A click gallery using a sliding set of thumbnail images to navigate. The large image is permanently on screen until another image is chosen EVEN when refreshing the page. With descriptive text and linking option.

The previous gallery but with the thumbnails arranged vertically instead of horizontal.

A sliding panel demo using CSS3 and IE time:animate for smooth sliding action.

Using CSS3, and a little TIME for Internet Explorer, to produce a vertical sliding menu to rival javascritp/jQuery.

Using CSS3 to animated a set of information panels of varying sizes.

A set of six 3D boxes sliding in a never ending pattern.

A horizontal left/right sliding panels menu with animation and permanent panel changes.

A CSS only method of hiding the control bar on Vimeo videos

Statement Highlights: In a new scientific statement, the American Heart Association supports the creation of specialized multidisciplinary clinical programs that combine cardiovascular medicine and genetics expertise. These specialized programs would use genetic information to better treat patients with inherited heart conditions, as well as assess family members without current heart problems and take steps to reduce their risk.

Embargoed until 8 a.m. CT / 9 a.m. ET Thursday, April 9, 2020   AHA COVID-19 newsroom   DALLAS, April 9, 2020 — With COVID-19 incidence currently increasing exponentially worldwide, the percentage of cardiac arrests with COVID-19 are also likely to...

MARIE "MAMALAKI" FRANCINE KASIDI
Iowa City

On Monday, April 27, 2020, Marie "Mamalaki" Francine Kasidi was called home by God after a brave battle with cancer. She was 57 years old. Marie loved the Lord Jesus Christ and was a pillar in the community.
Visitation will be this Friday at 4 to 8 p.m. at Gay & Ciha Funeral and Cremation Service. The burial service will be noon this Saturday at St. Joseph Cemetery in Iowa City. For instructions for the visitation and services, a complete obituary, to share a thought, memory or condolence, please visit the funeral home website at www.gayandciha.com.

This trip solidified my conviction to learning photography. A lot has happened since this shot was taken.
Can you pinpoint the moment you decided to pursue photography? (at Toronto, Ontario)

DJI has announced their new Matrice 300 RTK “flying platform” (big drone) and the Zenmuse H20 hybrid camera series, to provide “a safer and smarter solution” to their enterprise customers. The M300 RTK, DJI says, is their first to integrate modern aviation features, advanced AI, 6-direction sensing and positioning, a UAV health management system and […]

The post DJI’s new Matrice 300 RTK drone offers a ridiculous 55-minutes of flight time and 2.7kg payload appeared first on DIY Photography.

In this paper, we work on intra-variable handwriting, where the writing samples of an individual can vary significantly. Such within-writer variation throws a challenge for automatic writer inspection, where the state-of-the-art methods do not perform well. To deal with intra-variability, we analyze the idiosyncrasy in individual handwriting. We identify/verify the writer from highly idiosyncratic text-patches. Such patches are detected using a deep recurrent reinforcement learning-based architecture. An idiosyncratic score is assigned to every patch, which is predicted by employing deep regression analysis. For writer identification, we propose a deep neural architecture, which makes the final decision by the idiosyncratic score-induced weighted average of patch-based decisions. For writer verification, we propose two algorithms for patch-fed deep feature aggregation, which assist in authentication using a triplet network. The experiments were performed on two databases, where we obtained encouraging results.

Interaction languages such as MSC are often associated with formal semantics by means of translations into distinct behavioral formalisms such as automatas or Petri nets. In contrast to translational approaches we propose an operational approach. Its principle is to identify which elementary communication actions can be immediately executed, and then to compute, for every such action, a new interaction representing the possible continuations to its execution. We also define an algorithm for checking the validity of execution traces (i.e. whether or not they belong to an interaction's semantics). Algorithms for semantic computation and trace validity are analyzed by means of experiments.

