Location: Electronic Resource- 

Location: Engineering Library- TL240.5.C65L54 2016

Location: Engineering Library- TA418.9.C6G53 2016

Location: Engineering Library- QC463.P5S64 2016

Location: Engineering Library- TA481.5.A38 2016

Location: Engineering Library- TA409.L346 2016

350: Hymn Composed by St. Ephrem the Great | Mar Aprim Rabba (nightly bedtime prayer)

All Hourly Unions Job At Boeing Advance Composite Rework & Repair B 78806

The first time that pianist Sara Davis Buechner felt what she calls "the real spiritual power" of George Gershwin's music, she was 23 and building a reputation for virtuoso playing on the international concert circuit…

¿Por qué importa el estudio de la composición genética de una persona?

The purpose of this study was to assess the experiences of 1st-year college composition writing students in a synchronous online remote learning environment. The researcher, through this qualitative study, used a case study design to examine the quality of the learning experiences of the participant....

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En 6AM Hoy por Hoy estuvo Dalia Marleny Bernal, directora de Olímpica Estéreo, explicando detalles sobre la vida del artista

Available at Slow and Steady Records and Bandcamp. Trailblazing composer-trombonist Naomi Moon Siegel has announced the Nov...

A COMPOSER who produced music for films Mao’s Last Dancer and Russell Crowe’s Master and Commander is taking on the Coalition at the Federal Election over cuts to arts funding.

Have you gotten into gardening recently and want to learn how to make your own compost? Compost is a great resource for home gardens because it puts minerals back in the soil for peak production of flowers and veggies, plus you can make it out of things you already have around. Here is how to make your own clean compost, with a few tips on avoiding common problems. [...]

Alexi Kenney, a distinguished violinist, artist, and curator, will speak about his work.

Zosha Di Castri, a Canadian “composer of riotously inventive works” (The New Yorker), currently lives in New York. Her music has been performed across Canada, the United States, South America, Asia, and Europe and extends beyond purely concert music, including projects with electronics, sound arts, and collaborations with video and dance that encourage audiences to feel “compelled to return for repeated doses” (The Arts Desk). She is currently the Francis Goelet Associate Professor of Music at Columbia University and a 2023 American Academy of Arts and Letters Goddard Lieberson fellow. Zosha’s current projects include a large chamber work commissioned by the LA Phil and conducted by John Adams, receiving its premiere in spring 2024; a Koussevitzky commission from the Library of Congress for percussionist Steve Schick and ensemble, and upcoming collaborations with the Bozzini Quartet and Ensemble Paramirabo/Totem. Zosha recently curated an event showcasing her work as part of the New York Philharmonic’s 2023 Nightcap series. Her 2022 work, In the Half-Light, a song cycle for soprano Barbara Hannigan, with libretto by Tash Aw, was premiered by the Toronto Symphony Orchestra and will be performed again this season by the Montreal Symphony Orchestra. Other recent projects include We live the opposite daring for six voices written for Ekmeles, time>>T. - - I. - - M.(time) - - E, a commission for largechamber ensemble premiered by the Grossman Ensemble in Chicago; Hypha, a quartet for clarinet, violin, cello, and piano/keyboard commissioned by the Chamber Music Society of Lincoln Center; and Pentimento, a short piece for orchestra commissioned by the WDR Sinfonieorchester for its 75th anniversary. In July 2019, Zosha’s Long Is the Journey, Short Is the Memory for orchestra and chorus opened the first night of the BBC Proms at Royal Albert Hall, conducted by Karina Canellakis with the BBC Symphony and BBC Singers. Other large-scale projects include a 25-minute piece for soprano, recorded narrator and orchestra entitled Dear Life, based on a short-story by Alice Munro, and an evening-length new music theater piece, Phonobellow, co-written with David Adamcyk for the International Contemporary Ensemble with performances in New York and Montreal. Phonobellow features five musicians, a large kinetic sound sculpture, electronics, and video in a reflection on the influence of photography and phonography on human perception. Zosha’s orchestral compositions have been commissioned by John Adams, the Toronto Symphony, the San Francisco Symphony, New World Symphony, Esprit Orchestra, the National Arts Centre Orchestra, the Orchestre symphonique de Montréal, and the BBC, and have been featured by the the New York Philharmonic, Tokyo Symphony, Amazonas Philharmonic, The Philadelphia Orchestra, and the Cabrillo Festival Orchestra, among others. She has made appearances with the Chicago Symphony, the LA Philharmonic, and the San Francisco Contemporary Music Players in their chamber music series, and has worked with many leading new music groups, including Talea Ensemble, Wet Ink Ensemble, Ekmeles, Yarn/Wire, the NEM, Ensemble Cairn, and JACK and Parker Quartets. Other recent projects include a commission titled Hunger for the Orchestre symphonique de Montréal with improvised drummer, designed to accompany Peter Foldes’ 1973 eponymous silent film; a string quartet for the Banff International String Quartet Competition; a piece for Yarn/Wire for two pianists, two percussionists, and electronics premiered at Zosha’s Miller Theatre Composer Portrait concert; a solo piano work for Julia Den Boer commissioned by the Yvar Mikhashoff Trust Fund, and a string octet premiered by JACK Quartet and Parker Quartet at the Banff Centre. She was the recipient of the Jules Léger Prize for New Chamber Music for her work Cortège in 2012, and participated in Ircam’s Manifeste Festival in Paris, writing an interactive electronic work for Thomas Hauert’s dance company, ZOO. Zosha’s debut album Tachitipo was released on New Focus Recordings in November 2019 to critical acclaim, and the title track was nominated for The JUNO Awards’ 2021 Classical Composition of the Year. Tachitipo was named in Best of 2019 lists by The New Yorker, I Care if You Listen, AnEarful, Sequenza21, and New York Music Daily, and praised as “a formidable statement. It is so comprehensively realized, institutionally ratified, and sensitive to the creative exigencies of the 21st century that one wants to send a copy of it to the publishers of textbooks for music history survey courses in the hope that it will be included in a last chapter or two.” (I Care if You Listen) Zosha is a recipient of the 2021 Guggenheim Fellowship and was an inaugural fellow at the Institute for Ideas and Imagination in Paris in 2018-19. She completed her Bachelors of Music in Piano Performance and Composition at McGill University, and her DMA in Composition at Columbia University. Born in St. Albert, Alberta, Canada, Zosha currently lives with her family in New York City.

