channels SEMICONDUCTOR DEVICE INCLUDING NANOWIRE TRANSISTORS WITH HYBRID CHANNELS By www.freepatentsonline.com Published On :: Thu, 29 Jun 2017 08:00:00 EDT A semiconductor device is provided that includes an n-type field effect transistor including a plurality of vertically stacked silicon-containing nanowires located in one region of a semiconductor substrate, and a p-type field effect transistor including a plurality of vertically stacked silicon germanium alloy nanowires located in another region of a semiconductor substrate. Each vertically stacked silicon-containing nanowire of the n-type field effect transistor has a different shape than the shape of each vertically stacked silicon germanium alloy nanowire of the p-type field effect transistor. Full Article
channels Supervision of Input Signal Channels By www.freepatentsonline.com Published On :: Thu, 29 Jun 2017 08:00:00 EDT The present disclosure pertains to systems and methods for monitoring a plurality of analog-to-digital converters. In one embodiment, a plurality of input channels may each be in communication with a different phase of a three-phase electric power delivery system. The input channels may be configured to receive analog signals from the different phases. A composite signal subsystem may be configured to generate a composite signal based on the plurality of input channels. An analog-to-digital converter subsystem may be configured to produce a digitized representation of each of the plurality of input channels and a digitized representation of the composite signal. An analog-to-digital converter monitor subsystem may identify an error in the analog-to-digital conversion based on the digitized representation of the composite signal and the digitized representations of the plurality of input channels. Full Article
channels OPERATION OF DIAGNOSTIC DEVICES INVOLVING MICROCHANNELS AND ELECTRODES By www.freepatentsonline.com Published On :: Thu, 29 Jun 2017 08:00:00 EDT An assembly is provided for interfacing with a microfluidic chip having at least one microscopic channel configured to receive a liquid sample for analysis. The assembly includes a chip carrier, an electronics module, an optical module, and a mechanical module. The chip carrier includes a base and a cover defining a cavity to receive the microfluidic chip. The electronics module includes a signal generator which applies at least one electrokinetic signal electrode(s) of the chip. The optical module includes an excitation radiation source which causes excitation radiation to impinge on the sample, and an emission radiation detector which detects radiation emitted from the sample. The mechanical module includes a chip-carrier receiving structure, relatable with respect to the optical module for focus and at least one degree of translational freedom. Full Article
channels TANGENTIAL FILTER WITH A SUPPORTING ELEMENT INCLUDING A SET OF CHANNELS By www.freepatentsonline.com Published On :: Thu, 29 Jun 2017 08:00:00 EDT A tangential filter for filtration of a fluid includes a support element, wherein, along a transverse plane perpendicular to the central axis of the support element a) the support element includes in its central portion only inner channels that do not share a common wall with its outer surface, the inner channels having a substantially equivalent hydraulic diameter, b) the support element includes peripheral channels, including at least first and second adjacent peripheral channels, each of the two channels sharing a common wall with the outer surface, c) the ratio of the hydraulic diameter of the first channel to the hydraulic diameter of the second channel is greater than or equal to 1.1, d) the number of peripheral first channels is greater than or equal to the number of peripheral second channels, e) the second channel has a hydraulic diameter substantially identical to the hydraulic diameter of the inner channels. Full Article
channels COOLING OF ELECTRONICS USING FOLDED FOIL MICROCHANNELS By www.freepatentsonline.com Published On :: Thu, 29 Jun 2017 08:00:00 EDT Embodiments are generally directed to cooling of electronics using folded foil microchannels. An embodiment of an apparatus includes a semiconductor die; a substrate, the semiconductor die being coupled with the substrate; and a cooling apparatus for the semiconductor die, wherein the cooling apparatus includes a folded foil preform, the folded foil forming a plurality of microchannels, and a fluid coolant system to direct a fluid coolant through the microchannels of the folded foil. Full Article
channels Market dynamics are different for all channels; e-commerce ecosystem will stabilise: Tupperware MD Deepak Chhabra By retail.economictimes.indiatimes.com Published On :: 2020-02-07T15:46:40+05:30 Tupperware India's managing director Deepak Chhabra talks about how integrating the direct sales force with the retail franchisee model is working for the home and kitchen-ware maker. Full Article
channels Routing Maschine Channels to the SSL Mixer in Reason 11 By maschinetutorials.com Published On :: Thu, 21 Nov 2019 18:51:00 +0000 Still checking out the Reason 11 demo and wanted to make a quick video showing how to route channels from Maschine out to the SSL mixer in Reason. This gives you more control over individual pads or groups when creating a mixing. The post Routing Maschine Channels to the SSL Mixer in Reason 11 appeared first on Maschine Tutorials. Full Article DAW & Host Integration Free Maschine Tutorials