Graph convolution network (GCN) have achieved state-of-the-art performance in the task of node prediction in the graph structure. However, with the gradual various of graph attack methods, there are lack of research on the robustness of GCN. At this paper, we will design a robust GCN method for node prediction tasks. Considering the graph structure contains two types of information: node information and connection information, and attackers usually modify the connection information to complete the interference with the prediction results of the node, we first proposed a method to hide the connection information in the generator, named Anonymized GCN (AN-GCN). By hiding the connection information in the graph structure in the generator through adversarial training, the accurate node prediction can be completed only by the node number rather than its specific position in the graph. Specifically, we first demonstrated the key to determine the embedding of a specific node: the row corresponding to the node of the eigenmatrix of the Laplace matrix, by target it as the output of the generator, we designed a method to hide the node number in the noise. Take the corresponding noise as input, we will obtain the connection structure of the node instead of directly obtaining. Then the encoder and decoder are spliced both in discriminator, so that after adversarial training, the generator and discriminator can cooperate to complete the encoding and decoding of the graph, then complete the node prediction. Finally, All node positions can generated by noise at the same time, that is to say, the generator will hides all the connection information of the graph structure. The evaluation shows that we only need to obtain the initial features and node numbers of the nodes to complete the node prediction, and the accuracy did not decrease, but increased by 0.0293.

We identify the structure of the lexicographically least word avoiding 5/4-powers on the alphabet of nonnegative integers. Specifically, we show that this word has the form $p au(varphi(z) varphi^2(z) cdots)$ where $p, z$ are finite words, $varphi$ is a 6-uniform morphism, and $ au$ is a coding. This description yields a recurrence for the $i$th letter, which we use to prove that the sequence of letters is 6-regular with rank 188. More generally, we prove $k$-regularity for a sequence satisfying a recurrence of the same type.

Coordinating the operation of combined heat and power plants (CHPs) and heat pumps (HPs) at the interface between heat and power systems is essential to achieve a cost-effective and efficient operation of the overall energy system. Indeed, in the current sequential market practice, the heat market has no insight into the impacts of heat dispatch on the electricity market. While preserving this sequential practice, this paper introduces an electricity-aware heat unit commitment model. Coordination is achieved through bid validity constraints, which embed the techno-economic linkage between heat and electricity outputs and costs of CHPs and HPs. This approach constitutes a novel market mechanism for the coordination of heat and power systems, defining heat bids conditionally on electricity market prices. The resulting model is a trilevel optimization problem, which we recast as a mixed-integer linear program using a lexicographic function. We use a realistic case study based on the Danish power and heat system, and show that the proposed model yields a 4.5% reduction in total operating cost of heat and power systems compared to a traditional decoupled unit commitment model, while reducing the financial losses of each CHP and HP due to invalid bids by up-to 20.3 million euros.

A method, system and computer program product for generating answers to questions. In one embodiment, the method comprises receiving an input query, decomposing the input query into a plurality of different subqueries, and conducting a search in one or more data sources to identify at least one candidate answer to each of the subqueries. A ranking function is applied to each of the candidate answers to determine a ranking for each of these candidate answers; and for each of the subqueries, one of the candidate answers to the subquery is selected based on this ranking. A logical synthesis component is applied to synthesize a candidate answer for the input query from the selected the candidate answers to the subqueries. In one embodiment, the procedure applied by the logical synthesis component to synthesize the candidate answer for the input query is determined from the input query.

An information providing apparatus for vehicle has a remaining capacity detecting section 110 that detects a remaining capacity of a battery; a power consumption amount detecting section 130 that detects a power consumption amount of the battery; a power consumption amount history generating section 130 that generates a power consumption amount history on the basis of the power consumption amount detected by the power consumption amount detecting section 130; a charge necessity judgment information generating section 130 that generates, on the basis of the power consumption amount history generated by the power consumption amount history generating section 130, charge necessity judgment information which is information for user's judgment about whether or not charging of the battery is necessary; and a providing section 150 that provides information of the remaining capacity of the battery and the charge necessity judgment information with these information correlated with each other to the user. The information providing apparatus can properly provide the information for user's judgment about whether or not charging of the battery to the user.

Methods, systems, and computer-readable media for providing topical search suggestions are provided. Topical search suggestions allow a user to receive search results related to the designated topic or subject matter. The present invention may generate multiple topics based on search input provided by a user. The search input may be a search prefix that includes one or more words entered into the search query box before the completed search query is submitted to the search engine. A search interface then presents the topics derived from the search prefix to a user before the user submits the query. In another embodiment, the user designates multiple search inputs. The present invention generates search results based on the search inputs and then presents topics extracted from the search results. In one embodiment, the topics are extracted by performing a natural language analysis of search result metadata.

