cancer: A Translational Pilot Study

Visual Abstract




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How changes to drug prohibition could be good for the UK—an essay by Molly Meacher and Nick Clegg




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D-Wave Expands Board with Industry Veterans John DiLullo and Rohit Ghai

PALO ALTO, Calif., Oct. 30, 2024 — D-Wave Quantum Inc. today announced the appointments of veteran technology industry leaders, John DiLullo and Rohit Ghai, to its board of directors. The new […]

The post D-Wave Expands Board with Industry Veterans John DiLullo and Rohit Ghai appeared first on HPCwire.




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College Football Playoff: Oregon, Ohio State, Georgia, Miami top first rankings

Oregon, Ohio State, Georgia and Miami lead the first edition of the 2024-25 College Football Playoff rankings, the selection committee announced.




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U.S. Supreme Court Rejects Prohibition on Tax-Credit Scholarships for Religious Schools

The 5-4 decision involving a dispute in Montana appears to cast doubt on as many as 30 state constitutions that bar aid to religious schools.




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Ohio

State of the States: Education highlights from latest governor's address before the legislature.




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Ohio

The Buckeye State continues phasing in school districts as part of the Third Frontier Network, a statewide fiber-optic system that links K-12 schools with higher education and promotes research and education opportunities.




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Ohio Must Rethink How Online Charter Schools Are Funded, Says State's Auditor

Ohio auditor Dave Yost, a Republican, says that virtual schools should be compensated based on what their students learn.




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School Resource Officer Activates Taser to Awaken Sleeping Student in Ohio

Police in northeast Ohio have placed a school resource officer on unpaid leave for activating a Taser to wake up a sleeping student.




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Audit Finds Ohio Online Charter Inflated Attendance, School Could Owe Millions

Attendance and login records show that Ohio's Electronic Classroom of Tomorrow was paid for 9,000 students more than it should have been, according to a state audit.




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State of the States: D.C., Ohio

Here are summaries of recent annual addresses by governors around the country.




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Ohio

Gov. Strickland would like to make every high school student who meets certain academic requirements eligible to spend the 12th grade in an Ohio public university, tuition-free.




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Ohio Expected to Ban Most Suspensions, Expulsions for Youngest Students

Ohio Gov. John Kasich is expected to sign a bill into law that would ban suspensions and expulsions for children in prekindergarten through 3rd grade for minor offenses.




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Eligibility for Federal School Improvement Grants Helped Ohio Students, Study Says

Academic achievement at Ohio schools eligible for School Improvement Grants during the Obama administration increased for a few years, a new study says, but SIG's legacy remains complicated.




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Ohio




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ECOT Looms Over Ohio Gubernatorial Candidates' Education Plans

Any discussion in politics of the future of education in Ohio inevitably turns to the Electronic Classroom of Tomorrow.




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Bill Protecting Ohio E-School Heads to Governor

A bill shielding what is now Ohio's largest online school and its sponsor from the negative consequences of accepting thousands of former Electronic Classroom of Tomorrow students is headed to Gov. John Kasich for his signature.




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Educational Opportunities and Performance in Ohio

This Quality Counts 2019 Highlights Report captures all the data you need to assess your state's performance on key educational outcomes.




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Ohio District's Armed-Employee Program Struck Down Over Training Requirement

An Ohio appellate court struck down a district's policy allowing staff members to carry concealed weapons in school with 24 hours of "active shooter/killer training."




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Educational Opportunities and Performance in Ohio

This Quality Counts 2020 Highlights Report captures all the data you need to assess your state's performance on key educational outcomes.




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Ohio Supreme Court dismisses Toledo bullying lawsuit




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Ohio lawmakers urge school funding fix as session nears end




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Ohio lawmakers OK revamp of eligibility for school vouchers




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Ohio House OKs school funding plan; unclear if Senate will




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Ohio Supreme Court dismisses Toledo bullying lawsuit




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Ohio lawmakers OK revamp of eligibility for school vouchers




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Ohio lawmakers OK revamp of eligibility for school vouchers




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Ohio House OKs school funding plan; unclear if Senate will




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Tennessee School District Prohibits Crowdfunding for Class Supplies

A school district in Tennessee says it no longer wants teachers to use crowdfunding websites to get extra school supplies.




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College Football Playoff rankings: Texas rises to No. 3 behind Oregon, Ohio State

The second College Football Playoff rankings were released, with the big questions surrounding who would be No. 3 and where the SEC teams would land.




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No surprise: Ohio State football remains No. 2 in College Football Playoff rankings

Ohio State is No. 2 in the new CFP rankings, joining three other Big Ten teams in the top 5.




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Ohio State football one of four top-six Big Ten teams in CFP release

While Tuesday is exciting because college hoops fans get to take in the Champions Classic, the College Football Playoff results after this past week were released after the first of two basketball games on ESPN. Ohio State football, as expected, stay




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Where’s Ohio State in latest College Football Playoff bracket? Full playoff picture after Week 11

We're now eleven weeks into the college football season and that means we have an idea of where Ohio State when it comes to the landscape of the 2024 season. The Buckeyes beat Penn State on the road two weeks ago to boost its resumé and remain right




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Ohio State women's basketball adds Katie Smith, Jacy Sheldon to staff

Jacy Sheldon and Katie Smith are both returning to their alma mater to join the staff ran by Kevin McGuff.




