Fr. Stephen De Young discusses Genesis Chapter 36

Fr. Stephen De Young discusses Genesis Chapter 37.

Parental Advisory: This episode may contain some adult themes Fr. Stephen De Young discusses the beginning of Genesis Chapter 38.

Parental Advisory: This episode may contain some adult themes. Fr. Stephen De Young discusses the ending of Genesis Chapter 38.

Fr. Stephen De Young discusses Genesis Chapter 39.

Fr. Stephen De Young discusses Genesis Chapters 40 and 41

Fr. Stephen De Young discusses Genesis Chapter 42.

Fr. Stephen De Young discusses Genesis Chapters 43 through 45.

Fr. Stephen De Young discusses Genesis Chapter 46.

Fr. Stephen De Young discusses Genesis Chapter 47.

Fr. Stephen De Young discusses Genesis Chapter 48.

Fr. Stephen De Young discusses Genesis Chapters 49 and 50.

Fr. Harry Pappas, priest at Archangel Orthodox Church in Stanford, Connecticut, and an adjunct professor at St. Vladimir's, leads the seminary's second annual Public Lenten Retreat. Titled "Back to Basics: Old Testament and Life," his presentation is divided into three parts, the first of which, "How Life Begins," can be heard here.

I have been reading liberal theology since my college days—i.e. theologies which deny many, most, or all of the major tenets of the traditional Christian Faith. The theologies are as many and as varied as their authors, but they all share a conviction that Jesus of Nazareth didn’t say and do all the things which the New Testament recorded that He said and did, that the Gospels are not to be trusted as history, and that therefore the basic dogmas of the historical Church are wrong. The late Bishop John Spong (inset) is a modern and sterling example.

Adding physical activity to your daily routine could lead to a longer life – regardless of genetic predisposition, say researchers at the University of California, San Diego.

The post Exploratory Studies to Investigate Mechanisms of HIV infection, Replication, Latency, and/or Pathogenesis in the Context of Substance Use Disorders (R01 Clinical Trial Not Allowed) [Letter of Intent Due Date: July 14] was curated by information for practice.

Many pundits call this movement Christian nationalism. But while it may seem like a phenomenon born out of our current political moment, it represents the culmination of various movements with roots that trace back decades. The more extreme elements didn’t just materialize a few years ago. They’ve been there from the start.

The post The Genesis of Christian Nationalism was curated by information for practice.

A research team has identified 2,586 orphan genes (OGs) in Rosa chinensis, offering new insights into the role of these unique genes in flower development, stress response, and environmental adaptation.

A research team has identified 2,586 orphan genes (OGs) in Rosa chinensis, offering new insights into the role of these unique genes in flower development, stress response, and environmental adaptation.

[Sports] :
South Korean golfer An Byeong-hun claimed his first DP World Tour victory in nine years, defeating compatriot Kim Joo-hyung on Sunday in a playoff on home soil.  At Jack Nicklaus Golf Club Korea in Incheon, during the final round of the 2024 Genesis Championship, An secured his second career win on the DP ...

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A key prerequisite for the successful application of protein crystallography in drug discovery is to establish a robust crystallization system for a new drug-target protein fast enough to deliver crystal structures when the first inhibitors have been identified in the hit-finding campaign or, at the latest, in the subsequent hit-to-lead process. The first crucial step towards generating well folded proteins with a high likelihood of crystallizing is the identification of suitable truncation variants of the target protein. In some cases an optimal length variant alone is not sufficient to support crystallization and additional surface mutations need to be introduced to obtain suitable crystals. In this contribution, four case studies are presented in which rationally designed surface modifications were key to establishing crystallization conditions for the target proteins (the protein kinases Aurora-C, IRAK4 and BUB1, and the KRAS–SOS1 complex). The design process which led to well diffracting crystals is described and the crystal packing is analysed to understand retrospectively how the specific surface mutations promoted successful crystallization. The presented design approaches are routinely used in our team to support the establishment of robust crystallization systems which enable structure-guided inhibitor optimization for hit-to-lead and lead-optimization projects in pharmaceutical research.

Genesee Brewery announced its first official sum-all beer: Genesee Black Cherry Vanilla Kellerbier.

Stunning handmade 2D and 3D fiction NFTs with a Tremendous storyline

In a Time of Loss, Let Us Build to Heal- From Numbers to Names, Abraham I Am Calls for a Wall of Unity and Peace from Covid-19

Slightly Acidic Electrolyzed Water Produces 6-log reduction in L. Mono

New Peer Reviewed Science Links Increasing Incidence of Lymphatic Cancers to COVID-19 Virus as well as the mRNA Vaccines

Resident Selectress Iriela, New York based DJ & producer will bang the party alongside an all star lineup from around the world! April 13, guest Yukiko from Chicago joins the party. The event kicks off at 9pm at Ace Hotel New York!

