deno

Targeting adenosine in SSc




deno

Genetic and clinical correlates of entosis in pancreatic ductal adenocarcinoma




deno

Adenomyoepithelial tumors of the breast: molecular underpinnings of a rare entity




deno

Antibody-free enzyme-assisted chemical approach for detection of <i>N</i><sup>6</sup>-methyladenosine




deno

Molecular profiling of stroma highlights stratifin as a novel biomarker of poor prognosis in pancreatic ductal adenocarcinoma




deno

The expression of YAP1 is increased in high-grade prostatic adenocarcinoma but is reduced in neuroendocrine prostate cancer




deno

Oncolytic adenovirus encoding LIGHT (TNFSF14) inhibits tumor growth via activating anti-tumor immune responses in 4T1 mouse mammary tumor model in immune competent syngeneic mice




deno

Node 14.2.0, plus Deno 1.0 is coming

#337 — May 7, 2020

Read on the Web

✍️ With a few of the links today, this is a good time to note we sometimes link to things we disagree with or that are controversial if they are newsworthy or of relevance to our community. Inclusion is not always endorsement but you can read any summaries we write alongside items to get our take on things ????

Node Weekly

Node v14.2.0 (Current) Released — The latest version of Node gains a new experimental way — assert.CallTracker — to track and verify function calls and the amount of times they occur. Also, require('console').Console now supports different group indentations

Node.js

Deno 1.0: What You Need to Know — Two years ago Ryan Dahl, the original creator of Node, gave a popular talk called 10 Things I Regret About Node.js where he revealed Deno, his prototype of how he'd build a better V8-based JavaScript runtime. With 1.0 due next week, Deno is poised to be a particularly exciting release and this article does a good job of cruising through the reasons why.

David Else

Enhance Node.js Performance with Datadog APM — Debug errors and bottlenecks in your code by tracing requests across web servers and services in your environment. Then correlate between distributed request traces, metrics, and logs to troubleshoot issues without switching tools or contexts. Try Datadog APM free.

Datadog APM sponsor

Deno Weekly: Our Newest Newsletter — We really like what we see from Deno (above) so far, so we're launching a new newsletter all about it! ???? Rather than keep mentioning Deno in Node Weekly, we'll be giving it its own space. Even if you're not planning to use Deno, feel free to subscribe for a while, see what happens, then unsubscribe if it doesn't suit you — the next issue will drop on 1.0's release (due next Wednesday).

Cooperpress

Controlling GUIs Automatically with Nut.js — Write Node code that clicks on things, opens apps, types, clicks buttons, etc. Works on Windows, macOS and Linux. Hit the GitHub repo to learn more or check out some examples.

Simon Hofmann

A Practical Guide to Node Buffers — You’ll often encounter Buffer objects for holding binary data in the form of a sequence of bytes during interactions with the operating system, working with files, network transfers, etc.

DigitalOcean

???? Jobs

Node.js Developer at X-Team (Remote) — Join X-Team and work on projects for companies like Riot Games, FOX, Coinbase, and more. Work from anywhere.

X-Team

Find a Job Through Vettery — Vettery specializes in tech roles and is completely free for job seekers. Create a profile to get started.

Vettery

ℹ️ If you're interested in running a job listing in this newsletter, there's more info here.

???? Articles & Opinions

How to Build a REST Service with Fastify — How to build a basic RESTful service using Fastify, a popular Node Web framework focused on performance/low overheads.

Wisdom Ekpot

▶  How to Use Node.js for Load Testing — A straightforward tour of an approach for hitting a Web site over and over from multiple child processes.

Tom Baranowicz

How to Fix ESLint Errors Upon Save in VS Code — A quick fire tip.

David Walsh

Faster CI/CD for All Your Software Projects Using Buildkite — See how Shopify scaled from 300 to 1800 engineers while keeping their build times under 5 minutes.

Buildkite sponsor

Avoiding Memory Leaks in Node: Best Practices for Performance — Covers very similar ground to another memory leak article we linked recently.

Deepu K Sasidharan

'Some thoughts on the npm acquisition..' — The creator of Hapi and an investor in npm Inc. shared his thoughts on GitHub’s acquisition of npm. I disagree with his conclusion (and his views have also caused concern on Twitter) but it’s nonetheless interesting to get views from behind the curtain.