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Chance Gray ties program record with 9 3-pointers to help No. 12 Ohio State women beat Charlotte

Chance Gray scored 14 of her career-high 31 points in the third quarter and she tied a program-best with nine 3-pointers to help No. 12 Ohio State beat Charlotte 94-53 on Tuesday night. Gray finished 9 of 14 from 3-point range to top her previous best of six makes. Gray scored 11 points in the first half after making all three of her 3-pointers to help Ohio State build a 43-17 lead.




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Ohio State records 40-plus point win vs Charlotte despite apparent Jaloni Cambridge injury

Early in the second half, Ohio State freshman Jaloni Cambridge went down with an apparent lower-back injury.




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What Goes Into a 1920s Prohibition Cocktail

Read more at http://www.smithsonianmag.com/history-archaeology/Wayne-B-Wheeler-The-Man-Who-Turned-Off-the-Taps.html Beverage expert Derek Brown shows how to make three cocktails from the early 20th century at his Washington, D.C. bar.




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Three Sisters in Ohio Just Sold a Rare 1975 Dime With a Missing 'S' Mint Mark for $500,000

The owners inherited the valuable coin from their brother, who kept it locked in a bank vault for decades. He purchased it with his mother in 1978 to provide financial security for the family farm




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SolidWorks Helps Ohio State Students Focus on Creativity and Innovation

Easy-to-Learn CAD Software Keeps Ideas Flowing




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Ohio Supreme Court dismisses Toledo bullying lawsuit




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Ohio lawmakers OK revamp of eligibility for school vouchers




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Singham Again: Rohit Shetty Reveals Why Ranveer Singh And Deepika Padukone Had No Scenes Together - "It Would Have Gone Wrong For Us"

Rohit Shetty shared that it was his conscious choice to not cast Ranveer and Deepika together in a scene, as it might have received backlash




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FAA prohibits US airlines from flying to Haiti; UN suspends flights

PORT-AU-PRINCE, Haiti — The Federal Aviation Administration announced Tuesday that it will prohibit U.S. airlines from flying to Haiti for 30 days after gangs shot a Spirit Airlines flight. The United Nations also said it will suspend flights, "obviously limiting the flow of humanitarian aid and humanitarian personnel into the country."  The bullets hit the plane when it was about to land Monday in the country's capital, Port-au-Prince, injuring a flight attendant. It was part of a wave of violence that erupted in Haiti as the country swore in its new prime minister after a politically tumultuous process.  Life in much of Haiti's capital was frozen after the wave of violence, which came to a head when gangs shot the Spirit Airlines airplane Monday, forcing the airport to shut down. Photos and videos obtained by The Associated Press show bullet holes dotting the interior of a plane. A number of airlines suspended flights to Haiti through Thursday, but it was unclear how long closures could drag on.  Neither the former interim prime minister, Garry Conille, nor the newly inaugurated Alix Didier Fils-Aime commented on the violence.  But Luis Abinader, who as president of the neighboring Dominican Republic has cracked down on Haitian migration, called firing on the airplane terrorism.  "This was a terrorist act; the countries that are following and helping Haiti should declare these armed gangs as terrorist groups," Abinader said in a news conference.  On Tuesday, heavily armed police in armored cars outside the airport checked trucks used for public transportation passing by.  Schools were closed, as were banks and government offices. The streets, where just a day before gangs and police were locked in a fierce firefight, were eerily empty.  The sound of heavy gunfire was heard in the streets in the afternoon — a reminder that despite political maneuvering by Haiti's elites and a strong push by the international community to restore peace, the country's toxic slate of gangs kept its firm hold on much of the Caribbean nation.  The United Nations estimates that gangs control 85% of the capital. A U.N.-backed mission led by Kenyan police to quell gang violence struggles with a lack of funding and personnel, prompting calls for a U.N. peacekeeping mission.




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3 Big Pharmacy Chains Must Pay $650 Million to Ohio Counties for Role in Opioid Crisis

Title: 3 Big Pharmacy Chains Must Pay $650 Million to Ohio Counties for Role in Opioid Crisis
Category: Health News
Created: 8/18/2022 12:00:00 AM
Last Editorial Review: 8/18/2022 12:00:00 AM




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CDC Investigating E. coli Outbreak in Ohio, Michigan

Title: CDC Investigating E. coli Outbreak in Ohio, Michigan
Category: Health News
Created: 8/18/2022 12:00:00 AM
Last Editorial Review: 8/19/2022 12:00:00 AM




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Correlation of FAPI PET Uptake with Immunohistochemistry in Explanted Lungs from Patients with Advanced Interstitial Lung Disease

