nan Towards just transition in Africa: Continental coordination on green financing and job creation By www.chathamhouse.org Published On :: Thu, 08 Sep 2022 14:07:13 +0000 Towards just transition in Africa: Continental coordination on green financing and job creation 6 October 2022 — 7:00AM TO 3:30PM Anonymous (not verified) 8 September 2022 Addis Ababa and online At this hybrid conference in Addis Ababa, speakers take stock of preparations ahead of the ‘African COP27’ in November and discuss the key priorities for streamlining continental cooperation on policy approaches to just transition. At this hybrid conference in Addis Ababa, speakers will take stock of policy efforts and preparations ahead of the ‘African COP27’ in November and discuss the key priorities for streamlining continental cooperation on policy approaches to just transition. Global climate policies towards a ‘just transition’ under the Paris Agreement should align with and support African states’ national sustainable development priorities – in particular, the need for decent and fair job creation, as well as resilient and sustainable land, environment and ecosystem management policies. They must also be cognizant of African nations’ urgent requirements for sustainable and accessible energy to underpin economic development. Achieving green growth requires innovative and more accessible financing models, especially as wealthy nations’ financial pledges have fallen short. It also requires clarity and cooperation to unlock investment in both renewable and transitional energy. African countries face collective climate and employment-related challenges. However, policymaking often remains regionally siloed according to differing political, energy sector and ecological realities. There is a need for transformational strategic thinking and context-specific action from African governments, civil society, businesses and financiers, in their green financing demands and national implementation plans. At this hybrid conference in Addis Ababa, speakers will take stock of policy efforts and preparations ahead of the ‘African COP27’ in November and discuss the key priorities for streamlining continental cooperation on policy approaches to just transition, job creation and green financing. This event is the third in a series on Towards just transition: Connecting green financing and sustainable job creation in Africa, supported by the Chatham House Sustainability Accelerator. Agenda: Towards a just transition in Africa (English) (PDF) Agenda: Towards a just transition in Africa (French) (PDF) Full Article
nan Separation and identification of permethylated glycan isomers by reversed phase nanoLC-NSI-MS By www.mcponline.org Published On :: 2020-12-29 Simone KurzDec 29, 2020; 0:RA120.002266v1-mcp.RA120.002266Research Full Article
nan Angiostatic cues from the matrix: Endothelial cell autophagy meets hyaluronan biology [Glycobiology and Extracellular Matrices] By www.jbc.org Published On :: 2020-12-04T00:06:06-08:00 The extracellular matrix encompasses a reservoir of bioactive macromolecules that modulates a cornucopia of biological functions. A prominent body of work posits matrix constituents as master regulators of autophagy and angiogenesis and provides molecular insight into how these two processes are coordinated. Here, we review current understanding of the molecular mechanisms underlying hyaluronan and HAS2 regulation and the role of soluble proteoglycan in affecting autophagy and angiogenesis. Specifically, we assess the role of proteoglycan-evoked autophagy in regulating angiogenesis via the HAS2-hyaluronan axis and ATG9A, a novel HAS2 binding partner. We discuss extracellular hyaluronan biology and the post-transcriptional and post-translational modifications that regulate its main synthesizer, HAS2. We highlight the emerging group of proteoglycans that utilize outside-in signaling to modulate autophagy and angiogenesis in cancer microenvironments and thoroughly review the most up-to-date understanding of endorepellin signaling in vascular endothelia, providing insight into the temporal complexities involved. Full Article
nan GUCY2D mutations in retinal guanylyl cyclase 1 provide biochemical reasons for dominant cone-rod dystrophy but not for stationary night blindness [Cell Biology] By www.jbc.org Published On :: 2020-12-25T00:06:31-08:00 Mutations in the GUCY2D gene coding for the dimeric human retinal membrane guanylyl cyclase (RetGC) isozyme RetGC1 cause various forms of blindness, ranging from rod dysfunction to rod and cone degeneration. We tested how the mutations causing recessive congenital stationary night blindness (CSNB), recessive Leber's congenital amaurosis (LCA1), and dominant cone–rod dystrophy-6 (CORD6) affected RetGC1 activity and regulation by RetGC-activating proteins (GCAPs) and retinal degeneration-3 protein (RD3). CSNB mutations R666W, R761W, and L911F, as well as LCA1 mutations R768W and G982VfsX39, disabled RetGC1 activation by human GCAP1, -2, and -3. The R666W and R761W substitutions compromised binding of GCAP1 with RetGC1 in HEK293 cells. In contrast, G982VfsX39 and L911F RetGC1 retained the ability to bind GCAP1 in cyto but failed to effectively bind RD3. R768W RetGC1 did not bind either GCAP1 or RD3. The co-expression of GUCY2D allelic combinations linked to CSNB did not restore RetGC1 activity in vitro. The CORD6 mutation R838S in the RetGC1 dimerization domain strongly dominated the Ca2+ sensitivity of cyclase regulation by GCAP1 in RetGC1 heterodimer produced by co-expression of WT and the R838S subunits. It required higher Ca2+ concentrations to decelerate GCAP-activated RetGC1 heterodimer—6-fold higher than WT and 2-fold higher than the Ser838-harboring homodimer. The heterodimer was also more resistant than homodimers to inhibition by RD3. The observed biochemical changes can explain the dominant CORD6 blindness and recessive LCA1 blindness, both of which affect rods and cones, but they cannot explain the selective loss of rod function in recessive CSNB. Full Article
