afick is another file integrity checker, designed to be fast and fully portable between Unix and Windows platforms. It works by first creating a database that represents a snapshot of the most essential parts of your computer system. Then a user can run the script to discover all modifications made since the snapshot was taken (i.e. files added, changed, or removed). The configuration syntax is very close to that of aide or tripwire, and a graphical interface is provided.

afick is another file integrity checker, designed to be fast and fully portable between Unix and Windows platforms. It works by first creating a database that represents a snapshot of the most essential parts of your computer system. Then a user can run the script to discover all modifications made since the snapshot was taken (i.e. files added, changed, or removed). The configuration syntax is very close to that of aide or tripwire, and a graphical interface is provided.

afick is another file integrity checker, designed to be fast and fully portable between Unix and Windows platforms. It works by first creating a database that represents a snapshot of the most essential parts of your computer system. Then a user can run the script to discover all modifications made since the snapshot was taken (i.e. files added, changed, or removed). The configuration syntax is very close to that of aide or tripwire, and a graphical interface is provided.

afick is another file integrity checker, designed to be fast and fully portable between Unix and Windows platforms. It works by first creating a database that represents a snapshot of the most essential parts of your computer system. Then a user can run the script to discover all modifications made since the snapshot was taken (i.e. files added, changed, or removed). The configuration syntax is very close to that of aide or tripwire, and a graphical interface is provided.

afick is another file integrity checker, designed to be fast and fully portable between Unix and Windows platforms. It works by first creating a database that represents a snapshot of the most essential parts of your computer system. Then a user can run the script to discover all modifications made since the snapshot was taken (i.e. files added, changed, or removed). The configuration syntax is very close to that of aide or tripwire, and a graphical interface is provided.

afick is another file integrity checker, designed to be fast and fully portable between Unix and Windows platforms. It works by first creating a database that represents a snapshot of the most essential parts of your computer system. Then a user can run the script to discover all modifications made since the snapshot was taken (i.e. files added, changed, or removed). The configuration syntax is very close to that of aide or tripwire, and a graphical interface is provided.

afick is another file integrity checker, designed to be fast and fully portable between Unix and Windows platforms. It works by first creating a database that represents a snapshot of the most essential parts of your computer system. Then a user can run the script to discover all modifications made since the snapshot was taken (i.e. files added, changed, or removed). The configuration syntax is very close to that of aide or tripwire, and a graphical interface is provided.

afick is another file integrity checker, designed to be fast and fully portable between Unix and Windows platforms. It works by first creating a database that represents a snapshot of the most essential parts of your computer system. Then a user can run the script to discover all modifications made since the snapshot was taken (i.e. files added, changed, or removed). The configuration syntax is very close to that of aide or tripwire, and a graphical interface is provided.

afick is another file integrity checker, designed to be fast and fully portable between Unix and Windows platforms. It works by first creating a database that represents a snapshot of the most essential parts of your computer system. Then a user can run the script to discover all modifications made since the snapshot was taken (i.e. files added, changed, or removed). The configuration syntax is very close to that of aide or tripwire, and a graphical interface is provided.

afick is another file integrity checker, designed to be fast and fully portable between Unix and Windows platforms. It works by first creating a database that represents a snapshot of the most essential parts of your computer system. Then a user can run the script to discover all modifications made since the snapshot was taken (i.e. files added, changed, or removed). The configuration syntax is very close to that of aide or tripwire, and a graphical interface is provided.

Samhain is a file system integrity checker that can be used as a client/server application for centralized monitoring of networked hosts. Databases and configuration files can be stored on the server. Databases, logs, and config files can be signed for tamper resistance. In addition to forwarding reports to the log server via authenticated TCP/IP connections, several other logging facilities (e-mail, console, and syslog) are available. Tested on Linux, AIX, HP-UX, Unixware, Sun and Solaris.