A spatiotemporal proteomic map of human adipogenesis  Nature.com

Proteomics approach to discovering non-invasive diagnostic biomarkers and understanding the pathogenesis of endometriosis: a systematic review and meta-analysis  Journal of Translational Medicine

In this hour, stories from the double helix -- genetic makeup, inherited disease, and family secrets. It's all in the DNA. This hour is hosted by Moth Artistic Director Catherine Burns. The Moth Radio Hour is produced by The Moth and Jay Allison of Atlantic Public Media.

Storytellers: 

Mike Birbiglia works to get healthy and mitigate his bad genes.

Carmen Rita Wong uncovers the complicated layers of her family's past.

Beth Bucher makes a hard decision to protect her health.

When applying for a green card, Paul Nurse discovers a family secret.

Podcast: 649

Era un diógenes intenso pero no repugnante El piso estaba atestado de blisters de medicinas, de bolsas de El Corte Inglés llenas de papeles y de objetos absurdos, pero no olía a muerte ni a miseria Leer

Manolín, como era conocido, pasó toda su vida profesional en Efe, buena parte de ella durante la Transición, cubriendo la actividad parlamentaria y política del país y siguiendo también a la Casa Real Leer

En Familia, discutimos las implicaciones de utilizar imágenes de niños en publicidad.

El expresidente de la CUT Diógenes Orjuela recalcó la "falta de atención y negociación con los sindicatos" por parte del gobierno. 

Genesis Lynea has been cast in the latest series of the global hit television series Dr Who. The 34-year-old, who has had starring roles in Death in Paradise, Casualty, Shadow and Bone, and Silent Witness, will join the upcoming series of the BBC sci-fi show. In the latest issue of Doctor Who magazine, showrunner Russell […]

Mohamad Navab
Jun 1, 2004; 45:993-1007
Thematic Reviews

Weerapan Khovidhunkit
Jul 1, 2004; 45:1169-1196
Thematic Reviews

IJ Goldberg
Apr 1, 1996; 37:693-707
Reviews

Lorin Crawford explains how he uses math to analyze interactions between genes. Your DNA (the biological instruction manual in all of your cells) contains a mind-boggling amount of information represented in roughly 20,000 genes that encode proteins, plus a similar number of genes with other functions. As the cost of analyzing an individual's DNA has plummeted, it has become possible to search the entire human genome for genetic variants that are associated with traits such as height or susceptibility to certain diseases. Sometimes, one gene has a straightforward impact on the trait. But in many cases, the effect of one gene variant depends on which variants of other genes are present, a phenomenon called "epistasis." Studying such interactions involves huge datasets encompassing the DNA of hundreds of thousands of people. Mathematically, that requires time-intensive calculations with massive matrices and a good working knowledge of statistics.

Madison T Wright
Nov 18, 2020; 0:RA120.002168v1-mcp.RA120.002168
Research

Mingkun Yang
Nov 24, 2020; 0:RA120.002144v1-mcp.RA120.002144
Research

Qin Zhang
Nov 17, 2020; 0:RA120.002325v1-mcp.RA120.002325
Research

Kailun Fang
Nov 30, 2020; 0:RA120.002081v1-mcp.RA120.002081
Research

Priyanka Tripathi
Dec 30, 2020; 0:jlr.RA120001190v1-jlr.RA120001190
Research Articles

Melissa Gómez
Dec 1, 2020; 61:1658-1674
Research Articles

Jiayan Guo
Dec 1, 2020; 61:1764-1775
Research Articles

Microtubules are polymers composed of αβ-tubulin subunits that provide structure to cells and play a crucial role in in the development and function of neuronal processes and cilia, microtubule-driven extensions of the plasma membrane that have sensory (primary cilia) or motor (motile cilia) functions. To stabilize microtubules in neuronal processes and cilia, α tubulin is modified by the posttranslational addition of an acetyl group, or acetylation. We discovered that acetylated tubulin in microtubules interacts with the membrane sphingolipid, ceramide. However, the molecular mechanism and function of this interaction are not understood. Here, we show that in human iPS cell-derived neurons, ceramide stabilizes microtubules, which indicates a similar function in cilia. Using proximity ligation assays, we detected complex formation of ceramide with acetylated tubulin in C. reinhardtii flagella and cilia of human embryonic kidney (HEK293T) cells, primary cultured mouse astrocytes, and ependymal cells. Using incorporation of palmitic azide and click chemistry-mediated addition of fluorophores, we show that a portion of acetylated tubulin is S-palmitoylated. S-palmitoylated acetylated tubulin is colocalized with ceramide-rich platforms (CRPs) in the ciliary membrane, and it is coimmunoprecipitated with Arl13b, a GTPase that mediates transport of proteins into cilia. Inhibition of S-palmitoylation with 2-bromo palmitic acid or inhibition of ceramide biosynthesis with fumonisin B1 reduces formation of the Arl13b-acetylated tubulin complex and its transport into cilia, concurrent with impairment of ciliogenesis. Together, these data show, for the first time, that CRPs mediate membrane anchoring and interaction of S-palmitoylated proteins that are critical for cilium formation, stabilization, and function.