Simple pieces of equipment decrease the danger of moving small volumes of chemicals prone to igniting

Filed under: Arts and Culture, North America, United States

Joanne and Gary, rival travel agents compete for their industry's top honor, the Globel Prize, while trying to address their clients' impossible demands in an Off-Broadway comedy that debuts this week, "Craving for Travel."

The 85-minute, two-actor, 30-character comedy was commissioned and produced by Jim Strong, president of the Dallas-based Strong Travel Services travel agency.

"Travel agents are always asked to do the impossible, and this play shows how that is done, from finding the impossible rooms to making dreams come true," Strong told the "Dallas Morning News." "I decided to bring it to life on stage as a comedy in New York."

From "Craving for Travel's" press release:

With their reputations on the line, travel agents Joanne and Gary will tackle any request, no matter how impossible, and any client, no matter how unreasonable. Full of overzealous travelers, overbooked flights, and hoteliers who are just over it, Craving for Travel reminds us why we travel-and everything that can happen when we do.

"Craving for Travel" opens Thursday at the Peter J. Sharp Theater, where it'll run through Feb. 9. Tickets are $32.50 and $49. They can be purchased at CravingForTravel.com, 212-279-4200 or the Ticket Central Box Office (416 W. 42nd St., 12-8 p.m. daily). More than half of the shows are already sold out.

Continue reading Off-Broadway Comedy 'Craving for Travel' Showcases Travel Agents Trying to do the Impossible

Off-Broadway Comedy 'Craving for Travel' Showcases Travel Agents Trying to do the Impossible originally appeared on Gadling on Tue, 07 Jan 2014 10:19:00 EST. Please see our terms for use of feeds.

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Nearly half of the declared chemical weapons in Syria have been removed from the country, a U.N. monitoring mission said Thursday.

Thousands of vital coronavirus 'contact tracers' are only now being recruited by the Government - two weeks after the Health Secretary first announced they would be hired.

Thousands of vital coronavirus 'contact tracers' are only now being recruited by the Government - two weeks after the Health Secretary first announced they would be hired.

Archives, Room Use Only - HE7677.M6 M67 1907

Although there is evidence of harmful health and ecological effects associated with exposure to high doses of chemicals known as hormonally active agents – or endocrine disrupters – little is understood about the harm posed by exposure to the substances at low concentrations, such as those that typically exist in the environment, says a new report from a National Research Council committee.

This article discusses Atherosclerosis (narrowing of blood vessels) due to heavy metal poisoning and its treatment through chelation. Also, explains the factors based on which the chelating agents work.

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Realty Partners LLC, The Agent Owned Company™, announced today that it is providing the 'Realty Partners Agent Healthcare Plan' to its agents in partnership with Clearwater Benefits.

Dugan's Travels names 42 agents as Five Star Agents for 2020.

Safe Harbor offers cutting edge booking technology, real-time reporting to better understand, measure and grow your business, unlimited complimentary training, a dedicated help team, marketing assistance plus the opportunity for customization.

The Complaint alleges that DSV misclassified its Agents as exempt from the Fair Labor Standards Act's ("FLSA") overtime protections, and improperly denied them overtime pay.

Realty Partners LLC, The Agent Owned Company™, announced today that it will provide all of its services absolutely free of charge to new agents joining the company during the COVID-19 crisis as part of its #WeAreAllInThisTogether campaign.

The time is right to focus on the role of virtual agents in improving customers' service experiences

In the future we can expect that artificial intelligent agents, once deployed, will be required to learn continually from their experience during their operational lifetime. Such agents will also need to communicate with humans and other agents regarding the content of their experience, in the context of passing along their learnings, for the purpose of explaining their actions in specific circumstances or simply to relate more naturally to humans concerning experiences the agent acquires that are not necessarily related to their assigned tasks. We argue that to support these goals, an agent would benefit from an episodic memory; that is, a memory that encodes the agent's experience in such a way that the agent can relive the experience, communicate about it and use its past experience, inclusive of the agents own past actions, to learn more effective models and policies. In this short paper, we propose one potential approach to provide an AI agent with such capabilities. We draw upon the ever-growing body of work examining the function and operation of the Medial Temporal Lobe (MTL) in mammals to guide us in adding an episodic memory capability to an AI agent composed of artificial neural networks (ANNs). Based on that, we highlight important aspects to be considered in the memory organization and we propose an architecture combining ANNs and standard Computer Science techniques for supporting storage and retrieval of episodic memories. Despite being initial work, we hope this short paper can spark discussions around the creation of intelligent agents with memory or, at least, provide a different point of view on the subject.

