moda UP Assembly will be able to accommodate only 200 of 403 MLAs with social distancing: Speaker By www.business-standard.com Published On :: Sun, 10 May 2020 12:32:52 +0530 Only 200 of the 403 MLAs will be able to sit inside the Uttar Pradesh Assembly if social distancing norms are implemented in the House as there are not enough seats, Speaker Hriday Narayan Dixit said. However, Dixit is "optimistic" and feels that by the time the next sitting of the Legislative Assembly is convened the situation will improve. "At present, the House is not in session. The Monsoon Session of the UP Legislative Assembly should be held some time in August and I am optimistic that by then the situation would have changed," the speaker told PTI in an interview. When asked to elaborate, Dixit said, "If we adhere to social distancing and leave one seat vacant, we will not have enough seats. There are 403 MLAs. Already there are not enough seats for everyone." "There is a shortage of 10-12 seats. The work goes on as (generally) 10-12 (members) are absent. In these circumstances, if one seat is left vacant then not more than 200 MLAs will be able to sit," he said. On being asked Full Article
moda UP Assembly will be able to accommodate only 200 of 403 MLAs with social distancing: Speaker By www.oneindia.com Published On :: Sun, 10 May 2020 12:57:40 +0530 Lucknow, May 10: Only 200 of the 403 MLAs will be able to sit inside the Uttar Pradesh Assembly if social distancing norms are implemented in the House as there are not enough seats, Speaker Hriday Narayan Dixit said. However, Dixit Full Article
moda ‘Accommodate Keralites in return special trains’ By www.thehindu.com Published On :: Sat, 09 May 2020 23:01:03 +0530 A large number of people from the State stuck at various places: Malayalees Association Full Article Andhra Pradesh
moda Synchrotron multimodal imaging in a whole cell reveals lipid droplet core organization By scripts.iucr.org Published On :: 2020-04-23 A lipid droplet (LD) core of a cell consists mainly of neutral lipids, triacylglycerols and/or steryl esters (SEs). The structuration of these lipids inside the core is still under debate. Lipid segregation inside LDs has been observed but is sometimes suggested to be an artefact of LD isolation and chemical fixation. LD imaging in their native state and in unaltered cellular environments appears essential to overcome these possible technical pitfalls. Here, imaging techniques for ultrastructural study of native LDs in cellulo are provided and it is shown that LDs are organized structures. Cryo soft X-ray tomography and deep-ultraviolet (DUV) transmittance imaging are showing a partitioning of SEs at the periphery of the LD core. Furthermore, DUV transmittance and tryptophan/tyrosine auto-fluorescence imaging on living cells are combined to obtain complementary information on cell chemical contents. This multimodal approach paves the way for a new label-free organelle imaging technique in living cells. Full Article text
moda Center for Hope's Volunteers Bring Additional Support and Alternative Modalities to Hospice and Palliative Care Patients By www.24-7pressrelease.com Published On :: Fri, 07 Feb 2020 07:00:00 GMT Move-in Assistance, Healing Touch and Polarity Therapies are Now Offered Full Article
moda Nett Technologies Announces Facilities Move to Accommodate Growth! By www.24-7pressrelease.com Published On :: Fri, 10 Nov 2017 07:00:00 GMT Nett Technologies, the leading emission control manufacturer, is pleased to announce its move to new, larger facilities on December 15th, 2017. Full Article
moda Dreamers Writing Farm Offers Unique Off-Grid Accommodations to Writers and Readers By www.24-7pressrelease.com Published On :: Sat, 31 Aug 2019 07:00:00 GMT Workshops, retreats, and general accommodations in beautiful Bruce Peninsula, Ontario, Canada Full Article
moda Atlanta Gear Works Launches New Website and Brochure to Accommodate its Growth By www.24-7pressrelease.com Published On :: Tue, 09 Jul 2019 07:00:00 GMT Gearbox service and support for any make, any model, anywhere, anytime Full Article
moda Global Cannabinoids Signs 20,000 SF Lease in Las Vegas to Accommodate Increased Wholesale Hemp CBD Oil Distribution Growth By www.24-7pressrelease.com Published On :: Thu, 12 Sep 2019 07:00:00 GMT This new GMP certified facility enables the company to manufacture and distribute the highest quality CBD products in a new, state of the art facility. Full Article
