El secretario de Seguridad Bogotá, César Restrepo recomendó en 6AM a los ciudadanos tomar rutas alternas, porque las inundaciones continúan.

El secretario de Seguridad Bogotá, César Restrepo recomendó en 6AM a los ciudadanos tomar rutas alternas porque las inundaciones continúan, mientras que el concejal Samir Abisambra alertó por nuevas emergencias.

Listen to O'Brien's conversation from 2009 with Eleanor Wachtel. O'Brien died on July 27, 2024 at the age of 93.

How a multi-Billion dollar campaign to arm Ukraine might fuel the illicit arms trade; How Iran's board game cafes allowed young people to imagine a different future; Bayonetta 3 is out this week — should you play it?; a brief history of targeting art for political protest; author Andy Campbell says the era of political violence the Proud Boys helped usher in is here to stay; and more.

[Written by Stephen Wright] Bermudian boxer Saundre “Dash” Simmons has described himself as a “road warrior” as he prepares for his first fight outside the United States against Victor Aceves in Tijuana, Mexico, on Sunday [May 19]. Although Simmons will step into a ring on foreign soil for the first time, the cruiserweight has fought […]

De Fiber Carrier Association (FCA) presenteerde onlangs haar jaarlijkse rapport over de status van glasvezel in Nederland. Het zal niemand verbazen dat de verglazing van ons land ook in 2022 weer grote stappen gezet heeft. De FCA ziet naast al dat goede nieuws echter ook enkele bedreigingen. De verhardende concurrentiestrijd bijvoorbeeld en daarmee het risico dat er in steden meerdere glasvezelnetwerken komen te liggen.

Después de una larga investigación, el documentalista David Baute llega a una conclusión. “A estas alturas ya no podemos ir con muchos paños calientes”, dice. via Pocket

La Coordinadora Vecinal del Baix Besòs ha emitido un comunicado para apremiar a las administraciones públicas a aportar una solución definitiva al barraquismo con presencia en los márgenes del río Besòs desde hace años. via Pocket

POLITICO’s California Playbook discusses the latest in state politics. How Kamala Harris’s upbringing and earlier campaigns shaped her candidacy. Finally, fashion designer Samuel Rose talks about his creative process and an upcoming exhibition.

Tune in at 8pm to hear Giacomo Puccini's Il Trittico (3 one act operas) staring Renata Scotto in Il Tabarro and Suor Angelica and Tito Gobbi in Gianni Schicchi.

Looking to build out a showstopping cheese board for your holiday guests? Grab the biggest board you've got and fill it with baguette slices, cheeses and these two incredible cheesy dips.

Sometimes, you just have to return to the classics.

On a perfect autumn afternoon, the Rams won in front of an announced sellout crowd of 36,980.

Look back at celebrity couples who have walked the BET Awards red carpet, including Will and Jada Pinkett Smith, Alicia Keys and Swizz Beatz, Dwyane Wade and Gabrielle Union, and more.

The 21-year-old welterweight had a first round TKO.

BermudAir announced that Nico Buchholz has been appointed President of the company as of August and will also serve as Deputy CEO. A spokesperson said, “Mr. Buchholz is well known as a global leader in the aviation industry, bringing over 30 years of experience and expertise as an accomplished aerospace C-suite executive from firms across North […]

The Argus Group paid tribute to Sheila Nicoll, saying her “distinguished career and her significant contributions to the insurance and reinsurance industry will always be remembered.” A spokesperson said, “The Argus Group announces with great sadness the passing of our cherished former Chairman, Sheila Nicoll. Ms. Nicoll’s distinguished career and her significant contributions to the insurance […]

Arch Capital Group Ltd. appointed Nicolas Papadopoulo as CEO and Board member, effective immediately, following Marc Grandisson’s retirement. A spokesperson said, “Arch Capital Group Ltd. [NASDAQ: ACGL, Arch, our or the Company] today announced that Nicolas Papadopoulo has been named Chief Executive Officer and is joining the Board of Directors effective immediately. Papadopoulo has held […]

[Written by Stephen Wright] Boxer Saundre “Dash” Simmons scored his third successive first-round stoppage win with a TKO over Mexican Victor Aceves in Tijuana yesterday [May 19]. Simmons dropped Aceves [2-7-2] twice in the opening stanza before the referee waved the fight off, handing the Bermudian his fourth straight victory since turning professional. Dismantling his […]