The present application describes modulators of MCP-1 or CCR-2 of formula or stereoisomers or prodrugs or pharmaceutically acceptable salts thereof, wherein m, n, W, X, R1 and R6, are defined herein. In addition, methods of treating and preventing inflammatory diseases such as asthma and allergic diseases, as well as autoimmune pathologies such as rheumatoid arthritis and transplant rejection using modulators of formula (I) are disclosed.

Disclosed embodiments provide pyrimidinediamine compounds useful for inhibiting kinase activity, including the activity of polo-like kinase 1 (PLK1). Also disclosed are pharmaceutical compositions comprising these compounds and methods of treating diseases associated with kinase activity, in particular enhanced PLK1 catalytic activity, such as diseases associated with abnormal cell proliferation, including neoplastic disorders.

The invention relates compounds of general formula (I) and pharmaceutically acceptable salts and solvates thereof wherein R1 is halogen, vinylene-aryl, substituted aryl, heteroaryl or a benzo[1,3]dioxolil group,W is a group of formula —NH—SO2—R2 or heteroaryl group or NHR3 group where R3 is hydrogen or heteroaryl; and n is 1, 2, 3 or 4. Furthermore, the present invention is directed to pharmaceutical composition containing at least one compound of general formula (I) and/or pharmaceutically acceptable salts or solvates thereof and for the use of them for the preparation of pharmaceutical compositions for the prophylaxis and/or the treatment of protein kinase related, especially CDK9-related diseases e.g. cell proliferative disease, infectious disease, pain, cardiovascular disease and inflammation.

The present invention pertains generally to the field of therapeutic compounds. More specifically the present invention pertains to certain pyridyl-amino-pyrazine carbonitrile compounds that, inter alia, inhibit Checkpoint Kinase 1 (CHK1) kinase function. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit CHK1 kinase function, and in the treatment of diseases and conditions that are mediated by CHK1, that are ameliorated by the inhibition of CHK1 kinase function, etc., including proliferative conditions such as cancer, etc., optionally in combination with another agent, for example, (a) a DNA topoisomerase I or II inhibitor; (b) a DNA damaging agent; (c) an antimetabolite or thymidylate synthase (TS) inhibitor; (d) a microtubule targeted agent; and (e) ionizing radiation.

The present invention provides 4,6-disubstituted pyrimidine compounds useful as kinase inhibitors, pharmaceutically acceptable compositions thereof, and methods of using the same.

The present application is directed to solid forms of compounds of formula I: and pharmaceutically acceptable salts thereof, that inhibit bacterial gyrase and/or Topo IV and pharmaceutical compositions comprising said compounds and salts. These compounds and salts are useful in treating bacterial infections.

The invention relates to oxazolopyrimidine compounds of formula I, where A, R1 and R2 are defined as stated in the claims. The compounds of formula I are suitable, for example, for wound healing.

The present invention relates to compounds of formula (I) wherein X1 to X5, Y, Z1 to Z3, and R have the meaning as cited in the description and the claims. Said compounds are useful as JAK inhibitors for the treatment or prophylaxis of immunological, inflammatory, autoimmune, allergic disorders, and immunologically-mediated diseases. The invention also relates to pharmaceutical compositions including said compounds, the preparation of such compounds as well as the use as medicaments.

The present invention relates to compounds of formula (I) or pharmaceutically acceptable salts thereof, wherein Q, T, V, W, X, Y, Z, ring A, R1, R2, R3, R4, R5, R5a, R6, R7, R8, R9, R10, R11, R12, R13, R14, R15, R16, R17 and m are defined herein. There novel pyrrolopyrimidine and purine derivatives are useful in the treatment of abnormal cell growth, such as cancer, in mammals. Additional embodiments relate to pharmaceutical compositions containing the compounds and to methods of using the compounds and compositions in the treatment of abnormal cell growth in mammals.