  RSS Ground was always about “other people’s content”… Until now!   Starting today you can create and distribute your own content! Create your own personal feeds and compose your original posts in them. With the help of our WYSIWYG editor you can apply basic formatting, add links, images, videos, tables and, if needed, tweak […]

The post Compose Your Own Posts In Personal Feeds! appeared first on RSSground.com.

These musicians bring both sensitivity and creativity to their work, blending tradition with innovation in a way that’s sure to make this concert an unforgettable experience.

Lars Jønson
May 1, 2007; 6:798-811
Research

Voltage-gated Cav1 and Cav2 Ca2+ channels are comprised of a pore-forming α1 subunit (Cav1.1-1.4, Cav2.1-2.3) and auxiliary β (β1-4) and α2δ (α2δ−1−4) subunits. The properties of these channels vary with distinct combinations of Cav subunits and alternative splicing of the encoding transcripts. Therefore, the impact of disease-causing mutations affecting these channels may depend on the identities of Cav subunits and splice variants. Here, we analyzed the effects of a congenital stationary night blindness type 2 (CSNB2)-causing mutation, I745T (IT), in Cav1.4 channels typical of those in human retina: Cav1.4 splice variants with or without exon 47 (Cav1.4+ex47 and Cav1.4Δex47, respectively), and the auxiliary subunits, β2X13 and α2δ-4. We find that IT caused both Cav1.4 splice variants to activate at significantly more negative voltages and with slower deactivation kinetics than the corresponding WT channels. These effects of the IT mutation, along with unexpected alterations in ion selectivity, were generally larger in channels lacking exon 47. The weaker ion selectivity caused by IT led to hyperpolarizing shifts in the reversal potential and large outward currents that were evident in channels containing the auxiliary subunits β2X13 and α2δ-4 but not in those with β2A and α2δ-1. We conclude that the IT mutation stabilizes channel opening and alters ion selectivity of Cav1.4 in a manner that is strengthened by exclusion of exon 47 and inclusion of β2X13 and α2δ-4. Our results reveal complex actions of IT in modifying the properties of Cav1.4 channels, which may influence the pathological consequences of this mutation in retinal photoreceptors.