[Updated] The Bermuda national women’s hockey team is matching up against Mexico this evening [Sept 22] as part of the Pan American Challenge at the National Sports Centre, and you can watch replay below. Update: The Bermuda women’s national hockey team faced tournament favourites Mexico in their second pool game in the Women’s Pan American Challenge […]

Tournament favourites Mexico won their second game at the Women’s Pan American Challenge at the National Sports Centre yesterday [September 23] after defeating Brazil 3-1. Maribel Acosta, Grecia Mendoza and Dariana Cardiel scored for Mexico; meanwhile, Mayara Eiko netted for Brazil. In today’s games, Brazil face Paraguay at 3.45 pm and Bermuda play Guyana at […]

The Mexico women’s national hockey team won their third straight game at the Women’s Pan American Challenge after beating Paraguay 3-1 at the National Sports Centre yesterday [September 25]. Dariana Cardiel, Arlette Estrada and Grecia Mendoza scored for Mexico; meanwhile, Abril Sanabria found the net for Paraguay. In tomorrow’s games, Mexico, the pool leaders, play […]

In their final game of the Davis Cup Division III, Bermuda lost 3 – 0 to Puerto Rico. In the opener, Trey Mallory went down in a three-setter to Jake Fellows 6-7, 6-1, 6-2. Daniel Phillips was defeated in straight sets 6-4, 6-2 to Marko Mesarovic. James Finnigan and Jack Keyes then took to the […]

The Stationery Store partnered with 15-year-old local artist Nico Bean to launch a new collection of custom notebooks just in time for the back-to-school season. A spokesperson said, “As students gear up for the new school year, the Stationery Store is excited to announce a special partnership with 15-year-old local artist Nico Bean on his […]

Masterworks Museum of Bermuda Art will be showcasing the work of award-winning Bermudian documentary photographer and visual storyteller, Nicola Muirhead, in the next Rick Faries Gallery exhibition entitled ‘Descendants of Summer: A Preview,’ which will be opening on Friday, October 4. A spokesperson said, “This exhibition showcases a sample of Muirhead’s ongoing documentary series Descendants […]

“Beyond a general feel-good, this Government doesn’t seem to know why it is even joining Caricom,” Opposition Leader Jarion Richardson said, while the PLP said “instead of being distracted by the OBA’s fearmongering, the PLP is focused on building a fairer Bermuda for Bermudians.” OBA Statement Mr Richardson said, “This Government continues to force Bermudians […]

Bermuda’s distinct style has taken centre-stage in Vogue magazine’s latest feature, “In the Birthplace of Bermuda Shorts, the Style Is Always in Season.” A spokesperson said, “The Bermuda Tourism Authority [BTA] is excited to announce Bermuda’s distinct style has taken centre-stage in Vogue magazine’s latest feature, ‘In the Birthplace of Bermuda Shorts, the Style Is […]

Zvyšování daní nebo hromadné výpovědi lékařů ve slovenských nemocnicích se premiér Robert Fico snažil zametat pod koberec, jak jen to bylo možné, a dělal všechno pro to, aby odlákal pozornost veřejnosti k něčemu jinému. Nakonec přestal experimentovat a vrátil se k osvědčené klasice „za to můžou ostatní“. V tomto případě za to můžou ostatní politické strany, kterých je prostě moc.

What kind of malware is UnicornSpy?

UnicornSpy is malware used to steal sensitive information. Cybercriminals have been observed using UnicornSpy to target energy companies, factories, and suppliers (and developers) of electronic components. The channel used for the distribution of this malware is email. However, threat actors may also deliver UnicornSpy using other methods.

The CIA from the very first days of the Trump administration, even before he was inaugurated, devoted themselves to sabotaging the administration because Donald Trump questioned just a few of their pieties. And that can't be done in Washington. Whoever does that must be destroyed. And so the CIA and the Deep State operatives became heroes of the liberal left, the people who support the Democratic party. They're now in a full union with the neocons, the Bush Cheney operatives, the CIA, Silicon Valley, and Wall Street. That is the union of power along with mainstream media outlets that are fully behind the Democratic party, which is likely to at least take over one branch of government, if not all of them, with the coming election, and that is a very alarming proposition because they're authoritarian, they believe in censorship, and they believe in suppression of information that exposes them in any kind of a critical light. Continue reading →

NEWS – The color-capable K2 Plus has been a hot topic, since Creality, a world-leading 3D printer brand, heralded it in the spring of 2024. “Your dreams in color come true” as the K2 Plus x CFS Combo hits the shelve on November 11. Unifying multicolor, speed, intelligence, and a 350mm cubed format in one, […]

Британская модель Николь Нил (Nicole Neal) уже в двадцать лет стала звездой таких мужских изданий, как FHM, Nuts, Front, Loaded, The Sun и многие другие. “В Британии ощущается недостаток горячих блондинок”, – утверждает Николь Нил. – “Если вы посмотрите вокруг, то увидите много брюнеток, нескольких рыженьких девушек и практически ни одной блондинки. Думаю, данный факт [...]

