SANTA CLARA, Calif., Aug. 13, 2024 — Pure Storage today announced that it joined Ultra Ethernet Consortium (UEC), a Linux Foundation initiative dedicated to building a complete, open, and accessible Ethernet-based […]

The post Pure Storage Embraces Next-Gen Networking for AI with Ultra Ethernet Consortium Membership appeared first on HPCwire.

Aug. 19, 2024 — SURF’s innovation department recently collaborated with Cornelis Networks to advance networking capabilities for high-performance computing (HPC) clusters. The collaboration marks a new step forward for SURF […]

The post Cornelis Networks Partners with SURF to Enhance HPC Cluster Networking Capabilities appeared first on HPCwire.

Oct. 29, 2024 — NVIDIA has announced that xAI’s Colossus supercomputer cluster comprising 100,000 NVIDIA Hopper GPUs in Memphis, Tennessee, achieved this massive scale by using the NVIDIA Spectrum-X Ethernet […]

The post NVIDIA Ethernet Networking Accelerates xAI’s Colossus AI Supercomputer appeared first on HPCwire.

A large ball python found slithering in the parking lot of a Chili's restaurant in North Carolina turned out to have been an escaped pet missing for two months.

We hear a lot about quantum computers – sometimes too much – but not as much about quantum networking which will also be a critical component in making widespread use […]

The post EPB Offers Commercial Quantum Network for Quantum Developers appeared first on HPCwire.

The U.S. Navy conducted a two-missile test flight of unarmed life-extended Trident II-D5LE missiles from the USS Wyoming in the Eastern Test Range off the coast of Cape Canaveral, Fla, the Navy announced.

COLLEGE PARK, Md. and VISTA, Calif., Nov. 8, 2024 — IonQ has announced that it has reached a definitive agreement to acquire substantially all of the operating assets of Qubitekk, […]

The post IonQ to Expand Quantum Networking Portfolio with Qubitekk Acquisition appeared first on HPCwire.

Two additional cases of a new strain of mpox have been detected in Britain, national health officials said Monday, less than a week after the first case was announced to the public.

BOSTON, Dec. 12, 2023 — Aliro Quantum today announced the controlled availability of Aliro Simulator, a versatile, modular quantum network simulator equipped to model all portions of a quantum network from […]

The post Aliro Quantum Debuts Aliro Simulator, Enhancing Quantum Network Simulation and Visualization appeared first on HPCwire.

The Federal Aviation Administration has banned flights to-and-from Haiti for at least 30 days after JetBlue and Spirit Airlines planes were hit by gunfire Monday during attempts to land in Port-au-Prince.

Both happiness and general well-being were boosted in the study of 395 people.

Networking doesn’t always have to feel like a self-serving transaction, says executive coach Daniel Hallak. Highlighting the importance of focusing on giving rather than taking when it comes to making connections, he outlines a mindset shift to help you build better relationships — in a way that doesn't feel gross.

Teachers in North Carolina and Oregon plan to walk out of their classrooms in protest in May.

Teachers in North Carolina and Oregon plan to walk out of their classrooms in protest in May.

Students returning to schools in Virginia and New York this fall will be required to participate in mental-health education as part of their health and physical education courses.

Biden's campaign announced March 31 that the 2020 Democratic presidential candidate backs two local attempts to raise more tax revenue for schools.

The school board in Gwinnett County, Ga., will shift from a 4-1 white Republican majority to a 3-2 Black Democratic majority, mirroring demographic changes in the county.

The school district, which serves about 11,200 students, postponed opening because of the protests following the death of Michael Brown, the 18-year-old black teenager who was shot by a white police officer.

Reimer could be reclaimed by Buffalo and sent directly to the AHL

How did the Miami and Georgia losses impact the CFP rankings in their second release?

Marie Pino, who taught generations of children in her Navajo community, died at 67. She had lost one of her sons, a school basketball coach, to coronavirus-related illness just weeks before; her husband, an emergency medical coordinator and pastor, died of the illness shortly after she did.

Laura Medlock
Apr 13, 2022; 42:3133-3149
Systems/Circuits

Prithviraj Rajebhosale
Oct 23, 2024; 44:e0063242024-e0063242024
Cellular

William W. Seeley
Dec 11, 2019; 39:9878-9882
Progressions

AP Georgopoulos
Nov 1, 1982; 2:1527-1537
Articles

Kong-Fatt Wong
Jan 25, 2006; 26:1314-1328
BehavioralSystemsCognitive

Umut Güçlü
Jul 8, 2015; 35:10005-10014
BehavioralSystemsCognitive

Neuregulin1 (Nrg1) signaling is critical for neuronal development and function from fate specification to synaptic plasticity. Type III Nrg1 is a synaptic protein which engages in bidirectional signaling with its receptor ErbB4. Forward signaling engages ErbB4 phosphorylation, whereas back signaling engages two known mechanisms: (1) local axonal PI3K-AKT signaling and (2) cleavage by -secretase resulting in cytosolic release of the intracellular domain (ICD), which can traffic to the nucleus (Bao et al., 2003; Hancock et al., 2008). To dissect the contribution of these alternate signaling strategies to neuronal development, we generated a transgenic mouse with a missense mutation (V₃₂₁L) in the Nrg1 transmembrane domain that disrupts nuclear back signaling with minimal effects on forward signaling or local back signaling and was previously found to be associated with psychosis (Walss-Bass et al., 2006). We combined RNA sequencing, retroviral fate mapping of neural stem cells, behavioral analyses, and various network analyses of transcriptomic data to investigate the effect of disrupting Nrg1 nuclear back signaling in the dentate gyrus (DG) of male and female mice. The V₃₂₁L mutation impairs nuclear translocation of the Nrg1 ICD and alters gene expression in the DG. V₃₂₁L mice show reduced stem cell proliferation, altered cell cycle dynamics, fate specification defects, and dendritic dysmorphogenesis. Orthologs of known schizophrenia (SCZ)-susceptibility genes were dysregulated in the V₃₂₁L DG. These genes coordinated a larger network with other dysregulated genes. Weighted gene correlation network analysis and protein interaction network analyses revealed striking similarity between DG transcriptomes of V₃₂₁L mouse and humans with SCZ.