moda Canadian permanent residents stranded in India as special flights are only accommodating citizens By economictimes.indiatimes.com Published On :: 2020-04-16T14:17:03+05:30 In official emails to permanent residents who have enquired about the availability of these flights, the high commission has indicated that at this point, the flights are available only to Canadian citizens and their immediate family members who are permanent residents and accompanying them on the flights. Full Article
moda Justice Department Settles with Public Accommodations to Protect the Rights of Veterans Who Use Service Dogs By www.justice.gov Published On :: Wed, 06 Nov 2019 00:00:00 -0500 As we mark Veterans Day 2019, the Justice Department announced two settlement agreements under the Americans with Disabilities Act (ADA) to protect and advance equal access for veterans with disabilities who use service dogs. One agreement is with Deerfield Inn & Suites, in Gadsden, Alabama. The second agreement is with the Landmark Hotel Group in Virginia Beach, Virginia, which manages the Holiday Inn Express in Hampton, Virginia. These matters were investigated and resolved in furtherance of the Department’s commitment to ensuring that our veterans enjoy equal access to public accommodations, such as restaurants, hotels, and shops. Full Article
moda CSSplay - A CSS ONLY modal windows template By www.cssplay.co.uk Published On :: 2015-08-28 A simple CSS ONLY modal windows template, suitable for all the latest browsers. Full Article
moda MISA: Modality-Invariant and -Specific Representations for Multimodal Sentiment Analysis. (arXiv:2005.03545v1 [cs.CL]) By arxiv.org Published On :: Multimodal Sentiment Analysis is an active area of research that leverages multimodal signals for affective understanding of user-generated videos. The predominant approach, addressing this task, has been to develop sophisticated fusion techniques. However, the heterogeneous nature of the signals creates distributional modality gaps that pose significant challenges. In this paper, we aim to learn effective modality representations to aid the process of fusion. We propose a novel framework, MISA, which projects each modality to two distinct subspaces. The first subspace is modality invariant, where the representations across modalities learn their commonalities and reduce the modality gap. The second subspace is modality-specific, which is private to each modality and captures their characteristic features. These representations provide a holistic view of the multimodal data, which is used for fusion that leads to task predictions. Our experiments on popular sentiment analysis benchmarks, MOSI and MOSEI, demonstrate significant gains over state-of-the-art models. We also consider the task of Multimodal Humor Detection and experiment on the recently proposed UR_FUNNY dataset. Here too, our model fares better than strong baselines, establishing MISA as a useful multimodal framework. Full Article
moda Unsupervised Multimodal Neural Machine Translation with Pseudo Visual Pivoting. (arXiv:2005.03119v1 [cs.CL]) By arxiv.org Published On :: Unsupervised machine translation (MT) has recently achieved impressive results with monolingual corpora only. However, it is still challenging to associate source-target sentences in the latent space. As people speak different languages biologically share similar visual systems, the potential of achieving better alignment through visual content is promising yet under-explored in unsupervised multimodal MT (MMT). In this paper, we investigate how to utilize visual content for disambiguation and promoting latent space alignment in unsupervised MMT. Our model employs multimodal back-translation and features pseudo visual pivoting in which we learn a shared multilingual visual-semantic embedding space and incorporate visually-pivoted captioning as additional weak supervision. The experimental results on the widely used Multi30K dataset show that the proposed model significantly improves over the state-of-the-art methods and generalizes well when the images are not available at the testing time. Full Article
