PFAS, common chemicals used to make everything from pizza boxes to take-out containers, are associated with risk of miscarriages, according to a new study from Yale.

This week, we’re trying an experiment that will give you a little something extra while you’re listening. To get started text “Hey Al” to 202-873-8325.

The world’s first “test tube baby” turns 40 next year. As she’s grown up, so has the medical specialty that produced her: in vitro fertilization. It’s a big business addressing a big demand.

On this episode of Reveal, we examine the stakes – and high costs – of IVF.

Desperate to have a child, a couple puts its trust in a fertility clinic that promises more than it can deliver. They enter a world where some clinics take unnecessary risks to make them look far more successful than they are in reality.

From reporter Jonathan Jones and Reveal’s Bernice Yeung and Emily Harris.

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Motherhood, for now, looks vastly different for Sarah Roberts than she expected it to – but nonetheless, the actor wants to speak candidly about the heartbreak she and husband James Stewart endured after she suffered two miscarriages in the past year.

The former mayor of the Fraser Coast Regional Council has been found guilty of using his position to push for his former campaign manager to be appointed his chief-of-staff.

How did Oedipus become such a naughty little boy? Is it all the fault of his mother? Perth Theatre Company's latest show is an imaginative take on the Greek myth, says ABC 720's cultural correspondent Victoria Laurie

A formal investigation begins over the actions of Noosa Shire Councillor Jess Glasgow as a contestant on reality TV dating program The Bachelorette, with comments he made on the dating show described as "crude" and "highly offensive".

First-time mayors and councillors who are the subject of minor misconduct complaints will get a three-month amnesty, Queensland's Office of the Independent Assessor says.

A woman who suffered a miscarriage in mandatory COVID-19 quarantine was forced to stay in a hotel room for five days after the traumatic event because the Victorian Health Department failed to act on an order to release her.

A group of friends with disabilities is about to undertake a cycling adventure to challenge the misconceptions about people with disabilities. They're going to ride from Australia's lowest point at Lake Eyre to the highest point Mt Kosciuszko. Two of them will peddle the 2000 kilometres together on a tandem trike.

Removed From Troubles (OPEN for application) Fonts: Pixel / Bitmap (Graphics / Layouts / Effects); Domains (.com) (Web Miscellany)

By Wadner Pierre

This article was originally published by UnlessWeCare.org

Screen Shot 2015-11-06 at 6.34.24 AM It has been over a month since Haiti’s Conseil Electoral Provisoire (Electoral Provisory Counsel), known as CEP, published its foreknown controversial fraudulent results for the first round presidential and second round legislative elections. The CEP’s preliminary results for the presidential elections placed President Michel Martelly’s hand-picked candidate Jovenel Moise of Parti Haïtien Tèt Kale, or P.H.T.K in the first place with 32.8 percent of the popular votes. Jaccéus Joseph, a member of the electoral council, qualified the results as unacceptable.

Miami Herald’s Jacqueline Charles reported, Joseph refused to sign “the presidential and legislative preliminary results” because of irregularities and frauds that plagued them. Joseph thought his refusal to endorse the results would prompt the Tabulation Center to verify “the allegations of electoral fraud, including checking the voter registration lists against the ballots cast in the Oct. 25” elections to avert an unnecessary electoral crisis.

Joseph said, “We asked the director of the Tabulation Center did he have enough time to thoroughly verify if there was fraud.” According to Joseph, the director told them, “[H]e didn’t have enough time for that.”

Despite Joseph’s insistence on verifying and correcting the irregularities and frauds threatening the credibility of the results, CEP’s President Pierre-Louis Opont decided to publish the tainted results. The electoral crisis that was avoidable is now becoming an inevitable crisis. This man-made electoral dispute could further derail the political and social stability of the country.

read more

Kawhi Leonard scored 30 points, Paul George added 24 as the Clippers overcome defensive issues in a 136-130 victory over the Philadelphia 76ers.

Students accused of sexual misconduct gain stronger protections under controversial new Title IX rules announced by Education Secretary Betsy DeVos.

Expert

The developing nervous system is remarkably sensitive to environmental signals, including disruptive toxins, such as polybrominated diphenyl ethers (PBDEs). PBDEs are an environmentally pervasive class of brominated flame retardants whose neurodevelopmental toxicity mechanisms remain largely unclear. Using dissociated cortical neurons from embryonic Rattus norvegicus, we found here that chronic exposure to 6-OH–BDE-47, one of the most prevalent hydroxylated PBDE metabolites, suppresses both spontaneous and evoked neuronal electrical activity. On the basis of our previous work on mitogen-activated protein kinase (MAPK)/extracellular signal-related kinase (ERK) (MEK) biology and our observation that 6-OH–BDE-47 is structurally similar to kinase inhibitors, we hypothesized that certain hydroxylated PBDEs mediate neurotoxicity, at least in part, by impairing the MEK–ERK axis of MAPK signal transduction. We tested this hypothesis on three experimental platforms: 1) in silico, where modeling ligand–protein docking suggested that 6-OH–BDE-47 is a promiscuous ATP-competitive kinase inhibitor; 2) in vitro in dissociated neurons, where 6-OH–BDE-47 and another specific hydroxylated BDE metabolite similarly impaired phosphorylation of MEK/ERK1/2 and activity-induced transcription of a neuronal immediate early gene; and 3) in vivo in Drosophila melanogaster, where developmental exposures to 6-OH–BDE-47 and a MAPK inhibitor resulted in offspring displaying similarly increased frequency of mushroom-body β–lobe midline crossing, a metric of axonal guidance. Taken together, our results support that certain ortho-hydroxylated PBDE metabolites are promiscuous kinase inhibitors and can cause disruptions of critical neurodevelopmental processes, including neuronal electrical activity, pre-synaptic functions, MEK–ERK signaling, and axonal guidance.

