Date: May 1, 2020

Also known as May Day or International Workers’ Day, Labour Day is celebrated on May 1st in many countries around the world. Today’s Doodle celebrates the day by illustrating a handful of the many professions across the labor force.

Recognized around the world, Labour Day originated from the 19th-century labour movement. First declared a holiday by trade unions in 1889, Labour Day commemorates worker’s rights and their fight for weekends, better working conditions, and shorter working days. 

Here’s to everyone contributing to the livelihoods of those around them each and every day. 

Happy Labour Day!

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IBM today announced the opening of a new data centre facility in Fortitude Valley, Brisbane, Queensland. The data centre will augment IBM’s existing recovery centre located nearby, to provide exceptional and unrivalled risk mitigation for client information and data.

For $20, fans of German soccer club Borussia can have a cut-out of themselves placed in the stands at BORUSSIA-PARK. According to the club, over 12,000 cut-outs have been ordered and 4,500 have already been put in place. Here is the tweet and photo. And some sports bettors are betting on simulated sporting events.  (Again, […]

The post Coronavirus sports markets in everything, multiple simulations edition appeared first on Marginal REVOLUTION.

Well things are not looking good for Computex as many companies are simply pulling out of the show all together, even though it has been rescheduled.

The post Multiple Motherboard and VGA Vendors Pulling out of Computex appeared first on ThinkComputers.org.

Ma'am, Are you in need of roadside assistance?

When the news came out that the pandemic had take over Europe I was still working on a cruise ship in the Caribbean. Now almost two month later we are still stuck on the ship. I know that this is a very hard time for everyone and while I would have lik

There’s more trouble for the team behind the popular HGTV series “Windy City Rehab.” Though Season 2 is expected to premiere later this year, the TV stars face multiple lawsuits, and they are starting to turn on each other.

Too much work and too much energy kill a man just as effectively as too much assorted vice or too much drink.

Researchers used artificial intelligence to reevaluate elevations vulnerable to rising sea levels.

In an attempt to keep the matter under wraps, the Los Angeles County Sheriff's Department quietly ordered deputies to delete any photos of the Kobe Bryant helicopter crash scene after a citizen complained that a deputy was showing the gruesome images at a Norwalk bar, two public safety sources with knowledge of the events said.

A graph of the spread of fake news -- conspiracy theories, propaganda and disinformation -- would likely run parallel to that of the coronavirus itself.

Angels owner Arte Moreno explained how Gerrit Cole was his team's primary target in the offseason, but despite his team's big offer, "you knew no matter what I did, we were going to get outbid."

Ross Stripling, who hopes to start this season but seems likely to return to a swingman bullpen role, gave up one run in three innings Friday night.

The Dodgers nearly traded away Ross Stripling to the Angels, but the pitcher is more concerned with perfecting his changeup as the team's swingman.

China has gone on a "charm offensive" to try to make the world overlook Beijing's culpability in the coronavirus crisis and the country's aggressive moves against its neighbors.

Fauci and Birx could storm out and publicly speak their minds, but then they'd lose any influence they have on President Trump.

A small oil town in Southern California is pummeled by the economy during the coronavirus outbreak and economic downturn

'People entering French territory from European countries (EU/Schengen and United Kingdom) will not be affected by the quarantine measure,' says French consulate

They may not be classics, but people are watching and talking about 'Trolls World Tour,' 'The Platform' and 'Onward.'

ELON Musk's Neuralink company will implant a computer-brain interface into a human in "less than a year", the controversial billionaire has revealed.

Quadrant Resource LLC (Redmond, WA) has multiple positions (12) as a Software Engineer (M-F 8 am to 5 pm). Job duties are: Analyze business requirements and deliver new and complex high quality software solutions. Identify and select tools such as any of: Java, Dot Net,Asp, Sap Erp, Oracle ERP, sfd

PeopleTech Group (Bellevue, WA) has a 6 positions as a Software Engineer. Job duties are: Analyze business requirements and deliver new and complex high-quality software solutions. Identify and select tools such as any of: Java ,Dot Net, ASP SAP, ERP, Oracle, ERP SFDC, Quality Engineer, Microsoft D

Lenora Systems Inc (Redmond, WA) has 12 positions for Software Engineer. Job duties are: Analyze business requirements and deliver new and complex high quality software solutions. Identify and select tools such as any of: Java *Dot Net * ASP * SAP ERP* Oracle ER * SFDC * Quality Engineer

The suspect is a 21-year-old Noblesville man who is facing three felony charges.

Orta Doğu'da barış sürecini canlandırmak için diplomasi atağı başlatan ABD son olarak da Başkan Barack Obama'nın ulusal güvenlik danışmanı James Jones'u bölgeye gönderdi.

Who would you select in an all-time Indian Premier League XI?

Late Tuesday night, police officers in Visalia, a San Joaquin Valley city about 40 miles southeast of Fresno, responded to a report of shots fired at a high school.