nan A kinetic dissection of the fast and superprocessive kinesin-3 KIF1A reveals a predominant one-head-bound state during its chemomechanical cycle [Molecular Biophysics] By www.jbc.org Published On :: 2020-12-25T00:06:30-08:00 The kinesin-3 family contains the fastest and most processive motors of the three neuronal transport kinesin families, yet the sequence of states and rates of kinetic transitions that comprise the chemomechanical cycle and give rise to their unique properties are poorly understood. We used stopped-flow fluorescence spectroscopy and single-molecule motility assays to delineate the chemomechanical cycle of the kinesin-3, KIF1A. Our bacterially expressed KIF1A construct, dimerized via a kinesin-1 coiled-coil, exhibits fast velocity and superprocessivity behavior similar to WT KIF1A. We established that the KIF1A forward step is triggered by hydrolysis of ATP and not by ATP binding, meaning that KIF1A follows the same chemomechanical cycle as established for kinesin-1 and -2. The ATP-triggered half-site release rate of KIF1A was similar to the stepping rate, indicating that during stepping, rear-head detachment is an order of magnitude faster than in kinesin-1 and kinesin-2. Thus, KIF1A spends the majority of its hydrolysis cycle in a one-head-bound state. Both the ADP off-rate and the ATP on-rate at physiological ATP concentration were fast, eliminating these steps as possible rate-limiting transitions. Based on the measured run length and the relatively slow off-rate in ADP, we conclude that attachment of the tethered head is the rate-limiting transition in the KIF1A stepping cycle. Thus, KIF1A's activity can be explained by a fast rear-head detachment rate, a rate-limiting step of tethered-head attachment that follows ATP hydrolysis, and a relatively strong electrostatic interaction with the microtubule in the weakly bound post-hydrolysis state. Full Article
nan Problem Notes for SAS®9 - 66500: A content release on the SAS Risk Governance Framework fails to load when you use SAS 9.4M7 (TS1M7) on the Microsoft Windows operating system By Published On :: Wed, 19 Aug 2020 17:45:15 EST When you log on to the SAS Risk Governance Framework and choose a solution, the web application might fail to load the solution content. When the problem occurs, you continue to see "Loading..." on the screen, an Full Article RGPBNDL+SAS+Risk+Governance+Framework
nan Interleukin 6 reduces allopregnanolone synthesis in the brain and contributes to age-related cognitive decline in mice [Research Articles] By www.jlr.org Published On :: 2020-10-01T00:05:17-07:00 Cognitive decline with age is a harmful process that can reduce quality of life. Multiple factors have been established to contribute to cognitive decline, but the overall etiology remains unknown. Here, we hypothesized that cognitive dysfunction is mediated, in part, by increased levels of inflammatory cytokines that alter allopregnanolone (AlloP) levels, an important neurosteroid in the brain. We assessed the levels and regulation of AlloP and the effects of AlloP supplementation on cognitive function in 4-month-old and 24-month-old male C57BL/6 mice. With age, the expression of enzymes involved in the AlloP synthetic pathway was decreased and corticosterone (CORT) synthesis increased. Supplementation of AlloP improved cognitive function. Interestingly, interleukin 6 (IL-6) infusion in young animals significantly reduced the production of AlloP compared with controls. It is notable that inhibition of IL-6 with its natural inhibitor, soluble membrane glycoprotein 130, significantly improved spatial memory in aged mice. These findings were supported by in vitro experiments in primary murine astrocyte cultures, indicating that IL-6 decreases production of AlloP and increases CORT levels. Our results indicate that age-related increases in IL-6 levels reduce progesterone substrate availability, resulting in a decline in AlloP levels and an increase in CORT. Furthermore, our results indicate that AlloP is a critical link between inflammatory cytokines and the age-related decline in cognitive function. Full Article
nan Predominant phosphorylation patterns in Neisseria meningitidis lipid A determined by top-down MS/MS [Research Articles] By www.jlr.org Published On :: 2020-11-01T00:05:43-07:00 Among the virulence factors in Neisseria infections, a major inducer of inflammatory cytokines is the lipooligosaccharide (LOS). The activation of NF-B via extracellular binding of LOS or lipopolysaccharide (LPS) to the toll-like receptor 4 and its coreceptor, MD-2, results in production of pro-inflammatory cytokines that initiate adaptive immune responses. LOS can also be absorbed by cells and activate intracellular inflammasomes, causing the release of inflammatory cytokines and pyroptosis. Studies of LOS and LPS have shown that their inflammatory potential is highly dependent on lipid A phosphorylation and acylation, but little is known on the location and pattern of these posttranslational modifications. Herein, we report on the localization of phosphoryl groups on phosphorylated meningococcal lipid A, which has two to three phosphate and zero to two phosphoethanolamine substituents. Intact LOS with symmetrical hexa-acylated and asymmetrical penta-acylated lipid A moieties was subjected to high-resolution ion mobility spectrometry MALDI-TOF MS. LOS molecular ions readily underwent in-source decay to give fragments of the oligosaccharide and lipid A formed by cleavage of the ketosidic linkage, which enabled performing MS/MS (pseudo-MS3). The resulting spectra revealed several patterns of phosphoryl substitution on lipid A, with certain species predominating. The extent of phosphoryl substitution, particularly phosphoethanolaminylation, on the 4'-hydroxyl was greater than that on the 1-hydroxyl. The heretofore unrecognized phosphorylation patterns of lipid A of meningococcal LOS that we detected are likely determinants of both pathogenicity and the ability of the bacteria to evade the innate immune system. Full Article