channels I need to watch 9 different channels. By ask.metafilter.com Published On :: Fri, 01 May 2020 09:22:42 -0800 I need 9 TV tuners so I can display 9 different over the air TV channels on 9 separate screens. 9 TVs is not an option. Output resolution is not at all critical. What is the cheapest solution you can come up with? Full Article television televisiontuner panopticon zeitgeist iamnotelvis resolved
channels Channels near Windorah By www.abc.net.au Published On :: Sun, 21 Jul 2019 09:49:00 +1000 Full Article ABC Western Queensland westqld Disasters and Accidents:Drought:All Disasters and Accidents:Floods:All Environment:Climate Change:All Rural:Livestock:Beef Cattle Rural:Sustainable and Alternative Farming:All Australia:QLD:Birdsville 4482 Australia:QLD:Longreach 4730
channels International Duo Channels Past And Present To Win Best Rock Act At Worlds Largest Indie Music Awards By feedproxy.google.com Published On :: Follow No One, Colorado-based Vocalist Rich Hall And Portuguese Guitarist Pedro Murino Almeida, Won Best Rock Act At The 2019 JMAs In Dollywood. Full Article
channels International Duo Channels Past And Present To Win Best Rock Act At Worlds Largest Indie Music Awards By feedproxy.google.com Published On :: Follow No One, Colorado-based Vocalist Rich Hall And Portuguese Guitarist Pedro Murino Almeida, Won Best Rock Act At The 2019 JMAs In Dollywood. Full Article
channels Normani Channels Icon, Mariah Carey By www.bet.com Published On :: Sun, 24 Jun 2018 23:24:56 EDT We hope Miss Mariah knows her! Full Article Mariah Carey Normani Kodei Fashion BET Awards Style BET Her
channels Allen Iverson Channels Kobe Bryant And Nipsey Hussle In Message Of Hope By feeds.bet.com Published On :: Wed, 8 Apr 2020 14:00:00 EDT He has some uplifting words for anyone struggling right now. Full Article Allen Iverson Kobe Bryant Nipsey Hussle Sports News
channels Nancy Kanter, Key Exec At Disney Channels Worldwide, To Leave Company After 20 Years By feedproxy.google.com Published On :: Wed, 06 May 2020 15:31:48 +0000 Kanter oversaw the launch of Disney Junior and the development of many Disney tv shows. The post Nancy Kanter, Key Exec At Disney Channels Worldwide, To Leave Company After 20 Years appeared first on Cartoon Brew. Full Article Business Disney Disney Channel Disney Channels Worldwide Disney Junior Gary Marsh Nancy Kanter
channels Food YouTube is the best YouTube: 6 channels to watch while you're cooped up By www.latimes.com Published On :: Thu, 23 Apr 2020 09:00:01 -0400 When you're down and troubled and need a helping hand, these food YouTubers are here to guide the way. Full Article
channels DHHC7-mediated palmitoylation of the accessory protein barttin critically regulates the functions of ClC-K chloride channels [Cell Biology] By feedproxy.google.com Published On :: 2020-05-01T00:06:09-07:00 Barttin is the accessory subunit of the human ClC-K chloride channels, which are expressed in both the kidney and inner ear. Barttin promotes trafficking of the complex it forms with ClC-K to the plasma membrane and is involved in activating this channel. Barttin undergoes post-translational palmitoylation that is essential for its functions, but the enzyme(s) catalyzing this post-translational modification is unknown. Here, we identified zinc finger DHHC-type containing 7 (DHHC7) protein as an important barttin palmitoyl acyltransferase, whose depletion affected barttin palmitoylation and ClC-K-barttin channel activation. We investigated the functional role of barttin palmitoylation in vivo in Zdhhc7−/− mice. Although palmitoylation of barttin in kidneys of Zdhhc7−/− animals was significantly decreased, it did not pathologically alter kidney structure and functions under physiological conditions. However, when Zdhhc7−/− mice were fed a low-salt diet, they developed hyponatremia and mild metabolic alkalosis, symptoms characteristic of human Bartter syndrome (BS) type IV. Of note, we also observed decreased palmitoylation of the disease-causing R8L barttin variant associated with human BS type IV. Our results indicate that dysregulated DHHC7-mediated barttin palmitoylation appears to play an important role in chloride channel dysfunction in certain BS variants, suggesting that targeting DHHC7 activity may offer a potential therapeutic strategy for reducing hypertension. Full Article
channels Delineating an extracellular redox-sensitive module in T-type Ca2+ channels [Membrane Biology] By feedproxy.google.com Published On :: 2020-05-01T00:06:09-07:00 T-type (Cav3) Ca2+ channels are important regulators of excitability and rhythmic activity of excitable cells. Among other voltage-gated Ca2+ channels, Cav3 channels are uniquely sensitive to oxidation and zinc. Using recombinant protein expression in HEK293 cells, patch clamp electrophysiology, site-directed mutagenesis, and homology modeling, we report here that modulation of Cav3.2 by redox agents and zinc is mediated by a unique extracellular module containing a high-affinity metal-binding site formed by the extracellular IS1–IS2 and IS3–IS4 loops of domain I and a cluster of extracellular cysteines in the IS1–IS2 loop. Patch clamp recording of recombinant Cav3.2 currents revealed that two cysteine-modifying agents, sodium (2-sulfonatoethyl) methanethiosulfonate (MTSES) and N-ethylmaleimide, as well as a reactive oxygen species–producing neuropeptide, substance P (SP), inhibit Cav3.2 current to similar degrees and that this inhibition is reversed by a reducing agent and a zinc chelator. Pre-application of MTSES prevented further SP-mediated current inhibition. Substitution of the zinc-binding residue His191 in Cav3.2 reduced the channel's sensitivity to MTSES, and introduction of the corresponding histidine into Cav3.1 sensitized it to MTSES. Removal of extracellular cysteines from the IS1–IS2 loop of Cav3.2 reduced its sensitivity to MTSES and SP. We hypothesize that oxidative modification of IS1–IS2 loop cysteines induces allosteric changes in the zinc-binding site of Cav3.2 so that it becomes sensitive to ambient zinc. Full Article