The plasma membrane of a cell is characterized by an asymmetric distribution of lipid species across the exofacial and cytofacial aspects of the bilayer. Regulation of membrane asymmetry is a fundamental characteristic of membrane biology and is crucial for signal transduction, vesicle transport, and cell division. The type IV family of P-ATPases, or P4-ATPases, establishes membrane asymmetry by selection and transfer of a subset of membrane lipids from the lumenal or exofacial leaflet to the cytofacial aspect of the bilayer. It is unclear how P4-ATPases sort through the spectrum of membrane lipids to identify their desired substrate(s) and how the membrane environment modulates this activity. Therefore, we tested how the yeast plasma membrane P4-ATPase, Dnf2, responds to changes in membrane composition induced by perturbation of endogenous lipid biosynthetic pathways or exogenous application of lipid. The primary substrates of Dnf2 are glucosylceramide (GlcCer) and phosphatidylcholine (PC, or their lyso-lipid derivatives), and we find that these substrates compete with each other for transport. Acutely inhibiting sphingolipid synthesis using myriocin attenuates transport of exogenously applied GlcCer without perturbing PC transport. Deletion of genes controlling later steps of glycosphingolipid production also perturb GlcCer transport to a greater extent than PC transport. In contrast, perturbation of ergosterol biosynthesis reduces PC and GlcCer transport equivalently. Surprisingly, application of lipids that are poor transport substrates differentially affects PC and GlcCer transport by Dnf2, thus altering substrate preference. Our data indicate that Dnf2 exhibits exquisite sensitivity to the membrane composition, thus providing feedback onto the function of the P4-ATPases.

Mass spectrometry has become an indispensable tool for the characterization of glycosylation across biological systems. Our ability to generate rich fragmentation of glycopeptides has dramatically improved over the last decade yet our informatic approaches still lag behind. Although glycoproteomic informatics approaches using glycan databases have attracted considerable attention, database independent approaches have not. This has significantly limited high throughput studies of unusual or atypical glycosylation events such as those observed in bacteria. As such, computational approaches to examine bacterial glycosylation and identify chemically diverse glycans are desperately needed. Here we describe the use of wide-tolerance (up to 2000 Da) open searching as a means to rapidly examine bacterial glycoproteomes. We benchmarked this approach using N-linked glycopeptides of Campylobacter fetus subsp. fetus as well as O-linked glycopeptides of Acinetobacter baumannii and Burkholderia cenocepacia revealing glycopeptides modified with a range of glycans can be readily identified without defining the glycan masses before database searching. Using this approach, we demonstrate how wide tolerance searching can be used to compare glycan use across bacterial species by examining the glycoproteomes of eight Burkholderia species (B. pseudomallei; B. multivorans; B. dolosa; B. humptydooensis; B. ubonensis, B. anthina; B. diffusa; B. pseudomultivorans). Finally, we demonstrate how open searching enables the identification of low frequency glycoforms based on shared modified peptides sequences. Combined, these results show that open searching is a robust computational approach for the determination of glycan diversity within bacterial proteomes.

A key point in achieving accurate intact glycopeptide identification is the definition of the glycan composition file that is used to match experimental with theoretical masses by a glycoproteomics search engine. At present, these files are mainly built from searching the literature and/or querying data sources focused on posttranslational modifications. Most glycoproteomics search engines include a default composition file that is readily used when processing MS data. We introduce here a glycan composition visualizing and comparative tool associated with the GlyConnect database and called GlyConnect Compozitor. It offers a web interface through which the database can be queried to bring out contextual information relative to a set of glycan compositions. The tool takes advantage of compositions being related to one another through shared monosaccharide counts and outputs interactive graphs summarizing information searched in the database. These results provide a guide for selecting or deselecting compositions in a file in order to reflect the context of a study as closely as possible. They also confirm the consistency of a set of compositions based on the content of the GlyConnect database. As part of the tool collection of the Glycomics@ExPASy initiative, Compozitor is hosted at https://glyconnect.expasy.org/compozitor/ where it can be run as a web application. It is also directly accessible from the GlyConnect database.

