illness California’s Indoor Heat Illness Prevention Regulation Takes Immediate Effect By www.littler.com Published On :: Fri, 26 Jul 2024 14:49:54 +0000 California’s indoor heat illness regulation, the first of its kind in the United States, is now in effect. New requirements apply to all indoor work areas where the temperature is 82° F or above, with few exceptions. Additional requirements apply for higher temperatures. California employers with any work settings that are covered by the new regulation should immediately develop indoor heat illness plans and provide training to their employees. Full Article
illness House Subcommittee Hearing Raises Concerns About Proposed Heat Illness Rule By www.littler.com Published On :: Thu, 01 Aug 2024 20:07:49 +0000 Felicia Watson discusses three concerns about a proposed OSHA rule that would protect indoor and outdoor workers from heat illness. SHRM View (Subscription required) Full Article
illness California’s New Indoor Heat Illness Prevention Regulation Is Already in Effect By www.littler.com Published On :: Mon, 29 Jul 2024 19:58:24 +0000 Full Article
illness Depression: A Treatable Illness - NIMH By www.assessmentpsychology.com Published On :: Tue, 30 Sep 2008 04:00:00 UTC A detailed description of the symptoms, causes, and treatments, with information on getting help and coping by the National Institute of Mental Health. Full Article
illness VIDEO: OSHA’s New National Emphasis Program on Heat Illness By www.roofingcontractor.com Published On :: Wed, 30 Oct 2024 09:00:00 -0400 With OSHA preparing rulemaking for heat injury prevention, now is the time to prepare your roofing company and crews to stay safe when the sun is blazing. Full Article
illness How Ancient Societies Viewed Mental Illness and the Horrific Treatments of That Time By www.discovermagazine.com Published On :: Wed, 18 Sep 2024 16:30:00 GMT When it comes to mental illness, we’ve come a long way since the days of superstition and sorcery. But we still have work to do. Full Article Mind
illness Smelling Illness: Volatile Organic Compounds as Neurological Disease Biomarkers By www.the-scientist.com Published On :: Wed, 23 Oct 2024 14:53:39 GMT Scientists advance Parkinson’s disease biomarker research one sniff at a time. Full Article Podcasts
illness Blueface's Artist Chrisean Rock Not Taking Slick Woods' Illness as Excuse for Starting Altercation By www.aceshowbiz.com Published On :: Thu, 06 May 2021 05:38:26 +0000 The 'Blue Girls Club' star cites her Christian faith as the reason why she didn't fight back when the model slapped Chrisean's phone out of her hand at a party. Full Article celebrity Slick Woods Chrisean Rock
illness Blueface's Artist Chrisean Rock Not Taking Slick Woods' Illness as Excuse for Starting Altercation By www.aceshowbiz.com Published On :: Thu, 06 May 2021 05:38:26 +0000 The 'Blue Girls Club' star cites her Christian faith as the reason why she didn't fight back when the model slapped Chrisean's phone out of her hand at a party. Full Article celebrity Slick Woods Chrisean Rock
illness Author Mary Beth Keane's 'Ask Again, Yes' Explores Addiction, Mental Illness And Forgiveness By www.gpbnews.org Published On :: Fri, 29 May 2020 20:47:28 +0000 Mary Beth Keane’s 2019 novel Ask Again, Yes was an instant New York Times bestseller, and is now out on paperback. The book follows the families of two New York City police officers who live next door to each other in a suburb north of the city – and a tragedy that divides them and their children over four decades. Full Article
illness Brockman’s Illness May Delay Tax Fraud Case By bernews.com Published On :: Thu, 08 Apr 2021 09:28:21 +0000 Robert Brockman – an American billionaire accused of allegedly “using a Bermuda-based family charitable trust and other offshore entities to hide assets from the Internal Revenue Service while failing to pay taxes” – has been admitted to a Houston hospital following an unspecified medical event, causing the case against him to face a possible setback. […] Full Article All Business Crime #BermudaBusiness #InternationalCrime #RobertBrockman #WorldNews
illness US must address addiction as an illness, not as a moral failing, Surgeon General says By www.bmj.com Published On :: Tuesday, November 22, 2016 - 11:25 Full Article
illness Is Scurvy Making a Comeback? Two Recent Cases Highlight How the Illness Can Appear in the Modern World By www.smithsonianmag.com Published On :: Wed, 23 Oct 2024 19:17:00 +0000 Scurvy diagnoses in Australia and Canada suggest doctors should consider testing for vitamin C deficiency in patients experiencing poverty, food insecurity and social isolation Full Article