nan Site-specific N-glycosylation Characterization of Recombinant SARS-CoV-2 Spike Proteins [Research] By www.mcponline.org Published On :: 2020-10-19T13:35:16-07:00 The glycoprotein spike (S) on the surface of SARS-CoV-2 is a determinant for viral invasion and host immune response. Herein, we characterized the site-specific N-glycosylation of S protein at the level of intact glycopeptides. All 22 potential N-glycosites were identified in the S-protein protomer and were found to be preserved among the 753 SARS-CoV-2 genome sequences. The glycosites exhibited glycoform heterogeneity as expected for a human cell-expressed protein subunit. We identified masses that correspond to 157 N-glycans, primarily of the complex type. In contrast, the insect cell-expressed S protein contained 38 N-glycans, completely of the high-mannose type. Our results revealed that the glycan types were highly determined by the differential processing of N-glycans among human and insect cells, regardless of the glycosites’ location. Moreover, the N-glycan compositions were conserved among different sizes of subunits. Our study indicate that the S protein N-glycosylation occurs regularly at each site, albeit the occupied N-glycans were diverse and heterogenous. This N-glycosylation landscape and the differential N-glycan patterns among distinct host cells are expected to shed light on the infection mechanism and present a positive view for the development of vaccines and targeted drugs. Full Article
nan Separation and identification of permethylated glycan isomers by reversed phase nanoLC-NSI-MS [Research] By www.mcponline.org Published On :: 2020-12-29T12:35:15-08:00 High performance liquid chromatography has been employed for decades to enhance detection sensitivity and quantification of complex analytes within biological mixtures. Among these analytes, glycans released from glycoproteins and glycolipids have been characterized as underivatized or fluorescently tagged derivatives by HPLC coupled to various detection methods. These approaches have proven extremely useful for profiling the structural diversity of glycoprotein and glycolipid glycosylation but require the availability of glycan standards and secondary orthogonal degradation strategies to validate structural assignments. A robust method for HPLC separation of glycans as their permethylated derivatives, coupled with in-line MSn fragmentation to assign structural features independent of standards, would significantly enhance the depth of knowledge obtainable from biological samples. Here, we report an optimized workflow for LC-MS analysis of permethylated glycans that includes sample preparation, mobile phase optimization, and MSn method development to resolve structural isomers on-the-fly. We report baseline separation and MSn fragmentation of isomeric N- and O-glycan structures, aided by supplementing mobile phases with Li+, which simplifies adduct heterogeneity and facilitates cross-ring fragmentation to obtain valuable monosaccharide linkage information. Our workflow has been adapted from standard proteomics-based workflows and, therefore, provides opportunities for laboratories with expertise in proteomics to acquire glycomic data with minimal deviation from existing buffer systems, chromatography media, and instrument configurations. Furthermore, our workflow does not require a mass spectrometer with high-resolution/accurate mass capabilities. The rapidly evolving appreciation of the biological significance of glycans for human health and disease requires the implementation of high-throughput methods to identify and quantify glycans harvested from sample sets of sufficient size to achieve appropriately powered statistical significance. The LC-MSn approach we report generates glycan isomeric separations, robust structural characterization, and is amenable to auto-sampling with associated throughput enhancements. Full Article
nan Dance of the Trillions: Developing Countries and Global Finance By www.chathamhouse.org Published On :: Fri, 06 Jul 2018 10:50:25 +0000 Dance of the Trillions: Developing Countries and Global Finance Book sysadmin 6 July 2018 David Lubin tells the story of what makes money flow from high-income countries to lower-income ones; what makes it flow out again; and how developing countries have sought protection against the volatility of international capital flows. Selected by the Financial Times as one of the best economics books of 2018, Dance of the Trillions traces an arc from the 1970s, when developing countries first gained access to international financial markets, to the present day. Underlying this story is a discussion of how the relationship between developing countries and global finance appears to be moving from one governed by the ‘Washington Consensus’ to one more likely to be shaped by Beijing. This book is part of the Insights series. Praise for Dance of the Trillions This brilliant, well-written book shows how the destinies of developing countries have been shaped by the capricious flows of trillions of US dollars in international capital. When the funds gushed in, many emerging markets flourished but were just as quickly left stricken when the tides of international capital deserted them. James Kynge, emerging markets editor, Financial Times and author of China Shakes the World About the author David Lubin is managing director and head of emerging markets economics at Citi, an American bank, where he is responsible for a team of more than 30 economists in 15 locations globally. Purchase UK (via Amazon) Rest of world (via Brookings Institution Press) Students (via Browns Books) Full Article
