High-resolution pictures or atomic-level detail of chikungunya virus interacting with a protein found on the cell surface in the joints was snapped by

The polar bear, floating mournfully away on an ice floe as his habitat melts around him, is perhaps one of the most well-travelled symbols of the impacts of climate change.

Danielle Young, based in Brisbane, Australia, said she originally considered purchasing Shona Joy dresses for $240, but wanted to keep costs down as much as possible.

Catalina Suarez Gomez made the type of discovery that most scientists only dream about – and she did it while interning at the Smithsonian Tropical […]

The post Intern aids in discovery of Titanoboa appeared first on Smithsonian Insider.

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The molecular mechanism used by many bacteria to kill neighboring cells has redundancy built into its genetic makeup, which could allow for the mechanism to be expressed in different environments, say researchers at Penn State and the University of Wisconsin-Madison. Their new study provides insights into the molecular mechanisms of competition among bacteria. "Many organisms, including humans, acquire bacteria from their environment," said Tim Miyashiro, a biochemist and molecular biologist at Penn State and the leader of the research team. "These bacteria can contribute to functions within the host organism, like how our gut bacteria help us digest food. We're interested in the interactions among bacteria cells, and between bacteria and their hosts, to better understand these mutually beneficial symbiotic relationships." Cells of the bioluminescent bacteria Vibrio fisheri take up residence in the light organ of newly hatched bobtail squid. At night, the bacteria produce a blue glow that researchers believe obscures a squid's silhouette and helps protect it from predators. The light organ has pockets, or crypts, in the squid's skin that provide nutrients and a safe environment for the bacteria. "When the squid hatches, it doesn't yet have any bacteria in its light organ," said Miyashiro. "But bacteria in the environment quickly colonize the squid's light organ." Some of these different bacteria strains can coexist, but others can't. "Microbial symbioses are essentially universal in animals, and are crucial to the health and development of both partners," says Irwin Forseth, a program director in the National Science Foundation's Division of Integrative Organismal Systems, which funded the research. "The results from this study highlight the role small genetic changes can play in microbe interactions. Increased understanding will allow us to better predict organisms' performance in changing environments."

Image credit: Andrew Cecere

The Supreme Court's second day of arguments by phone was devoted to a new version of a case it decided seven years ago involving federal money to fight AIDS around the world.; Credit: Andrew Harnik/AP

The Supreme Court kicked off a second day of telephone arguments Tuesday with a case that mingles sex, the HIV/AIDS epidemic and free speech.

At issue is whether the government can require private nonprofits to denounce prostitution in order to qualify for U.S foreign aid grants aimed at fighting the worldwide AIDS epidemic. This is the second time the court has faced this issue, but this time it comes with a twist.

In 2003, Congress, at the urging of President George W. Bush, enacted a major foreign aid program to fight the HIV/AIDS pandemic and prevent new infections worldwide. In appropriating the money, Congress included a provision requiring any private organization that received funding through the program to adopt an explicit policy denouncing prostitution and sex trafficking.

In 2013, the Supreme Court struck down that provision, declaring it unconstitutional because it compelled U.S. nonprofits to adopt an explicit policy as a condition for receiving grant money. By a 6-2 vote, the high court said such a requirement interfered with the free speech rights of private U.S. organizations engaged in the fight against AIDS.

The case was back Tuesday, but this time, the question was whether foreign organizations closely affiliated with those same U.S. nonprofits can be required to adopt the policy denouncing prostitution.

Defending the provision was Assistant to the Solicitor General Christopher Michel. He argued that foreign affiliates of U.S. organizations like Save The Children, CARE and WorldVision are separate legal entities from their parent U.S. organizations, and that as foreign entities, they have no rights under the U.S. Constitution.

Chief Justice John Roberts, who wrote the 2013 decision, seemed unpersuaded.

"Is it reasonable to insist on formal corporate ties in this context?" he asked. "It's undisputed that to be effective in many of the foreign countries involved here, you have to operate through a foreign entity."

Michel responded that if the U.S. nonprofits "make the choice to operate through a foreign entity because they decide that is more convenient or more effective, they have to accept the bitter with the sweet."

Roberts still seemed doubtful, noting that the U.S. nonprofits and their foreign affiliates "have the same name, the same logo, the same brand. And I wonder if it makes more sense to think of the foreign entity as simply another channel for the domestic entity's speech."

Representing the nonprofits was lawyer David Bowker. He maintained that for all practical purposes, there is no difference between the U.S. nonprofits and their foreign affiliates, so making the affiliate adopt an anti-prostitution message effectively puts words in the mouth of the U.S. nonprofit.