Recent studies have demonstrated promising results of fibroblast activation protein (FAP) inhibitor (FAPI) PET in prognosticating and monitoring interstitial lung diseases (ILDs). As a first step toward successful translation, our primary aim was to validate the FAPI PET uptake through immunohistochemistry in patients with advanced ILD who underwent lung transplantation after a FAPI PET scan. Methods: This is a preliminary analysis of a single-center, open-label, single-arm, prospective exploratory biodistribution study of 68Ga-FAPI-46 PET imaging in patients with ILD (NCT05365802). Patients with ILD confirmed by high-resolution CT and scheduled for lung transplant were included. Tissue samples of explanted lungs were obtained from both the central and peripheral lung parenchyma of each lobe. Additional samples were obtained from areas of the lung corresponding to regions of FAPI PET activity. Immunohistochemical staining was performed with an anti-FAP antibody. Percentages of FAP immunohistochemistry-positive area were measured semiautomatically using QuPath software. SUVs in the areas of pathologic samples were measured on FAPI PET/CT by referencing the gross photomap of the explanted lung. A Spearman correlation coefficient test was used to assess the relationship between FAPI PET uptake and FAP immunohistochemical expression in each specimen. Results: Four patients with advanced ILD who underwent FAPI PET/CT before lung transplantation were included. The types of ILD were idiopathic pulmonary fibrosis (n = 2), rheumatoid arthritis–associated ILD (n = 1), and nonspecific interstitial pneumonia (n = 1). FAPI uptake was visualized mainly in the fibrotic area on CT. Twenty-nine surgical pathology samples from 3 patients were analyzed. FAP staining was predominantly positive in fibroblastic foci. FAPI PET SUVmax and SUVmean showed a positive correlation with the immunohistochemical FAP expression score (SUVmax: r = 0.57, P = 0.001; SUVmean: r = 0.54, P = 0.002). Conclusion: In this analysis conducted in patients who underwent lung transplantation after a FAPI PET scan, FAPI PET uptake was positively correlated with FAP immunohistochemistry. These findings provide a rationale for further investigation of FAPI PET as a potential imaging biomarker for ILD.




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As Rohingya refugees continue to flee from persecution, here’s how you can help

A Rohingya refugee girl poses with a chicken at the Balukhali refugee camp near Cox’s Bazar in Bangladesh. Photo by Jorge Silva/Reuters

More than 500,000 Rohingya Muslims have fled their homes since August to escape systematic violence at the hands of government soldiers in Myanmar. The U.N. has called the actions taken by Myanmar forces against the group “a textbook example of ethnic cleansing.”

A report released by Amnesty International on Wednesday documents widespread rape, killings and burnings of Rohingya across the Rakhine State in Myanmar. The report includes extensive interviews of Rohingya refugees who tell stories of live burnings, sexual violence and mass shootings at the hands of soldiers.

To escape persecution, Rohingya refugees are fleeing in droves to neighboring Bangladesh, a country described by some as a reluctant host for the thousands of refugees behind its borders. Conditions within Bangladesh show refugee camps beyond capacity, as organizations struggle to keep up with humanitarian aid.

Find out more: Rohingya Muslims have been denied citizenship in Myanmar since 1982, though they’ve lived in the area since the 12th century. They are not considered one of the country’s official ethnic groups. As such, their lack of official identity bars them from government services and travel.

Officials from Myanmar, a majority Buddhist state, claim Rohingya are actually immigrants from Bangladesh to justify their exclusion of the group. This most recent burst of violence comes from Myanmar’s crackdown following clashes with the Arakan Rohingya Salvation Army (ARSA). After the government declared ARSA a terrorist organization, the retaliation escalated into hundreds of Rohingya villages.

Where to give: BRAC, a top-ranked NGO based out of Bangladesh, is scaling up humanitarian efforts for clean water, health, sanitation and child care for refugees from Myanmar. You can learn more about their efforts here.

An emergency appeal was made by the Disasters Emergency Committee for immediate crisis relief funds. DEC distributes funds to 13 member aid organizations.
UNHCR, UNICEF and Save the Children have donation pages dedicated to the crisis, as does the International Rescue Committee. CNN’s Public Good page provides a user-friendly resource to find NGOs that match your giving goals.

To give to starvation relief, try Action Against Hunger or the World Food Programme.

Be sure to research organizations receiving your financial contributions, not only to find the best organization aligned with your goals, but also to avoid potential scams. For the latest information on aid organizations and charities, visit GuideStar or Charity Navigator to ensure your donations are going in the right direction.

The post As Rohingya refugees continue to flee from persecution, here’s how you can help appeared first on PBS NewsHour.





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Rohit Shetty confirms standalone film on Deepika Padukone’s character from ‘Singham Again’

‘Singham Again’ had an ensemble cast which includes Ajay Devgn, Akshay Kumar, Ranveer Singh, Tiger Shroff, Kareena Kapoor Khan, Deepika Padukone, Arjun Kapoor and Jackie Shroff




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US prohibits airlines from flying to Haiti after planes were shot by gangs

The shootings were part of a wave of violence that erupted as the country plagued by gang violence swore in its new prime minister after a politically tumultuous process.