Teacher question: I understand your claims that teaching students with grade-level texts instead of instructional level texts increases children’s opportunities to learn. However, what about children’s emotional needs, self-esteem, motivation, and self-starting skills when text is challenging. Children who struggle with sight words or sounding out words who are given a hard piece of text will shut down and refuse to try or will act out in the classroom.

Loss and damage: Where are we now and what happens next? 25 January 2022 — 1:00PM TO 2:00PM Anonymous (not verified) 17 January 2022 Online

This event discusses the progress of the loss and damage agenda within climate negotiations. 

Loss and damage refers to harms and destruction caused by climate change impacts that cannot be avoided through mitigation or adaptation.

While it has gained increasing recognition in international climate change negotiations, turning the concept of loss and damage into tangible action for climate-vulnerable countries has been contentious.

Loss and damage is interwoven with issues of fairness and equity. The issue is highly disputed due to its connection with the historical responsibility of developed countries in causing climate change, as well as associated calls for compensation from developing countries.

At COP26, Scotland became the first government to pledge funds for loss and damage for countries in the Global South. However, most climate-vulnerable countries left disappointed by the failure of the Glasgow Climate Pact to secure the establishment of a dedicated loss and damage financing facility.

Developing countries have made it clear that they will continue to push for a new financing facility in the Glasgow Dialogue, a set of international discussions on loss and damage kicking off in June.

The Environment and Society Discussion Series is hosting two events on loss and damage ahead of that date. This first event outlines the key debates and discuss what progress has been made on advancing the loss and damage agenda within climate negotiations to date.

The second event focuses on solutions and possible ways forward, looking ahead to the COP27 negotiations in Egypt later in 2022, where loss and damage is expected to be a high-profile agenda item.

A deep dive into loss and damage solutions 8 February 2022 — 1:00PM TO 2:15PM Anonymous (not verified) 31 January 2022 Online

This second event of our loss and damage series cuts through polarized debate by bringing together international experts to discuss innovative legal and financial approaches.

This event will focus on a deep dive into constructive solutions and progress made to address loss and damage.

Following the first event of this two-part series, ‘Loss and Damage – where are we now and what happens next’, this event focuses on a deep dive into constructive solutions and progress made to address loss and damage.

Loss and damage refers to harms and destruction caused by climate change impacts that cannot be avoided through mitigation or adaptation. While it has gained increasing recognition in international climate change negotiations, turning the concept of loss and damage into tangible action for climate-vulnerable countries has been contentious.

Loss and damage is interwoven with issues of fairness and equity. The issue is highly disputed due to its connection with the historical responsibility of developed countries in causing climate change, as well as associated calls for compensation from developing countries.

At COP26, Scotland became the first government to pledge funds for loss and damage for countries in the Global South. However, most climate-vulnerable countries left disappointed by the failure of the Glasgow Climate Pact to secure the establishment of a dedicated loss and damage financing facility.

Developing countries have made it clear that they will continue to push for a new financing facility in the Glasgow Dialogue, a set of international discussions on loss and damage kicking off in June. The Environment and Society Discussion Series is hosting two events on loss and damage ahead of that date.

This second event convenes a deep dive into the progress and potential on loss and damage solutions, while also examining the hurdles that are still to overcome to make loss and damage support a reality.

We have observed overexpression of PACS-1, a cytosolic sorting protein in primary cervical tumors. Absence of exonic mutations and overexpression at the RNA level suggested a transcriptional and/or posttranscriptional regulation. University of California Santa Cruz genome browser analysis of PACS-1 micro RNAs (miR), revealed two 8-base target sequences at the 3' terminus for hsa-miR-34a and hsa-miR-449a. Quantitative RT-PCR and Northern blotting studies showed reduced or loss of expression of the two microRNAs in cervical cancer cell lines and primary tumors, indicating dysregulation of these two microRNAs in cervical cancer. Loss of PACS-1 with siRNA or exogenous expression of hsa-miR-34a or hsa-miR-449a in HeLa and SiHa cervical cancer cell lines resulted in DNA damage response, S-phase cell cycle arrest, and reduction in cell growth. Furthermore, the siRNA studies showed that loss of PACS-1 expression was accompanied by increased nuclear γH2AX expression, Lys382-p53 acetylation, and genomic instability. PACS-1 re-expression through LNA-hsa-anti-miR-34a or -449a or through PACS-1 cDNA transfection led to the reversal of DNA damage response and restoration of cell growth. Release of cells post 24-h serum starvation showed PACS-1 nuclear localization at G1-S phase of the cell cycle. Our results therefore indicate that the loss of hsa-miR-34a and hsa-miR-449a expression in cervical cancer leads to overexpression of PACS-1 and suppression of DNA damage response, resulting in the development of chemo-resistant tumors.