moda Categorical Vector Space Semantics for Lambek Calculus with a Relevant Modality. (arXiv:2005.03074v1 [cs.CL]) By arxiv.org Published On :: We develop a categorical compositional distributional semantics for Lambek Calculus with a Relevant Modality !L*, which has a limited edition of the contraction and permutation rules. The categorical part of the semantics is a monoidal biclosed category with a coalgebra modality, very similar to the structure of a Differential Category. We instantiate this category to finite dimensional vector spaces and linear maps via "quantisation" functors and work with three concrete interpretations of the coalgebra modality. We apply the model to construct categorical and concrete semantic interpretations for the motivating example of !L*: the derivation of a phrase with a parasitic gap. The effectiveness of the concrete interpretations are evaluated via a disambiguation task, on an extension of a sentence disambiguation dataset to parasitic gap phrase one, using BERT, Word2Vec, and FastText vectors and Relational tensors. Full Article
moda Multi-modality nanoparticles having optically responsive shape By www.freepatentsonline.com Published On :: Tue, 19 May 2015 08:00:00 EDT In certain embodiments novel nanoparticles (nanowontons) are provided that are suitable for multimodal imaging and/or therapy. In one embodiment, the nanoparticles include a first biocompatible (e.g., gold) layer, an inner core layer (e.g., a non-biocompatible material), and a biocompatible (e.g., gold) layer. The first gold layer includes a concave surface that forms a first outer surface of the layered nanoparticle. The second gold layer includes a convex surface that forms a second outer surface of the layered nanoparticle. The first and second gold layers encapsulate the inner core material layer. Methods of fabricating such nanoparticles are also provided. Full Article
moda Bi-modal emulsions By www.freepatentsonline.com Published On :: Tue, 17 Mar 2015 08:00:00 EDT A process for preparing bi-modal water emulsions is disclosed comprising: I) forming a mixture comprising; A) 100 parts by weight of a hydrophobic oil, B) 1 to 1000 part by weight of a water continuous emulsion having at least one surfactant, II) admixing additional quantities of the water continuous emulsion and/or water to the mixture from step I) to form a bi-modal emulsion. Full Article
moda Modalities for the treatment of degenerative diseases of the retina By www.freepatentsonline.com Published On :: Tue, 26 May 2015 08:00:00 EDT This invention relates to methods for improved cell-based therapies for retinal degeneration and for differentiating human embryonic stem cells and human embryo-derived into retinal pigment epithelium (RPE) cells and other retinal progenitor cells. Full Article
moda Pre-stressed haptic for accommodating intraocular lens By www.freepatentsonline.com Published On :: Tue, 26 May 2015 08:00:00 EDT An intraocular lens is disclosed with an optic that changes shape in response to forces exerted by the zonules of the eye. A haptic with an inner and outer ring couples the optic to the capsular bag of the eye. The haptic stresses the optic when the intraocular lens is in a natural state such that the internal stress is present throughout the accommodation range in order to prevent ripples and/or waves in the optic. Full Article
moda Accommodating intraocular lens using trapezoidal phase shift By www.freepatentsonline.com Published On :: Tue, 26 May 2015 08:00:00 EDT An accommodating intraocular lens (AIOL) includes an optic adapted to produce a trapezoidal phase shift and a plurality of haptics. Each haptic extends from a haptic-optic junction to at least one transverse arm contacting a capsular bag of the eye, and each haptic has sufficient length and rigidity to stretch a capsular bag of the eye to contact ciliary muscles of the eye. The haptic-optic junctions vault the optic forward relative to the haptics and compression of the haptics by the ciliary muscles moves the anterior optic forward. A combined accommodative power produced by the motion of the anterior optic and the trapezoidal phase shift is at least 0.5 Diopters. Full Article
moda Cartridge for accomodating a disc-shaped recording medium By www.freepatentsonline.com Published On :: Tue, 10 Mar 2015 08:00:00 EDT There is provided a cartridge including a running portion which causes both end portions of a disc-shaped recording medium to run, and a pressing portion which presses one end portion of the disc-shaped recording medium to press the other end portion against the running portion. Static friction coefficients of a portion of the pressing portion coming in contact with the one end portion and a portion of the running portion coming in contact with the other end portion are different. Full Article