Eran Hammer

???? Tools, Resources and Libraries

npm 6.14.5 Released — Just a couple of minor bug fixes.

The npm Blog

actions-cli: Monitor Your GitHub Actions in Real Time from the Command Line

Tommaso De Rossi

SQL Template Tag: Tagged Template Strings for Preparing SQL Statements — For use with pg and mysql, for example.

Blake Embrey

webpack-blocks: Configure webpack using Functional Feature Blocks

Andy Wermke

JavaScript Error Tracking with AppSignal v1.3.0 is Here

AppSignal sponsor

FarmHash 3.1: A Node Implementation of Google's High Performance Hash FunctionsFarmHash is a family of non-cryptographic hash functions built by Google mostly for quickly hashing strings.

Lovell Fuller

do-wrapper 4.0: A Node Wrapper for the DigitalOcean v2 API

Matthew Major




deno

KKK flyers denouncing Martin Luther King found in Virginia

At least 10 people in Leesburg, Virginia, discovered freezer bags containing the flyers along with bird seed and candy over the weekend and ahead of Martin Luther King Day.




deno

French Eurovision song denounced by country's culture minister for using English lyrics

Frank Riester criticised the song, The Best In Me, after it was unveiled by singer Tom Leeb on Sunday. Mr Riester did not object to its artistic quality but instead was critical of the fact that half the song is in English.




deno

Iraqis hang effigies of Trump and denounce 'US terrorism' in Baghdad - demand expulsion of US troops

Populist shi'ite cleric Moqtada al-Sadr's calls for a 'million man march' in Baghdad on Friday fell well short and the crowds dissipated after a few hours.




deno

Marco Rubio is ridiculed and denounced after blaming Venezuela power outages on 'German Dam' blast

Marco Rubio is being criticized for a number of tweets he has posted over the past few days about the increasingly fraught situation in Venezuela, including one in which eh confused a dam.




deno

'Every pub is closed. As an Irishman, I can safely say this denotes the Apocalypse is truly upon us'

James Blunt messaged me. He owns a pub in Chelsea and wasn't sure if he should close it after the Prime Minister said he was 'suggesting', not ordering, people to avoid pubs




deno

'Every pub is closed. As an Irishman, I can safely say this denotes the Apocalypse is truly upon us'

James Blunt messaged me. He owns a pub in Chelsea and wasn't sure if he should close it after the Prime Minister said he was 'suggesting', not ordering, people to avoid pubs




deno

Women leaders denounce amendment to panchayat law


The Karnataka state legislature's amendment to the Panchayati Raj law has already attracted severe criticism from civil society. The governor had also expressed his objections. There is now an outpouring of wrath from women panchayat members around the state as protests intensify. Kathyayini Chamaraj reports.




deno

Diversion of forest land denounced


The grant of close to 10000 acres of forest land in Chitradurga district for non-forestry purposes threatens the ecology as well as the means of subsistence of local communities, leading irate villagers to decide to boycott the impending State Assembly elections. Malini Shankar reports.




deno

An expedient synthesis of new imino-thiazolidinone grafted dispiro-pyrrolidine-oxindole/indeno hybrids via a multicomponent [3+2] cycloaddition reaction in a deep eutectic solvent

New J. Chem., 2020, Advance Article
DOI: 10.1039/D0NJ00801J, Paper
Ruby Singh, Munna Ram Saini, Diksha Bhardwaj, Aakash Singh
A facile and selective synthesis of novel factionalized dispiro-pyrrolidines via a three component [3+2] cycloaddition reaction using a deep eutectic solvent.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




deno

Physicochemical properties of a urea/zinc chloride eutectic mixture and its improved effect on the fast and high yield synthesis of indeno[2,1-c]quinolines

New J. Chem., 2020, Advance Article
DOI: 10.1039/D0NJ01342K, Paper
Diana Peña-Solórzano, Vladimir V. Kouznetsov, Cristian Ochoa-Puentes
An environmentally friendly and efficient method for the synthesis of indeno[2,1-c]quinolines is developed using a urea/zinc chloride eutectic mixture as a green mildly acidic medium.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




deno

Computational and experimental approaches in materials science and engineering: proceedings of the International Conference of Experimental and Numerical Investigations and New Technologies, CNNTech 2019 / Nenad Mitrovic, Milos Milosevic, Goran Mladenovic