Samhain is a file system integrity checker that can be used as a client/server application for centralized monitoring of networked hosts. Databases and configuration files can be stored on the server. Databases, logs, and config files can be signed for tamper resistance. In addition to forwarding reports to the log server via authenticated TCP/IP connections, several other logging facilities (e-mail, console, and syslog) are available. Tested on Linux, AIX, HP-UX, Unixware, Sun and Solaris.

Samhain is a file system integrity checker that can be used as a client/server application for centralized monitoring of networked hosts. Databases and configuration files can be stored on the server. Databases, logs, and config files can be signed for tamper resistance. In addition to forwarding reports to the log server via authenticated TCP/IP connections, several other logging facilities (e-mail, console, and syslog) are available. Tested on Linux, AIX, HP-UX, Unixware, Sun and Solaris.

Samhain is a file system integrity checker that can be used as a client/server application for centralized monitoring of networked hosts. Databases and configuration files can be stored on the server. Databases, logs, and config files can be signed for tamper resistance. In addition to forwarding reports to the log server via authenticated TCP/IP connections, several other logging facilities (e-mail, console, and syslog) are available. Tested on Linux, AIX, HP-UX, Unixware, Sun and Solaris.

Samhain is a file system integrity checker that can be used as a client/server application for centralized monitoring of networked hosts. Databases and configuration files can be stored on the server. Databases, logs, and config files can be signed for tamper resistance. In addition to forwarding reports to the log server via authenticated TCP/IP connections, several other logging facilities (e-mail, console, and syslog) are available. Tested on Linux, AIX, HP-UX, Unixware, Sun and Solaris.

Samhain is a file system integrity checker that can be used as a client/server application for centralized monitoring of networked hosts. Databases and configuration files can be stored on the server. Databases, logs, and config files can be signed for tamper resistance. In addition to forwarding reports to the log server via authenticated TCP/IP connections, several other logging facilities (e-mail, console, and syslog) are available. Tested on Linux, AIX, HP-UX, Unixware, Sun and Solaris.

Samhain is a file system integrity checker that can be used as a client/server application for centralized monitoring of networked hosts. Databases and configuration files can be stored on the server. Databases, logs, and config files can be signed for tamper resistance. In addition to forwarding reports to the log server via authenticated TCP/IP connections, several other logging facilities (e-mail, console, and syslog) are available. Tested on Linux, AIX, HP-UX, Unixware, Sun and Solaris.

Samhain is a file system integrity checker that can be used as a client/server application for centralized monitoring of networked hosts. Databases and configuration files can be stored on the server. Databases, logs, and config files can be signed for tamper resistance. In addition to forwarding reports to the log server via authenticated TCP/IP connections, several other logging facilities (e-mail, console, and syslog) are available. Tested on Linux, AIX, HP-UX, Unixware, Sun and Solaris.

Samhain is a file system integrity checker that can be used as a client/server application for centralized monitoring of networked hosts. Databases and configuration files can be stored on the server. Databases, logs, and config files can be signed for tamper resistance. In addition to forwarding reports to the log server via authenticated TCP/IP connections, several other logging facilities (e-mail, console, and syslog) are available. Tested on Linux, AIX, HP-UX, Unixware, Sun and Solaris.

Samhain is a file system integrity checker that can be used as a client/server application for centralized monitoring of networked hosts. Databases and configuration files can be stored on the server. Databases, logs, and config files can be signed for tamper resistance. In addition to forwarding reports to the log server via authenticated TCP/IP connections, several other logging facilities (e-mail, console, and syslog) are available. Tested on Linux, AIX, HP-UX, Unixware, Sun and Solaris.

Samhain is a file system integrity checker that can be used as a client/server application for centralized monitoring of networked hosts. Databases and configuration files can be stored on the server. Databases, logs, and config files can be signed for tamper resistance. In addition to forwarding reports to the log server via authenticated TCP/IP connections, several other logging facilities (e-mail, console, and syslog) are available. Tested on Linux, AIX, HP-UX, Unixware, Sun and Solaris.