Dialogue engines that incorporate different types of agents to converse with humans are popular.

However, conversations are dynamic in the sense that a selected response will change the conversation on-the-fly, influencing the subsequent utterances in the conversation, which makes the response selection a challenging problem.

We model the problem of selecting the best response from a set of responses generated by a heterogeneous set of dialogue agents by taking into account the conversational history, and propose a emph{Neural Response Selection} method.

The proposed method is trained to predict a coherent set of responses within a single conversation, considering its own predictions via a curriculum training mechanism.

Our experimental results show that the proposed method can accurately select the most appropriate responses, thereby significantly improving the user experience in dialogue systems.

The present invention relates to a cationic lipid having one or more biodegradable groups located in the mid- or distal section of a lipidic moiety (e.g., a hydrophobic chain) of the cationic lipid. These cationic lipids may be incorporated into a lipid particle for delivering an active agent, such as a nucleic acid. The invention also relates to lipid particles comprising a neutral lipid, a lipid capable of reducing aggregation, a cationic lipid of the present invention, and optionally, a sterol. The lipid particle may further include a therapeutic agent such as a nucleic acid.

Herbicidally active 5-amino-1-phenyl-pyrazoles, most of which are new, of the formula ##STR1##

The present application is directed to a novel composition which acts as a barrier to noxious agents while adding self-detoxifying catalytic treatments to neutralize the noxious and harmful warfare agents when applied for example on a fabric, or other solid support.

Emulsions, and processes for making the emulsions, useful for imparting water resistance to gypsum products are disclosed. Process for making the emulsion and gypsum products made from the emulsion are also disclosed. The emulsions of the invention include at least one paraffin wax and a hydrophilic metallic salt. The emulsions of the invention may further include a saponifiable wax substitute for montan wax. The emulsions of the invention may further include a biocide.

Emulsions, and processes for making the emulsions, useful for imparting water resistance to gypsum products are disclosed. Process for making the emulsion and gypsum products made from the emulsion are also disclosed. The emulsions of the invention include at least one paraffin wax and a hydrophilic metallic salt. The emulsions of the invention may further include a saponifiable wax substitute for montan wax. The emulsions of the invention may further include a biocide.

Addition-fragmentation agents of the formula are disclosed having the following functional groups: 1) a labile addition-fragmentation group that can cleave and reform to relieve strain, 2) a free-radically polymerizable group, and 3) a surface-modifying functional group that associates with the surface of a substrate.

The invention features methods and compositions for the synthesis of multimerizing agents. An exemplary method for producing AP20187 may comprise: (a) coupling 2-N,Ndimethylaminomethyl-1,3-diaminopropane with AP20792 to produce the dimeric alcohol, AP20793; and (b) coupling the AP20793 so produced with API7362 to yield AP20187. In particular embodiments, the method further includes the step of producing API7362 by coupling API7360 with methyl-L-pipecolic acid, or a salt thereof.

The present disclosure provides reagents that can be used to label synthetic oligonucleotides with rhodamine dyes or dye networks that contain rhodamine dyes.

The present invention provides aryl ketone compounds and compositions containing them which facilitate the delivery of active agents. The aryl ketone compounds have the formula or a salt thereof, where n=1 to 9, and R1 to R5 are independently hydrogen, C1 to C4 alkyl, C1 to C4 alkoxy, C2 to C4 alkenyl, halogen, hydroxyl, —NH—C(O)—CH3, or —O—C6H5.

An efficient process for synthesizing phosphaplatins in large quantities is disclosed by adding platinum complex to a concentrated pyrophosphate solution at pH from between about 6.0 to 8.5. After stirring, the temperature and pH are lowered to precipitate out desired phosphaplatins. Particularly, the disclosed processes reduce the need to use large volumes of starting materials, and shorten the reaction time. In addition, disclosed is a process for recycling un-reacted materials from a first phosphaplatins synthesis.

Mixtures of silicon-containing coupling reagents comprising (mercaptoorganyl)alkylpolyethersilanes containing silanol groups and (mercaptoorganyl)alkylpolyethersilanes free of silanol groups in a weight ratio of from 5:95 to 95:5. The mixtures can be prepared by transesterification and hydrolysis. The mixtures can be used in rubber mixtures.