illness Stay Cool, Hydrated, And Informed to Prevent Heat-Related Illness By news.delaware.gov Published On :: Wed, 01 Jun 2022 21:11:37 +0000 As temperatures soar into the high 80s this week and humidity rises, the Division of Public Health (DPH) reminds Delawareans how to avoid heat-related illnesses such as heat stroke, heat exhaustion, and heat cramps. Full Article Division of Public Health extreme heat heat exhaustion heat stroke hydration
illness Risk for Mental Illness Varies by Gender By www.medicinenet.com Published On :: Mon, 29 Aug 2022 00:00:00 PDT Title: Risk for Mental Illness Varies by GenderCategory: Health NewsCreated: 8/23/2011 11:00:00 AMLast Editorial Review: 8/23/2011 12:00:00 AM Full Article
illness Mental and Substance Disorders Major Cause of Nonfatal Illnesses By www.medicinenet.com Published On :: Mon, 29 Aug 2022 00:00:00 PDT Title: Mental and Substance Disorders Major Cause of Nonfatal IllnessesCategory: Health NewsCreated: 8/28/2013 7:35:00 PMLast Editorial Review: 8/29/2013 12:00:00 AM Full Article
illness Chronic Illness Can Plunge Young Adults Into Despair By www.medicinenet.com Published On :: Mon, 29 Aug 2022 00:00:00 PDT Title: Chronic Illness Can Plunge Young Adults Into DespairCategory: Health NewsCreated: 8/31/2017 12:00:00 AMLast Editorial Review: 9/1/2017 12:00:00 AM Full Article
illness Climate Change Raises Athletes' Risk of Heat Illness By www.medicinenet.com Published On :: Mon, 29 Aug 2022 00:00:00 PDT Title: Climate Change Raises Athletes' Risk of Heat IllnessCategory: Health NewsCreated: 8/27/2019 12:00:00 AMLast Editorial Review: 8/27/2019 12:00:00 AM Full Article
illness Health Tip: Mental Illness Warning Signs By www.medicinenet.com Published On :: Mon, 29 Aug 2022 00:00:00 PDT Title: Health Tip: Mental Illness Warning SignsCategory: Health NewsCreated: 8/29/2019 12:00:00 AMLast Editorial Review: 8/29/2019 12:00:00 AM Full Article
illness Family History of Mental Illness Ups Odds for Postpartum Depression By www.medicinenet.com Published On :: Tue, 23 Aug 2022 00:00:00 PDT Title: Family History of Mental Illness Ups Odds for Postpartum DepressionCategory: Health NewsCreated: 8/22/2022 12:00:00 AMLast Editorial Review: 8/23/2022 12:00:00 AM Full Article
illness Evidence-based management of symptoms in serious respiratory illness: what is in our toolbox? By err.ersjournals.com Published On :: 2024-10-30T01:30:15-07:00 Extract Living with a respiratory illness requires patients to manage a wide range of symptoms, many of which will worsen as a disease progresses. Breathlessness is a hallmark feature of respiratory conditions, occurring in almost all individuals with COPD and interstitial lung disease (ILD) [1, 2]. Cough is present in 78% of people with ILD and is frequently distressing, with physical, social and emotional impacts [1, 3]. Full Article
illness Multicomponent services for symptoms in serious respiratory illness: a systematic review and meta-analysis By err.ersjournals.com Published On :: 2024-10-30T01:30:15-07:00 Background People living with serious respiratory illness experience a high burden of symptoms. This review aimed to determine whether multicomponent services reduce symptoms in people with serious illness related to respiratory disease. Methods Electronic databases were searched to identify randomised controlled trials (RCTs) evaluating multicomponent services that enrolled patients due to symptoms, rather than underlying disease, and provided at least one nonpharmacological intervention. The primary outcome was chronic breathlessness and secondary outcomes were health-related quality of life (HRQoL), cough, fatigue and adverse events. At least two authors independently screened studies, assessed risk of bias and extracted data. Results Five RCTs, involving 439 patients, were included. In comparison to usual care, multicomponent services improved breathlessness mastery (Chronic Respiratory Questionnaire (CRQ) mastery scale, mean difference (MD) 0.43 points, 95% CI 0.20–0.67, three RCTs, 327 participants) and HRQoL (CRQ total score, MD 0.24 points, 95% CI 0.04–0.40, two RCTs, 237 participants). Fatigue did not improve with multicomponent services and no studies evaluated cough. No serious adverse events were reported. The one study evaluating mortality found increased survival in those accessing a multicomponent service. The certainty of evidence was very low, mainly due to detection and reporting bias. Conclusion Multicomponent services improve breathlessness mastery and HRQoL, with minimal risk. These findings support the use of multicomponent symptom-directed services for people living with serious respiratory illness. Full Article
