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Integrity Week is an annual event organised by the OECD and its CleanGovBiz Initiative to actively support governments and organisations in their efforts to strengthen integrity, build trust, and fight corruption.

This brochure describes the multiple domains where the OECD is engaged in fighting corruption and boosting integrity. It relates how the CleanGovBiz initiative is drawing together for the first time these anti-corruption tools under a single umbrella.

A series of high-level public events and committee meetings addressing the issue of integrity and anti-corruption take place at the OECD during the week of 22-26 April 2013.

The 2013 Forum on Integrity brought together high-level government, business and civil society representatives to exchange and discuss best practices in implementing integrity.

The Forum addressed key challenges in designing and implementing a system that ensures compliance in a cost-effective way.

How can we earn back the trust of young people? Improving openness, transparency, accountability, and access to information is essential. On the occasion of the International Anti-Corruption Day and Transparency International’s 20th Anniversary, the OECD and Transparency International are inviting young people for a discussion about how to push the integrity agenda forward together.

The Government of Mexico have requested an OECD Integrity Review focusing on anti-corruption, conflict of interest prevention and integrity in the public service.

Integrity Week is an annual event organised by the OECD and its CleanGovBiz Initiative to actively support governments and organisations in their efforts to strengthen integrity, build trust, and fight corruption.

The OECD welcomed the legislative package on democratic regeneration recently approved by the Spanish Parliament in order to fight corruption and promote both integrity and transparency in political activities and institutions.

Uzbekistan has adopted its first anti-corruption action plan and established an anti-corruption coordination commission. Nevertheless corruption is widespread in Uzbekistan and remains a key obstacle for business.

This report takes stock of corporate practices tying business integrity considerations into corporate governance frameworks, strategy and operations. It also assesses what factors influence business decisions to implement business integrity measures in practice. This report is a timely response to a succession of disturbing corporate scandals to which no industry or country appears to be immune.

International trade is a motor of the global economy and represents increasingly large volumes of exchanged goods, services, and financial flows. Yet, corruption in the trade chain hampers economic activity and entails important health and safety risks for societies.The 2016 OECD Integrity Forum will put the spotlight on this hidden tariff.

This study explores what governments, business associations, NGOs, and companies do in order to strengthen business integrity with a particular focus on anti-corruption measures in and for the private sector in countries in Eastern Europe and Central Asia, as well as in selected other countries.

Corruption and abuse of public office are a blight on democracies and a drain on public finances. With trust in government flagging in many countries and voter disillusionment on the rise, raising standards of integrity is more important than ever.

The 2017 OECD Global Anti-Corruption and Integrity Forum will tackle issues related to fair competition and economic growth, the inequality gap, a level playing field for business, the public interest in policy making and trust in government and politics

An independent group of leading anti-corruption and integrity experts recommends doing more to enforce and develop anti-corruption standards and enhancing collaboration with other international organisations in a report on ways the OECD can strengthen its vital work in combating bribery and promoting integrity.

Combatting corruption and restoring trust in institutions by upholding the principles of public integrity will be at the heart of a major conference in Athens from 11-12 July 2017.

This report provides a map for strengthening the OECD’s work in combating corruption and promoting integrity. It will help to guide reflection on current and future work, with a view to ensuring that the Organisation's anti-corruption and integrity policies are more coherent, more globally relevant and impactful.

The International Partnership against Corruption in Sport (IPACS), a recently established multi-stakeholder platform, agreed to set up three taskforces to help tackle corruption in sport at its meeting at the OECD in Paris on 14 to 15 December 2017.

Ukraine has taken ambitious steps to tackle bribery and corruption across government, including public procurement and, law enforcement. It should now step up its efforts to tackle integrity risks and violations in education, such as unmerited grades, misappropriated school funds, and preferential access to schools and study programmes - according to a new OECD report.