An epoxide agent for an epoxy resin system, the epoxide agent comprising at least one non-acid functional rosin moiety and at least one epoxide moiety. Another embodiment is a curing agent for an epoxy resin system comprising at least one non-acid functional rosin moiety and at least one moiety that is reactive with an epoxy.

The disclosure provides compounds and methods of using Apogossypolone derivatives for treating diseases and disorders. In particular, the disclosure provides compounds of Formula I: or a pharmaceutically acceptable salt, hydrate, or solvate thereof, and provides methods for the preparation of compounds of Formula I; and methods for treating cancer, autoimmune diseases, and inflammation by administering a compound of Formula I.

The present invention generally relates to a method for minimizing the formation of insoluble salts of phenoxy herbicides. The method comprises (1) mixing a compatibility agent, amine salts of phenoxy acid herbicides, and a chemical containing non-amine cations in a aqueous system to form a stable and non-nozzle plugging solution; and (2) application of said stable and non-nozzle plugging solution onto target plants.

A thermal image receiver element dry image receiving layer has a Tg of at least 25° C. and is the outermost layer. The dry image receiving layer has a dry thickness of at least 0.5 μm and up to and including 5 μm. It comprises a water-dispersible release agent and a polymer binder matrix that consists essentially of: (1) a water-dispersible acrylic polymer comprising chemically reacted or chemically non-reacted hydroxyl, phospho, phosphonate, sulfo, sulfonate, carboxy, or carboxylate groups, and (2) a water-dispersible polyester that has a Tg of 30° C. or less. The water-dispersible acrylic polymer is present in an amount of at least 55 weight % and at a dry ratio to the water-dispersible polyester of at least 1:1. The thermal image receiver element can be used to prepare thermal dye images after thermal transfer from a thermal donor element.

The present disclosure relates to a method of melt processing an active agent. The method may include encapsulating an active agent in a first polymer material exhibiting a first processing temperature T1 and forming capsules including the active agent. The method may also include melt processing the capsules with a second polymer material exhibiting a second processing temperature T2, wherein T1>T2.

Distributed mobile device management including a plurality of management agents is disclosed. Management-related information may be retrieved from a storage location accessible to a plurality of management agents. The management-related information may have been provided to the storage location from a management agent associated with a managed application. And at least one operation may be performed based at least in part on the management-related information.

The present invention features compounds having the Formula (Ia) and (Ib) (e.g., a compound of any of Formulas ((Ia-2)-(Ia-21)), including other tautomers, stereoisomers, E/Z stereoisomers, prodrugs, pharmaceutically acceptable salts, and compositions thereof. The invention also features methods for treating or preventing pain (e.g., neuropathic pain), inflammation, or epilepsy in a patient by administering an effective amount of a compound of Formula (Ia) or (Ib). The invention also features a method for treating or preventing pain (e.g., neuropathic pain), inflammation, or epilepsy in a patient that includes administering to a patient in need thereof an effective amount of a compound of Formula (IIa) or (IIb) (e.g., a compound of any of Formulas ((IIa-2)-(IIa-6)). The compounds described herein (e.g., a compound of Formulas (Ia), (Ib), (IIa), or (IIb)) can also be used as anticonvulsants.

There are provided compounds of formula (I), wherein R1, R6, R8, Q2, Q3, Q3a, Q4, L and A have meanings given in the description, and pharmaceutically-acceptable salts thereof, which compounds are useful in the treatment of diseases in which inhibition of the activity of a member of the MAPEG family is desired and/or required, and particularly in the treatment of inflammation and/or cancer.

Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 or Bcl-xL proteins, compositions containing the compounds and methods of treating diseases during which are expressed anti-apoptotic Bcl-2 protein.

A lubricating oil composition comprising (a) a major amount of an oil of lubricating viscosity; and (b) an oil soluble epoxide compound having the following structure: wherein X is hydrogen or a substituted or unsubstituted C1 to C20 hydrocarbyl group, wherein the substituted hydrocarbyl group is substituted with one or more substituents selected from hydroxyl, alkoxy, ester or amino groups and Y is —CH2OR, —C(═O)OR1 or —C(═O)NHR2, wherein R, R1 and R2 are independently hydrogen or C1 to C20 alkyl or alkenyl groups; and further wherein the oil of lubricating viscosity does not contain a carboxylic acid ester.