moda IVC filter catheter with imaging modality By www.freepatentsonline.com Published On :: Tue, 26 May 2015 08:00:00 EDT A combined multi-lumen central access catheter and an embolic filter, further comprising an imaging modality to facilitate intravascular imaging of the filter. Full Article
moda IVC filter catheter with imaging modality By www.freepatentsonline.com Published On :: Tue, 26 May 2015 08:00:00 EDT A combined multi-lumen central access catheter and an embolic filter, further comprising an imaging modality to facilitate intravascular imaging of the filter. Full Article
moda Intermodal container By www.freepatentsonline.com Published On :: Tue, 14 Apr 2015 08:00:00 EDT An extendable, intermodal transport platform is disclosed. The invention comprises a standard ISO-length loading platform supported by main beams and crossmembers. The platform has ISO lifting and stacking fitments at its four corners. The platform has extendable supplemental platforms at each end, the extendable supplemental platforms fitting beneath the deck bed of the platform, or extendable to position stacking fitments at over-the-road trailer positions for North American fleet. Inner stacking fitments may laterally expand and retract so as to slide underneath the deck bed between the main beams. In some embodiments the platform includes posts that extend upward to position ISO lifting fitments at standard heights, such as under hydraulic power. Full Article
moda Bimodal clock generator By www.freepatentsonline.com Published On :: Tue, 28 Apr 2015 08:00:00 EDT An apparatus relates generally to a clock generator is disclosed. The clock generator is coupled to receive an input clock signal and further coupled to provide an output clock signal. An address and control register is coupled to receive an address signal and the output clock signal. An access generator is coupled to receive the output clock signal. The clock generator includes: an input node coupled to receive the input clock signal; at least one pulse generator coupled to the input node to receive the input clock signal and further coupled to provide a clock control signal; and a control gate coupled to the input node to receive the input signal and further coupled to the at least one pulse generator to receive the clock control signal. The clock control signal is provided in a non-toggling state for a high-frequency mode and in a toggling state for a low-frequency mode. Full Article
moda Localized wave generation via modal decomposition of a pulse by a wave launcher By www.freepatentsonline.com Published On :: Tue, 26 May 2015 08:00:00 EDT Implementations for exciting two or more modes via modal decomposition of a pulse by a wave launcher are generally disclosed. Full Article
moda System and methods of bimodal automatic power and frequency tuning of RF generators By www.freepatentsonline.com Published On :: Tue, 10 Feb 2015 08:00:00 EST A radio frequency generator includes a power control module, a frequency control module and a pulse generating module. The power control module is configured to generate a power signal indicating power levels for target states of a power amplifier. The frequency control module is configured to generate a frequency signal indicating frequencies for the target states of the power amplifier. The pulse generating module is configured to (i) supply an output signal to the power amplifier, (ii) recall at least one of a latest power level or a latest frequency for one of the target states of the power amplifier, and (iii) adjust a current power level and a current frequency of the output signal from a first state to a second state based on the power signal, the frequency signal, and at least one of the latest power level and the latest frequency of the power amplifier. Full Article