Liza Botros MD., Manon C. A. Pronk PhD., Jenny Juschten MD., John Liddle, Sofia K. S. H. Morsing, Jaap D. van Buul PhD., Robert H. Bates, Pieter R. Tuinman MD. PhD., Jan S. M. van Bezu, Stephan Huveneers PhD., Harm Jan Bogaard MD. PhD., Victor W. M. van Hinsbergh PhD., Peter L. Hordijk PhD., and Jurjan Aman MD. PhD.

Aims: Endothelial barrier dysfunction leads to edema and vascular leak, carrying high morbidity and mortality. Previously, Abl kinase inhibition was shown to protect against vascular leak. Using the distinct inhibitory profiles of clinically available Abl kinase inhibitors, we aimed to provide a mechanistic basis for novel treatment strategies against vascular leakage syndromes.

Methods & Results: Bosutinib most potently protected against inflammation-induced endothelial barrier disruption. In vivo, bosutinib prevented LPS-induced alveolar protein extravasation in an acute lung injury mice model. Mechanistically, Mitogen-activated Protein 4 Kinase 4 (MAP4K4) was identified as important novel mediator of endothelial permeability, which signals via ezrin, radixin and moesin proteins to increase turnover of integrin-based focal adhesions. The combined inhibition of MAP4K4 and Arg by bosutinib preserved adherens junction integrity and reduced turnover of focal adhesions, which synergistically act to stabilize the endothelial barrier during inflammation.

Conclusion: MAP4K4 was identified as important regulator of endothelial barrier integrity, increasing focal adhesion turnover and disruption of cell-cell junctions during inflammation. Inhibiting both Arg and MAP4K4, the clinically available drug bosutinib may form a viable strategy against vascular leakage syndromes.

Hem Sapkota, Jonathan D. Wren, and Gary J. Gorbsky

Centrosomes focus microtubules to promote mitotic spindle bipolarity, a critical requirement for balanced chromosome segregation. Comprehensive understanding of centrosome function and regulation requires a complete inventory of components. While many centrosome components have been identified, others may yet remain undiscovered. We have used a bioinformatics approach, based on "guilt by association" expression to identify novel mitotic components among the large group of predicted human proteins that have yet to be functionally characterized. Here we identify Chondrosarcoma-Associated Gene 1 (CSAG1) in maintaining centrosome integrity during mitosis. Depletion of CSAG1 disrupts centrosomes and leads to multipolar spindles more effectively in cells with compromised p53 function. Thus, CSAG1 may reflect a class of "mitotic addiction" genes whose expression is more essential in transformed cells.

All stakeholders in the scientific research enterprise -- researchers, institutions, publishers, funders, scientific societies, and federal agencies – should improve their practices and policies to respond to threats to the integrity of research, says a new report from the National Academies of Sciences, Engineering, and Medicine.

Providing financial support to "one family at a time"

Customer data management solution cleans and enriches dynamics data and provides actionable insights

The National Thoroughbred Racing Association (NTRA) Safety and Integrity Alliance today released a document outlining best practices for North American racetracks determined to prioritize the health and safety of all participants and employees, when conducting live racing in a spectator-free environment in the midst of the COVID-19 pandemic. The comprehensive document will assist racetracks that […]

The post NTRA Safety And Integrity Alliance Releases Best Practices For Spectator-Free Racing appeared first on Horse Racing News | Paulick Report.

The present disclosure includes apparatus (e.g., computing systems, memory systems, controllers, etc.) and methods for providing data integrity. One or more methods can include, for example: receiving a number of sectors of data to be written to a number of memory devices; appending first metadata corresponding to the number of sectors and including first integrity data to the number of sectors, the first metadata has a particular format; generating second integrity data to be provided in second metadata, the second integrity data corresponding to at least one of the number of sectors (wherein the second metadata has a second format); and generating third integrity data to be provided in the second metadata, the third integrity data including error data corresponding to the second integrity data and the at least one of the number of sectors.