The present invention relates to a rapid, sensitive, simple, and cost-effective spectrophotometric method of detecting and quantifying mycolic acid in a mycolic acid-fuschin dye complex with absorbance maxima ranging between 490-500 nm in the presence of various test compounds, for screening mycolic acid biosynthesis inhibitors useful as anti-microbial agents and a diagnostic kit thereof comprising basic fuschin dye in the concentration ranging between 0.1-1.0 gm/100 ml, phenol and 95% ethanol in the ratio ranging between 1:4 to 2:1 (v/v), and phenol and distilled water in the ratio ranging between 1:14 to 1:25.

A universal linker structure is provided, in which a functional group and activating leaving group are placed on a tether, allowing the placement of an electrophile at the end of any nucleic acid sequence. The electrophile on the tether can react with a second nucleic acid carrying a nucleophile when the two nucleic acids are hybridized near one another, resulting in release of the leaving group, and creation of a functional change. The linker can be designed to destabilize the ligation product without slowing the rate of reaction. This lowers product inhibition, and the target DNA or RNA can become a catalyst for isothermally generating multiple signals for detection. This enhanced signal is demonstrated in solution experiments and in solid supported assays. The universal linkers of the present invention are simple and inexpensive to prepare, and can be appended to any polynucleotide in automated steps on a standard DNA synthesizer.

The invention relates to compounds and methods for targeting radionuclide-based imaging agents to cells having receptors for a vitamin, or vitamin receptor binding derivative or analog thereof, by using such a vitamin as the targeting ligand for the imaging agent. The vitamin-based compounds can be used to target radionuclides to cells, such as a variety of tumor cell types, for use in diagnostic imaging of the targeted cells.

This invention relates to bis-azo colorants for use as bluing agents, laundry care compositions comprising bis-azo colorants that may serve as bluing agents, processes for making such bluing agents and laundry care compositions and methods of using the same. The bluing agents are generally comprised of at least two components: at least one chromophore component and at least one polymeric component. These bluing agents are advantageous in providing a whitening effect to fabrics, while not building up over time and causing undesirable blue discoloration to the treated fabrics.

Mono-pegylated arginase conjugate and method producing thereof. The mono-pegylated arginase is homogeneous in molecular weight and shows therapeutic effect for treating cancers and viral infections. The method of producing such arginase conjugate has a main step of genetically modifying the gene encoding an arginase so that the PEG moiety can attach to the enzyme at a predetermined, specific intended site. This is achieved by removing the PEG attaching amino acid residues at undesirable sites while keeping (or adding, if necessary) the one at the desirable site of the enzyme. Two exemplary mono-pegylated arginase conjugates so produced are human arginase I (HAI) where a polyethylene glycol (PEG) moiety is site-specific covalently bonded to Cys45 of the enzyme and Bacillus caldovelox arginase (BCA) where a polyethylene glycol (PEG) moiety is site-specific covalently bonded to Cys161 of the enzyme.

The present invention provides variable mass labeling reagents, a set of the variable mass labeling reagents, and a multiplexed set of variable mass labeling reagents.

A magnetic particle-polymer hybrid material can include: a substance having a structure of Formula 1 or derivative or salt thereof:Z(Y-Triazole-CH2—X—CH2—(FP)n)m (Formula 1), wherein Z is a magnetic particle smaller than 1 mm; n and m are independently integers; Y includes a first linker having an alkyl and/or aryl linked to the magnetic particle; X is CH2 or a heteroatom; FP is a functionalized polymer having: a first structure derived from a first norbornene compound linked to the magnetic particle through the Y-Triazole-CH2—X—CH2 linker; and one or more monomeric units each including a second structure derived from a second norbornene compound, where one of the monomeric units is linked to the first structure through a saturated or unsaturated alkyl, each monomeric unit includes a functional group capable of binding with another substance.

An ion conducting membrane for fuel cells involves coupling a compound having a sulfonic acid group with a polymeric backbone. Each of the compounds having a sulfonic acid group and the polymeric backbone are first functionalized with a halogen.

The invention relates to design of short oligonucleotides and analogs thereof (such as, di-, and trinucleotide compounds) useful for various therapeutic applications. It is believed that the compounds of the invention can be used as antiviral agents, anticancer agents and so on. In certain embodiments, the compounds of the invention can modulate immune-stimulatory pathways and non-TLR pathways. The invention also relates to design modified oligonucleotides for therapeutic applications, by excluding nucleotide segments having off-target effects from the modified oligonucleotides. In another aspect, the invention provides pharmaceutical compositions including one or more compounds of the invention. It is believed that the compounds and compositions as described herein have therapeutic utility against a variety of diseases, including viral diseases, autoimmune diseases (such as, allergy, asthma, and inflammatory disorders) and cancer.