Samhain is a file system integrity checker that can be used as a client/server application for centralized monitoring of networked hosts. Databases and configuration files can be stored on the server. Databases, logs, and config files can be signed for tamper resistance. In addition to forwarding reports to the log server via authenticated TCP/IP connections, several other logging facilities (e-mail, console, and syslog) are available. Tested on Linux, AIX, HP-UX, Unixware, Sun and Solaris.

Samhain is a file system integrity checker that can be used as a client/server application for centralized monitoring of networked hosts. Databases and configuration files can be stored on the server. Databases, logs, and config files can be signed for tamper resistance. In addition to forwarding reports to the log server via authenticated TCP/IP connections, several other logging facilities (e-mail, console, and syslog) are available. Tested on Linux, AIX, HP-UX, Unixware, Sun and Solaris.

Samhain is a file system integrity checker that can be used as a client/server application for centralized monitoring of networked hosts. Databases and configuration files can be stored on the server. Databases, logs, and config files can be signed for tamper resistance. In addition to forwarding reports to the log server via authenticated TCP/IP connections, several other logging facilities (e-mail, console, and syslog) are available. Tested on Linux, AIX, HP-UX, Unixware, Sun and Solaris.

Microsoft Windows Vista / Server 2008 suffer from a NtUserCheckAccessForIntegrityLevel use-after-free vulnerability.

The Windows kernel does not properly isolate broadcast messages from low integrity applications from medium or high integrity applications. This allows commands to be broadcasted to an open medium or high integrity command prompts allowing escalation of privileges. We can spawn a medium integrity command prompt, after spawning a low integrity command prompt, by using the Win+Shift+# combination to specify the position of the command prompt on the taskbar. We can then broadcast our command and hope that the user is away and doesn't corrupt it by interacting with the UI. Broadcast issue affects versions Windows Vista, 7, 8, Server 2008, Server 2008 R2, Server 2012, RT. But Spawning a command prompt with the shortcut key does not work in Vista so you will have to check if the user is already running a command prompt and set SPAWN_PROMPT false. The WEB technique will execute a powershell encoded payload from a Web location. The FILE technique will drop an executable to the file system, set it to medium integrity and execute it. The TYPE technique will attempt to execute a powershell encoded payload directly from the command line but it may take some time to complete.

Samhain is a file system integrity checker that can be used as a client/server application for centralized monitoring of networked hosts. Databases and configuration files can be stored on the server. Databases, logs, and config files can be signed for tamper resistance. In addition to forwarding reports to the log server via authenticated TCP/IP connections, several other logging facilities (e-mail, console, and syslog) are available. Tested on Linux, AIX, HP-UX, Unixware, Sun and Solaris.

Samhain is a file system integrity checker that can be used as a client/server application for centralized monitoring of networked hosts. Databases and configuration files can be stored on the server. Databases, logs, and config files can be signed for tamper resistance. In addition to forwarding reports to the log server via authenticated TCP/IP connections, several other logging facilities (e-mail, console, and syslog) are available. Tested on Linux, AIX, HP-UX, Unixware, Sun and Solaris.

Samhain is a file system integrity checker that can be used as a client/server application for centralized monitoring of networked hosts. Databases and configuration files can be stored on the server. Databases, logs, and config files can be signed for tamper resistance. In addition to forwarding reports to the log server via authenticated TCP/IP connections, several other logging facilities (e-mail, console, and syslog) are available. Tested on Linux, AIX, HP-UX, Unixware, Sun and Solaris.

Replication initiation in eukaryotic cells occurs asynchronously throughout S phase, yielding early- and late-replicating regions of the genome, a process known as replication timing (RT). RT changes during development to ensure accurate genome duplication and maintain genome stability. To understand the relative contributions that cell lineage, cell cycle, and replication initiation regulators have on RT, we utilized the powerful developmental systems available in Drosophila melanogaster. We generated and compared RT profiles from mitotic cells of different tissues and from mitotic and endocycling cells of the same tissue. Our results demonstrate that cell lineage has the largest effect on RT, whereas switching from a mitotic to an endoreplicative cell cycle has little to no effect on RT. Additionally, we demonstrate that the RT differences we observed in all cases are largely independent of transcriptional differences. We also employed a genetic approach in these same cell types to understand the relative contribution the eukaryotic RT control factor, Rif1, has on RT control. Our results demonstrate that Rif1 can function in a tissue-specific manner to control RT. Importantly, the Protein Phosphatase 1 (PP1) binding motif of Rif1 is essential for Rif1 to regulate RT. Together, our data support a model in which the RT program is primarily driven by cell lineage and is further refined by Rif1/PP1 to ultimately generate tissue-specific RT programs.