Online Resource




deno

Asymmetric synthesis of (−)-solanidine and (−)-tomatidenol

Org. Biomol. Chem., 2020, 18,3169-3176
DOI: 10.1039/D0OB00457J, Paper
Yun Wang, Guanxin Huang, Yong Shi, Wei-sheng Tian, Chunlin Zhuang, Fen-Er Chen
The asymmetric synthesis of (−)-solanidine (1) and (−)-tomatidenol (2) has been achieved by employing a cascade ringswitching reaction and a cascade azide reduction/intramolecular reductive amination with 32% and 18.7% overall yields respectively.
The content of this RSS Feed (c) The Royal Society of Chemistry




deno

Soft actuators: materials, modeling, applications, and future perspectives / Kinji Asaka, Hidenori Okuzaki, editors

Online Resource




deno

XV International Scientific-Technical Conference "Dynamic of Technical Systems" (DTS-2019): 11-13 September 2019, Rostov-on-Don, Russia / Editors: Vladimir Mladenovic, Pham Dinh Tung, Igor B. Sevostyanov, Tooraj Abbasian Najafabadi and Marko Pet

Online Resource




deno

Modern singular spectral-based denoising and filtering techniques for 2D and 3D reflection seismic data R.K. Tiwari, R. Rekapalli

Online Resource




deno

Simultaneous aptasensor assay of ochratoxin A and adenosine triphosphate in beer based on Fe3O4 and SiO2 nanoparticle as carriers

Anal. Methods, 2020, 12,2253-2259
DOI: 10.1039/D0AY00311E, Paper
Xiluan Yan, Mengmeng Jiang, Yuting Jian, Jing Luo, Xinxin Xue, Xin Chen, Xiangjuan Zheng, Fanrong Ai
In this work, a chemiluminescence (CL) method based on dual aptasensors using Fe3O4 and SiO2 nanoparticles (NPs) as carriers is developed for the simultaneous detection of ochratoxin A (OTA) and adenosine triphosphate (ATP) in beer.
The content of this RSS Feed (c) The Royal Society of Chemistry





deno

Polydopamine-assisted one-step modification of nanofiber surfaces with adenosine to tune the osteogenic differentiation of mesenchymal stem cells and the maturation of osteoclasts

Biomater. Sci., 2020, Advance Article
DOI: 10.1039/C9BM01990A, Paper
Taufiq Ahmad, Hayeon Byun, Hyeok Jun Shin, Jinkyu Lee, Sajeesh Kumar Madhurakkat Perikamana, Eun Mi Kim, Young Min Shin, Heungsoo Shin
Adenosine and its receptors have emerged as alternative targets to control cellular functions for bone healing.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




deno

Tumor localization of oncolytic adenovirus assisted by pH-degradable microgels with JQ1-mediated boosting replication and PD-L1 suppression for enhanced cancer therapy

Biomater. Sci., 2020, 8,2472-2480
DOI: 10.1039/D0BM00172D, Paper
Haishi Qiao, Xingmei Chen, Qiming Wang, Junmei Zhang, Dechun Huang, Enping Chen, Hongliang Qian, Yinan Zhong, Qi Tang, Wei Chen
Illustration of pH-degradable microgels (MGs) for the simultaneous encapsulation of OA and JQ1 for an enhanced oncolytic viral treatment with JQ1-meidated boosting viral replication and PD-L1 suppression.
The content of this RSS Feed (c) The Royal Society of Chemistry




deno

Statistical idealities and expected realities in the wavelet techniques used for denoising




deno

Marriage record of Grable, Walter Duncan and Gordenough, Emma Wellford




deno

Fabrication of highly proton-conductive chitosan whole-bio-membrane materials functionalized with adenine and adenosine monophosphate

Green Chem., 2020, 22,2426-2433
DOI: 10.1039/C9GC04104D, Paper
Guanglei Zhao, Yuanyuan Chen, Xiao-Feng Li, Sihan Zhang, Yuanqiu Situ
A successful strategy to prepare novel proton-conductive chitosan membrane biomaterials functionalized with adenine and adenosine monophosphate via a one-pot grafting procedure.
The content of this RSS Feed (c) The Royal Society of Chemistry




deno

Jan Frodeno completes home Ironman triathlon for charity




deno

Timea Babos, Kristina Mladenovic win second Australian Open doubles title