The present invention provides a method of testing the integrity of a microporous membrane using a colloid solution containing metal particles or metal compound particles that can accurately determine the integrity of a virus removal membrane formed of hydrophilized synthetic polymer that has been subjected to protein solution filtration, and to provide a method of producing the colloid solution. The colloid solution comprises a solvent and metal particles dispersed in the solvent, and the solvent comprises components (A) and (B), (A) and (C), or (A), (B), and (C), wherein the component (A) is an anionic polymer having a sulfonic acid group, the component (B) is at least one nonionic surfactant selected from the group consisting of a nonionic surfactant having a polycyclic structure in a hydrophobic moiety and a polyoxyethylene sorbitan fatty acid ester, and the component (C) is a water-soluble polymer having a pyrrolidone group.

The subject matter disclosed herein relates to determining whether a reported position of a wireless transmitter is sufficiently accurate in accordance with an accuracy metric based at least in part on a calculated range between an estimated position of a mobile station and the reported position and also based at least in part on one or more measurements taken from one or more signals transmitted by the wireless transmitter.

A train system that includes a plurality of train units including a first train unit and second train unit coupled together. Each first and second train unit includes a controller configured to detect a change in train configuration of the train units, and comprising a plurality of inputs; train integrity signal lines spanning each train unit and coupled with the controller at the plurality of inputs and configured to transmit signals between a front end and a rear end of the train system, the signals indicating a status of train integrity of the train system; and a plurality of relays in communication with the controller, and configured to indicate a coupling or non-coupling status of each train unit.

A sealing tube is wrapped around the rim and inflated such as to seal the gap between tire and rim if the seal between the tire bead and rim has lost its integrity. After this, the tire can be inflated to specified pressure at a slow rate using a portable compressor. The repair can be done at roadside on any vehicle using inflatable tires usually without demounting the wheel or even jacking up the defective wheel.

Fertilizer granules and methods of producing fertilizer granules. The fertilizer granules are formed from a fertilizer composition, such as a phosphate fertilizer, includes a fibrous material for the purpose of increasing the granule strength preventing or reducing attrition or dusting formation during storage, transport, and/or handling of the fertilizer. Dust formation can be reduced fifty percent or more. The base fertilizer composition can include a phosphate fertilizer, such as monoammonium phosphate (MAP) or diammonium phosphate (DAP), and optionally one or more micronutrients or secondary nutrients, such as elemental sulfur. The fibrous material is pulp or paper sludge, for example.

Various systems and methods for implementing fuse-based integrity protection are described herein. A system for validating a read-only memory (ROM), the system comprising a ROM reader logic, implemented at least partly in hardware, to: access a read-only memory (ROM) having a plurality of permanently programmable electric couplings (PPECs), the PPECs having been programmed; survey a number of permanently altered PPECs in the set of PPECs to produce a counter value; read a binary representation of the counter value from PPEC values stored as a PPEC signature; and read a binary representation of the binary complement of the counter value from PPEC values in the PPEC signature; and a ROM validation logic, implemented at least partly, in hardware, to verify the integrity of the ROM using a combination of at least two of: the counter value, the binary representation of the counter value, and the binary representation of the binary complement of the counter value.

Exemplary embodiments are disclosed of a climate control system that includes an igniter and a controller having an igniter relay. The controller senses a current level through the igniter and senses voltage between terminals of a second relay of the controller. In a given one of a plurality of operational phases of the system, the controller is configured to compare the sensed current level and sensed voltage to a current level and voltage associated with a specific condition of the igniter, igniter relay, or second relay in the given phase. Based on a result of the comparing, the controller is configured to distinguish between a failure of one of the relays and a failure of the igniter.

The NRL's integrity unit launches an investigation after a video posted on social media appears to show Melbourne Storm's Nelson Asofa-Solomona swinging punches during a brawl outside a nightclub.

A public servant improperly awarded, or attempted to influence, millions of dollars' worth of government contracts for the benefit of a close friend, an inquiry finds.

This page provides answers to frequently asked questions about Program Integrity issues for the second round of the 2009 negotiated rulemaking activities for higher education. This page provides information on credit hours.