channels Delineating an extracellular redox-sensitive module in T-type Ca2+ channels [Membrane Biology] By www.jbc.org Published On :: 2020-05-01T00:06:09-07:00 T-type (Cav3) Ca2+ channels are important regulators of excitability and rhythmic activity of excitable cells. Among other voltage-gated Ca2+ channels, Cav3 channels are uniquely sensitive to oxidation and zinc. Using recombinant protein expression in HEK293 cells, patch clamp electrophysiology, site-directed mutagenesis, and homology modeling, we report here that modulation of Cav3.2 by redox agents and zinc is mediated by a unique extracellular module containing a high-affinity metal-binding site formed by the extracellular IS1–IS2 and IS3–IS4 loops of domain I and a cluster of extracellular cysteines in the IS1–IS2 loop. Patch clamp recording of recombinant Cav3.2 currents revealed that two cysteine-modifying agents, sodium (2-sulfonatoethyl) methanethiosulfonate (MTSES) and N-ethylmaleimide, as well as a reactive oxygen species–producing neuropeptide, substance P (SP), inhibit Cav3.2 current to similar degrees and that this inhibition is reversed by a reducing agent and a zinc chelator. Pre-application of MTSES prevented further SP-mediated current inhibition. Substitution of the zinc-binding residue His191 in Cav3.2 reduced the channel's sensitivity to MTSES, and introduction of the corresponding histidine into Cav3.1 sensitized it to MTSES. Removal of extracellular cysteines from the IS1–IS2 loop of Cav3.2 reduced its sensitivity to MTSES and SP. We hypothesize that oxidative modification of IS1–IS2 loop cysteines induces allosteric changes in the zinc-binding site of Cav3.2 so that it becomes sensitive to ambient zinc. Full Article
channels DHHC7-mediated palmitoylation of the accessory protein barttin critically regulates the functions of ClC-K chloride channels [Cell Biology] By www.jbc.org Published On :: 2020-05-01T00:06:09-07:00 Barttin is the accessory subunit of the human ClC-K chloride channels, which are expressed in both the kidney and inner ear. Barttin promotes trafficking of the complex it forms with ClC-K to the plasma membrane and is involved in activating this channel. Barttin undergoes post-translational palmitoylation that is essential for its functions, but the enzyme(s) catalyzing this post-translational modification is unknown. Here, we identified zinc finger DHHC-type containing 7 (DHHC7) protein as an important barttin palmitoyl acyltransferase, whose depletion affected barttin palmitoylation and ClC-K-barttin channel activation. We investigated the functional role of barttin palmitoylation in vivo in Zdhhc7−/− mice. Although palmitoylation of barttin in kidneys of Zdhhc7−/− animals was significantly decreased, it did not pathologically alter kidney structure and functions under physiological conditions. However, when Zdhhc7−/− mice were fed a low-salt diet, they developed hyponatremia and mild metabolic alkalosis, symptoms characteristic of human Bartter syndrome (BS) type IV. Of note, we also observed decreased palmitoylation of the disease-causing R8L barttin variant associated with human BS type IV. Our results indicate that dysregulated DHHC7-mediated barttin palmitoylation appears to play an important role in chloride channel dysfunction in certain BS variants, suggesting that targeting DHHC7 activity may offer a potential therapeutic strategy for reducing hypertension. Full Article
channels Tandem Mass Tag Approach Utilizing Pervanadate BOOST Channels Delivers Deeper Quantitative Characterization of the Tyrosine Phosphoproteome By feedproxy.google.com Published On :: 2020-04-01 Xien Yu ChuaApr 1, 2020; 19:730-743Technological Innovation and Resources Full Article
channels Tandem Mass Tag Approach Utilizing Pervanadate BOOST Channels Delivers Deeper Quantitative Characterization of the Tyrosine Phosphoproteome [Technological Innovation and Resources] By feedproxy.google.com Published On :: 2020-04-01T00:05:32-07:00 Dynamic tyrosine phosphorylation is fundamental to a myriad of cellular processes. However, the inherently low abundance of tyrosine phosphorylation in the proteome and the inefficient enrichment of phosphotyrosine(pTyr)-containing peptides has led to poor pTyr peptide identification and quantitation, critically hindering researchers' ability to elucidate signaling pathways regulated by tyrosine phosphorylation in systems where cellular material is limited. The most popular approaches to wide-scale characterization of the tyrosine phosphoproteome use pTyr enrichment with pan-specific, anti-pTyr antibodies from a large amount of starting material. Methods that decrease the amount of starting material and increase the characterization depth of the tyrosine phosphoproteome while maintaining quantitative accuracy and precision would enable the discovery of tyrosine phosphorylation networks in rarer cell populations. To achieve these goals, the BOOST (Broad-spectrum Optimization Of Selective Triggering) method leveraging the multiplexing capability of tandem mass tags (TMT) and the use of pervanadate (PV) boost channels (cells treated with the broad-spectrum tyrosine phosphatase inhibitor