I’m running to Marshalls right now. READ MORE...

The post Soviet Helicopters appeared first on English Russia.

The project is from Mattel Films, Shadowmachine, Jennifer Lopez’s Nuyorican Productions, and actor-producer Anthony Ramos.

Learn how some of the great structures of the world—the Eiffel Tower, the Great Pyramids, and more—were built.

Em 2024 foram aplicadas quase 200 multas, a maioria por tráfego irregular de veículos, em áreas proibidas. Especialistas veem risco de erosão acelerada das dunas

Lando Norris cuts Max Verstappen’s lead to 47 points and labels his rival “dangerous” as the championship battle reaches boiling point at the Mexico City Grand Prix.

velocityconf: Call for speakers and registration is open for @webperfdays in Silicon Valley http://t.co/cJKBmynkjI June 22, Google HQ (cc @sfwebperf)

California's San Francisco Bay Area is still solidly blue — but less than it used to be.

November has turned into a remarkable month for cryptocurrency, with Bitcoin and meme coins like Dogecoin, Shiba Inu, and Pepe… Continue reading Meme Coins Are Soaring as Pepe Unchained Layer 2 ICO Raises $27.5 Million

The post Meme Coins Are Soaring as Pepe Unchained Layer 2 ICO Raises $27.5 Million appeared first on ReadWrite.

Winter is my favorite time of year and I always look forward to local festivals and events featuring colorful holiday displays. Last week I got to check out a new event here in the Bay Area, WinterFest at California’s Great America. On November 25, the Silicon Valley theme park was transformed into a winter wonderland […]

The article A Winter Wonderland in Silicon Valley originated at EverInTransit.com

Interview: Nicole Hemmer The World Today rescobales.drupal 27 September 2022

The political historian talks to Mike Higgins about how Donald Trump has transformed the US midterm elections and the Republican party’s lurch further right.

Partisans: The Conservative Revolutionaries Who Remade American Politics in the 1990s
Nicole Hemmer, Basic Books, $18.99

In Partisans, you argue that the American political far right had been preparing the conditions for Donald Trump for 25 years and ‘the puzzle pieces snapped into place’ when he was nominated in 2016. What did you mean by that?

There were changes happening in plain sight over a quarter of a century. Such as the rise of presidential candidates who had never held elected office but who had a following in conservative media and cable news more broadly. There was also a turn towards pessimism, to connections with extreme groups and to procedural extremism in the Republican Party, such as the impeachment of Bill Clinton over what most Americans agreed was a small indiscretion.

All that accelerates in the 2000s and 2010s to the point where if you look back from Trump’s election, he suddenly seems eligible in a way that I don’t think he was in 2015 during his ascendancy.

 How did the end of the Cold War open the door for the hard right in the early 1990s?

The Cold War is so important to making sense of conservative politics in the United States because it sat at the core of American conservatism for 50 years. Opposition to Soviet communism held together the conservative coalition. It brought together religious conservatives who talked about the atheistic Soviet Union with the libertarians who were fearful of a big state.

The Cold War forced conservatives to talk in a language of freedom and democracy because that was the way that the US was different from the Soviet Union. Ronald Reagan, in particular, was a master of this. It had real implications for domestic policy. Reagan embraced free trade and talked about immigration and diversity as things that were great for America.

And then the Cold War ends, and you have politicians like Pat Buchanan [a former White House Communications Director] who had been beating the Reagan line for years, coming out and saying: ‘You know what? Immigration is bad and immigrants are bad. They are harmful for the United States. Free Trade is bad. We need to have more protectionist economy and build Fortress America. And, by the way, democracy might not actually be the best form of government for our country. The Marine Corps and IBM are better run than the federal government, and those are autocratic governed institutions.’

It allowed a resurgence of a right-wing politics that the US hadn’t seen since the 1930s and 1940s. It would become a powerful political movement within conservatism that we ultimately see taking over the Republican Party by the 2010s.