Harmonics are an integral part of music, speech, and vocalizations of animals. Since the rest of the auditory environment is primarily made up of nonharmonic sounds, the auditory system needs to perceptually separate the above two kinds of sounds. In mice, harmonics, generally with two-tone components (two-tone harmonic complexes, TTHCs), form an important component of vocal communication. Communication by pups during isolation from the mother and by adult males during courtship elicits typical behaviors in female mice—dams and adult courting females, respectively. Our study shows that the processing of TTHC is specialized in mice providing neural basis for perceptual differences between tones and TTHCs and also nonharmonic sounds. Investigation of responses in the primary auditory cortex (Au1) from in vivo extracellular recordings and two-photon Ca²⁺ imaging of excitatory and inhibitory neurons to TTHCs exhibit enhancement, suppression, or no-effect with respect to tones. Irrespective of neuron type, harmonic enhancement is maximized, and suppression is minimized when the fundamental frequencies (F₀) match the neuron's best fundamental frequency (BF₀). Sex-specific processing of TTHC is evident from differences in the distributions of neurons’ best frequency (BF) and best fundamental frequency (BF₀) in single units, differences in harmonic suppressed cases re-BF₀, independent of neuron types, and from pairwise noise correlations among excitatory and parvalbumin inhibitory interneurons. Furthermore, TTHCs elicit a higher response compared with two-tone nonharmonics in females, but not in males. Thus, our study shows specialized neural processing of TTHCs over tones and nonharmonics, highlighting local network specialization among different neuronal types.

Words offer a unique opportunity to separate the processing mechanisms of object subcomponents from those of the whole object, because the phonological or semantic information provided by the word subcomponents (i.e., sublexical information) can conflict with that provided by the whole word (i.e., lexical information). Previous studies have revealed some of the specific brain regions and temporal information involved in sublexical information processing. However, a comprehensive spatiotemporal neural network for sublexical processing remains to be fully elucidated due to the low temporal or spatial resolutions of previous neuroimaging studies. In this study, we recorded stereoelectroencephalography signals with high spatial and temporal resolutions from a large sample of 39 epilepsy patients (both sexes) during a Chinese character oral reading task. We explored the activated brain regions and their connectivity related to three sublexical effects: phonological regularity (whether the whole character's pronunciation aligns with its phonetic radical), phonological consistency (whether characters with the same phonetic radical share the same pronunciation), and semantic transparency (whether the whole character's meaning aligns with its semantic radical). The results revealed that sublexical effects existed in the inferior frontal gyrus, precentral and postcentral gyri, temporal lobe, and middle occipital gyrus. Additionally, connectivity from the middle occipital gyrus to the postcentral gyrus and from postcentral gyrus to the fusiform gyrus was associated with the sublexical effects. These findings provide valuable insights into the spatiotemporal dynamics of sublexical processing and object recognition in the brain.

Today, FAO launched two new reports in time for the 160^th session of the Council:

-          FAO + Belgium: Inclusive approaches to end hunger and promote [...]

Rome - Two new sites in Japan - an inland fisheries and associated paddy farming system centred on the country’s largest lake and a traditional fruit-growing area  believed to have been the [...]

A clip from the father of video art's 1969 piece

Investigators discovered that the original print of "The Roaring Lion" had been sold to a buyer in Italy

Experts have confirmed that the image of "Knight, Death and the Devil" is a real master engraving by the renowned German artist Albrecht Dürer

A blockbuster exhibition in London examines the Dutch Post-Impressionist's creative output between 1888 and 1890, which was one of the most productive periods of his career

A roughly 33-foot-long asteroid called 2024 PT5 will chart a horseshoe-like path around our planet

As hundreds of motorists take to the desert, their tracks damage the massive geoglyphs made by Indigenous groups in northern Chile

The "John Evenson" tugboat was helping another ship enter the Sturgeon Bay Ship Canal in Wisconsin when it sank to the bottom of Lake Michigan in 1895

While expectations are high for some special sightings, experts warn that comets are notoriously fickle and unpredictable

A $1 million grant from the U.S. is the latest effort to support Ukraine's fight to preserve its rich past

A Dutch museum famous for displaying art in unconventional locations had placed a pair of painted beer cans in a glass elevator shaft

The notorious predators, nicknamed the “Man-Eaters of Tsavo,” terrorized railway workers in Kenya for roughly nine months

Scurvy diagnoses in Australia and Canada suggest doctors should consider testing for vitamin C deficiency in patients experiencing poverty, food insecurity and social isolation

The new research could change history's understanding of the sprawling trade network that connected Europe and the Middle East to East Asia

Ne’Kiya Jackson and Calcea Johnson of Louisiana published a new study proving the Pythagorean theorem using trigonometry, a feat mathematicians long thought could not be done

The one-minute composition, which dates to the 1830s, was found on a piece of paper about the size of an index card at a museum in New York City

This brief chapter of art history is often overlooked. Now, an exhibition in New York City makes a strong argument for the integral role played by four artists in the city of Siena

Steve Lazarides' personal collection of prints, original works, handwritten press releases and burner phones sold at auction for around $1.4 million