PV) selectively increased the relative abundance of pTyr-containing peptides. After PV boost channels facilitated selective fragmentation of pTyr-containing peptides, TMT reporter ions delivered accurate quantitation of each peptide for the experimental samples while the quantitation from PV boost channels was ignored. This method yielded up to 6.3-fold boost in pTyr quantification depth of statistically significant data derived from contrived ratios, compared with TMT without PV boost channels or intensity-based label-free (LF) quantitation while maintaining quantitative accuracy and precision, allowing quantitation of over 2300 unique pTyr peptides from only 1 mg of T cell receptor-stimulated Jurkat T cells. The BOOST strategy can potentially be applied in analyses of other post-translational modifications where treatments that broadly elevate the levels of those modifications across the proteome are available. Full Article
channels Roles of endogenous ether lipids and associated PUFA in the regulation of ion channels and their relevance for disease By feedproxy.google.com Published On :: 2020-04-07 Delphine FontaineApr 7, 2020; 0:jlr.RA120000634v1-jlr.RA120000634Research Articles Full Article
channels Roles of endogenous ether lipids and associated PUFA in the regulation of ion channels and their relevance for disease [Research Articles] By feedproxy.google.com Published On :: 2020-04-07T06:36:30-07:00 Ether lipids (ELs) are lipids characterized by the presence of either an ether linkage (alkyl lipids) or a vinyl ether linkage (i.e. plasmalogens [Pls]) at the sn1 position of the glycerol backbone and they are enriched in PUFAs at the sn2 position. In this review, we highlight that ELs have various biological functions, act as a reservoir for second messengers (such as PUFAs), and have roles in many diseases. Some of the biological effects of ELs may be associated with their ability to regulate ion channels that control excitation-contraction/secretion/mobility coupling and therefore cell physiology. These channels are embedded in lipid membranes, and lipids can regulate their activities directly or indirectly as second messengers or by incorporating into membranes. Interestingly, ELs and EL-derived PUFAs have been reported to play a key role in several pathologies, including neurological disorders, cardiovascular diseases, and cancers. Investigations leading to a better understanding of their mechanisms of action in pathologies have opened a new field in cancer research. In summary, newly identified lipid regulators of ion channels, such as ELs and PUFAs, may represent valuable targets to improve disease diagnosis and advance the development of new therapeutic strategies for managing a range of diseases and conditions. Full Article
channels Delineating an extracellular redox-sensitive module in T-type Ca2+ channels [Membrane Biology] By feedproxy.google.com Published On :: 2020-05-01T00:06:09-07:00 T-type (Cav3) Ca2+ channels are important regulators of excitability and rhythmic activity of excitable cells. Among other voltage-gated Ca2+ channels, Cav3 channels are uniquely sensitive to oxidation and zinc. Using recombinant protein expression in HEK293 cells, patch clamp electrophysiology, site-directed mutagenesis, and homology modeling, we report here that modulation of Cav3.2 by redox agents and zinc is mediated by a unique extracellular module containing a high-affinity metal-binding site formed by the extracellular IS1–IS2 and IS3–IS4 loops of domain I and a cluster of extracellular cysteines in the IS1–IS2 loop. Patch clamp recording of recombinant Cav3.2 currents revealed that two cysteine-modifying agents, sodium (2-sulfonatoethyl) methanethiosulfonate (MTSES) and N-ethylmaleimide, as well as a reactive oxygen species–producing neuropeptide, substance P (SP), inhibit Cav3.2 current to similar degrees and that this inhibition is reversed by a reducing agent and a zinc chelator. Pre-application of MTSES prevented further SP-mediated current inhibition. Substitution of the zinc-binding residue His191 in Cav3.2 reduced the channel's sensitivity to MTSES, and introduction of the corresponding histidine into Cav3.1 sensitized it to MTSES. Removal of extracellular cysteines from the IS1–IS2 loop of Cav3.2 reduced its sensitivity to MTSES and SP. We hypothesize that oxidative modification of IS1–IS2 loop cysteines induces allosteric changes in the zinc-binding site of Cav3.2 so that it becomes sensitive to ambient zinc. Full Article
channels Central KATP Channels Modulate Glucose Effectiveness in Humans and Rodents By diabetes.diabetesjournals.org Published On :: 2020-04-24T19:07:13-07:00 Hyperglycemia is a potent regulator of endogenous glucose production (EGP). Loss of this ‘glucose effectiveness’ is a major contributor to elevated plasma glucose concentrations in type 2 diabetes (T2D). ATP-sensitive potassium channels (KATP channels) in the central nervous system (CNS) have been shown to regulate EGP in humans and rodents. We examined the contribution of central KATP channels to glucose effectiveness. Under fixed hormonal conditions (‘pancreatic clamp’ studies), hyperglycemia suppressed EGP by ~50% in both non-diabetic humans and normal Sprague Dawley rats. By contrast, antagonism of KATP channels with glyburide significantly reduced the EGP-lowering effect of hyperglycemia in both humans and rats. Furthermore, the effects of glyburide on EGP and gluconeogenic enzymes in rats were abolished by intracerebroventricular (ICV) administration of the KATP channel agonist diazoxide. These findings indicate that about half of EGP suppression by hyperglycemia is mediated by central KATP channels. These central mechanisms may offer a novel therapeutic target for improving glycemic control in T2D. Full Article