illness The effect of graded exercise therapy on fatigue in people with serious respiratory illness: a systematic review By err.ersjournals.com Published On :: 2024-10-09T00:15:15-07:00 Background In adults with serious respiratory illness, fatigue is prevalent and under-recognised, with few treatment options. The aim of this review was to assess the impact of graded exercise therapy (GET) on fatigue in adults with serious respiratory illness. Methods Electronic databases were searched to identify randomised controlled trials (RCTs) testing GET (involving incremental increases in exercise from an established baseline) in adults with serious respiratory illness. The primary outcome was fatigue and secondary outcomes were health-related quality of life (HRQoL) and adverse events. Two authors independently screened for inclusion, evaluated risk of bias and extracted data. Results 76 RCTs were included with 3309 participants, most with a diagnosis of COPD or asthma. Reductions in fatigue measured by the Chronic Respiratory Disease Questionnaire fatigue domain score were demonstrated following GET consisting of aerobic with/without resistance training (mean difference (MD) 0.53 points, 95% CI 0.41–0.65, 11 RCTs, 624 participants) and GET using resistance training alone (MD 0.58 points, 95% CI 0.21–0.96, two RCTs, 82 participants) compared with usual care. Although the mean effect exceeded the minimal important difference, the lower end of the confidence intervals did not always exceed this threshold so the clinical significance could not be confirmed. GET consistently improved HRQoL in people with a range of chronic respiratory diseases on multiple HRQoL measures. No serious adverse events related to GET were reported. Conclusion GET may improve fatigue alongside consistent improvements in HRQoL in people with serious respiratory illness. These findings support the use of GET in the care of people with serious respiratory illness. Full Article
illness Breathing techniques to reduce symptoms in people with serious respiratory illness: a systematic review By err.ersjournals.com Published On :: 2024-10-30T01:30:15-07:00 Background In adults with serious respiratory illness, breathlessness is prevalent and associated with reduced health-related quality of life. The aim of this review was to assess the impact of breathing techniques on breathlessness in adults with serious respiratory illness. Methods Electronic databases were searched to identify randomised controlled trials testing breathing techniques (techniques that aim to alter the respiratory pattern, excluding respiratory muscle training) in people with serious respiratory illness. The primary outcome was breathlessness and secondary outcomes were health-related quality of life and adverse events. Two authors independently screened for inclusion, evaluated risk of bias and extracted data. Results 73 randomised controlled trials were included with 5479 participants, most with COPD or asthma. Breathing exercises (pursed lip and/or diaphragmatic breathing) reduced breathlessness measured by the modified Medical Research Council scale compared to usual care (mean difference (MD) –0.40 points, 95% CI –0.70– –0.11, eight studies, n=323), although the effect did not exceed the minimal important difference. Yoga breathing also improved modified Medical Research Council score compared to usual care (MD –1.05 points, 95% CI –2.45–0.35, three studies, n=175). Breathing techniques consistently improved health-related quality of life in people with COPD and asthma on multiple health-related quality of life measures in comparison to usual care, with effects that generally exceeded the minimal important difference. No adverse events related to breathing techniques were reported. Conclusion Breathing techniques may improve breathlessness, and consistently improve health-related quality of life, in people with serious respiratory illness. These findings support the use of breathing exercises in the care of people with serious respiratory illness. Full Article
illness Opioids for the palliation of symptoms in people with serious respiratory illness: a systematic review and meta-analysis By err.ersjournals.com Published On :: 2024-10-09T00:15:15-07:00 Background People living with serious respiratory illness experience a high burden of distressing symptoms. Although opioids are prescribed for symptom management, they generate adverse events, and their benefits are unclear. Methods We examined the efficacy and safety of opioids for symptom management in people with serious respiratory illness. Embase, MEDLINE and the Cochrane Central Register of Controlled Trials were searched up to 11 July 2022. Reports of randomised controlled trials administering opioids to treat symptoms in people with serious respiratory illness were included. Key exclusion criteria included <80% of participants having a nonmalignant lung disease. Data were extracted regarding study characteristics, outcomes of