Questioned by Justice Clarence Thomas, Bowker said that the harm suffered by the U.S. nongovernmental organizations is that their foreign affiliates must either lose their funding by refusing to comply with the anti-prostitution policy or undermine their mission by denouncing the very people they need to work with — namely prostitutes. And if the foreign affiliates make the pledge needed to get funding, he said, the U.S. parent organizations have to disavow their own affiliates' anti-prostitution pledge, thus harming the entire anti-AIDS fight.

"It's a Catch-22 for these U.S. organizations," said Bowker.

Justice Stephen Breyer followed up: "So why don't you simply write a grant to get all the money yourself and then you give it to CARE India? Why doesn't that work?"

Because, replied Bowker, under the statute, CARE USA, in subcontracting a grant to CARE India, would be required to impose the anti-prostitution pledge on its own affiliate on behalf of the government.

Justice Samuel Alito, who signed on to the court's 2013 decision, said he had more concerns in this case — mainly "that it will force Congress to either withhold foreign aid entirely or allow foreign aid to be used in ways that are contrary to the interests of the people of this country."

Justice Brett Kavanaugh followed up: "Suppose the U.S. government wants to fund foreign NGOs that support peace in the Middle East but only if the NGOs explicitly recognize Israel as a legitimate state. Are you saying the U.S. can't impose that kind of speech restriction on foreign NGOs that are affiliated with U.S. organizations?"

Bowker said that kind of a restriction would likely be acceptable because the aid in that case would be tied to the U.S. relationship with Israel.

Kavanaugh moved on to another question, noting, "The government says your position would unleash foreign affiliates of U.S. corporations to pump money" into U.S. election campaigns, something that is explicitly barred under current law.

Bowker replied that U.S. campaign laws, as ruled on by the Supreme Court in prior cases, allow the ban on foreign contributions because they do not come from U.S. entities at all.

A decision in the case is expected some time this summer. While the court usually concludes its work by the end of June, it is expected that this term will extend into July because the arguments in this and nine other cases were postponed for more than a month because of the coronavirus.

This content is from Southern California Public Radio. View the original story at SCPR.org.

Full Text:

The molecular mechanism used by many bacteria to kill neighboring cells has redundancy built into its genetic makeup, which could allow for the mechanism to be expressed in different environments, say researchers at Penn State and the University of Wisconsin-Madison. Their new study provides insights into the molecular mechanisms of competition among bacteria. "Many organisms, including humans, acquire bacteria from their environment," said Tim Miyashiro, a biochemist and molecular biologist at Penn State and the leader of the research team. "These bacteria can contribute to functions within the host organism, like how our gut bacteria help us digest food. We're interested in the interactions among bacteria cells, and between bacteria and their hosts, to better understand these mutually beneficial symbiotic relationships." Cells of the bioluminescent bacteria Vibrio fisheri take up residence in the light organ of newly hatched bobtail squid. At night, the bacteria produce a blue glow that researchers believe obscures a squid's silhouette and helps protect it from predators. The light organ has pockets, or crypts, in the squid's skin that provide nutrients and a safe environment for the bacteria. "When the squid hatches, it doesn't yet have any bacteria in its light organ," said Miyashiro. "But bacteria in the environment quickly colonize the squid's light organ." Some of these different bacteria strains can coexist, but others can't. "Microbial symbioses are essentially universal in animals, and are crucial to the health and development of both partners," says Irwin Forseth, a program director in the National Science Foundation's Division of Integrative Organismal Systems, which funded the research. "The results from this study highlight the role small genetic changes can play in microbe interactions. Increased understanding will allow us to better predict organisms' performance in changing environments."

Image credit: Andrew Cecere

Establishment of cooperative biogas projects is aided by strong community spirit, regional traditions and farmers' sense of responsibility for their local area, finds a new Italian study. The findings suggest that renewable energy policy could benefit from taking account of community aspects at the local and regional levels.

A recent study suggests that blocking ditches originally dug in peatlands to drain water is an effective restoration method, but is influenced by local conditions. Restoration efforts should therefore be monitored over long periods of time at the landscape level to fully evaluate their impacts.

Applying a low voltage to polluted river sediment can boost microbes’ natural ability to degrade harmful polychlorinated biphenyl (PCB) contaminants, according to a new study. The approach could be a cost-effective, sustainable strategy to bioremediate polluted sites.

A new methodology for mapping the global distribution of drought risk has been proposed, which should provide guidance on which locations should be further assessed to improve drought preparedness and management policies.