nan New Frontiers in Gender-responsive Governance: Five Years of the W20 By www.chathamhouse.org Published On :: Fri, 02 Nov 2018 11:41:53 +0000 New Frontiers in Gender-responsive Governance: Five Years of the W20 Research paper sysadmin 2 November 2018 After five years of the W20, women and gender equality remain at the margin of the G20. There is a real risk of the W20 representing a one-off territorial gain at a frontier that could easily be pushed back again. — A woman holds a female symbol model as workers take part in a rally to mark May Day, International Workers’ Day, in Istanbul, Turkey on 1 May 2016. Photo: Berk Ozkan/Anadolu Agency/Getty Images. Summary 2018 marks the fifth anniversary of the first grouping of the W20, the engagement group of the G20 that focuses on gender-inclusive economic growth and advocates for gender equality across the G20 agenda. Formally launched under the Turkish G20 presidency in 2015, the W20 is made up of women from business, international organizations, civil society, think-tanks and academia across the G20 member states. This paper takes stock of the critical steps in the development of the W20 over the last five years, examining its background, rationale and foundations, and identifying the areas of economic governance where it has so far contributed the most – and those where more action is needed. The W20 has filled a gap, it but needs to carefully assess its coherence with the UN agencies, the private sector, the G7 and other G20 engagement groups. The establishment of the W20 has contributed to defining new frontiers for economic governance and shifting the traditional approach from gender-neutral to gender-responsive. Whereas in 2013 gender in the G20 was considered a marginal issue better dealt with by ministers for equal opportunities, now gender equality and women’s economic empowerment are part of the mainstream economic dialogue. The next step is to ensure more structural and monitored policy reforms at the G20 level. Already, the W20 can count among its achievements the ‘25 by 25’ female labour force participation commitment adopted at the G20’s Brisbane summit in 2014, and the Women Entrepreneurs Finance Initiative (We-Fi) and Business Women Leaders’ Taskforce, both agreed at the Hamburg summit in 2017. The W20 is constrained in its policy impact by limited engagement with the finance track and a lack of consistent resourcing levels. Addressing these issues would strengthen its role as a credible player in shifting global economic governance while contributing to good gender-responsive domestic policies. Progress on gender equality has been too slow and too peripheral to drive change in the relatively short term – over one generation, for example. G20 governments must therefore embrace active, credible policies to bring more women into the labour market, improve access to education and finance, close the pay gap, invest in social infrastructure – especially childcare and assistance for the elderly – and support female entrepreneurs. These domestic policies need to be internationally coordinated so that action and benefits can be widespread. A feminist, inclusive agenda at the G20 level should highlight the current empirical evidence of women’s exclusion from the benefit of their economic activity, both in G20 members and beyond. The W20 should also focus on efforts to remedy the lack of women’s representation in G20 processes and in economic governance as a whole. 2018-11-06-gender-responsive-governance-five-years-w20-subacchi-rimmer (PDF) Full Article
nan The Role of Sub-state and Non-state Actors in International Climate Processes: Financial Institutions By www.chathamhouse.org Published On :: Thu, 20 Dec 2018 10:15:53 +0000 The Role of Sub-state and Non-state Actors in International Climate Processes: Financial Institutions Research paper sysadmin 20 December 2018 The trillions of dollars needed to secure the sustainable, climate-compatible pathway outlined in the 2015 Paris Agreement have focused attention on private finance and investment. — Photo by João Barbosa, ‘The need to keep growing’, 2018. This is one of four background papers feeding into a synthesis paper entitled The Role of Sub-state and Non-state Actors in International Climate Processes. Summary The trillions of dollars needed to secure the sustainable, climate-compatible pathway outlined in the 2015 Paris Agreement have focused attention on private finance and investment, and on the role of the financial sector as a potentially powerful non-state actor in the international climate debate. Leading individual financial institutions reacted to the Paris Agreement by framing it in terms of what it would mean for markets – i.e. risks and opportunities – and by underlining the importance of national implementation of climate change commitments. Key recent developments signal that the financial sector actively supports Paris-compatible government action on climate change, as well as company-level action to understand the physical and ‘transition’ risks and opportunities associated with climate change and policy responses. Financial sector engagement is taking place through well-organized and well-supported international initiatives and platforms. A critical part of this process entails robust activity by financial institutions to embed climate change and broader sustainability factors into strategies and operations. At country level, attention to implementation of Nationally Determined Contributions (NDCs) and associated sector-level policy development has been largely separate from the broader ‘sustainable finance’ dynamic. National-level action has not benefited from the same level of organized financial sector involvement evident in international action. One of the reasons for this is that, with some notable exceptions, international financial initiatives lack the capacity and resources to participate in the granular detail of national policy processes. Policymakers in turn often lack the internal capacity to consult or engage with the financial sector domestically. This paper includes some thoughts on further international and national climate actions. Ensuring that messages from successful international financial sector initiatives are heard in regional and non-climate forums offers one avenue for building a stronger foundation for greater climate ambition. Building the resource base for stronger national climate policy engagement, as a counter-voice to incumbent interests and to ensure that the quality of policy is ‘investment grade’, is another. This will be critical to the delivery of policy outcomes. Other key elements include the need to pool knowledge across relevant parts of the finance sector, build alliances, and shift action towards joint problem-solving with policymakers. A ‘Talanoa 2.020’-type initiative offers one potentially promising approach to advancing dialogue in this respect. 2018-12-21-non-state-actors-climate-financial-institutions-hamilton (PDF) Full Article