channels DHHC7-mediated palmitoylation of the accessory protein barttin critically regulates the functions of ClC-K chloride channels [Cell Biology] By feedproxy.google.com Published On :: 2020-05-01T00:06:09-07:00 Barttin is the accessory subunit of the human ClC-K chloride channels, which are expressed in both the kidney and inner ear. Barttin promotes trafficking of the complex it forms with ClC-K to the plasma membrane and is involved in activating this channel. Barttin undergoes post-translational palmitoylation that is essential for its functions, but the enzyme(s) catalyzing this post-translational modification is unknown. Here, we identified zinc finger DHHC-type containing 7 (DHHC7) protein as an important barttin palmitoyl acyltransferase, whose depletion affected barttin palmitoylation and ClC-K-barttin channel activation. We investigated the functional role of barttin palmitoylation in vivo in Zdhhc7−/− mice. Although palmitoylation of barttin in kidneys of Zdhhc7−/− animals was significantly decreased, it did not pathologically alter kidney structure and functions under physiological conditions. However, when Zdhhc7−/− mice were fed a low-salt diet, they developed hyponatremia and mild metabolic alkalosis, symptoms characteristic of human Bartter syndrome (BS) type IV. Of note, we also observed decreased palmitoylation of the disease-causing R8L barttin variant associated with human BS type IV. Our results indicate that dysregulated DHHC7-mediated barttin palmitoylation appears to play an important role in chloride channel dysfunction in certain BS variants, suggesting that targeting DHHC7 activity may offer a potential therapeutic strategy for reducing hypertension. Full Article
channels Tracing the Channels Refugees Use to Seek Protection in Europe By www.migrationpolicy.org Published On :: Thu, 31 Aug 2017 18:25:41 -0400 Following the 2015–16 crisis that saw record numbers of refugees arrive in Europe, policymakers have shown interest in creating managed, legal alternatives to the dangerous, unauthorized journeys many asylum seekers make. While these discussions should be informed by an understanding of current pathways and protection channels, it is "nearly impossible" to know how protection seekers enter and what legal channels are available to them, as this MPI Europe report explains. Full Article
channels Legal Channels for Refugee Protection in Europe: A Pivotal Moment for Strategic Thinking By www.migrationpolicy.org Published On :: Wed, 27 Sep 2017 18:49:24 -0400 Following the release of the mid-term review of the European Agenda on Migration, this webinar offers insights from EU Member States on how existing, new, and untapped legal pathways interact with other humanitarian policies, and fit into a larger protection strategy. Full Article
channels Deletion of Voltage-Gated Calcium Channels in Astrocytes during Demyelination Reduces Brain Inflammation and Promotes Myelin Regeneration in Mice By www.jneurosci.org Published On :: 2020-04-22T09:29:41-07:00 To determine whether Cav1.2 voltage-gated Ca2+ channels contribute to astrocyte activation, we generated an inducible conditional knock-out mouse in which the Cav1.2 α subunit was deleted in GFAP-positive astrocytes. This astrocytic Cav1.2 knock-out mouse was tested in the cuprizone model of myelin injury and repair which causes astrocyte and microglia activation in the absence of a lymphocytic response. Deletion of Cav1.2 channels in GFAP-positive astrocytes during cuprizone-induced demyelination leads to a significant reduction in the degree of astrocyte and microglia activation and proliferation in mice of either sex. Concomitantly, the production of proinflammatory factors such as TNFα, IL1β and TGFβ1 was significantly decreased in the corpus callosum and cortex of Cav1.2 knock-out mice through demyelination. Furthermore, this mild inflammatory environment promotes oligodendrocyte progenitor cells maturation and myelin regeneration across the remyelination phase of the cuprizone model. Similar results were found in animals treated with nimodipine, a Cav1.2 Ca2+ channel inhibitor with high affinity to the CNS. Mice of either sex injected with nimodipine during the demyelination stage of the cuprizone treatment displayed a reduced number of reactive astrocytes and showed a faster and more efficient brain remyelination. Together, these results indicate that Cav1.2 Ca2+ channels play a crucial role in the induction and proliferation of reactive astrocytes during demyelination; and that attenuation of astrocytic voltage-gated Ca2+ influx may be an effective therapy to reduce brain inflammation and promote myelin recovery in demyelinating diseases. SIGNIFICANCE STATEMENT Reducing voltage-gated Ca2+ influx in astrocytes during brain demyelination significantly attenuates brain inflammation and astrocyte reactivity. Furthermore, these changes promote myelin restoration and oligodendrocyte maturation throughout remyelination. Full Article
channels Entertainment channels going with reality shows, are they playing safe? By www.financialexpress.com Published On :: 2019-08-26T06:18:00+05:30 Multiple reality shows in the same genre is a trend most GECs are following. Easy fix or strategic programming? Full Article Industry