During meiotic prophase, concurrent transcription, recombination, and chromosome synapsis place substantial topological strain on chromosomal DNA, but the role of topoisomerases in this context remains poorly defined. Here, we analyzed the roles of topoisomerases I and II (Top1 and Top2) during meiotic prophase in Saccharomyces cerevisiae. We show that both topoisomerases accumulate primarily in promoter-containing intergenic regions of actively transcribing genes, including many meiotic double-strand break (DSB) hotspots. Despite the comparable binding patterns, top1 and top2 mutations have different effects on meiotic recombination. TOP1 disruption delays DSB induction and shortens the window of DSB accumulation by an unknown mechanism. By contrast, temperature-sensitive top2-1 mutants exhibit a marked delay in meiotic chromosome remodeling and elevated DSB signals on synapsed chromosomes. The problems in chromosome remodeling were linked to altered Top2 binding patterns rather than a loss of Top2 catalytic activity, and stemmed from a defect in recruiting the chromosome remodeler Pch2/TRIP13 to synapsed chromosomes. No chromosomal defects were observed in the absence of TOP1. Our results imply independent roles for Top1 and Top2 in modulating meiotic chromosome structure and recombination.

The proteostasis network is regulated by transcellular communication to promote health and fitness in metazoans. In Caenorhabditis elegans, signals from the germline initiate the decline of proteostasis and repression of cell stress responses at reproductive maturity, indicating that commitment to reproduction is detrimental to somatic health. Here we show that proteostasis and stress resilience are also regulated by embryo-to-mother communication in reproductive adults. To identify genes that act directly in the reproductive system to regulate somatic proteostasis, we performed a tissue targeted genetic screen for germline modifiers of polyglutamine aggregation in muscle cells. We found that inhibiting the formation of the extracellular vitelline layer of the fertilized embryo inside the uterus suppresses aggregation, improves stress resilience in an HSF-1-dependent manner, and restores the heat-shock response in the somatic tissues of the parent. This pathway relies on DAF-16/FOXO activation in vulval tissues to maintain stress resilience in the mother, suggesting that the integrity of the embryo is monitored by the vulva to detect damage and initiate an organismal protective response. Our findings reveal a previously undescribed transcellular pathway that links the integrity of the developing progeny to proteostasis regulation in the parent.

Crystal Palace winger Andros Townsend says the Premier League season must finish in order to maintain the integrity of the competition.

Ahead of Monday's crunch meeting of top-flight shareholders, the Hornets have joined Brighton and Aston Villa in making their opposition to the current 'Project Restart' plans clear

Former footballer, AFP assistant commissioner and ASADA boss David Sharpe says his first challenge at the newly former Sport Integrity Australia will be to tackle organised crime.

