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[Turkish] Osmanlıda ve Cumhuriyet’te Asker ve Sivil Bürokrat...

[Turkish] Osmanlıda ve Cumhuriyet’te Asker ve Sivil Bürokratların Kaleme Aldığı Asur ve Ermeni Raporları I



  • Government and Political Information

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Biden's embrace of Saudi prince shows that his only principle was defeating Trump

At this point, it may be fair to say President Joe Biden’s criticisms of his predecessor have nothing to do with principles. It was all politics, all the way down.




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CRISPR Immune Cells Not Only Survive, They Thrive After Infusion Into Cancer Patients

CRISPR Immune Cells Not Only Survive, They Thrive After Infusion Into Cancer Patients

In the first-ever (sanctioned) investigational use of multiple edits to the human genome, a study found that cells edited in three specific ways and then removed from patients and brought back into the lab setting were able to kill cancer months after their original manufacturing and infusion.

This is the first U.S. clinical trial to test the gene editing approach in humans, and the publication of this new data today follows on the initial report last year that researchers were able to use CRISPR/Cas9 technology to successfully edit three cancer patients' immune cells. The ongoing study is a cooperative between Tmunity Therapeutics, the Parker Institute for Cancer Immunotherapy, and the University of Pennsylvania. 

Patients on this trial were treated by Edward A. Stadtmauer, MD, section chief of Hematologic Malignancies at Penn, co-lead author on the study. The approach in this study is closely related to CAR T cell therapy, in which patient immune cells are engineered to fight cancer, but it has some key differences. Just like CAR T, researchers in this study began by collecting a patient's T cells from blood. However, instead of arming these cells with a receptor against a protein such as CD19, the team first used CRISPR/Cas9 editing to remove three genes. The first two edits removed a T cell's natural receptors so they can be reprogrammed to express a synthetic T cell receptor, allowing these cells to seek out and destroy tumors. The third edit removed PD-1, a natural checkpoint that sometimes blocks T cells from doing their job. 

Once the three genes are knocked out, a fourth genetic modification was accomplished using a lentivirus to insert the cancer-specific synthetic T cell receptor, which tells the edited T cells to target an antigen called NY-ESO-1. Previously published data show these cells typically survive for less than a week, but this new analysis shows the edited cells used in this study persisted, with the longest follow up at nine months. 

Several months after the infusion, researchers drew more blood and isolated the CRISPR-edited cells for study. When brought back into the lab setting, the cells were still able to kill tumors. 

The CRISPR-edited T cells used in this study are not active on their own like CAR T cells. Instead, they require the cooperation of a molecule known as HLA-A*02:01, which is only expressed in a subset of patients. This means that patients had to be screened ahead of time to make sure they were a match for the approach. Participants who met the requirements received other clinically-indicated therapy as needed while they waited for their cells to be manufactured. Once that process was completed, all three patients received the gene-edited cells in a single infusion after a short course of chemotherapy. Analysis of blood samples revealed that all three participants had the CRISPR-edited T cells take root and thrive in the patients. While none responded to the therapy, there were no treatment-related serious adverse events. 

CRISPR technology has not previously been tested in humans in the U.S. so the research team had to move through a comprehensive and rigorous series of institutional and federal regulatory approval steps, including approval by the National Institutes of Health's Recombinant DNA Research Advisory Committee and review by the U.S. Food and Drug Administration, as well as Penn's institutional review board and institutional biosafety committee. The entire process required more than two years.

 Researchers say these new data will open the door to later stage studies to investigate and extend this approach to a broader field beyond cancer, several of which are already planned at Penn.

sb admin Thu, 02/06/2020 - 14:52
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Washington's streak of 718 days without snow unlikely to be broken despite East Coast bracing for storm

Washington, D.C.'s streak of 718 days without heavy snow will not likely be broken anytime soon, even as the rest of the East Coast prepares for a winter storm this weekend.




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California plans to enlist AI to translate healthcare information

State officials want to use artificial intelligence to translate public healthcare and social services documents and websites. But some experts worry AI may introduce errors.