channels Going beyond airways: Radio channels are monetising content on digital By www.financialexpress.com Published On :: 2019-09-02T03:08:00+05:30 The report states that this “was driven by a 3% ad volume growth”. Full Article Industry
channels When silence speaks volumes: US cut off ALL communication channels with Caracas after botched mercenary raid, says Maduro By www.rt.com Published On :: Fri, 08 May 2020 03:08:00 +0000 Venezuelan President Nicolas Maduro has said that evidence will soon reveal the US leader himself was behind the failed incursion attempt, noting that Washington severed all remaining ties with Caracas thereafter. Read Full Article at RT.com Full Article
channels OnePlus devices are swapping left and right audio channels when connecting headphones By phandroid.com Published On :: Fri, 08 May 2020 12:00:00 +0000 In what seems like a rather weird glitch, it appears that there is a growing number of complaints amongst OnePlus users who are finding that their headphones audio channels are being wrongly swapped when connected. Full Article Handsets Headphones OnePlus
channels Instant money transfer through social media channels By www.banknetindia.com Published On :: Axis Bank's Ping Pay - Instant money transfer through social media channels Full Article
channels STIM1 interacts with termini of Orai channels in a sequential manner [RESEARCH ARTICLE] By jcs.biologists.org Published On :: 2020-04-29T03:28:24-07:00 Liling Niu, Fuyun Wu, Kaili Li, Jing Li, Shenyuan L. Zhang, Junjie Hu, and Qian Wang Store-operated Ca2+ entry (SOCE) is critical for numerous Ca2+-related processes. The activation of SOCE requires engagement between stromal interaction molecule 1 (STIM1) molecules on the endoplasmic reticulum and Ca2+ release-activated channel (CRAC) Orai on the plasma membrane. However, the molecular details of their interactions remain elusive. Here, we analyzed STIM1-Orai interactions using synthetic peptides derived from the N- and C-termini of Orai channels (Orai-NT and Orai-CT, respectively) and purified fragments of STIM1. The binding of STIM1 to Orai-NT is hydrophilic based, whereas binding to the Orai-CT is mostly hydrophobic. STIM1 decreases its affinity for Orai-CT when Orai-NT is present, supporting a stepwise interaction. Orai3-CT exhibits stronger binding to STIM1 than Orai1-CT, largely due to the shortness of one helical turn. The role of newly identified residues was confirmed by co-immunoprecipitation and Ca2+ imaging using full-length molecules. Our results provide important insight into CRAC gating by STIM1. Full Article
channels Lidocaine Binding Enhances Inhibition of Nav1.7 Channels by the Sulfonamide PF-05089771 [Articles] By molpharm.aspetjournals.org Published On :: 2020-05-06T13:11:09-07:00 PF-05089771 is an aryl sulfonamide Nav1.7 channel blocker that binds to the inactivated state of Nav1.7 channels with high affinity but binds only weakly to channels in the resting state. Such aryl sulfonamide Nav1.7 channel blockers bind to the extracellular surface of the S1-S4 voltage-sensor segment of homologous Domain 4, whose movement is associated with inactivation. This binding site is different from that of classic sodium channel inhibitors like lidocaine, which also bind with higher affinity to the inactivated state than the resting state but bind at a site within the pore of the channel. The common dependence on gating state with distinct binding sites raises the possibility that inhibition by aryl sulfonamides and by classic local anesthetics might show an interaction mediated by their mutual state dependence. We tested this possibility by examining the state-dependent inhibition by PF-05089771 and lidocaine of human Nav1.7 channels expressed in human embryonic kidney 293 cells. At –80 mV, where a small fraction of channels are in an inactivated state under drug-free conditions, inhibition by PF-05089771 was both enhanced and speeded in the presence of lidocaine. The results suggest that lidocaine binding to the channel enhances PF-05089771 inhibition by altering the equilibrium between resting states (with D4S4 in the inner position) and inactivated states (with D4S4 in the outer position). The gating state–mediated interaction between the compounds illustrates a principle applicable to many state-dependent agents. SIGNIFICANCE STATEMENT The results show that lidocaine enhances the degree and rate of inhibition of Nav1.7 channels by the aryl sulfonamide compound PF-05089771, consistent with state-dependent binding by lidocaine increasing the fraction of channels presenting a high-affinity binding site for PF-05089771 and suggesting that combinations of agents targeted to the pore-region binding site of lidocaine and the external binding site of aryl sulfonamides may have synergistic actions. Full Article
channels [Cell Signaling] Store-Operated Calcium Channels: From Function to Structure and Back Again By cshperspectives.cshlp.org Published On :: 2020-05-01T06:30:17-07:00 Store-operated calcium (Ca2+) entry (SOCE) occurs through a widely distributed family of ion channels activated by the loss of Ca2+ from the endoplasmic reticulum (ER). The best understood of these is the Ca2+ release-activated Ca2+ (CRAC) channel, which is notable for its unique activation mechanism as well as its many essential physiological functions and the diverse pathologies that result from dysregulation. In response to ER Ca2+ depletion, CRAC channels are formed through a diffusion trap mechanism at ER–plasma membrane (PM) junctions, where the ER Ca2+-sensing stromal interaction molecule (STIM) proteins bind and activate hexamers of Orai pore-forming proteins to trigger Ca2+ entry. Cell biological studies are clarifying the architecture of ER–PM junctions, their roles in Ca2+ and lipid transport, and functional interactions with cytoskeletal proteins. Molecular structures of STIM and Orai have inspired a multitude of mutagenesis and electrophysiological studies that reveal potential mechanisms for how STIM is toggled between inactive and active states, how it binds and activates Orai, and the importance of STIM-binding stoichiometry for opening the channel and establishing its signature characteristics of extremely high Ca2+ selectivity and low Ca2+ conductance. Full Article
