Presentación del reporte que refleja el contenido de encuentros del grupo de estudio sobre la migración México-Estados Unidos convocado por El Colegio de México y el Migration Policy Institute (MPI).

The warty comb jelly is native to the western Atlantic, but in recent decades, it has invaded the waters of Eurasia. New research suggests cannibalism is key to the species' ability to move into new environs.

La migración entre México y Estados Unidos ha cambiado dramáticamente en los últimos años, pero las políticas y la retórica política en ambos países no se han actualizado a este contexto a la misma velocidad. Este reporte explora esta nueva realidad migratoria y cómo los dos gobiernos podrían trabajar juntos para abordar los desafíos de políticas públicas que tienen en común.

Monarch butterflies are dying at an alarming rate around the world -- a looming extinction that could also put human life at risk. But we have just the thing to help save these insects, says author Mary Ellen Hannibal: citizen scientists. Learn how these grassroots volunteers are playing a crucial role in measuring and rescuing the monarch's dwindling population -- and how you could join their ranks to help protect nature. (You'll be in good company: Charles Darwin was a citizen scientist!)

Yushu Shi, Michael Martens, Anjishnu Banerjee, Purushottam Laud.

Source: Bayesian Analysis, Volume 14, Number 3, 677--702.

Abstract:
Dirichlet process mixture (DPM) models provide flexible modeling for distributions of data as an infinite mixture of distributions from a chosen collection. Specifying priors for these models in individual data contexts can be challenging. In this paper, we introduce a scheme which requires the investigator to specify only simple scaling information. This is used to transform the data to a fixed scale on which a low information prior is constructed. Samples from the posterior with the rescaled data are transformed back for inference on the original scale. The low information prior is selected to provide a wide variety of components for the DPM to generate flexible distributions for the data on the fixed scale. The method can be applied to all DPM models with kernel functions closed under a suitable scaling transformation. Construction of the low information prior, however, is kernel dependent. Using DPM-of-Gaussians and DPM-of-Weibulls models as examples, we show that the method provides accurate estimates of a diverse collection of distributions that includes skewed, multimodal, and highly dispersed members. With the recommended priors, repeated data simulations show performance comparable to that of standard empirical estimates. Finally, we show weak convergence of posteriors with the proposed priors for both kernels considered.

Two years before the Carthaginian general crossed the Alps, he won a decisive victory at the Battle of the Tagus

Clientes existentes podrían recibir beneficios adicionales en el mes de marzo 2020 y abril 2020 NEW CASTLE (30 marzo 2020) – Beneficios de emergencia serán disponibles a los participantes de El Programa de Asistencia Nutricional Suplementaria (SNAP) por los meses de marzo y abril como parte de una provisión establecida por el Acto Federal a […]

This package of regulations includes modifications to the HIPAA privacy, security, enforcement and breach notification rules, as required under the HITECH Act.

It is not for nothing that it is said that two heads are better than one. Then Prof. Kimse Okoko modified it to ‘two good heads.’ I believe that Gov. Nyesom Wike should involve his entire cabinet members (as it appears he does not) in managing Covid-19 in Rivers State. If he does that, I […]

Senibo Chris Finebone: Way to go in fighting COVID-19 in Rivers State(1)

Girls and women today have far more opportunities and role models than their mothers and grandmothers, but there is much more to be done.

Title: Ranibizumab Injections Reduce Retinal Swelling
Category: Health News
Created: 5/2/2008 2:00:00 AM
Last Editorial Review: 5/2/2008 12:00:00 AM

Long noncoding RNAs (lncRNA) have been found to play critical roles in tumorigenesis and the development of various cancers, including hepatocellular carcinoma (HCC). Metastasis associated with lung adenocarcinoma transcript-1 (MALAT1) has been identified as an oncogene and prognostic biomarker in HCC. Here, we demonstrated that MALAT1 expression was obviously high in sorafenib-resistant HCC cells. Furthermore, knockdown of MALAT1 increased sorafenib sensitivity in nonresponsive HCC cells, whereas forced expression of MALAT1 conferred sorafenib resistance to responsive HCC cells in vitro. In addition, loss/gain-of-function assays revealed that MALAT1 promoted cell proliferation, migration, and epithelial–mesenchymal transition in HCC cells. Mechanistically, MALAT1 regulated Aurora-A expression by sponging miR-140-5p, thus promoting sorafenib resistance in HCC cells. Moreover, MALAT1 inhibition enhanced the antitumor efficacy of sorafenib in vivo. Clinically, we found that MALAT1 expression was negatively correlated with miR-140-5p expression but positively correlated with Aurora-A expression in patients with HCC and that upregulated MALAT1 was closely correlated with poor survival outcomes in patients with HCC. These findings indicated that MALAT1 may be a novel target for prognosis prediction and therapeutic strategies in patients with HCC treated with sorafenib.