The United Nations wants the money to help people in 63 countries, mainly in Africa and Latin America.

If you are just starting up your website, perhaps you are selling tangible items, or you have a hit single that you’ll be offering digital copies of, one of your pressing questions may be: “Which payment gateway should I use to accept payments from my customers?“. While there are pros and cons of using any […]

The post Benefits of Adding Multiple Payment Gateways to Your Website’s Checkout appeared first on Tips and Tricks HQ.

O’Reilly has long been a leader in fostering community and building a direct sales channel. This week we took the next step in enhancing the customer’s direct buying experience by offering German editions for many of our ebook titles. Take …

strataconf: Moving to the open healthcare graph http:// http://t.co/YYTUDN3Vzn Achieving the triple aim in healthcare: better, cheaper, safer #stratarx

Police are investigating a house robbery in which a couple in Amanzimtoti, on the south coast of KwaZulu-Natal, believed to be in their 50s was stabbed.

After being pulled over for what started as a traffic violation, two Windsor men were arrested and face multiple drug, property, and weapon related charges.

Treatment of patients with triple-negative breast cancer (TNBC) is limited by a lack of effective molecular therapies targeting this disease. Recent studies have identified metabolic alterations in cancer cells that can be targeted to improve responses to standard-of-care chemotherapy regimens. Using MDA-MB-468 and SUM-159PT TNBC cells, along with LC-MS/MS and HPLC metabolomics profiling, we found here that exposure of TNBC cells to the cytotoxic chemotherapy drugs cisplatin and doxorubicin alter arginine and polyamine metabolites. This alteration was because of a reduction in the levels and activity of a rate-limiting polyamine biosynthetic enzyme, ornithine decarboxylase (ODC). Using gene silencing and inhibitor treatments, we determined that the reduction in ODC was mediated by its negative regulator antizyme, targeting ODC to the proteasome for degradation. Treatment with the ODC inhibitor difluoromethylornithine (DFMO) sensitized TNBC cells to chemotherapy, but this was not observed in receptor-positive breast cancer cells. Moreover, TNBC cell lines had greater sensitivity to single-agent DFMO, and ODC levels were elevated in TNBC patient samples. The alterations in polyamine metabolism in response to chemotherapy, as well as DFMO-induced preferential sensitization of TNBC cells to chemotherapy, reported here suggest that ODC may be a targetable metabolic vulnerability in TNBC.

Hasmik Keshishian
Dec 1, 2007; 6:2212-2229
Research

Leigh Anderson
Apr 1, 2006; 5:573-588
Research

Philip L. Ross
Dec 1, 2004; 3:1154-1169
Research

The canonical pathway of eicosanoid production in most mammalian cells is initiated by phospholipase A2-mediated release of arachidonic acid, followed by its enzymatic oxidation resulting in a vast array of eicosanoid products. However, recent work has demonstrated that the major phospholipase in mitochondria, iPLA2γ (patatin-like phospholipase domain containing 8 (PNPLA8)), possesses sn-1 specificity, with polyunsaturated fatty acids at the sn-2 position generating polyunsaturated sn-2-acyl lysophospholipids. Through strategic chemical derivatization, chiral chromatographic separation, and multistage tandem MS, here we first demonstrate that human platelet-type 12-lipoxygenase (12-LOX) can directly catalyze the regioselective and stereospecific oxidation of 2-arachidonoyl-lysophosphatidylcholine (2-AA-LPC) and 2-arachidonoyl-lysophosphatidylethanolamine (2-AA-LPE). Next, we identified these two eicosanoid-lysophospholipids in murine myocardium and in isolated platelets. Moreover, we observed robust increases in 2-AA-LPC, 2-AA-LPE, and their downstream 12-LOX oxidation products, 12(S)-HETE-LPC and 12(S)-HETE-LPE, in calcium ionophore (A23187)-stimulated murine platelets. Mechanistically, genetic ablation of iPLA2γ markedly decreased the calcium-stimulated production of 2-AA-LPC, 2-AA-LPE, and 12-HETE-lysophospholipids in mouse platelets. Importantly, a potent and selective 12-LOX inhibitor, ML355, significantly inhibited the production of 12-HETE-LPC and 12-HETE-LPE in activated platelets. Furthermore, we found that aging is accompanied by significant changes in 12-HETE-LPC in murine serum that were also markedly attenuated by iPLA2γ genetic ablation. Collectively, these results identify previously unknown iPLA2γ-initiated signaling pathways mediated by direct 12-LOX oxidation of 2-AA-LPC and 2-AA-LPE. This oxidation generates previously unrecognized eicosanoid-lysophospholipids that may serve as biomarkers for age-related diseases and could potentially be used as targets in therapeutic interventions.

7 May 2020 , Volume 96, Number 3

Research Event

Event participants

Research Event

Event participants

Ronald M. Krauss
Jan 1, 1982; 23:97-104
Articles