breathlessness, cough, health-related quality of life (HRQoL) and adverse events. Treatment effects were pooled using a generic inverse variance model with random effects. Risk of bias was assessed using the Cochrane Risk of Bias tool version 1. Results Out of 17 included trials, six were laboratory-based exercise trials (n=70), 10 were home studies measuring breathlessness in daily life (n=788) and one (n=18) was conducted in both settings. Overall certainty of evidence was "very low" to "low". Opioids reduced breathlessness intensity during laboratory exercise testing (standardised mean difference (SMD) –0.37, 95% CI –0.67– –0.07), but not breathlessness measured in daily life (SMD –0.10, 95% CI –0.64–0.44). No effects on HRQoL (SMD –0.42, 95% CI –0.98–0.13) or cough (SMD –1.42, 95% CI –3.99–1.16) were detected. In at-home studies, opioids led to increased frequency of nausea/vomiting (OR 3.32, 95% CI 1.70–6.51), constipation (OR 3.08, 95% CI 1.69–5.61) and drowsiness (OR 1.37, 95% CI 1.01–1.86), with serious adverse events including hospitalisation and death identified. Conclusions Opioids improved exertional breathlessness in laboratory exercise studies, but did not improve breathlessness, cough or HRQoL measured in daily life at home. There were significant adverse events, which may outweigh any benefits. Full Article
illness Mosquito-borne illnesses are spiking across the world By www.newscientist.com Published On :: Wed, 28 Aug 2024 23:22:46 +0100 Climate change is extending mosquito season and helping to drive outbreaks of dengue fever, Oropouche virus and eastern equine encephalitis Full Article
illness A sharp interrogation of why we retreat from other people's illnesses By www.newscientist.com Published On :: Wed, 09 Oct 2024 19:00:00 +0100 How well do we look after people who are seriously sick? Astonishingly, research is scant – which makes Neil Vickers and Derek Bolton's ambitious new book, Being Ill, very welcome Full Article
illness Poultry tops cost of illness estimates in Australia By www.foodsafetynews.com Published On :: Thu, 07 Nov 2024 05:03:00 +0000 Estimates on the cost of foodborne illness in Australia have revealed poultry is associated with the highest burden. In 2023, Food Standards Australia New Zealand (FSANZ) commissioned the University of Melbourne and the Australian National University to estimate the annual cost of foodborne illness caused by food commodities and pathogens.... Continue Reading Full Article Science & Research World Australia Campylobacter cost of illness Food Standards Australia New Zealand (FSANZ) Listeria poultry products Salmonella Toxoplasma Yersinia
illness Trump's plan for people struggling with mental illness, addiction and homelessness By www.npr.org Published On :: Tue, 12 Nov 2024 16:47:28 -0500 Trump wants to return to the use of mental institutions and proposes tent cities to deal with people who are unhoused and have mental illness. Experts say it's beyond the scope of federal authority. Full Article
illness Pakistan limits outdoor activities, market hours to curb air pollution-related illness By www.asiaone.com Published On :: Tue, 12 Nov 2024 10:21:25 +0800 LAHORE — Pakistan's Punjab province banned most outdoor activities and ordered shops, markets and malls in some areas to close early from Monday (Nov 11) to curb illnesses caused by intense air pollution. The province has closed educational institutions and public spaces like parks and zoos until Nov. 17 in places including Lahore, the world's most polluted city in terms of air quality, according to Swiss group IQAir's live ratings. The districts of Lahore, Multan, Faisalabad and Gujranwala have seen an unprecedented rise in patients with respiratory diseases, eye and throat irritation, and pink eye disease, the Punjab government said in an order issued late on Sunday. The new restrictions will also remain in force until Nov. 17. "The spread of conjunctivitis/ pink eye disease due to bacterial or viral infection, smoke, dust or chemical exposure is posing a serious and imminent threat to public health," the Punjab government said. Full Article
illness Civil war, mental illness, poverty, gang violence: the many roots of homelessness By www.newint.org Published On :: 2017-07-03T06:22:38-07:00 We talked to homeless in different countries and they revealed housing insecurity's different causes around the world. Full Article
illness Patient : the true story of a rare illness / Ben Watt. By encore.st-andrews.ac.uk Published On :: London : Bloomsbury, 2014. Full Article
illness Recasting care models for mental illness and homelessness By www.thehindu.com Published On :: Mon, 29 Jul 2024 00:16:00 +0530 An outline of a care paradigm and shift in mindset that advance the rights of homeless persons with mental illness Full Article Health