The Energy and Commerce Committee today announced a Health Subcommittee Hearing for Thursday, May 14, entitled “Protecting Scientific Integrity in the COVID-19 Response.”  The hearing notice follows this note to the media.   NOTE TO THE MEDIA: Due to COVID-19, the Committee will make every effort to adhere to the safety recommendations from the Centers for Disease Control and Prevention (CDC) and the Attending Physician.  Therefore, media access will be limited.  Please contact your respective gallery for details.  As always, congressional press credentials will be required.   May 7, 2020   HEARING  NOTICE   TO:                      Members of the Subcommittee on Health FROM:                Anna G. Eshoo, Chairwoman SUBJECT:           Subcommittee Hearing on “Protecting Scientific Integrity in the COVID-19 Response” The Subcommittee on Health of the Committee on Energy and Commerce will hold a hearing on Thursday, May 14, 2020, at 10 a.m. in the John D. Dingell Room, 2123 of the Rayburn House Office Building.  The hearing is entitled, “Protecting Scientific Integrity in the COVID-19 Response.”  Witnesses will be by invitation only.  Among the witnesses invited to testify is Dr. Rick A. Bright, former Director of the Biomedical Advanced Research and Development Authority. The logistics of this hearing will be different due to the current circumstances of conducting a public hearing during the COVID-19 pandemic.  Members will be advised regarding specifics on hearing procedures and briefings as soon as they become finalized. If you have any questions, please contact Meghan Mullon with the Committee staff at (202) 225-2927. The U.S. House of Representatives Office Buildings and the U.S. Capitol Complex are currently closed to the public.  Official meetings of the Committee and its subcommittees are broadcast and available on the Committee’s website:  www.energycommerce.house.gov. ###

The Subcommittee on Health of the Committee on Energy and Commerce will hold a hearing on Thursday, May 14, 2020, at 10 a.m. in the John D. Dingell Room, 2123 of the Rayburn House Office Building. The hearing is entitled, “Protecting Scientific Integrity in the COVID-19 Response.”  

"We come here for two reasons: To celebrate what has been accomplished since Global Forum One; and – more important -- to recommit ourselves to the task that remains -- the task of fighting corruption wherever it manifests itself. We have made progress in this fight -- but we must do more."

"Over the last few decades – and, especially, in recent years – your efforts have become essential not only in making the organizations you serve more efficient, more effective, and more accountable – but also in preserving the principles that define who we are, and must continue to be – both as a government, and as a people," said Attorney General Holder.

Yokogawa Electric Corporation (TOKYO: 6841) announces the November 14 release of Plant Resource Manager (PRM) R4.03, the latest version of a software package in the OpreX Asset Management and Integrity family that facilitates the monitoring and control of plant operations by centralizing the management of large volumes of data from instrumentation and manufacturing equipment. PRM R4.03 features powerful device diagnostic functions that help to optimize plant maintenance and ensure safe operations.

Much has been written, and rightly so, about the potential that artificial intelligence (AI) can be used to create and promote misinformation. But there is a less well-recognized but equally important application for AI in helping to detect misinformation and limit its spread. This dual role will be particularly important in geopolitics, which is closely…

• Scott Duxbury: ‘How is there any semblance of fairness?’
• League would ‘bear no resemblance to the one we started’

Watford have joined Aston Villa and Brighton in voicing objections to the Premier League’s plan to play out the season at neutral venues on police advice, claiming it would be unfair to relegate clubs on the basis of a competition that “bears no resemblance to the one that was started”.

Sitting just above the bottom three when the league was suspended and uncomfortably aware Villa could leapfrog them if they play and win their game in hand, Watford were due to play five of their remaining nine fixtures at Vicarage Road and feel that being deprived of home advantage could affect the number of points they gather.

The South African Revenue Service announced on October 30 that it had paid over ZAR120bn (USD8.4bn) in refunds across all tax types in the last seven months, from the beginning of April of the tax season to date.

On 8 June 2012 an International Seminar on « Ensuring Transparency and Integrity in Lobbying : Towards a Regulatory Framework » will take place in Moscow, Russia.

This brochure describes the multiple domains where the OECD is engaged in fighting corruption and boosting integrity. It relates how the CleanGovBiz initiative is drawing together for the first time these anti-corruption tools under a single umbrella.

As part of OECD Integrity Week 2019 (18-22 March), this event will bring together international experts to discuss these issues of integrity, transparency and trust in the tax system, and the research, tools and approaches needed to identify and implement policies to increase tax morale.

This brochure describes the multiple domains where the OECD is engaged in fighting corruption and boosting integrity. It relates how the CleanGovBiz initiative is drawing together for the first time these anti-corruption tools under a single umbrella.

Integrity Week is an annual event organised by the OECD and its CleanGovBiz Initiative to actively support governments and organisations in their efforts to strengthen integrity, build trust, and fight corruption.