Objective

To assess whether neuropathy with anti-myelin-associated glycoprotein (MAG) antibody may improve after treatment with ibrutinib, an oral inhibitor of Bruton tyrosine kinase, we prospectively treated with ibrutinib a cohort of 3 patients with anti-MAG neuropathy and Waldenström macroglobulinemia (WM).

Fnr is a transcriptional regulator that controls the expression of a variety of genes in response to oxygen limitation in bacteria. Genome sequencing revealed four genes (fnr1, fnr3, fnr5, and fnr7) coding for Fnr proteins in Paenibacillus polymyxa WLY78. Fnr1 and Fnr3 showed more similarity to each other than to Fnr5 and Fnr7. Also, Fnr1 and Fnr3 exhibited high similarity with Bacillus cereus Fnr and Bacillus subtilis Fnr in sequence and structures. Both the aerobically purified His-tagged Fnr1 and His-tagged Fnr3 in Escherichia coli could bind to the specific DNA promoter. Deletion analysis showed that the four fnr genes, especially fnr1 and fnr3, have significant impacts on growth and nitrogenase activity. Single deletion of fnr1 or fnr3 led to a 50% reduction in nitrogenase activity, and double deletion of fnr1 and fnr3 resulted to a 90% reduction in activity. Genome-wide transcription analysis showed that Fnr1 and Fnr3 indirectly activated expression of nif (nitrogen fixation) genes and Fe transport genes under anaerobic conditions. Fnr1 and Fnr3 inhibited expression of the genes involved in the aerobic respiratory chain and activated expression of genes responsible for anaerobic electron acceptor genes.

IMPORTANCE The members of the nitrogen-fixing Paenibacillus spp. have great potential to be used as a bacterial fertilizer in agriculture. However, the functions of the fnr gene(s) in nitrogen fixation and other metabolisms in Paenibacillus spp. are not known. Here, we found that in P. polymyxa WLY78, Fnr1 and Fnr3 were responsible for regulation of numerous genes in response to changes in oxygen levels, but Fnr5 and Fnr7 exhibited little effect. Fnr1 and Fnr3 indirectly or directly regulated many types of important metabolism, such as nitrogen fixation, Fe uptake, respiration, and electron transport. This study not only reveals the function of the fnr genes of P. polymyxa WLY78 in nitrogen fixation and other metabolisms but also will provide insight into the evolution and regulatory mechanisms of fnr in Paenibacillus.

BRAF^V600 mutations occur in a wide range of tumor types, and RAF inhibition has become standard in several of these cancers. Despite this progress, BRAF^V600 mutations have historically been considered a clear demonstration of tumor lineage context–dependent oncogene addiction, based predominantly on the insensitivity to RAF inhibition in colorectal cancer. However, the true broader activity of RAF inhibition pan-cancer remains incompletely understood. To address this, we conducted a multicohort "basket" study of the BRAF inhibitor vemurafenib in non-melanoma BRAF^V600 mutation–positive solid tumors. In total, 172 patients with 26 unique cancer types were treated, achieving an overall response rate of 33% and median duration of response of 13 months. Responses were observed in 13 unique cancer types, including historically treatment-refractory tumor types such as cholangiocarcinoma, sarcoma, glioma, neuroendocrine carcinoma, and salivary gland carcinomas. Collectively, these data demonstrate that single-agent BRAF inhibition has broader clinical activity than previously recognized.

Pemigatinib was effective in patients with cholangiocarcinomas with FGFR2 fusions or rearrangements.

Recurrent hotspot (p.Gly17Val) mutations in RHOA encoding a small GTPase, together with loss-of-function mutations in TET2 encoding an epigenetic regulator, are genetic hallmarks of angioimmunoblastic T-cell lymphoma (AITL). Mice expressing the p.Gly17Val RHOA mutant on a Tet2-null background succumbed to AITL-like T-cell lymphomas due to deregulated T-cell receptor (TCR) signaling. Using these mice to investigate therapeutics for AITL, we found that dasatinib, a multikinase inhibitor prolonged their survival through inhibition of hyperactivated TCR signaling. A phase I clinical trial study of dasatinib monotherapy in 5 patients with relapsed/refractory AITL was performed. Dasatinib was started at a dose of 100 mg/body once a day and continued until days 10–78 (median day 58). All the evaluable patients achieved partial responses. Our findings suggest that AITL is highly dependent on TCR signaling and that dasatinib could be a promising candidate drug for AITL treatment.Significance:Deregulated T-cell receptor signaling is a critical molecular event in angioimmunoblastic T-cell lymphoma and can be targeted with dasatinib.