channels MAGA channels the fury of the Chilean protests on ‘Calma’ By www.factmag.com Published On :: Wed, 06 May 2020 15:00:09 +0000 All the profits from the track will go to the Brigada Cascos Rojos, an independent aid squad set up to help those affected by the riots. Chilean producer MAGA channels the fury of the civil protests taking place throughout Chile in the moody visual from Juegos Artificiales for their new track, ‘Calma’. “On October 18 […] The post MAGA channels the fury of the Chilean protests on ‘Calma’ appeared first on FACT Magazine. Full Article Video Salviatek MAGA
channels YouTube TV subscribers getting access to Viacom channels including VH1, BET, MTV and others By rssfeeds.usatoday.com Published On :: Thu, 07 May 2020 18:57:31 +0000 MTV, Nickelodeon, Paramount Network and TV Land are among the channels launching on YouTube TV in the coming months. Full Article
channels The Duchess of Cambridge channels French girl chic for virtual interview about the NHS, coronavirus and mental health By www.standard.co.uk Published On :: 2020-04-17T08:29:36Z She and Prince William dialled in from their Norfolk home Full Article
channels The Drug Channels Coronavirus Industry Impact Survey By feeds.feedblitz.com Published On :: Tue, 17 Mar 2020 11:30:00 +0000 It’s a unique and troubling time. We are all of course concerned about the coronavirus and its disruption to our personal and professional lives.I presume that life will return to normal later this year. But what happens then? Will there be long-term changes to how the drug channel operates? Will we see permanent changes in behavior, policy, and industry structure?To answer these questions, I want to tap the collective insights of Drug Channels’ 30,000+ audience.Click here to complete our Coronavirus Industry Impact Survey.This survey should take 10 minutes or less. I will provide a full review of the results next week on Drug Channels. The survey will close on March 20.You can respond anonymously. Any information you provide will be kept confidential. Per Drug Channels' long-standing policy, I never publish, release, or disclose any personal data without your permission.Thanks in advance for sharing your insights.Regards,Adam Full Article Blog Administration Industry Trends
channels Drug Channels News Roundup, March 2020: Sanofi’s Gross-to-Net Bubble, Drug Pricing Findings, Amazon Replaces Express Scripts, and Drug Channels Video By feeds.feedblitz.com Published On :: Tue, 31 Mar 2020 11:30:00 +0000 First, let me say thank you to all of the healthcare workers who are putting themselves at risk during this crisis.As I noted last week, many of the crucial issues for our healthcare system will remain after we all get through this challenging period. In that regard, here’s a look at some noteworthy news from the past month: Sanofi discloses new data about insulin pricesExcellent new academic research on list vs. net drug prices Three notable researchers overturn their earlier research on drug costsAmazon switches PBM vendors for some of its employeesPlus, we unveil the teaser trailer for Drug Channels Video!P.S. Join the more than 9,000 followers of my daily links to neat stuff at @DrugChannels on Twitter. My recent tweets have highlighted such topics as:How GoodRx shares patients’ prescription data2019 drug trend at Prime TherapeuticsControversy about the independent pharmacy marketA new $5 generic mail order program, Medicare Part D reformRetail pharmacy’s futureJob openings at Amazon Frozen cookie doughAnd much more!I have also been tweeting many under-the-radar stories about how the coronavirus affects drug channels.Read more » Full Article Benefit Design Costs/Reimbursement Gross-to-Net Bubble PBMs
channels Introducing: Drug Channels Video! By feeds.feedblitz.com Published On :: Thu, 09 Apr 2020 11:30:00 +0000 In 2006, I launched the Drug Channels website to explore the economics of the U.S. reimbursement and distribution system for prescription pharmaceuticals. More than 30,000 professionals in the pharmaceutical and related industries rely on Drug Channels for timely analysis and provocative, fact-based insights. Today, I am pleased to announce the launch of our new delivery platform: Drug Channels Video!You can look forward to:Information and analysis via our new YouTube channel (Never fear. I’ll still be publishing articles on the website every week.)Livestream video webinars (Stay tuned next week for an announcement about our first two events.) Private, live virtual keynotes and remote presentations (Email me to schedule a safe social distancing event for your team.) Online video courses (Coming later in 2020) Please watch my brief video introduction below. (Click here if you can’t see the video.) I hope you and your families stay safe and healthy in these challenging times. I look forward to reconnecting with you in person soon. Full Article Blog Administration