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Trump posted a fake Taylor Swift image. AI and deepfakes are only going to get worse this election cycle

The surge in deepfake images and videos online of U.S. presidential candidates Donald Trump and Kamala Harris have raised questions over whether the false information could impact the election.




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Online fraudster on the loose after bilking investors out of millions with fake inventions, websites

Santa Clara County fraudster Dennis Fountaine fled sentencing last month. Fountaine was convicted of three felony counts of grand theft by fraud. He also admitted to the aggravated white-collar enhancement for defrauding four victims of over $350,000.




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Opinion: The risks of sharing your DNA with online companies aren't a future concern. They're here now

Turmoil at 23andMe, and a lawsuit alleging that GEDmatch shares data with Facebook, highlights how far your genetic information could travel without your consent.




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To keep deepfakes from infiltrating its site, Yahoo News enlists help from McAfee

To buttress its defenses against bogus, AI-generated images, Yahoo News is integrating deepfake-detection technology from McAfee into its system.




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Automating Liquid Biopsy: Unleashing New Potential in Diagnostics

Discover how automation increases the efficiency and reliability of blood-based liquid biopsy assays.




nl

Unlocking the Metabolic Drivers of Alzheimer’s Disease

Cellular oxygen consumption in the brain may shed new light on Alzheimer’s disease onset, progression, and treatment.




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Seattle's Only News Quiz

Our news quiz is back and ready to roll, just in time for... well, a week that feels like it might be kind of important! by Sally Neumann & Leah Caglio

 



  • Seattle's Only News Quiz

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Seattle's Only News Quiz

Well, something sure has happened. And frankly, if we have to read one more fact about that man and his sycophantic oligarchical cabal, we will lose our shit. So we’re going to do some radical self-care by cooking a cauldron of Strega Nona-style pasta and writing about all the joyful things, and scraps of progress we can find. Here are some (relatively! Low bar, but it’s what we have!) GOOD things to have come out of this election. Let’s start off with Washington: our very own Big Blue House. by Sally Neumann & Leah Caglio

Create your own user feedback survey



  • Seattle's Only News Quiz

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How to Build an Online Portfolio and Drive Traffic To It

When you’re a web designer, graphic designer, or similar professional in a creative field, you have two essential tools for attracting new clients: word of mouth and a stellar portfolio. The latter can be invaluable so it’s critical that you’re able to build a strong one and drive traffic to it. Neglect these tasks and […]



  • eBusiness Tips
  • online marketing ideas
  • social network marketing
  • targeted traffic tips

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Online media release on Internet News Bureau

Our online media release is published on Internet News Bureau.




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Newlook Marketing accepts PayPal online payment

Newlook Marketing has registered a business account with PayPal, to accept all types of online payment of its online purchases. Accepted Credit Cards are Visa, MasterCard, American Express card, Discover and e-Check.




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Online Tutorial for Navigating the Website

An online tutorial that shows shoppers in a step-by-step guide to search for hosiery and socks of interest and on how to place an online order.




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Post your comments online at the product page

If you have any comments regarding the hosiery shown on the website, you are most welcome to post your comments online at any webpage showing the product details. All comment links are available at the bottom of every product page on the website.




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Online Newsletter

Here's our newsletter archive, for the benefit of non-registered users. Newlook Marketing periodically sends out updates and announcement (about once in 2 months) via email to registered users. Registered users may opt out from our mailing list by updating their user profile or send an email to webmaster@newlook.com.sg.




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Election results 2024: Who won, and which races are too close to call in the Inland Northwest

While many were focused on the race for the White House, Inland Northwest contests were also largely decided on Tuesday night. With at least 31,000 ballots remaining to be counted, Spokane County voter turnout hovered around 56% of registered voters as of Tuesday, which is significantly lower than expected in a presidential election…




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Across the Inland Northwest, national and local talent comes together to deliver top-tier entertainment throughout the year

When you take stock of all the performing and fine arts offerings around the region, there's little doubt that entertainment lovers are spoiled for choice…



  • Arts & Entertainment

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Where I Can Find an Inlander?