nan Innovative Financing for Humanitarian Energy Interventions By www.chathamhouse.org Published On :: Thu, 28 Feb 2019 03:42:23 +0000 Innovative Financing for Humanitarian Energy Interventions Research paper sysadmin 28 February 2019 This paper explores the increase in resources and funding needed to improve the access of displaced people to modern and sustainable energy services. — SOLARKIOSK stall in Talek, Kenya on 17 May 2017. Photo: Getty Images Summary In settings that host displaced and refugee communities, energy can act as an enabler for improved healthcare, education and access to clean water. More efficient sources of energy can also save money that can be reinvested in life-saving interventions. A range of challenges exist that inhibit the uptake and effective management of cleaner energy solutions in displacement settings. These are magnified by a lack of available and appropriate funding. The current funding gap is significant. In many cases, involving the private sector (both enterprises and investors) is viewed as a way to accelerate delivery of sustainable energy solutions, leverage additional capital, efficiency and expertise, and adopt more sustainable and market-based approaches. Displacement settings are an extreme example of complex and unpredictable operating environments. Traditional approaches to the financing of energy access will not be supported by the risk/return characteristics of this market opportunity, so alternative structures are needed. Such structures can include mechanisms such as grants, guarantees, ‘results-based financing’ and ‘impact bonds’. These blended financial instruments should aim to leverage first losses – whereby, in the case of default, the first loss is taken by the ‘impact-first’ investors, or guarantors, thereby fully or partially protecting ‘finance-first’ investors. Given the specific constraints of displacement settings, any financing mechanisms at present are likely to fall between the categories of providing ‘more efficient aid’ and ‘more efficient aid through markets’. They are likely to constitute a transitional step from grant-making towards the use of commercial investment vehicles. While a number of financial mechanisms could be applied to attract private-sector engagement, most remain theoretical, with few being implemented extensively or at scale. Where such financial mechanisms have already been used, access to relevant data is poor, especially in circumstances where the desired outcomes were not achieved. The Moving Energy Initiative (MEI) completed feasibility work into the concept of an energy humanitarian fund and found that, while a need for this type of facility has emerged, it sits in a difficult position between energy access, climate and humanitarian funding sources. Key donors are needed to drive forward innovative financing vehicles and further testing of these mechanisms, in order to generate market data and evidence for further iterations and additional investments. 2019-02-2019-InnovativeFinancingforHumanitarianEnergy (PDF) Full Article
nan Hernandez healthy, ready to run atop lineup By mlb.mlb.com Published On :: Mon, 18 Feb 2019 14:01:44 EDT Cesar Hernandez scored 91 runs last season, the Phillies' highest mark since Rollins scored 102 in 2012. Now the luster is no longer there for players who score 100 runs or post 100 RBIs, but Hernandez should score at least 100 runs this season, if he stays healthy and if the Phillies' offense improves as expected. Full Article
nan Whooping cough: Health officials urge pregnant women to get vaccinated as another infant dies By www.bmj.com Published On :: Friday, August 9, 2024 - 12:56 Full Article
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nan POSTPONED: Zimbabwe Futures 2025: Financial Sector Expansion and Policy Priorities By www.chathamhouse.org Published On :: Mon, 06 Nov 2017 15:00:00 +0000 POSTPONED: Zimbabwe Futures 2025: Financial Sector Expansion and Policy Priorities 15 November 2017 — 9:00AM TO 11:30AM Anonymous (not verified) 6 November 2017 Harare, Zimbabwe This roundtable will draw on current best practice and senior level expertise to identify policy options for financial stability and sector growth. A depoliticized analysis of the development agenda will highlight requisite conditions and prospective policies for a business-driven roadmap to the economic recovery of Zimbabwe, with a specific focus on the financial sector.Participants will discuss macro-economic policy and stability, retail banking products and services, fintech, mobilizing domestic finance for national infrastructure and balancing consumer price index and inflation. This event is being held in partnership with the Zimbabwe Business Club.PLEASE NOTE, THIS EVENT HAS BEEN POSTPONED UNTIL FURTHER NOTICE. Full Article