moda Packing box used for accommodation of plate bodies By www.freepatentsonline.com Published On :: Tue, 26 May 2015 08:00:00 EDT The present invention relates to a packing box for accommodation of plate bodies, which comprises a backplane, and a side plate vertically arranged at the periphery of the backplane, the plate body including a main body, and a PCB plate connected through a flexible sheet to the edge of the main body, a positioning member being further arranged in the space enclosed by the backplane and the side plate for preventing the PCB plate from moving relative to the main body. The positioning member of the present invention can prevent the PCB plate from moving relative to the main body of the plate body, playing a role in protecting the circuit on the flexible sheet and having low costs. Full Article
moda Device for accommodating objects, trolley, method for manufacturing a trolley, as well as transport means By www.freepatentsonline.com Published On :: Tue, 19 May 2015 08:00:00 EDT A device for accommodating objects, in particular for use in an airplane, comprises at least one panel. The panel has at least one outer edge which is provided with a rim in order to form a shock-absorbing edge. The rim comprises plastic that is integrally molded onto the outer edge of the panel. The device can be an airplane trolley, folding trolley, container or galley. Full Article
moda Sleeve for accommodating propellant charge powder By www.freepatentsonline.com Published On :: Tue, 15 Jul 2014 08:00:00 EDT The invention relates to a combustible sleeve for accommodating propellant charge powder, to munitions designed using such a sleeve, and to a production method for such sleeves. The sleeve according to the invention is designed for accommodating propellant charge powder and has a jacket wall made of combustible felted fibrous material and an inlay of intersecting threads in the jacket wall. The threads are disposed therein at a distance from one another such that felted fibrous material reaches through the regions between the threads. The method comprises the following steps: preparing a jacket wall made of combustible felted fibrous material and inserting an inlay made of intersecting threads into the jacket wall. The threads are disposed therein at a distance from one another such that the felted fibrous material extends through the regions between the threads. Full Article
moda HOUSING FOR ACCOMMODATION OF A PLURALITY OF BATTERY CELLS HAVING A COOLING DEVICE INTEGRATED IN THE HOUSING By www.freepatentsonline.com Published On :: Thu, 29 Jun 2017 08:00:00 EDT The invention relates to a housing (10) for accommodating a plurality of battery cells (20), in particular lithium-ion battery cells, wherein the housing (10), in particular a plastic housing, comprises a cooling device with an inlet point (30) and an outlet point (40) for an air stream (22) for cooling the battery cells (20). In addition, the housing (10) is designed as a single piece together with the cooling device integrated in the housing (10), and the cooling device additionally has spacers (34; 34a, 34b) for arranging all accommodated battery cells (20) with an intermediate space (23) for guiding air between the battery cells (20), by which means an air channel (25) is provided for the air stream (22) between the battery cells (20). The invention further relates to a battery pack (50) and to a motor vehicle comprising such a battery pack (50). Full Article
moda Street wardens help homeless man find job and accommodation By thebirminghampress.com Published On :: Fri, 28 Feb 2020 00:00:37 +0000 How a warden's intervention put a life back on track. Full Article Business Community Eating out Aziz Khan Dilbar Shaeed Latif Westside Business Improvement District
moda Google Accommodates Search History Buffs By www.washingtonpost.com Published On :: Fri, 6 May 2005 11:07:06 GMT Don't take this personally, but Google wants your Web search history. Full Article
moda Airbnb faces new clampdown in push to regulate short-stay accommodation By www.abc.net.au Published On :: Thu, 26 Sep 2019 18:51:00 +1000 At least 20,000 short-term rental properties in WA would be forced to register their details as part of a mandatory scheme designed to level the accommodation playing field and give peace of mind to consumers. Full Article ABC Radio Perth perth Business Economics and Finance:Industry:Tourism Lifestyle and Leisure:Travel and Tourism:All Australia:WA:All Australia:WA:Perth 6000