In nucleotide excision repair, bulky DNA lesions such as UV-induced cyclobutane pyrimidine dimers are removed from the genome by concerted dual incisions bracketing the lesion, followed by gap filling and ligation. So far, two dual-incision patterns have been discovered: the prokaryotic type, which removes the damage in 11–13-nucleotide-long oligomers, and the eukaryotic type, which removes the damage in 24–32-nucleotide-long oligomers. However, a recent study reported that the UvrC protein of Mycobacterium tuberculosis removes damage in a manner analogous to yeast and humans in a 25-mer oligonucleotide arising from incisions at 15 nt from the 3´ end and 9 nt from the 5´ end flanking the damage. To test this model, we used the in vivo excision assay and the excision repair sequencing genome-wide repair mapping method developed in our laboratory to determine the repair pattern and genome-wide repair map of Mycobacterium smegmatis. We find that M. smegmatis, which possesses homologs of the Escherichia coli uvrA, uvrB, and uvrC genes, removes cyclobutane pyrimidine dimers from the genome in a manner identical to the prokaryotic pattern by incising 7 nt 5´ and 3 or 4 nt 3´ to the photoproduct, and performs transcription-coupled repair in a manner similar to E. coli.

Timely repair of DNA double-strand breaks (DSBs) is essential to maintaining genomic integrity and preventing illnesses induced by genetic abnormalities. We previously demonstrated that the E3 ubiquitin ligase SMURF2 plays a critical tumor suppressing role via its interaction with RNF20 (ring finger protein 20) in shaping chromatin landscape and preserving genomic stability. However, the mechanism that mobilizes SMURF2 in response to DNA damage remains unclear. Using biochemical approaches and MS analysis, we show that upon the onset of the DNA-damage response, SMURF2 becomes phosphorylated at Ser384 by ataxia telangiectasia mutated (ATM) serine/threonine kinase, and this phosphorylation is required for its interaction with RNF20. We demonstrate that a SMURF2 mutant with an S384A substitution has reduced capacity to ubiquitinate RNF20 while promoting Smad3 ubiquitination unabatedly. More importantly, mouse embryonic fibroblasts expressing the SMURF2 S384A mutant show a weakened ability to sustain the DSB response compared with those expressing WT SMURF2 following etoposide treatment. These data indicate that SMURF2-mediated RNF20 ubiquitination and degradation controlled by ataxia telangiectasia mutated–induced phosphorylation at Ser384 constitutes a negative feedback loop that regulates DSB repair.

A pair of strong earthquakes has struck off the southern coast of Cuba, inflicting damage and causing landslides.

A B-2 Spirit stealth bomber made an emergency landing at Whiteman Air Force Base in Missouri earlier this week after the high-tech aircraft malfunctioned during a training flight.

Cochlear hair cells (HCs) sense sound waves and allow us to hear. Loss of HCs will cause irreversible sensorineural hearing loss. It is well known that DNA damage repair plays a critical role in protecting cells in many organs. However, how HCs respond to DNA damage and how defective DNA damage repair contributes to hearing loss remain elusive. In this study, we showed that cisplatin induced DNA damage in outer hair cells (OHCs) and promoted OHC loss, leading to hearing loss in mice of either sex. Cisplatin induced the expression of Brca1, a DNA damage repair factor, in OHCs. Deficiency of Brca1 induced OHC and hearing loss, and further promoted cisplatin-induced DNA damage in OHCs, accelerating OHC loss. This study provides the first in vivo evidence demonstrating that cisplatin mainly induces DNA damage in OHCs and that BRCA1 promotes repair of DNA damage in OHCs and prevents hearing loss. Our findings not only demonstrate that DNA damage–inducing agent generates DNA damage in postmitotic HCs but also suggest that DNA repair factors, like BRCA1, protect postmitotic HCs from DNA damage–induced cell death and hearing loss.