nan Rebuilding Zimbabwe's Economy: Emmerson Mnangagwa’s Immediate Priorities By www.chathamhouse.org Published On :: Wed, 13 Dec 2017 14:41:18 +0000 Rebuilding Zimbabwe's Economy: Emmerson Mnangagwa’s Immediate Priorities Expert comment sysadmin 13 December 2017 Zimbabwe cannot expect to rebuild in the same economic model that brought previous prosperity. — Emmerson Mnangagwa is sworn in as president on 24 November. Photo: Getty Images. Returning to Harare as Zimbabwe’s president-designate Emmerson Mnangagwa declared, ‘We want to grow our economy, we want peace, we want jobs, jobs, jobs.’ Robert Mugabe leaves a legacy of an independent Zimbabwe in a deep economic crisis. Much remains uncertain as to what a new government in Zimbabwe will look like, and there is sure to be continuity as well as considerable change. What is clear is that a new administration under Mnangagwa will need to turn the economy around to garner support and legitimacy from the Zimbabwean people. Zimbabwe’s economic output halved over the period 1997–2008, and it has not recovered. With more than 80 per cent of Zimbabweans in the informal economy, and with social and economic resilience undermined by previous crises and decades of mismanagement, the stakes for the new leader are very high. Reform will be difficult particularly because politically connected elites have acquired businesses through uncompetitive means. They will be reluctant to see significantly more competition. But they will also want an improved economic environment. And there is scope for the people of Zimbabwe to benefit from this. An important change will be in the prioritization of economic stability. Mugabe demonstrated that he was willing to make political decisions irrespective of the economic consequences. Mnangagwa is thought to be less ideological and more of a pragmatist. For him, delivering economic recovery will be crucial to building political support. The most pressing fiscal priority is the public wage bill. Employment costs account for over 80 per cent of government expenditure, crowding out spending on social programmes, health and education. But the fragility of the economy means that reform cannot be fast-tracked. The public wage bill accounts for over 20 per cent of GDP and is an essential driver of demand. Public sector workers are also politically influential. Another further priority is the reform of state-owned enterprises that are pressuring the fiscus. A new administration will need to rebuild confidence. Policymakers have been operating in a low-confidence environment for a long time, but for any meaningful change to take root there has to be trust between the government, businesses and the people of Zimbabwe. Businesses and citizens will want to see a plan of action for remonetizing the economy. Zimbabwe faces an acute liquidity crisis. A shortage of US dollars and a lack of confidence in government-issued bond notes are testing resilience. The financial system has recovered from a crisis of nonperforming loans – triggered by high debt amassed during the post-dollarization boom, and weak corporate governance. But the system remains highly fragile and swamped with government debt. Hard cash US dollar deposits fell from 49 per cent ($582 million) in 2009 to just six per cent ($269 million) in 2016. In 2015, industrial utilization stood at just 34.3 per cent of installed capacity, and it was estimated that just five per cent of the country’s businesses were viable. The crux of the Zimbabwean economy is the linkage between agriculture and manufacturing. Commercial agriculture contributes approximately 12 per cent of the country’s GDP, and more than 60 per cent of inputs into the manufacturing sector. Tobacco in particular is a vital earner of much needed foreign exchange. Policies to support mid-scale farmers will have multiplier effects. They drive agricultural growth and generate jobs throughout the supply chain. Zimbabwe also has world-class natural resource endowments including ferrochrome, gold, copper, iron ore, lithium, diamonds and platinum group metals. But longer investment-gestation periods and industry risk adversity will mean that payoffs from fresh investments in this sector will take longer to materialize. Domestic finance will need to be mobilized to generate recovery, and this will need to be supported by international investment. But international investors entering the country must be cognizant of Zimbabwean’s expectations and also historical perceptions – especially around the scepticism of neoliberal economics as a result of failed structural adjustment programmes in the 1990s. Zimbabweans have high social expectations for international investors. Educated, tech-savvy, internationally connected youth are at the core of the consumer class that investors will be targeting, to both sell products to but also to staff offices in country. But this cohort also has a greater expectation of international companies to adhere to the norms and standards that they abide by at home and not take advantage of weak governance or poor regulation to exploit citizens. Investors in Zimbabwe must also recognize that behind the controversial Mugabe policies of land reform and indigenization – the empowerment of local citizens through shared ownership – was a popular desire for postcolonial economic transformation. This sentiment remains. Working in partnership with local entities and communicating the economic contribution made to society will be necessary to build a long-term presence in Zimbabwe, and reap the dividend of what many hope to be a new start for the country. Fresh thinking is required from domestic policymakers and international partners. A skilled population and estimated 3-5 million-strong diaspora will bring international experience and make a considerable contribution to this process. Some of this thinking has been done. The Lima process of re-engagement with international financial institutions that was agreed at the end of 2015 has laid some of the groundwork, especially around international expectations regarding both economic and governance reform – the substance of which was analysed in a 2016 Chatham House paper. The implementation of recommendations of the well-regarded auditor-general’s report on SOE reform will also be a key prerequisite for long-term reform. Zimbabweans are not alone in processing what has happened and how to react. Investors have long been poised to capitalize on what is perceived to be one of the continent’s best long-term prospects. A lot will remain unchanged following the transition. But significantly, for the first time in decades, there is a real opportunity to effect positive change and improve the livelihoods of millions of Zimbabweans. This article was originally published at the Huffington Post. Full Article