Unspecific bone uptake (UBU) related to [¹⁸F]PSMA-1007 PET/CT imaging represents a clinical challenge. We aimed to assess whether a combination of clinical, biochemical, and imaging parameters could predict skeletal metastases in patients with [¹⁸F]PSMA-1007 bone focal uptake, aiding in result interpretation. Methods: We retrospectively analyzed [¹⁸F]PSMA-1007 PET/CT performed in hormone-sensitive prostate cancer (PCa) patients at 3 tertiary-level cancer centers. A fourth center was involved in performing an external validation. For each, a volume of interest was drawn using a threshold method to extract SUV_max, SUV_mean, PSMA tumor volume, and total lesion PSMA. The same volume of interest was applied to CT images to calculate the mean Hounsfield units (HU_mean) and maximum Hounsfield units. Clinical and laboratory data were collected from electronic medical records. A composite reference standard, including follow-up histopathology, biochemistry, and imaging data, was used to distinguish between PCa bone metastases and UBU. PET readers with less (n = 2) or more (n = 2) experience, masked to the reference standard, were asked to visually rate a subset of focal bone uptake (n = 178) as PCa metastases or not. Results: In total, 448 bone [¹⁸F]PSMA-1007 focal uptake specimens were identified in 267 PCa patients. Of the 448 uptake samples, 188 (41.9%) corresponded to PCa metastases. Ongoing androgen deprivation therapy at PET/CT (P < 0.001) with determination of SUV_max (P < 0.001) and HU_mean (P < 0.001) independently predicted bone metastases. A composite prediction score, the bone uptake metastatic probability (BUMP) score, achieving an area under the receiver-operating-characteristic curve (AUC) of 0.87, was validated through a 10-fold internal and external validation (n = 89 bone uptake, 51% metastatic; AUC, 0.92). The BUMP score’s AUC was significantly higher than that of HU_mean (AUC, 0.62) and remained high among lesions with HU_mean in the first tertile (AUC, 0.80). A decision-curve analysis showed a higher net benefit with the score. Compared with the visual assessment, the BUMP score provided added value in terms of specificity in less-experienced PET readers (88% vs. 54%, P < 0.001). Conclusion: The BUMP score accurately distinguished UBU from bone metastases in PCa patients with [¹⁸F]PSMA-1007 focal bone uptake at PET imaging, offering additional value compared with the simple assessment of the osteoblastic CT correlate. Its use could help clinicians interpret imaging results, particularly those with less experience, potentially reducing the risk of patient overstaging.

More than 250 years after a teenage Mozart wrote "Serenade in C," a copy of the piece has surfaced in the collections of a German library

Austrian manufacturer also optimizes creation of assembly documentation and related bills of material

New Version reduces production costs with easily understood images and animations

Interactive 3D manuals increase customer appreciation and satisfaction

Composting food scraps along with yard waste reduces waste going to Delaware’s landfills and produces organic material that can be used to enrich garden soil. DNREC is encouraging residents to try composting by promoting a community sale of compost bins online. Through strategic bulk purchasing, DNREC is able to offer compost bins, rain barrels and accessories at reduced prices, just in time for International Composting Awareness Week, May 6 to 12.

Noted Kannada actor and director Guruprasad was found dead in his Bengaluru apartment today, the police said.

Later this month on September 27th, NIS America will release FuRyu’s action RPG Reynatis for Switch, Steam, PS5, and PS4 …

Continue reading "Reynatis Interview: Creative Producer TAKUMI, Scenario Writer Kazushige Nojima, and Composer Yoko Shimomura discuss the game, coffee, and more"

As humans leave space junk behind, there may come a time when human bodies would need to decompose in space. Learn how this happens and why it's a slow process.

Le corps ligoté en état de décomposition retrouvé le 30 octobre dans l’un des parcs les plus achalandés de Montréal est celui de Kevin Mirshahi.

Recycling waste and delivering a safe nutrient-rich fertilizer for food production

The post Press Release: New compost plant to aid the greening of Ghana’s economy first appeared on International Water Management Institute (IWMI).

The composite drought indicator (CDI) supports operational drought management decision making in Jordan, Lebanon, Morocco and Tunisia.

The post Development of a composite drought indicator for operational drought monitoring in the MENA region first appeared on International Water Management Institute (IWMI).

Composition (per 100 gm) Of 9 Common Vegetables.

Understanding food and...

On Monday, the government extended the due date for filing of annual GST returns for 2019-20 by composition dealers to 31 October. It is the second extension in as many months given by the government. Earlier, the original deadline of 15