With over half of Europe’s species dependent on agricultural habitats, protecting ‘high nature value’ farmland is vital to biodiversity conservation. However, the identification and assessment of such farmland requires careful co-ordination, concludes a recent study. The researchers present a framework to help with this process and make a set of key recommendations.

Applying a low voltage to polluted river sediment can boost microbes’ natural ability to degrade harmful polychlorinated biphenyl (PCB) contaminants, according to a new study. The approach could be a cost-effective, sustainable strategy to bioremediate polluted sites.

Applying a low voltage to polluted river sediment can boost microbes’ natural ability to degrade harmful polychlorinated biphenyl (PCB) contaminants, according to a new study. The approach could be a cost-effective, sustainable strategy to bioremediate polluted sites.

The Earth's globally-perceptible seismic 'hum' is now being used to peer into its depths, shedding new light on the planet's inner layers.

Six-year-old Connor Johnson has big dreams for the future, and he needs our help to keep them alive.

Probably 45 percent of baby boomers could use Starkey's new Livio AIs or Healthables. What's keeping them away?

The new Starkey Halo 2 hearables put the internet in your head.

IQbuds Boost hearables are blurring the distinction between wireless earbuds and those so-called medical devices.

A need for better surgical care led Dr. Mit Desai to establish The Surgicalist Group, offering dedicated inpatient acute care surgeons to hospital partners. Today, under the same philosophy, he impacts hundreds through his mission work abroad.

Online bill payment features, expanded services and more

Moving Franchise Displays Newly Discovered Rare Sculpture at World Headquarters to Offer Inspiration to the Community and Recognize the Ongoing Fight Against HIV/AIDS, Discrimination and COVID-19 Pandemic

The invention refers to an ironing aid and a device for safekeeping of ironing aids for smoothing closed tubular items of clothing. The object was to propose a solution in the application of which a wire frame shaped ironing aid is an integral part of the aid for thermal smoothing of items of clothing and better handling is ensured. The object is achieved by their insertion in a profile bracket provided with an adhesion means. According to the invention, several ironing aids can be combined with a profile bracket, at least one of the ironing aids having a loop-like rounding at its end. Furthermore, one of the ironing aids can have a slight kink at a right angle to its planar extension (FIGS. 1/2).

In this podcast, Scott Davert shows us the features available with MFi supported hearing aids or Cochlear Implant processors from the perspective of a VoiceOver user. MFi compatible hearing aids come from many manufacturers and there are numerous models supported. You can see Apple's official support page which gives a fairly accurate account of which hearing aids have MFi support. However, this article has not been updated since October 2018, so anything newer than that will not be listed on this page.

For more general information about hearing aids from a blindness perspective, you can listen to this Accessibility Moving Forward podcast featuring some familiar voices to AppleVis.

Finally, there is a mailing list for blind hearing aid users that you can join by sending a blank email to blindhearingaidusers+subscribe@groups.io.

Police watchdog to probe botched slavery investigation on Chinese restaurants.

Our special 100th episode finds us with a flood of special guests. We have Metermaids, an NYC rap duo signed to Sage Francis’ Strange Famous label. Their newest album We Brought Knives is a powerful examination of fatherhood, legacies, changing times, and the awesomeness of Bruce Springsteen.

They’re followed by Gabriel Roth. Roth is the co-founder of Daptone Records, a Brooklyn-based label that has released some of the finest soul, funk, Afrobeat, and other roots music of this generation. The band he leads, The Dap-Kings (who normally back the powerful singer Sharon Jones), played a key part in one of the most popular records in recent memory, Amy Winehouse’s Back To Black.

This being an anniversary party, we start the show with a special surprise guest.

See http://theciphershow.com/episode/100/ for full show notes and comments.

Glynn Purnell leads Health for Life cookathon.

Den Ursprung einer Epidemie zu finden ist nicht leicht, sagt Fabian Leendertz. Er jagt seit Jahrzehnten Erreger – und hat die Quelle für Ebola in Westafrika gefunden. Der Forscher erklärt, warum die Suche so schwierig ist und welche Rolle Affen dabei spielen.

The coronavirus is on all of our minds, and for some, it brings back memories of another public health crisis, when the federal government was slow to respond and communities had to take care of each other: the AIDS epidemic.

The federal government should create a corps of AIDS specialists and deploy them in the hard-hit countries targeted by the Bush administration's five-year, $15-billion global AIDS program, according to a panel of experts.