DFT (Design for testing) Engineer: 4-6 years of experience Experience with Synopsys Toolset is mandatory. Scan insertion, Debug DRC, ATPG patterns Gate Level Simulation ( timing and no-timing) Knowledge in P1500 and JTAG is an advantage. Knowledge in MBIST is an advantage. Phy

Heterotrimeric G proteins mediate a variety of signaling processes by coupling G protein–coupled receptors to intracellular effector molecules. In Drosophila, the Gαq gene encodes several Gαq splice variants, with the Gαq1 isoform protein playing a major role in fly phototransduction. However, Gαq1 null mutant flies still exhibit a residual light response, indicating that other Gαq splice variants or additional Gq α subunits are involved in phototransduction. Here, we isolated a mutant fly with no detectable light responses, decreased rhodopsin (Rh) levels, and rapid retinal degeneration. Using electrophysiological and genetic studies, biochemical assays, immunoblotting, real-time RT-PCR, and EM analysis, we found that mutations in the Gαq gene disrupt light responses and demonstrate that the Gαq3 isoform protein is responsible for the residual light response in Gαq1 null mutants. Moreover, we report that Gαq3 mediates rhodopsin synthesis. Depletion of all Gαq splice variants led to rapid light-dependent retinal degeneration, due to the formation stable Rh1-arrestin 2 (Arr2) complexes. Our findings clarify essential roles of several different Gαq splice variants in phototransduction and retinal integrity in Drosophila and reveal that Gαq3 functions in rhodopsin synthesis.

Nica M. Borradaile
Dec 1, 2006; 47:2726-2737
Research Articles

Heterotrimeric G proteins mediate a variety of signaling processes by coupling G protein–coupled receptors to intracellular effector molecules. In Drosophila, the Gαq gene encodes several Gαq splice variants, with the Gαq1 isoform protein playing a major role in fly phototransduction. However, Gαq1 null mutant flies still exhibit a residual light response, indicating that other Gαq splice variants or additional Gq α subunits are involved in phototransduction. Here, we isolated a mutant fly with no detectable light responses, decreased rhodopsin (Rh) levels, and rapid retinal degeneration. Using electrophysiological and genetic studies, biochemical assays, immunoblotting, real-time RT-PCR, and EM analysis, we found that mutations in the Gαq gene disrupt light responses and demonstrate that the Gαq3 isoform protein is responsible for the residual light response in Gαq1 null mutants. Moreover, we report that Gαq3 mediates rhodopsin synthesis. Depletion of all Gαq splice variants led to rapid light-dependent retinal degeneration, due to the formation stable Rh1-arrestin 2 (Arr2) complexes. Our findings clarify essential roles of several different Gαq splice variants in phototransduction and retinal integrity in Drosophila and reveal that Gαq3 functions in rhodopsin synthesis.

Heterotrimeric G proteins mediate a variety of signaling processes by coupling G protein–coupled receptors to intracellular effector molecules. In Drosophila, the Gαq gene encodes several Gαq splice variants, with the Gαq1 isoform protein playing a major role in fly phototransduction. However, Gαq1 null mutant flies still exhibit a residual light response, indicating that other Gαq splice variants or additional Gq α subunits are involved in phototransduction. Here, we isolated a mutant fly with no detectable light responses, decreased rhodopsin (Rh) levels, and rapid retinal degeneration. Using electrophysiological and genetic studies, biochemical assays, immunoblotting, real-time RT-PCR, and EM analysis, we found that mutations in the Gαq gene disrupt light responses and demonstrate that the Gαq3 isoform protein is responsible for the residual light response in Gαq1 null mutants. Moreover, we report that Gαq3 mediates rhodopsin synthesis. Depletion of all Gαq splice variants led to rapid light-dependent retinal degeneration, due to the formation stable Rh1-arrestin 2 (Arr2) complexes. Our findings clarify essential roles of several different Gαq splice variants in phototransduction and retinal integrity in Drosophila and reveal that Gαq3 functions in rhodopsin synthesis.