moda Anzac commemorations spark accommodation worries By www.abc.net.au Published On :: Thu, 27 Feb 2014 15:22:00 +1100 Several accommodation providers in Albany have expressed frustration at delays in finalising plans for the city's Anzac centenary commemorations. Full Article ABC South Coast southcoast Business Economics and Finance:Industry:Tourism Community and Society:All:All Event:ANZAC Day:All Lifestyle and Leisure:Travel and Tourism:All Australia:WA:Albany 6330
moda New-age librarians embrace new technologies to accommodate growing communities needs By www.abc.net.au Published On :: Thu, 24 Oct 2019 08:08:00 +1100 One high-tech regional library hosts a "zoom room" for video conferencing, an interactive jumping floor for kids, eBooks and eAudiobooks and yes, plenty of good, old-fashioned printed books. Full Article ABC North West Queensland westqld northwest Arts and Entertainment:Books (Literature):All Arts and Entertainment:Books (Literature):Fantasy Arts and Entertainment:Library Museum and Gallery:All Community and Society:Regional:All Science and Technology:Computers and Technology:Internet Science and Technology:Information Technology:All Australia:QLD:Longreach 4730 Australia:QLD:Mount Isa 4825
moda Broome tourism businesses divided on Airbnb and other 'sharing economy' accommodation websites By www.abc.net.au Published On :: Fri, 06 Sep 2019 07:31:00 +1000 Some Broome tourism businesses hope a parliamentary inquiry will lead to a crackdown on accommodation websites, while others say 'the sharing economy' needs support. Full Article ABC Kimberley kimberley Business Economics and Finance:Regulation:All Government and Politics:Parliament:All Government and Politics:Parliament:State Parliament Lifestyle and Leisure:All:All Lifestyle and Leisure:Travel and Tourism:All Australia:WA:Broome 6725
moda Moda Health Plan, Inc. v. US By feeds.findlaw.com Published On :: 2018-06-14T08:00:00+00:00 (United States Federal Circuit) - In this insurance law claim a health insurer contends that the US failed to satisfy its payment obligation under a federal health insurance pool program. The Court of Federal Claims entered judgement for the insurer. The Court of Appeals reversed the judgment stating that Congress suspended the governments obligation and that subsequent regulation did not create a contract promising full payment. Full Article Insurance Law Administrative Law Government Contracts
moda Highway Capacity Manual, Sixth Edition: A Guide for Multimodal Mobility Analysis By www.trb.org Published On :: Mon, 27 Apr 2020 11:54:52 GMT Now available to order from the TRB Bookstore, the Highway Capacity Manual, Sixth Edition: A Guide for Multimodal Mobility Analysis (HCM) provides methods for quantifying highway capacity. In its current form, it serves as a fundamental reference on concepts, performance measures, and analysis techniques for evaluating the multimodal operation of streets, highways, freeways, and off-street pathways. The Sixth Edition incorporates the latest research on highway capacity, quality of service, Active Traffic... Full Article http://www.trb.org/Resource.ashx?sn=HCM6cover
moda Multimodal transportation investments By www.trb.org Published On :: Thu, 07 May 2020 06:21:45 GMT Fostering Multimodal Connectivity Newsletter for April 2020 , released by the U.S. Federal Highway Administration Full Article
moda IBM and West Virginia University’s Center for Disability Inclusion Unveil Mobile Workplace Accommodation Case Management App By www.ibm.com Published On :: Mon, 12 Jun 2017 02:29:16 GMT IBM and West Virginia University’s Center for Disability Inclusion (CDI) today announced they are developing a first generation mobile workplace accommodation case management app to help U.S. businesses create inclusive workplaces for employees with disabilities. Full Article IBM MobileFirst
moda Ilusión, Fiorentina y David's Bridal abren la puerta a la transformación digital en la moda con IBM By www.ibm.com Published On :: jue, 15 nov 2018 04:15:52 GMT Diltex -empresa mexicana propietaria de las marcas Ilusión y Fiorentina, socios de Vanity Fair Brands y franquiciatarios de David's Bridal en México- e IBM, anunciaron que la compañía dedicada a la industria de la moda está mejorando la experiencia del cliente y fortaleciendo su producción, distribución y comercialización a través de su transformación digital. Full Article All Topics