channels Drug Channels News Roundup, April 2020: Drug Pricing Outlook, COVID-19 Data Tracker, Community Oncology Clinics, and My Favorite Chart of 2020 By feeds.feedblitz.com Published On :: Thu, 30 Apr 2020 11:30:00 +0000 Rumor has it that Spring has finally reached our worldwide headquarters here in beautiful downtown Philadelphia. (See photo at right.) While we wait to go outside, please enjoy this month’s selection of noteworthy news:The outlook for drug pricesA outstanding (and free!) resource for tracking COVID-19 daily dataWhat’s up with community oncology practices?Plus, I share my favorite chart of 2020 (so far). P.S. Join the more than 9,200 followers of my curated links to neat stuff at @DrugChannels on Twitter. My recent tweets have highlighted: Prime Therapeutics new gene therapy offering, AmerisourceBergen’s laudable deal with the Justice Department, the Costco/Instacart deal, Rite Aid’s new CEO, clinical trial trends, vaccine pricing, and much more! I have also been tweeting under-the-radar stories about how the coronavirus is affecting drug channels.Tomorrow (May 1), Drug Channels Institute will host the first of two live video webinars: Industry Update and COVID-19 Impact: Retail & Specialty Pharmacies. We'll host the second video webinar—Industry Update and COVID-19 Impact: PBMs & Payers—on May 8. CLICK HERE TO LEARN MORE AND SIGN UP. Contact Paula Fein (paula@drugchannelsinstitute.com) for our special promo codes for multiple viewing sites. DCI will donate 20% of all profits from these events to The Center for Disaster Philanthropy’s COVID-19 Response Fund.Read more » Full Article Buy-and-Bill Costs/Reimbursement Gross-to-Net Bubble Physicians
channels Insurers + PBMs + Specialty Pharmacies + Providers: Will Vertical Consolidation Disrupt Drug Channels in 2020? (rerun) By feeds.feedblitz.com Published On :: Mon, 04 May 2020 11:30:00 +0000 This week, I’m rerunning some popular posts while I prepare for this Friday’s video webinar: Industry Update and COVID-19 Impact: PBMs & Payers. Life was very different when I originally published today’s article. 2020 is not turning out to be quite what any of us expected. However, the pandemic has exposed some intriguing pros and cons of vertical consolidation. Click here to see the original post and comments from December 2019.The largest insurers, PBMs, and specialty pharmacies have now combined into vertically-integrated organizations. As I explain below, these companies have also been rapidly integrating with healthcare providers.I also provide an updated look at these companies and highlight strategies that they are using—or could use—to control the channel. I believe that these insurer / PBM / specialty pharmacy / provider organizations are poised to restructure U.S. drug channels by exerting greater control over patient access, sites of care/dispensing, and pricing.If they can effectively coordinate their sprawling business operations, they will pose a substantial threat of disruption to the existing commercial strategies of pharma companies. Will they succeed by better managing care and costs, or merely by extracting higher profits from our convoluted system?Read more » Full Article Accountable Care Organizations (ACOs) Buy-and-Bill Channel Management Mergers and Acquisitions PBMs Pharmacy Physicians Retail Clinics Specialty Drugs
channels What are the channels for investment in sustainable energy? By www.oecd.org Published On :: Mon, 09 Feb 2015 11:13:00 GMT This report develops a framework that classifies investments according to different types of financing instruments and investment funds, and highlights the risk mitigants and transaction enablers that intermediaries can use to mobilise institutionally held capital. Full Article
channels YouTube TV to gain 14 more ViacomCBS channels in expanded distribution deal By techcrunch.com Published On :: Thu, 07 May 2020 11:00:39 +0000 YouTube TV is expanding its lineup of channels thanks to a new, multi-year distribution agreement with ViacomCBS, announced this morning. The Google-owned streaming TV service is gaining 14 new ViacomCBS channels as a result of the deal, including news, sports, and entertainment offerings. It will also continue to carry CBS broadcast stations, CBS Sports Network, […] Full Article Media Google streaming service streaming TV television tv ViacomCBS YouTube YouTube TV
channels YouTube TV to gain 14 more ViacomCBS channels in expanded distribution deal By feedproxy.google.com Published On :: Thu, 07 May 2020 11:00:39 +0000 YouTube TV is expanding its lineup of channels thanks to a new, multi-year distribution agreement with ViacomCBS, announced this morning. The Google-owned streaming TV service is gaining 14 new ViacomCBS channels as a result of the deal, including news, sports, and entertainment offerings. It will also continue to carry CBS broadcast stations, CBS Sports Network, […] Full Article Media Google streaming service streaming TV television tv ViacomCBS YouTube YouTube TV
channels Ed Sheeran channels his inner Jackson Pollock by taking up painting AND opens a pub in London By www.dailymail.co.uk Published On :: Sat, 28 Sep 2019 00:33:19 GMT Ed Sheeran has been making the most of his time off from music, as he reveals he has branched out into painting and opened a new pub with his manager. Full Article
channels Maroon 5 channels Rage Against the Machine at Halloween party By www.dailymail.co.uk Published On :: Fri, 01 Nov 2019 20:01:03 GMT Maroon 5 hosted their 15th annual Halloween bash at Rolling Greens in downtown Los Angeles on Thursday night. This year's theme was Area 51, featuring aliens, army trucks, and flying saucers. Full Article