GREAT FALLS, Mont. — For patrons at a Montana tiki bar that has a back wall of a window into a motel swimming pool, it’s typical to see mermaids in the water five nights a week. So as the owner of the O’Haire Motor Inn and the Sip ‘n Dip Lounge in Great Falls began […]

GREAT FALLS, Mont. (AP) — For patrons at a Montana tiki bar that has a back wall of a window into a motel swimming pool, it’s typical to see mermaids in the water five nights a week. So as the owner of the O’Haire Motor Inn and the Sip ‘n Dip Lounge in Great Falls […]

There's evidence we've covered in the past that paracetamol isn't very effective in back pain. But what about so called non-steroidal anti-inflammatory drugs, NSAIDs, the most commonly used in Australia being ibuprofen?

The Australian Federal Police has raided ABC offices in Sydney over a series of 2017 stories known as The Afghan Files.

The ABC's editorial director Craig McMurtrie says the raids by the federal police on the ABC's Sydney offices are an uncomfortable development with implications for press freedom.

(United States Fourth Circuit) - Summary judgment in favor of defendant in an action for trade-dress infringement and unfair competition under sections 32(1)(a) and 43(a) of the Trademark Act of 1946 (Lanham Act) and Virginia common law, is vacated and remanded, where: 1) plaintiff alleges that defendant used a similar dot pattern on its GoodNites bed mats as plaintiff used on plaintiff's absorbent products; 2) plaintiff has presented sufficient evidence to create a genuine factual question as to whether their selection of a pixel pattern was a purely aesthetic choice among many alternatives; and thus, 3) plaintiff has presented sufficient evidence to raise a genuine issue of material fact regarding the functionality of its pixel pattern.

(United States Federal Circuit) - Affirming the dismissal of a declaratory judgment action filed against the producer of several antiviral drugs used in the treatment of AIDS by an organization providing medical care to AIDS sufferers seeking to have patents declared invalid because the action failed to meet the requirements of the Declaratory Judgment Act.

Braids are nothing new to Black women.

Spencer Garrett, who portrayed Simon Tarses in The Next Generation: The Drumhead episode, spoke to StarTrek.com about getting the role, what the...

The way the gay community responded to the AIDS crisis of the 1980s and 1990s has lessons for us all in the coronavirus pandemic.

We're comparing the number of Americans to have died from COVID-19 to war casualties. Why not consider AIDS?

Russell E. Glasgow
Apr 1, 2001; 14:
Feature Articles

Hongbin Zhang, Lang Wu.

Source: The Annals of Applied Statistics, Volume 13, Number 4, 2140--2157.

Abstract:
For a time-to-event outcome with censored time-varying covariates, a joint Cox model with a linear mixed effects model is the standard modeling approach. In some applications such as AIDS studies, mechanistic nonlinear models are available for some covariate process such as viral load during anti-HIV treatments, derived from the underlying data-generation mechanisms and disease progression. Such a mechanistic nonlinear covariate model may provide better-predicted values when the covariates are left censored or mismeasured. When the focus is on the impact of the time-varying covariate process on the survival outcome, an accelerated failure time (AFT) model provides an excellent alternative to the Cox proportional hazard model since an AFT model is formulated to allow the influence of the outcome by the entire covariate process. In this article, we consider a nonlinear mixed effects model for the censored covariates in an AFT model, implemented using a Monte Carlo EM algorithm, under the framework of a joint model for simultaneous inference. We apply the joint model to an HIV/AIDS data to gain insights for assessing the association between viral load and immunological restoration during antiretroviral therapy. Simulation is conducted to compare model performance when the covariate model and the survival model are misspecified.

A virus that spreads fear and stigma, as well as disease. It’s the story of HIV/AIDS as well as COVID-19. The former executive director of AIDS Thunder Bay reflects on the similarities he sees between HIV 35 years ago, and the coronavirus now.

In this country, where the dank, grim days of winter are as short as a resigned sigh, the onset of some decent, dry spring weather doesn’t half raise the morale. Well, it would if the coronavirus wasn’t lurking all over the parish.

Former Swiss internationals including Pascal Zuberbühler helped turn the UEFA European Women's Under-17 Championship semi-finals into a family-orientated festival of football.

Demographic data concerning health care providers working long-term in resource-limited areas with religious groups or other government or nongovernment organizations are limited. Health outcomes from these programs vary with the focus of the individual program.

This study describes the composition and evaluation of a long-term global health corps program. Other groups interested in long-term physician placement in resource-limited areas will be able to use these data while developing their program. (Read the full article)