moda DPstreet rompe las barreras de la moda urbana con IBM By www.ibm.com Published On :: vie, 06 oct 2017 03:48:59 GMT La marca de moda urbana DPStreet, filial del corporativo GrupoDP, ha dado a conocer su intención de transformar el modelo comercial y de negocio apoyados en la habilitación de distintas estrategias digitales, una de las principales es una tienda virtual desarrollada por IBM (Digital Commerce) e implementada por Solemti S.A. de C.V., su asociado de negocios en el área digital. Full Article IBM Watson
moda LA City Council plans to shame hotels that refuse to accommodate homeless By www.travelmole.com Published On :: Fri, 08 May 2020 13:50:01 -0400 Hotels could be 'commandeered' Full Article
moda Fire at sheltered accommodation - Edmonton By www.london-fire.gov.uk Published On :: Mon, 04 May 2020 09:32:35 +0100 Firefighters led one man to safety Full Article
moda Indiana Election Commission moves deadlines, makes changes to accommodate June 2 primary By rssfeeds.indystar.com Published On :: Wed, 25 Mar 2020 17:15:55 +0000 The Indiana Election Commission on Wednesday ratified several changes that Gov. Eric Holcomb recommended at a news conference last week. Full Article
moda Stop Video on Modal Close By forums.digitalpoint.com Published On :: Sat, 09 May 2020 17:02:45 +0000 Full Article
moda Combination upstream and downstream treatment modalities for RECOVERY from COVID-19 By feeds.bmj.com Published On :: Friday, May 8, 2020 - 11:27 Full Article
moda Multimodality Imaging of Inflammation and Ventricular Remodeling in Pressure-Overload Heart Failure By jnm.snmjournals.org Published On :: 2020-04-01T06:00:28-07:00 Inflammation contributes to ventricular remodeling after myocardial ischemia, but its role in nonischemic heart failure is poorly understood. Local tissue inflammation is difficult to assess serially during pathogenesis. Although 18F-FDG accumulates in inflammatory leukocytes and thus may identify inflammation in the myocardial microenvironment, it remains unclear whether this imaging technique can isolate diffuse leukocytes in pressure-overload heart failure. We aimed to evaluate whether inflammation with 18F-FDG can be serially imaged in the early stages of pressure-overload–induced heart failure and to compare the time course with functional impairment assessed by cardiac MRI. Methods: C57Bl6/N mice underwent transverse aortic constriction (TAC) (n = 22), sham surgery (n = 12), or coronary ligation as an inflammation-positive control (n = 5). MRI assessed ventricular geometry and contractile function at 2 and 8 d after TAC. Immunostaining identified the extent of inflammatory leukocyte infiltration early in pressure overload. 18F-FDG PET scans were acquired at 3 and 7 d after TAC, under ketamine-xylazine anesthesia to suppress cardiomyocyte glucose uptake. Results: Pressure overload evoked rapid left ventricular dilation compared with sham (end-systolic volume, day 2: 40.6 ± 10.2 μL vs. 23.8 ± 1.7 μL, P < 0.001). Contractile function was similarly impaired (ejection fraction, day 2: 40.9% ± 9.7% vs. 59.2% ± 4.4%, P < 0.001). The severity of contractile impairment was proportional to histology-defined myocardial macrophage density on day 8 (r = –0.669, P = 0.010). PET imaging identified significantly higher left ventricular 18F-FDG accumulation in TAC mice than in sham mice on day 3 (10.5 ± 4.1 percentage injected dose [%ID]/g vs. 3.8 ± 0.9 %ID/g, P < 0.001) and on day 7 (7.8 ± 3.7 %ID/g vs. 3.0 ± 0.8 %ID/g, P = 0.006), though the efficiency of cardiomyocyte suppression was variable among TAC mice. The 18F-FDG signal correlated with ejection fraction (r = –0.75, P = 0.01) and ventricular volume (r = 0.75, P < 0.01). Western immunoblotting demonstrated a 60% elevation of myocardial glucose transporter 4 expression in the left ventricle at 8 d after TAC, indicating altered glucose metabolism. Conclusion: TAC induces rapid changes in left ventricular geometry and contractile function, with a parallel modest infiltration of inflammatory macrophages. Metabolic remodeling overshadows inflammatory leukocyte signal using 18F-FDG PET imaging. More selective inflammatory tracers are requisite to identify the diffuse local inflammation in pressure overload. Full Article
moda Dispensatorium universale ad tempora nostra accommodatum, et ad formam lexici chimico-pharmaceutici redactum / Christ. Frider. Reuss. By feedproxy.google.com Published On :: Argentorati : Sumtibus Amandi Koenig, 1786-1787. Full Article