illness Reconceptualizing Mental Illness in the Viral Age [electronic resource] : Souls in the Machine / by Elliott B. Martin, Jr. By darius.uleth.ca Published On :: Newcastle upon Tyne : Cambridge Scholars Publishing, 2024. Full Article
illness Anti-viral drug trio found to shorten COVID-19 illness in mild cases: study - Yahoo News Australia By news.google.com Published On :: Fri, 08 May 2020 22:31:00 GMT Anti-viral drug trio found to shorten COVID-19 illness in mild cases: study Yahoo News AustraliaTriple antiviral drug shows early promise in COVID-19 trial msnNOWTriple combination of interferon beta-1b, lopinavir–ritonavir, and ribavirin in the treatment of patients admitted to hospital with COVID-19: an open-label, randomised, phase 2 trial The LancetNew triple antiviral drug combination shows early promise for treating COVID-19 in phase 2 randomized trial Medical XpressTriple anti-viral drug shows COVID-19 promise in Hong Kong study Al Jazeera EnglishView Full coverage on Google News Full Article
illness 3 New York Children Died From Rare Illness Tied To COVID-19: Governor By www.ndtv.com Published On :: Sat, 09 May 2020 22:28:01 +0530 Three children in New York have died from a rare inflammatory syndrome believed to be linked to the novel coronavirus, Governor Andrew Cuomo told a daily briefing on Saturday. Full Article World
illness UK Discrimination Law Review: Mental illness, culpability and gross misconduct By www.eversheds.com Published On :: 2015-02-03 Mental illness, culpability and gross misconduct A recent appeal case illustrates the difficulties that can arise when dealing with instances of apparent misconduct where a mental impairment could have affected an employees ability to control ... Full Article
illness Anti-viral drug trio found to shorten COVID-19 illness By feedproxy.google.com Published On :: Sun, 10 May 2020 06:00:00 +0500 PARIS: Researchers in Hong Kong have found that patients suffering milder illness caused by the new coronavirus recover more quickly if they are treated with a three-drug antiviral cocktail soon after symptoms appear.Authors of the study, published in the Lancet on Friday, described the findings... Full Article
illness Anti-viral drug trio found to shorten Covid-19 illness in mild cases By feedproxy.google.com Published On :: Sun, 10 May 2020 06:00:00 +0500 Paris: Researchers in Hong Kong have found that patients suffering milder illness caused by the new coronavirus recover more quickly if they are treated with a three-drug antiviral cocktail soon after symptoms appear. Authors of the study, published in the Lancet on Friday, described the findings... Full Article
illness Covid 19: Kids develop mysterious illness possibly tied to coronavirus By www.nzherald.co.nz Published On :: Sun, 10 May 2020 10:40:44 +1200 Critically ill children have been ending up in intensive care units with shock-like symptoms in recent weeks, adding yet another mysterious layer to the coronavirus pandemic. New York health officials began issuing alerts on... Full Article
illness New York warns of children's illness linked to Covid-19 after three deaths By www.theguardian.com Published On :: 2020-05-09T20:24:53Z State reports 73 cases of children falling severely ill with toxic shock-like reaction that has symptoms similar to Kawasaki diseaseCoronavirus – latest US updatesCoronavirus – latest global updatesThe deaths of three children in New York of inflammatory complications possibly linked to Covid-19 has prompted Andrew Cuomo, the state’s governor, to warn of “an entirely different chapter” of a disease that had been believed to cause only mild symptoms in children.The governor reported the first death, of a five-year old boy, on Friday. At his morning press conference on Saturday, Cuomo raised the number of fatalities to three, after the death of a seven-year-old and a teenager. Continue reading... Full Article Coronavirus outbreak Children US news Infectious diseases Society Medical research New York
illness Will Covid-19 survivors face a lifetime of illness like those who battled polio? By Published On :: Sun, 10 May 2020 00:11:41 +0100 Kirstin Coutney, pictured with her daughter Tilly, contracted Covid-19. The 49-year-old mother of two from Bath is still suffering crippling fatigue, six weeks after developing the virus. Full Article
illness Will Covid-19 survivors face a lifetime of illness like those who battled polio? By www.dailymail.co.uk Published On :: Sat, 09 May 2020 23:11:41 GMT Kirstin Coutney, pictured with her daughter Tilly, contracted Covid-19. The 49-year-old mother of two from Bath is still suffering crippling fatigue, six weeks after developing the virus. Full Article