Home to more than 300 artists, the neighborhood was submerged under the record-high waters of the French Broad River

The sprawling estate, which is the largest privately owned home in the country, will open its doors in November after a month-long closure

Emergency officials said the fire at the Herring Pub and Restaurant on Water Street broke out around 4 p.m. and appears to have started in an air conditioning unit.   

Team Reid Carruthers has started the search for a new second after Derek Samagalski's decision to step back from the Winnipeg-based rink.

A Saskatoon woman is accused of damaging multiple vehicles and assaulting a man with a baseball bat on Nov. 11.

'Breakaway link' is key feature in new, safer utility connector

Four of Fotress's properties were affected by floods. But the company said only minor flood damage and no significant structural damage has been identified so far.

WILMINGTON – The Delaware Children’s Department is reporting an incident at Ferris School that resulted in the significant damage of state property. Ferris School is a Level V locked secure facility under the Delaware Division of Youth Rehabilitative Services. Youth committed to Ferris School are identified as serious and/or chronic, repeat offenders who have been deemed […]

Palworld developer Pocketpair has shared details from the patent infringement lawsuit brought against it by Nintendo and The Pokémon Company in September, shedding light on the plaintiffs’ demands. The two companies are seeking an injunction on Palworld, a survival game with monsters that bear alleged similarities to the creatures from the Pokémon franchise.

The State of Delaware and E. I. du Pont de Nemours and Company, The Chemours Company, DuPont de Nemours, Inc. and Corteva, Inc, (the “Companies”), businesses with a long history of operations within the State, today announced a settlement agreement designed to benefit Delaware’s natural resources and the people of the State of Delaware now, […]

Smryna – The Delaware Emergency Management Agency (DEMA) Emergency Operations Center is requesting that Delaware residents with damage to their properties fill out the following survey report linked below.  This information is important to help determine eligibility for a disaster declaration.   Delaware Damage Report – Click Here Residents with severe damage or other direct evidence […]

The Delaware Emergency Management Agency (DEMA), Delaware State Police, Delaware Department of Health and Social Services, Sussex County Emergency Operations Center, DelDOT, and numerous volunteer organizations are mobilizing resources and personnel to respond to yesterday’s statewide damage from severe storms and likely tornado in Sussex County. Officials confirmed a fatality at a collapsed structure along Tuckers Road southeast of Greenwood, Sussex County. It’s the first confirmed death from a tornado in Delaware since 1983 according to the National Weather Service.

Governor John C. Carney, Jr. joined State and Sussex County officials to tour areas near Bridgeville today after a confirmed tornado tore through the region on Saturday night, April 1. Preliminary estimates show more than 60 structures were damaged or destroyed along a 14-mile-long path through the communities of Bridgeville, Greenwood, and Ellendale. The survey also included a DelDOT maintenance yard on Newton Road where several buildings were damaged and destroyed, including one where winds pulled a wooden beam out of the ground, shifting the concrete footing.

During the routine biennial inspection of the bridge carrying Route 896 over I-95, a crack was found in one beam that was caused by an oversized vehicle. As a result, the Delaware Department of Transportation (DelDOT) announces that the rightmost lane on the Route 896 southbound bridge over I-95 will remain closed indefinitely until a […]

DNREC announced that the Michael N. Castle Trail along the C&D Canal has been reopened at the South Lums Parking Area following repairs to a section of the trail damaged in March by storms.

The explosion occurred in Telangana Spice Kitchen on Road Number One Jubilee Hills. According to police, the explosion damaged the boundary wall of the hotel.

Dolphins in the Gulf of Mexico have tiny bits of plastic in their breath, and this is probably a worldwide problem

Could potassium fortification be the answer we're looking for when it comes to battling our unhealthy addiction to salt?