nan Zimbabwe’s Economic Governance and Regional Integration By www.chathamhouse.org Published On :: Fri, 06 Nov 2020 13:59:46 +0000 Zimbabwe’s Economic Governance and Regional Integration 17 November 2020 — 12:00PM TO 1:30PM Anonymous (not verified) 6 November 2020 Online Panellists discuss policy and governance for long-term economic prosperity in Zimbabwe, reflecting on the role of institutional change and regional integration in the context of the shocks caused by the coronavirus pandemic. At this virtual event, panellists and participants will discuss policy and governance for long-term economic prosperity in Zimbabwe, reflecting on the role of institutional change and regional integration. The government of Zimbabwe has emphasized its commitment to economic reform and its ambition to achieve upper-middle-income status by 2030, but there are considerable challenges to overcome. The COVID-19 pandemic has exacerbated existing economic fragility. Improving the business climate to attract international private-sector investment will be contingent on clear, consistent and coherent policy and implementation, including targeting abuse and corruption. Zimbabwe has, in recent years, successfully strengthened its regional trade integration, although some trade frictions remain. This is an important factor not only for catalysing economic growth in Zimbabwe, but for supporting regional prosperity and post-COVID recovery. This webinar is the second in a series of events held in partnership with the Konrad Adenauer Stiftung on Zimbabwe’s economic reform and recovery. Read a meeting summary This event will also be broadcast live on the Africa Programme Facebook page. Full Article
nan Quantum Motion and Goldman Sachs Identify Quantum Applications in Financial Services Project By www.hpcwire.com Published On :: Fri, 01 Nov 2024 14:31:05 +0000 LONDON, Nov. 1, 2024 — Quantum Motion, a UK-based quantum computing scale-up founded by Professor John Morton, University College London (UCL), and Professor Simon Benjamin, University of Oxford, has worked […] The post Quantum Motion and Goldman Sachs Identify Quantum Applications in Financial Services Project appeared first on HPCwire. Full Article
nan IonQ Announces 3rd Quarter 2024 Financial Results By www.hpcwire.com Published On :: Thu, 07 Nov 2024 14:01:38 +0000 COLLEGE PARK, Md., Nov. 7, 2024 — IonQ (NYSE: IONQ), a leader in the quantum computing industry, has announced financial results for the quarter ended September 30, 2024. “We had yet […] The post IonQ Announces 3rd Quarter 2024 Financial Results appeared first on HPCwire. Full Article
nan NANO Nuclear Energy Raises Over $40M from Recent Underwritten Follow-On Offering By www.hpcwire.com Published On :: Fri, 01 Nov 2024 13:05:29 +0000 NEW YORK, Nov. 1, 2024 — NANO Nuclear Energy Inc. has announced the October 29, 2024 closing of the sale of an additional 317,646 shares of its common stock at […] The post NANO Nuclear Energy Raises Over $40M from Recent Underwritten Follow-On Offering appeared first on HPCwire. Full Article
nan What makes a good life? A neuroscientist and a global financial CEO answer | Annabel Spring and Wendy Suzuki By www.ted.com Published On :: Fri, 27 Sep 2024 14:18:29 +0000 What's the connection between long-term health and financial stability? Neuroscientist Wendy Suzuki and HSBC Global Private Banking and Wealth's CEO Annabel Spring explore the critical components of a good life — and how simple actions like exercise and financial planning can boost your present and future well-being. They discuss how to maximize your sense of joy, transform your anxiety into a force for good and keep your brain healthy over the course of your life. (This content is made possible by HSBC. It however does not necessarily reflect the views of HSBC.) Full Article Higher Education
nan How quadratic funding could finance your dreams | Kevin Owocki By www.ted.com Published On :: Mon, 30 Sep 2024 14:54:21 +0000 What if your $1 donation could result in a $100 contribution to a cause you believe in? That's the promise of quadratic funding: a new kind of crowdfunding model that uses math to distribute funds based on the number of contributors, rather than the amount given. Gitcoin founder Kevin Owocki dives into the principles and pitfalls of this approach to philanthropy, where "many small donors are more powerful than one large donor." Full Article Higher Education
nan Nation Gets a 'C' on School Finance, Even as Economic Downturn Takes Hold By www.edweek.org Published On :: Tue, 02 Jun 2020 00:00:00 +0000 Wyoming once again takes the top spot in Quality Counts' annual ranking of the states on school finance, while 22 states receive grades between C-minus and D-minus. Full Article Wyoming
nan Here's Why a Maryland School Finance Overhaul Could Prove Groundbreaking By blogs.edweek.org Published On :: Fri, 21 Feb 2020 00:00:00 +0000 Maryland's legislature has proposed a unique way to fund schools and also wants to hold school districts more accountable for how they spend their money as part of a new funding formula. Full Article Maryland
nan North Carolina schools chief running for lieutenant governor By www.edweek.org Published On :: Wed, 13 Nov 2019 00:00:00 +0000 Full Article North_Carolina
nan Nation Gets a 'C' on School Finance, Even as Economic Downturn Takes Hold By www.edweek.org Published On :: Tue, 02 Jun 2020 00:00:00 +0000 Wyoming once again takes the top spot in Quality Counts' annual ranking of the states on school finance, while 22 states receive grades between C-minus and D-minus. Full Article Vermont
nan South Carolina a unanimous No. 1 in women's AP Top 25 after 2 wins to open repeat bid; Stanford, Oregon crack rankings By sports.yahoo.com Published On :: Mon, 11 Nov 2024 16:59:09 GMT South Carolina a unanimous No. in women's AP Top 25 after 2 wins to open repeat bid; Stanford, Oregon crack rankings. Full Article article News