The present invention provides 2,4-pyrimidinediamine compounds that inhibit the IgE and/or IgG receptor signaling cascades that lead to the release of chemical mediators, intermediates and methods of synthesizing the compounds and methods of using the compounds in a variety of contexts, including in the treatment and prevention of diseases characterized by, caused by or associated with the release of chemical mediators via degranulation and other processes effected by activation of the IgE and/or IgG receptor signaling cascades.

4,6-dichloro-2-methyl-5-(1-acyl-2-imidazolin-2-yl)-aminopyrimidine is reacted with methanol in the presence of a non-ionic organic base, and moxonidine is obtained directly from the reaction mixture.

Compounds of formula (I) ##STR1## in which R1 is hydrogen, O°, CN, NO, cyanomethyl, C1 -C12 -alkyl, C3 -C12 -alkenyl or C3 -C12 -alkynyl subject to the proviso that the carbon atom attached to the nitrogen atom is a primary carbon atom, C7 -C12 -aralkyl, C1 -C12 -acyl, 2,3-epoxypropyl, OH-monosubstituted C2 -C6 -alkyl or 2,3-dihydroxypropyl, R2 is hydrogen, C1 -C18 -alkyl, C5 -C18 -cycloalkyl, C6 -C18 -aryl or C7 -C18 -aryalkyl, R3 is C6 -C18 -aryl or a group of the formula (II) ##STR2## in which R1 is as defined above, n is an integer from 1 to 4 and R4 is an organic or inorganic radical of a valency equal to n are useful for stabilizing organic material against oxidative, thermal and/or light induced degradation.

1,4-Dihydropyridine-3-carboxylate derivatives are produced having vasodilating and hypotensive action.

A class of pyridine phosphonate compounds is disclosed that are useful as ligands in the one manufacture of oxidation-reduction catalysts. In particular, pyridine-2,6-disphosphonic acid is a specie of the pyridine phosphonate ligands that can be combined with a polyvalent metal to produce a catalyst to convert hydrogen sulfide to solid sulfur.

Disclosed is a method for removing weakly basic nitrogen compounds from a hydrocarbon feed stream by contacting the hydrocarbon feed stream with acidic clay to produce a hydrocarbon effluent stream having a lower weakly basic nitrogen compound content relative to the hydrocarbon feed stream. The hydrocarbon feed stream comprises an aromatic compound and a weakly basic nitrogen compound.

A system, method and computer program product for avoiding a processing flaw in a computer processor triggered by a predetermined sequence of hardware events. The system may include a detecting unit and a power-on reset unit. The detecting unit detects that the predetermined sequence of hardware events is going to occur at the computer processor. The power-on reset unit initializes the computer processor to a state stored in computer memory in response to detecting the sequence of hardware events.

The present disclosure includes apparatus (e.g., computing systems, memory systems, controllers, etc.) and methods for providing data integrity. One or more methods can include, for example: receiving a number of sectors of data to be written to a number of memory devices; appending first metadata corresponding to the number of sectors and including first integrity data to the number of sectors, the first metadata has a particular format; generating second integrity data to be provided in second metadata, the second integrity data corresponding to at least one of the number of sectors (wherein the second metadata has a second format); and generating third integrity data to be provided in the second metadata, the third integrity data including error data corresponding to the second integrity data and the at least one of the number of sectors.

Method of extracting syngas between the zone in a furnace where oxygen-starved combustion of biomass occurs and the zone in the furnace where secondary air is added to complete combustion, conditioning and cleaning the extracted syngas, and delivering it in a metered amount to the oxidizer or upstream of the oxidizer to reduce or eliminate the need for additional fossil fuels once the oxidizer has achieved its operating temperature. The gasifier or furnace burns solid waste and produces a syngas containing relatively high levels of CO, which is extracted from the furnace, conditioned, and introduced into an RTO as a fuel source. In certain embodiments, no extraction of syngas from the furnace takes place; the furnace conditions are manipulated so that normally undesirable levels of CO and other VOC's remain in the process stream. The heat from the furnace is used as intended (e.g., to heat a dryer), the stream is conditioned, and ultimately proceeds to a downstream RTO. Since the gas stream remains rich in CO and VOC's, its fuel value in the RTO is substantially higher than otherwise would be the case.