The developing nervous system is remarkably sensitive to environmental signals, including disruptive toxins, such as polybrominated diphenyl ethers (PBDEs). PBDEs are an environmentally pervasive class of brominated flame retardants whose neurodevelopmental toxicity mechanisms remain largely unclear. Using dissociated cortical neurons from embryonic Rattus norvegicus, we found here that chronic exposure to 6-OH–BDE-47, one of the most prevalent hydroxylated PBDE metabolites, suppresses both spontaneous and evoked neuronal electrical activity. On the basis of our previous work on mitogen-activated protein kinase (MAPK)/extracellular signal-related kinase (ERK) (MEK) biology and our observation that 6-OH–BDE-47 is structurally similar to kinase inhibitors, we hypothesized that certain hydroxylated PBDEs mediate neurotoxicity, at least in part, by impairing the MEK–ERK axis of MAPK signal transduction. We tested this hypothesis on three experimental platforms: 1) in silico, where modeling ligand–protein docking suggested that 6-OH–BDE-47 is a promiscuous ATP-competitive kinase inhibitor; 2) in vitro in dissociated neurons, where 6-OH–BDE-47 and another specific hydroxylated BDE metabolite similarly impaired phosphorylation of MEK/ERK1/2 and activity-induced transcription of a neuronal immediate early gene; and 3) in vivo in Drosophila melanogaster, where developmental exposures to 6-OH–BDE-47 and a MAPK inhibitor resulted in offspring displaying similarly increased frequency of mushroom-body β–lobe midline crossing, a metric of axonal guidance. Taken together, our results support that certain ortho-hydroxylated PBDE metabolites are promiscuous kinase inhibitors and can cause disruptions of critical neurodevelopmental processes, including neuronal electrical activity, pre-synaptic functions, MEK–ERK signaling, and axonal guidance.

Mona Radwan
Apr 1, 2020; 19:640-654
Research

C9ORF72-associated Motor Neuron Disease patients feature abnormal expression of 5 dipeptide repeat (DPR) polymers. Here we used quantitative proteomics in a mouse neuronal-like cell line (Neuro2a) to demonstrate that the Arg residues in the most toxic DPRS, PR and GR, leads to a promiscuous binding to the proteome compared with a relative sparse binding of the more inert AP and GA. Notable targets included ribosomal proteins, translation initiation factors and translation elongation factors. PR and GR comprising more than 10 repeats appeared to robustly stall on ribosomes during translation suggesting Arg-rich peptide domains can electrostatically jam the ribosome exit tunnel during synthesis. Poly-GR also recruited arginine methylases, induced hypomethylation of endogenous proteins, and induced a profound destabilization of the actin cytoskeleton. Our findings point to arginine in GR and PR polymers as multivalent toxins to translation as well as arginine methylation that may explain the dysfunction of biological processes including ribosome biogenesis, mRNA splicing and cytoskeleton assembly.

The developing nervous system is remarkably sensitive to environmental signals, including disruptive toxins, such as polybrominated diphenyl ethers (PBDEs). PBDEs are an environmentally pervasive class of brominated flame retardants whose neurodevelopmental toxicity mechanisms remain largely unclear. Using dissociated cortical neurons from embryonic Rattus norvegicus, we found here that chronic exposure to 6-OH–BDE-47, one of the most prevalent hydroxylated PBDE metabolites, suppresses both spontaneous and evoked neuronal electrical activity. On the basis of our previous work on mitogen-activated protein kinase (MAPK)/extracellular signal-related kinase (ERK) (MEK) biology and our observation that 6-OH–BDE-47 is structurally similar to kinase inhibitors, we hypothesized that certain hydroxylated PBDEs mediate neurotoxicity, at least in part, by impairing the MEK–ERK axis of MAPK signal transduction. We tested this hypothesis on three experimental platforms: 1) in silico, where modeling ligand–protein docking suggested that 6-OH–BDE-47 is a promiscuous ATP-competitive kinase inhibitor; 2) in vitro in dissociated neurons, where 6-OH–BDE-47 and another specific hydroxylated BDE metabolite similarly impaired phosphorylation of MEK/ERK1/2 and activity-induced transcription of a neuronal immediate early gene; and 3) in vivo in Drosophila melanogaster, where developmental exposures to 6-OH–BDE-47 and a MAPK inhibitor resulted in offspring displaying similarly increased frequency of mushroom-body β–lobe midline crossing, a metric of axonal guidance. Taken together, our results support that certain ortho-hydroxylated PBDE metabolites are promiscuous kinase inhibitors and can cause disruptions of critical neurodevelopmental processes, including neuronal electrical activity, pre-synaptic functions, MEK–ERK signaling, and axonal guidance.

School authorities in Utah have failed to report educator misconduct, possibly allowing teachers to offend again by moving to other schools, according to a new audit.

Several women told local newspapers that Pennsylvania state board chair Larry Wittig pursued sexual relationships with them when they were teenagers.

Libraries.

Miscarriage.

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