We at the Inlander remain committed to keeping people informed and connected during the coronavirus outbreak, supporting our readers and local businesses in the ways we always have. We have experienced some disruption in where we distribute papers, but we're stocking and restocking thousands of copies at local Rosauers, Super 1, URM Cash & Carry, Yoke's, Albertson's and Safeway stores, plus Papa Murphy's locations, My Fresh Basket and more…



  • News/Local News

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The Inlander teamed up with a Rogers art teacher to paint a tribute to 2020 grads in Riverfront Park

As a general rule, if you start spray-painting Riverfront Park, Riverfront Park gets mad at you…



  • News/Local News

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Inlander Insights: Super Sparkle gets ready to say goodbye

Super Sparkle is returning to say au revoir…



  • Music/Music News

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Inlander Insights: Spokane String Quartet's Amanda Howard-Phillips

While there's always an impressive power hearing a full symphony fill a room with sound, there's a stirring subtlety that can only be achieved via classic music on a smaller scale.  That's a sonic itch that the Spokane String Quartet is always happy to scratch. Before the Spokane String Quartet takes the stage at The Fox this Sunday for a program featuring special guest pianist Archie Chen, we caught up with violinist Amanda Howard-Phillips—who has played with the quartet since 2011 and  is also second violin in the Spokane Symphony — to chat about the communal expression of string quartet music, SSQ's upcoming shows, and the unique place the group occupies in Spokane…



  • Music/Music News

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Inlander Insights: The Sweeplings

The folk duo with Spokane connections wrestles with grief on its new album, 'Debris.' Loss is never easy. Loss during a pandemic is even tougher…



  • Music/Music News

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LA-based BODYTRAFFIC brings its signature contemporary dance style to the Inland Northwest

When Tina Berkett moved from New York City to Los Angeles in 2007, she immediately noticed the West Coast's creative spirit…



  • Arts & Culture

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Cloverland, Wash: The only original building left in this briefly booming orchard town in Asotin County is its well-preserved garage

Though a sign on Washington State Route 129 points you in the right direction, driving the nearly 12 miles along Cloverland Road to arrive at the Cloverland Garage in Asotin County can make you feel like you're, well, chasing ghosts…



  • Arts & Culture

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Scouting the Inland Northwest's college hoops programs for the 2024-25 season

WASHINGTON STATE MEN…




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Discover five Inland Northwest ghost towns where the past still eerily echoes

As early settlers flocked to the American West to extract the land's rich resources, small towns spread across the landscape…



  • Arts & Culture

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Inland Northwest tribes are using technology to track young salmon in hopes of returning runs to the Columbia and Spokane rivers

It starts raining just as two trucks hauling juvenile salmon arrive near the end of a gravel road at Chief Joseph Dam in the Central Washington town of Bridgeport on Friday, May 6…



  • News/Local News

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Meet the Mild Riders, Spokane's chillest (and only) scooter gang

Whizzing through West Central Spokane on the back of a scooter, the wind whipping around your face, offers a new perspective to getting around town…



  • Culture/Arts & Culture

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Fentanyl is flooding into the Inland Northwest, triggering a deadlier phase of the opioid crisis

Allan didn't know it was fentanyl…



  • News/Local News

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The Childhood Cancer Coalition eases the disease's burden on Inland Northwest families, one kindness at a time

On Meagan Glubrecht's right forearm is an unmistakable tattoo…




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Light A Lamp works to support Inland Northwest students who struggle with anxiety and depression, one act of kindness at a time

Angella Southerly believes that a single act of kindness, no matter how small, has the power to change someone's life…




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Annual Manual 2024: Explore the Inland Northwest

Think about the last time you went on a trip, whether halfway around the globe or just an hour or two away by car…




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After an Inlander article about her links to conspiracy theory websites, Rep. Jenny Graham responds with profanity, threats and another conspiracy website

State Rep. Jenny Graham (R-Spokane) called me on my cellphone the day the Inlander published my story about her unwittingly linking to conspiracy theory posts on Facebook. I called her back immediately — while she was still leaving a voicemail — and was greeted with two blasts of profanity. "You cocksucker!…



  • News/Local News

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I've been to my fair share of breweries, but #steamwhistle ranks right up there. There's not many other breweries that only do *one thing* but do it so well.

marusin posted a photo:

via Instagram ift.tt/2hkUMfs




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Janet Mock Rants Against Hollywood at 'Pose' Premiere After Only Getting Paid $40,000 Per Episode

During her speech, the producer and director of the show also apologizes to boyfriend Angel Bismark Curiel as she admits to having cheated on him during the show's production.