illness Three New York Children Die from Rare Illness Tied to Covid-19, Says Governor Andrew Cuomo By www.news18.com Published On :: Sat, 9 May 2020 09:40:39 +0530 Cuomo had on Friday disclosed the death of a 5-year old linked to the coronavirus and a syndrome that shares symptoms with toxic shock and Kawasaki disease, which was the first known fatality tied to the rare illness in New York. Full Article
illness Scientists at a new National Zoo laboratory use DNA to diagnose illnesses and discover new species of animals By insider.si.edu Published On :: Thu, 30 Sep 2010 08:27:13 +0000 Researchers at the Smithsonian's National Zoo's new genetics lab use animal DNA to diagnose new diseases, discover new species help in conservation efforts and solve mysteries. The post Scientists at a new National Zoo laboratory use DNA to diagnose illnesses and discover new species of animals appeared first on Smithsonian Insider. Full Article Video conservation endangered species mammals new species reptiles Smithsonian's National Zoo veterinary medicine
illness Indoor Mold, Building Dampness Linked to Respiratory Problems and Require Better Prevention - Evidence Does Not Support Links to Wider Array of Illnesses By feedproxy.google.com Published On :: Tue, 25 May 2004 04:00:00 GMT Scientific evidence links mold and other factors related to damp conditions in homes and buildings to asthma symptoms in some people with the chronic disorder, as well as to coughing, wheezing, and upper respiratory tract symptoms in otherwise healthy people, says a new report from the Institute of Medicine of the National Academies. Full Article
illness New Report Finds Gulf War Illness Continues to Be Major Health Effect Linked to Persian Gulf War Military Service By feedproxy.google.com Published On :: Thu, 11 Feb 2016 06:00:00 GMT Although more than $500 million in federally funded research on Persian Gulf War veterans between 1994 and 2014 has produced many findings, there has been little substantial progress in the overall understanding of the health effects, particularly Gulf War illness, resulting from military service in the war, says a new report from the Institute of Medicine (IOM) of the National Academies of Sciences, Engineering, and Medicine. Full Article
illness NIOSH, BLS, and OSHA Should Strengthen Coordination for Occupational Injury, Illness, and Exposure Surveillance By feedproxy.google.com Published On :: Tue, 09 Jan 2018 06:00:00 GMT The National Institute for Occupational Safety and Health (NIOSH) should lead a collaborative effort with the U.S. Bureau of Labor Statistics (BLS), Occupational Safety and Health Administration (OSHA), and the states to establish and strengthen regional occupational safety and health surveillance programs, says a new report by the National Academies of Sciences, Engineering, and Medicine. Full Article
illness Will Antibodies After COVID-19 Illness Prevent Reinfection? By feeds.scpr.org Published On :: Thu, 07 May 2020 16:00:06 -0700 Richard Harris | NPRMost people infected with the novel coronavirus develop antibodies in response. But scientists don't know whether people who have been exposed to the coronavirus will be immune for life, as is usually the case for the measles, or if the disease will return again and again, like the common cold. "This to me is one of the big unanswered questions that we have," says Jeffrey Shaman, a professor of environmental health sciences at Columbia University, "because it really says, 'What is the full exit strategy to this and how long are we going to be contending with it?' " He's one of many scientists on a quest for answers. And the pieces are starting to fall into place. Antibodies, which are proteins found in the blood as part of the body's immune response to infection, are a sign that people could be developing immunity. But they are by no means a guarantee they will be protected for life – or even for a year. Shaman has been studying four other coronaviruses that cause the common cold. "They're very common and so people seem to get them quite often," Shaman says. Ninety percent of people develop antibodies to those viruses, at least in passing, but "our evidence is those antibodies are not conferring protection." That may simply because colds are relatively mild, so the immune system doesn't mount a full-blown response, suggests Dr. Stanley Perlman, a pediatrician who studies immunology and microbiology at the University of Iowa. "That's why people get colds over and over again," he says. "It doesn't really tickle the immune response that much." He's studied one of the most severe coronaviruses, the one that causes SARS, and he's found that the degree of immunity depended on the severity of the disease. Sicker people remained immune for much longer, in some cases many years. For most people exposed to the novel coronavirus, "I