Photographer Diane Tuft has documented how global warming is affecting bodies of water around the world

Title: Pot Might Blunt Damage of Binge Drinking
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Created: 8/21/2009 4:10:00 PM
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Organic anion transporting polypeptides (OATP, gene symbol SLCO) are well-recognized key determinants for the absorption, distribution, and excretion of a wide spectrum of endogenous and exogenous compounds including many antineoplastic agents. It was therefore proposed as a potential drug target for cancer therapy. In our previous study, it was found that low-dose X-ray and carbon ion irradiation both upregulated the expression of OATP family member OATP1A2 and in turn, led to a more dramatic killing effect when cancer cells were cotreated with antitumor drugs such as methotrexate. In the present study, the underlying mechanism of the phenomenon was explored in breast cancer cell line MCF-7. It was found that the nonreceptor tyrosine kinase v-YES-1 Yamaguchi sarcoma viral oncogene homolog 1 (YES-1) was temporally coordinated with the change of OATP1A2 after irradiation. The overexpression of YES-1 significantly increased OATP1A2 both at the mRNA and protein level. The signal transducer and activator of transcription 3 (STAT3) pathway is likely the downstream target of YES-1 because phosphorylation and nuclear accumulation of STAT3 were both enhanced after overexpressing YES-1 in MCF-7 cells. Further investigation revealed that there are two possible binding sites of STAT3 localized at the upstream sequence of SLCO1A2, the encoding gene of OATP1A2. Electrophoretic mobility shift assay and chromatin immunoprecipitation analysis suggested that these two sites bound to STAT3 specifically and the overexpression of YES-1 significantly increased the association of the transcription factor with the putative binding sites. Finally, inhibition or knockdown of YES-1 attenuated the induction effect of radiation on the expression of OATP1A2.

Nintendo and The Pokémon Company in September filed a patent infringement lawsuit against Palworld developer Pocketpair. 

At the time Nintendo did not share which patents Palworld infringed on, however, Pocketpair has now revealed what patents Nintendo are claiming were infringed on.

"As announced on September 19, 2024, The Pokémon Company and Nintendo Co Ltd (hereinafter referred to as the Plaintiffs) have filed a patent infringement lawsuit against us," said Pocketpair. "We have received inquiries from various media outlets regarding the status of the lawsuit, and we would like to report the details and current status of this case as follows.

"The Plaintiffs claim that Palworld, released by us on January 19, 2024, infringes upon the following three patents held by the Plaintiffs, and are seeking an injunction against the game and compensation for a portion of the damages incurred between the date of registration of the patents and the date of filing of this lawsuit."

Nintendo and The Pokémon Company are each seeking an injunction and damages of five million yen plus late payment damages.

Pocketpair added, "We will continue to assert our position in this case through future legal proceedings. Please note that we will refrain from responding individually to inquiries regarding this case. If any matters arise that require public notice, we will announce them on our website, etc."

A life-long and avid gamer, William D'Angelo was first introduced to VGChartz in 2007. After years of supporting the site, he was brought on in 2010 as a junior analyst, working his way up to lead analyst in 2012 and taking over the hardware estimates in 2017. He has expanded his involvement in the gaming community by producing content on his own YouTube channel and Twitch channel. You can contact the author on Twitter @TrunksWD.

Full Article - https://www.vgchartz.com/article/463022/nintendo-and-the-pokemon-company-seeking-injunction-and-damages-from-pocketpair/

The radio host criticized Jenner, a transgender woman, for supporting Donald Trump

Hospitals have been forced to innovate with new ways of hydrating patients and giving them medications, after a key factory that produces IV fluid bags flooded during Hurricane Helene. (This story first aired on Morning Edition on Nov. 7, 2024.)

State Farm: Spring Home Maintenance Tips

The warming impact of the vapour trails that emerge from airplanes is being discussed at climate gathering.

Tiny, self-organized three-dimensional (3D) tissue cultures (Organoids) derived from medlinkstem cells/medlink have been developed to produce teeth-protecting

Youssef Brouziyne, IWMI Middle East and North Africa (MENA) Regional Representative, says two key questions will dominate discussions around the Loss and Damage Fund at COP28.

The post At COP28, science and research are critical to the loss and damage conversation first appeared on International Water Management Institute (IWMI).

Sickle cell disease is an inherited red blood cell disorder that affects hemoglobin, the protein carrying oxygen through the body. In this condition,

A common ingredient in plastic may cause breaks in DNA strands, leading to egg cells with an abnormal number of chromosomes in roundworms, reveals a new

New research based on patient health records on lowering high cholesterol suggests that rosuvastatin can harm the kidneys, especially at high doses of the medicine.

Roughly 50% of those diagnosed with medlinkhigh blood pressure/medlink (BP), or hypertension, face the risk of long-term kidney damage, potentially