Yell at yer friends in 1-4 player co-op while working under time pressure to serve up meals to an unforgiving god in Overc—er sorry, Cannibal Cuisine. It’s certainly got a familiar vibe to it, so if you liked the frantic food prep of that other friendship-ender perhaps you’ll like doing it with a new secret […]

Xenosaga Chronicles 2 is here. Did you get a switch just for it? Chris and Alex talk through their experiences. Johnathan, meanwhile, has been delving...

An strange, invasive species of jellyfish in Europe eats its own young when food is low, a new study claims.

The impressive clinical response to ibrutinib seen in mantle cell lymphoma clinical trials can be achieved in the National Health Service, say UK clinicians, although progression rates remain high.
Medscape News UK

Under siege from much cheaper rivals and with lenders unwilling to support it, pay TV operator Foxtel is increasingly looking like a threatened species.

Biopharmaceutical company RedHill Biopharma Ltd. (RDHL) on Monday provided an additional update on the compassionate use program with its investigational drug, opaganib (Yeliva, ABC294640)1, in patients with confirmed SARS-CoV-2 infection (the cause of COVID-19) in Israel.

The International Water Management Institute (IWMI) was a valued partner in conceptualising the workshop content and was well represented at the workshop with the participation of its senior officials.

Nigeria Three Month Interbank Rate (Nibor) was at 8.01 percent on Friday May 8. Interbank Rate in Nigeria averaged 13.76 percent from 2007 until 2020, reaching an all time high of 38.96 percent in September of 2013 and a record low of 0 percent in November of 2017. The interbank rate is the rate of interest charged on short-term loans made between banks in the local currency. This page provides - Nigeria Interbank Rate- actual values, historical data, forecast, chart, statistics, economic calendar and news.

X Factor : Celebrity winner Megan McKenna took a 'watermelon break' on Wednesday, seen lounging around on her Instagram page as she kicked back for New Year's Day.

The adorable creature perches on railings next to the woman in Mangrove Park, Perak, Malaysia. It moves behind the woman to kick her before nibbling on the sleeve of her shirt.

Fingers crossed Storm Dennis doesn't prove the ultimate menace and Yala Enki (Haydock, nap, 3.15) is given the chance to shine in the Unibet Grand National Trial today.

The film 'Mr Jones' which is due to be released on February 7 shows Jones - played by James Norton - eating the remains of a young boy. But Jones's great-nephew said this is completely false.

The cannibal, identified only as Oleksandr (pictured with his girlfriend), is said to have been frying and eating his victim's legs when police raided his house in the city of Kryvyi Rih.

Dani tribe live in the isolated Baliem Valley in West Papua, Indonesia. Macabre traditions iclude greasing mummified bodies with pork fat and removing the fingertips of a tribeswoman.

Pakistani beauty queen Zanib Naveed was killed in a road accident in College Park, Maryland, on Sunday evening after her car flipped over into oncoming traffic.

The accused pinned the man to the car and told him he was a 'cannibal' and would rape, murder and eat him if he told anyone what had happened.

A Russian scientist reveals the animals are feeding on each other in the Arctic as melting ice and fossil fuel extraction companies are forcing the animals out of their traditional hunting grounds.

Researchers working in Alaska observed wolf spiders eating juvenile spiders due to a warming Arctic that is making them grow larger and produce more offspring, resulting in less resources.

Online Resource

Hayden Library - PN6728.B358 B39 2017

NIB

A gruesome relic informs a desperate history. Historic Jamestowne’s Senior Archaeological Curator Bly Straube describes the find that let scientists and historians confirm the tales of cannibalism in America’s fledgling years.

WIRED reviews the Lamy Dialog 3 Fountain Pen Pall

Senior Editor Peter Rubin sits down with the eclectic Eric Andre, Hannibal Buress, and Derrick Beckles—star of Adult Swim’s upcoming spoof celebrity news show, Hot Package—to talk about the new season of The Eric Andre Show, and the weirdest thing they’ve seen on the oddball network.

Eli Roth’s new horror film The Green Inferno delves into the world of cannibalism as only Roth can. Ahead of the new movie, the director breaks down his rules for engaging in cannibalism and shares the type of person he’d want to eat.

Following Cabin Fever and Hostel, The Green Inferno is the latest film in Eli Roth’s travel trilogy. The director explains what inspired his new cannibalistic horror movie, and how he achieved a realistic look and feel while shooting on set in the Amazon.

Autor: Bühler, Franz, 1760-1824
Erschienen 1821
BSB-Signatur 4 Mus.pr. 45583

URN: urn:nbn:de:bvb:12-bsb11148962-3
URL: http://reader.digitale-sammlungen.de/de/fs1/object/display/bsb11148962_00001.html/

Autor: Königsperger, Marianus, 1708-1769
Erschienen 1747
BSB-Signatur 4 Mus.pr. 44470

URN: urn:nbn:de:bvb:12-bsb11148805-6
URL: http://reader.digitale-sammlungen.de/de/fs1/object/display/bsb11148805_00001.html/