think in the short term you're going to get some protection," Perlman says. "It's really the time of the protection that matters." Perlman notes that for some people the symptoms of COVID-19 are no worse than a cold, while for others they are severe. "That's why it's tricky," he says, to predict the breadth of an immune response. And it's risky to assume that experiences with other coronaviruses are directly applicable to the new one. "Unforutunately, we cannot really generalize what kind of immunity is needed to get protection against a virus unless we really learn more about the virus," says Akiko Iwasaki, a Howard Hughes Medical Institute investigator at the Yale University School of Medicine. An immunobiologist, she is part of a rapidly expanding effort to figure this out. She and her colleagues are already studying the immune response in more than 100 patients in the medical school hospital. She's encouraged that most people who recover from the coronavirus have developed antibodies that neutralize the coronavirus in a petri dish. "Whether that's happening inside the body we don't really know," she cautions. Research like hers will answer that question, eventually. But not all antibodies are protective. Iwasaki says some can actually contribute to the disease process and make the illness worse. These antibodies can contribute to inflammation and lead the body to overreact. That overreaction can even be deadly. "Which types of antibodies protect the host versus those that enhance the disease? We really need to figure that out," she says. The studies at Yale will follow patients for at least a year, to find out how slowly or quickly immunity might fade. "I wish there was a shortcut," Iwasaki says, "but we may not need to wait a year to understand what type of antibodies are protective." That's because she and other immunologists are looking for patterns in the immune response that will identify people who have long-term immunity. Researchers long ago figured out what biological features in the blood (called biomarkers) correlate with immunity to other diseases, says Dr. Kari Nadeau, a pediatrician and immunologist at the Stanford University School of Medicine. She expects researchers will be able to do the same for the new coronavirus. Nadeau is working on several studies, including one that seeks to recruit 1,000 people who were previously exposed to the coronavirus. One goal is to identify people who produce especially strong, protective antibody responses. She says the antibody-producing cells from those people can potentially be turned into vaccines. Another critical question she's zeroing in on is whether people who become immune are still capable of spreading the virus. "Because you might be immune, you might have protected yourself against the virus," she says, "but it still might be in your body and you're giving it to others." That would have huge public health implications if it turns out people can still spread the disease after they've recovered. Studies from China and South Korea seemed to suggest this was possible, though further studies have cast doubt on that as a significant feature of the disease. Nadeau is also trying to figure out what can be said about the antibody blood-tests that are now starting to flood the market. There are two issues with these tests. First, a positive test may be a false-positive result, so it may be necessary to run a confirmatory test to get a credible answer. Second, it's not clear that a true positive test result really indicates a person is immune, and if so for how long. Companies would like to be able to use these tests to identify people who can return to work without fear of spreading the coronavirus. "I see a lot of business people wanting to do the best for their employees, and for good reason," Nadeau says. "And we can never say you're fully protected until we get enough [information]. But right now we're working hard to get the numbers we need to be able to see what constitutes protection and what does not." It could be a matter of life or death to get this right. Answers to these questions are likely to come with the accumulation of information from many different labs. Fortunately, scientists around the world are working simultaneously to find answers. You can contact NPR Science Correspondent Richard Harris at rharris@npr.org. Copyright 2020 NPR. To see more, visit https://www.npr.org. This content is from Southern California Public Radio. View the original story at SCPR.org. Full Article
illness How much does a good attitude matter when you're fighting a serious illness? By www.mnn.com Published On :: Mon, 24 Aug 2015 18:57:59 +0000 Experts are divided on the power of spirituality and an upbeat mindset. Full Article Fitness & Well-Being