Background: Functional magnetic resonance imaging (fMRI) studies have reported altered integrity of large-scale neurocognitive networks (NCNs) in dementing disorders. However, findings on specificity of these alterations in patients with Alzheimer’s disease (AD) and behavioral variant frontotemporal dementia (bvFTD) are still very limited. Recently, NCNs have been successfully captured using positron emission tomography (PET) with F18-fluordesoxyglucose (FDG). Methods: Network integrity was measured in 72 individuals (38 male) with mild AD, bvFTD, and healthy controls using a simultaneous resting state fMRI and FDG-PET. Indices of network integrity were calculated for each subject, network, and imaging modality. Results: In either modality, independent component analysis revealed four major NCNs: anterior default mode network (DMN), posterior DMN, salience network, and right central executive network (CEN). In fMRI data, integrity of posterior DMN was found to be significantly reduced in both patient groups relative to controls. In the AD group anterior DMN and CEN appeared to be additionally affected. In PET data, only integrity of posterior DMN in patients with AD was reduced, while three remaining networks appeared to be affected only in patients with bvFTD. In a logistic regression analysis, integrity of anterior DMN as measured with PET alone accurately differentiated between the patient groups. A correlation between indices of two imaging modalities was overall low. Conclusion: FMRI and FDG-PET capture partly different aspects of network integrity. A higher disease specificity of NCNs as derived from PET data supports metabolic connectivity imaging as a promising diagnostic tool.

Around 1 in 10 children and young people worldwide have mental health difficulties that substantially affect their lives. Child mental health services often concentrate on risk reduction, at the expense of the wider aspects of a child's wellbeing. As part of the high integrity healthcare series, this podcast focuses on novel ways of providing...

Diabetes triggers peripheral nerve alterations at a structural and functional level, collectively referred to as diabetic peripheral neuropathy (DPN). This work highlights the role of the liver X receptor (LXR) signaling pathway and the cross talk with the reactive oxygen species (ROS)–producing enzyme NADPH oxidase-4 (Nox4) in the pathogenesis of DPN. Using type 1 diabetic (T1DM) mouse models together with cultured Schwann cells (SCs) and skin biopsies from patients with type 2 diabetes (T2DM), we revealed the implication of LXR and Nox4 in the pathophysiology of DPN. T1DM animals exhibit neurophysiological defects and sensorimotor abnormalities paralleled by defective peripheral myelin gene expression. These alterations were concomitant with a significant reduction in LXR expression and increase in Nox4 expression and activity in SCs and peripheral nerves, which were further verified in skin biopsies of patients with T2DM. Moreover, targeted activation of LXR or specific inhibition of Nox4 in vivo and in vitro to attenuate diabetes-induced ROS production in SCs and peripheral nerves reverses functional alteration of the peripheral nerves and restores the homeostatic profiles of MPZ and PMP22. Taken together, our findings are the first to identify novel, key mediators in the pathogenesis of DPN and suggest that targeting LXR/Nox4 axis is a promising therapeutic approach.

afick is another file integrity checker, designed to be fast and fully portable between Unix and Windows platforms. It works by first creating a database that represents a snapshot of the most essential parts of your computer system. Then a user can run the script to discover all modifications made since the snapshot was taken (i.e. files added, changed, or removed). The configuration syntax is very close to that of aide or tripwire, and a graphical interface is provided.

afick is another file integrity checker, designed to be fast and fully portable between Unix and Windows platforms. It works by first creating a database that represents a snapshot of the most essential parts of your computer system. Then a user can run the script to discover all modifications made since the snapshot was taken (i.e. files added, changed, or removed). The configuration syntax is very close to that of aide or tripwire, and a graphical interface is provided.

afick is another file integrity checker, designed to be fast and fully portable between Unix and Windows platforms. It works by first creating a database that represents a snapshot of the most essential parts of your computer system. Then a user can run the script to discover all modifications made since the snapshot was taken (i.e. files added, changed, or removed). The configuration syntax is very close to that of aide or tripwire, and a graphical interface is provided.