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Olivia Rodrigo, Lil Nas X and Others Tapped to Appear in Final Episodes of 'SNL' Season 46

Meanwhile, 'The Predator' actor Keegan-Michael Key and 'The Queen's Gambit' star Anya Taylor-Joy have been set to host the final episodes of the NBC show's current season.



  • tv
  • Saturday Night Live

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Elon Musk Plays Down Rumors of 'SNL' Cast's Uproar Over His Hosting Gig

When asked how rehearsals with the stars of the NBC sketch show have been going in light of the alleged protest, the Tesla CEO says it's all 'much ado about nothing.'




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Pete Davidson 'Really Excited' for Elon Musk's 'SNL' Hosting Gig Despite Fellow Cast's Criticisms

The 'Trainwreck' actor is looking forward to the upcoming episode which will see the Tesla boss as a host although some of his co-stars are seemingly not happy with the casting.



  • tv
  • Saturday Night Live
  • Pete Davidson;Elon Musk

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NLE Choppa Addresses Viral Video of Him and His Crew Jumping a Fan

Taking to his Twitter account, the 'Walk Em Down' rapper plays down the fact that he got punched by the said fan even though all of his crew helped him during the physical altercation at the beach.




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Julianna Margulies Always Loses to Son in Cooking Contest as She Enlists Neighbors as Judges

The former 'ER' actress reveals she spent Covid-19 lockdown having a bake-off with her son and the judges that involve their neighbors always love the kid's cookies more.




nl

Elon Musk Plays Down Rumors of 'SNL' Cast's Uproar Over His Hosting Gig

When asked how rehearsals with the stars of the NBC sketch show have been going in light of the alleged protest, the Tesla CEO says it's all 'much ado about nothing.'




nl

Pete Davidson 'Really Excited' for Elon Musk's 'SNL' Hosting Gig Despite Fellow Cast's Criticisms

The 'Trainwreck' actor is looking forward to the upcoming episode which will see the Tesla boss as a host although some of his co-stars are seemingly not happy with the casting.



  • tv
  • Saturday Night Live
  • Pete Davidson;Elon Musk

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Hugh Jackman Enlists NY Cop to Pressure Ryan Reynolds Into Getting Him in 'Deadpool 3'

In a video posted on his social media accounts, an officer named John Dobkowski tells the 'Deadpool' star to get the 'Logan' actor in the upcoming movie, or else he will be ticketing Reynolds.




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AppleVis Unleashed April 2023: A Little Bank

In this month's edition of AppleVis Unleashed, Thomas Domville and Mike Malarsie discuss recent Apple news and other topics of interest. Topics featured in this episode include:

  • Here Comes the WWDC 2023 (00:04:20)
  • The Musical Chairs Continues for the iPhone 15 Rumors (00:12:50)
  • Apple Turns on HomePod's Smoke Alarm Recognition (00:18:40)
  • Move Over! There is a New Bank in Town (00:23:18(
  • Subscription Fatigue (00:33:18(
  • Upcoming Apple Watch OS Getting a Big Interface Changes (00:41:09)
  • More Leaks in What We Could See in the Upcoming iOS 17 (00:43:06)
  • What's in this month AppleVis News (00:57:42) Closing (01:00:36)

Links:

If you have feedback or questions for the Unleashed team, you can reach them by…




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Introducing Pride Counseling: An iOS App That Provides Online Therapy for the LGBTQ+ Community

In this episode, Ida introduces us to Pride Counseling, an iOS app that provides access to the company's online therapy platform specifically designed for the LGBTQ+ community. She discusses the app's features, such as live chat and video calls with licensed professionals who specialize in LGBTQ+ issues. Ida explains how Pride Counseling provides personalized therapy that is convenient and discreet.