nan South Carolina a unanimous No. 1 in women's AP Top 25, Stanford and Oregon crack rankings By sports.yahoo.com Published On :: Mon, 11 Nov 2024 17:02:55 GMT The Gamecocks earned a hard-fought six-point win over Michigan in Las Vegas to open the season and beat then-No. 9 North Carolina State on Sunday by 14. The two victories made the defending champions a unanimous choice from the 31-member national media panel. In the preseason poll, No. 2 UConn got two first-place votes and No. 3 USC one. Full Article article Sports
nan Enhancing corporate governance for FAO publications By www.fao.org Published On :: Mon, 29 Nov 2021 00:00:00 GMT As a knowledge leader, FAO is committed to publishing information that enables Members to drive transformation to more efficient, inclusive, resilient and sustainable agrifood systems resulting in better production, better nutrition, a better environment, and a better life, leaving no one behind. The Director-General announced in the DG Bulletin on [...] Full Article
nan Weird Science: Pregnant Dads? By www.smithsonianmag.com Published On :: Wed, 25 Sep 2024 00:00:00 -0000 Sometimes, in fact, nature is stranger than fiction Full Article
nan Ask Smithsonian: What Are the Weirdest Things Pregnant Women Crave? By www.smithsonianmag.com Published On :: Thu, 03 Oct 2024 00:00:00 -0000 Our host explains why you should never say ‘no’ to a hungry pregnant woman Full Article
nan Skiing the Nantucket Slush By www.smithsonianmag.com Published On :: Fri, 04 Oct 2024 00:00:00 -0000 Visitors to Nantucket were able to ski through wide strips of slushy ice left on the beach in February 2015. Full Article
nan Maurizio Cattelan's Perishable Sculpture Drove Some Critics Bananas. Now, It Could Sell for $1.5 Million By www.smithsonianmag.com Published On :: Mon, 28 Oct 2024 18:36:10 +0000 The banana duct-taped to a wall was created to be a "reflection on what we value." An upcoming auction may deliver an answer Full Article
nan CBRM to seek new CAO, but not before municipality's financial situation is known By www.cbc.ca Published On :: Tue, 12 Nov 2024 18:30:15 EST The new mayor and council are planning big changes for the Cape Breton Regional Municipality, and one of those is at the top of the staff organizational chart now that chief administrative officer Marie Walsh is set to retire. Full Article News/Canada/Nova Scotia
nan 'Financially desperate' Winnipeg business swindled out of 2 properties, lawsuit alleges By www.cbc.ca Published On :: Tue, 12 Nov 2024 06:00:00 EST A Winnipeg business owner is suing a man she alleges swindled her out of ownership of two properties after promising financial help — the latest in a string of court proceedings against the man, whom a judge previously described as showing the signs of a "predator" who seeks out financially vulnerable clients. Full Article News/Canada/Manitoba
nan Tajon Buchanan back with Canadian men's national soccer team after recovering from broken leg By www.cbc.ca Published On :: Fri, 08 Nov 2024 11:18:15 EST Inter Milan winger Tajon Buchanan, recovered from a broken leg suffered in training at this summer's Copa America, is back in Jesse Marsch's Canada squad for the CONCACAF Nations League quarterfinal against Suriname. Full Article Sports/Soccer
nan SolidWorks Helps Design that Matters Create Low-Cost, Low Maintenance Infant Incubator for Third World By www.solidworks.com Published On :: Mon, 05 Oct 2009 00:00:00 -0500 Non-Profit Cooperative Assembled Virtual Team to Prove $1,000 Incubator Was Possible, Safe, and Reliable Full Article
nan High-end speaker maker Sonance creates beautiful music with SOLIDWORKS software By www.solidworks.com Published On :: Mon, 04 Dec 2006 00:00:00 -0500 Company's award-winning designs pack big performance into small spaces, bringing great sound to elegant homes Full Article
nan Sports ministry changes lives in Antananarivo By www.om.org Published On :: Wed, 14 Dec 2011 12:30:02 +0000 OM Madagascar uses sport as tool for reaching youth with the gospel and relationship building. Full Article
nan MENAnews: Shared grief opens door to share hope By www.om.org Published On :: Tue, 22 Nov 2016 01:03:14 +0000 An unexpected connection on a prayer walk leads to multiple opportunities to share spiritual truth with one Muslim family. Full Article
nan News24 Business | MONEY CLINIC | How can I take better control of my finances? By www.news24.com Published On :: Sunday Aug 28 2022 09:50:15 In the spirit of Women’s Month in August, Tamryn Lamb, head of retail distribution at Allan Gray, shares a few lessons she has learnt over the years to help other women to take control of their finances. Full Article
nan News24 Business | MONEY CLINIC | I'm in financial trouble. Can I get a loan from my provident fund? By www.news24.com Published On :: Tuesday Sep 27 2022 12:09:59 A Fin24 reader facing financial hardship wants to know if it would be possible to get a loan from his provident fund. Full Article
nan News24 Business | MONEY CLINIC | What are the financial considerations of divorce? By www.news24.com Published On :: Wednesday Oct 26 2022 07:00:12 Simon Dippenaar, founder and managing partner at Simon Dippenaar & Associates, looks at the financial consequences of divorce and what you should consider. Full Article
nan News24 Business | MONEY CLINIC | I want to invest. What questions should I ask the financial services provider? By www.news24.com Published On :: Saturday Nov 26 2022 05:00:25 The South African Association of Treasury Advisors highlights the importance of dealing only with an authorised financial services provider when making any investment. Full Article
nan News24 Business | MONEY CLINIC | How do interest rate hikes affect my finances? By www.news24.com Published On :: Tuesday Jan 31 2023 05:00:13 Kondi Nkosi, country head at Schroders in South Africa, discusses interest rates and the role it plays personal finance and the greater economy. Full Article
nan News24 Business | MONEY CLINIC | How can I financially prepare for life's unpredictable events? By www.news24.com Published On :: Thursday May 25 2023 12:40:14 George Kolbe, Head of Life Insurance Marketing at Momentum discusses the recommended ways to prepare for unexpected occurrences. Full Article