A method includes configuring a processing circuit to perform: receiving a control word for an I/O operation, forwarding a transport command control block (TCCB) from the channel subsystem to a control unit, gathering data associated with the I/O operation, and transmitting the gathered data to the control unit in the I/O processing system. Gathering the data includes accessing entries of a list of storage addresses that collectively specifying the data. Based on an entry of the list comprising a not-set first flag and a corresponding first storage address, gathering data from a corresponding storage location, and based on an entry of the list comprising a set first flag and a corresponding second storage address, obtaining a next entry of the list from a second storage location.

Method and system are provided for managing components of a storage operating environment having a plurality of virtual machines that can access a storage device managed by a storage system. The virtual machines are executed by a host platform that also executes a processor-executable host services module that interfaces with at least a processor-executable plug-in module for providing information regarding the virtual machines and assists in storage related services, for example, replicating the virtual machines.

The present invention primarily concerns certain 4-alkyl pyridines of the following formula (I), wherein R is C8-C12 alkyl, odiferous substance mixtures and aromatic substance mixtures containing these 4-alkyl pyridines, the respective uses thereof as an odiferous or aromatic substance (mixture) and corresponding perfumed products.

The present invention relates to novel pyrimidine derivatives and their use in perfume compositions. The novel pyrimidine derivatives of the present invention are represented by the following formula: wherein m and n are integers of 0 or 1, with the proviso that when m is 0, n is 1 and when m is 1, n is 0; andwherein the dashed circle represents either single or double bonds.

The present invention relates to catalysts and to chemical processes employing such catalysts. The catalysts are preferably used for converting acetic acid to ethanol. The catalyst comprises acidic sites and two or more metals. The catalyst has acidic sites on the surface and the balance favors Lewis acid sites.

A process for selective formation of ethanol from acetic acid by hydrogenating acetic acid in the presence of a catalyst comprises a first metal on an acidic support. The acidic support may comprise an acidic support material or may comprise an support having an acidic support modifier. The catalyst may be used alone to produced ethanol via hydrogenation or in combination with another catalyst. In addition, the crude ethanol product is separated to obtain ethanol.

Provided are an apparatus and method of providing path information based on a status of a path and/or a purpose of the use of the path. A path information providing server collects environmental information from a sensing device. The path information providing server receives a path information request including a departure and a destination from a terminal device, and provides path information generated by mapping environmental data to a searched path.

Aspects of the invention relate to techniques of generating guiding patterns for via-type feature groups. A guiding pattern may be constructed for a via-type feature group that comprises two or more via-type features in a layout design. A backbone structure may then be determined for the guiding pattern. Based on the backbone structure and a self-assembly model, simulated locations of the two or more via-type features are computed. The simulated locations are compared with targeted locations. If the simulated locations do not match the targeted locations based on a predetermined criterion, the simulated locations adjusted to derive modified locations. Using the modified locations, the above operations may be repeated until the simulated locations match the targeted location based on a predetermined criterion or for a predetermined number of times.

Acidic viscoelastic cleaning compositions are disclosed which use non polymer thickening agents. According to the invention, cleaning compositions have been developed using viscoelastic surfactants in acidic cleaning formulations. These provide the dual benefit of thickening as well as an additional cleaning, thereby improving performance. Applicants have also identified several pseudo linking agents which when, used with viscoelastic surfactants provide enhanced viscoelasticity and cleaning.

A speech recognition system, method of recognizing speech and a computer program product therefor. A client device identified with a context for an associated user selectively streams audio to a provider computer, e.g., a cloud computer. Speech recognition receives streaming audio, maps utterances to specific textual candidates and determines a likelihood of a correct match for each mapped textual candidate. A context model selectively winnows candidate to resolve recognition ambiguity according to context whenever multiple textual candidates are recognized as potential matches for the same mapped utterance. Matches are used to update the context model, which may be used for multiple users in the same context.

A messaging response system is disclosed wherein a service providing system provides services to users via messaging communications. In accordance with an exemplary embodiment of the present invention, multiple respondents servicing users through messaging communications may appear to simultaneously use a common “screen name” identifier.