 What was it that allowed far-right figures such as Rush Limbaugh to take advantage of the transformation of the media in the 1990s?

Part of what they saw in it was interactivity. We tend to associate that with the internet and with the rise of social media, but call-in national radio and cable TV gave people an opportunity to have their voices heard.

The most popular TV show on CNN was Larry King Live, a call-in show. That interactivity fed into this idea that a frustrated populace suddenly had a voice, and it was easy to play on that sense of frustration. Also, the right was innovative because they had been focused on alternative media for decades.

So, as you get new formats in the 1990s like political talk radio and cable news, conservatives were already in that space looking for ways to get their message across.

Also, journalistic objectivity in the 1990s became getting a voice from the right and a voice from the left, which opened the door for a new generation of conservative pundits such as TV hosts Laura Ingraham and Ann Coulter. You have these incentives drawing the right into this new media and all of these conservatives in the base who are looking for right-wing voices.

There are hearings into the January 6, 2021, Capitol invasion and an FBI investigation into the alleged presence of confidential papers at Trump’s residence Mar-a-Lago. Are we about to witness the insurgent far right within the Republican Party being brought to account legally?

There has been more accountability than I anticipated at the beginning of the Trump presidency. Some innovative legal techniques are being used successfully, such as sedition and conspiracy charges against some of the Capitol rioters.

Steve Bannon, one of Trump’s chief advisers in the 2016 campaign, has been charged with money laundering, conspiracy and fraud during the Trump presidency. Will that accountability lead to a fundamental transformation of right-wing politics in the US? I wouldn’t bet on that.

How is the radicalism of the Republican party shaping the upcoming mid-term elections?

The real radicalism in the Republican Party now is its willingness to use both procedural mechanisms but also mob violence to get the electoral outcomes that it wants – something that we saw with the insurrection on January 6, 2021.

That makes the mid-terms an existential election if Republicans are able to vote in candidates who are running on a platform of throwing out election results if Republicans don’t win. That is a real challenge to the future of American democracy.

As long as the political system is organized around one party that respects the rules of democracy and one party that fights against them, each election is going to be existential. It will make mid-term elections have the weight that the 2016 and 2020 presidential elections had.

Did the far right misunderstand the electorate when it comes to abortion, considering the strong reaction to the Dobbs ruling?

I think that is exactly right, and it’s fascinating. A major turn happens in American politics between the 1980s and the 1990s, especially on the right. Ronald Reagan built these broad coalitions. He was winning landslide elections, and building this ‘big tent’ party that would bring in people who didn’t identify as Republicans or conservatives.

By the time you get to the 1990s, you have this idea of the Rino – politicians who are ‘Republican in name only’. You had to be purer and purer when it came to your right-wing politics. And the Republican Party grew a lot more unpopular. It has lost elections because of the extremism of its candidates, but it has still been able to win democratic elections without majorities, something we saw in 2000 and 2016.

The outcome of it all is exactly what you are seeing right now, that in many ways the conservative movement has got something it wanted for half a century, which is the overturning of Roe v Wade – something that energized its space for a very long time. Now that the dog has caught the fire truck, it is looking around and saying: ‘Oh, people do not like this.’

August’s referendum in Kansas that upheld the right to abortion mobilized lots of voters who normally wouldn’t have come out for an off-year election.

As you get more stories of 10-year-old rape victims who have to go to a different state to get an abortion, or stories of women who have high-risk pregnancies not able to get medical care because of these new extremist laws, that really does mobilize a population who understand what is at stake.

It is not just their access to abortion, but to reproductive healthcare more broadly. Not everywhere, but in some places that is going to change the dynamics of these mid-term races.

Evolving evidence suggests that nicotine may contribute to impaired asthma control by stimulating expression of nerve growth factor (NGF), a neurotrophin associated with airway remodeling and airway hyperresponsiveness. We explored the hypothesis that nicotine increases NGF by reducing lung fibroblast (LF) microRNA-98 (miR-98) and PPARγ levels, thus promoting airway remodeling. Levels of NGF, miR-98, PPARγ, fibronectin 1 (FN1), endothelin-1 (EDN1, herein referred to as ET-1), and collagen (COL1A1 and COL3A1) were measured in human LFs isolated from smoking donors, in mouse primary LFs exposed to nicotine (50 μg/ml), and in whole lung homogenates from mice chronically exposed to nicotine (100 μg/ml) in the drinking water. In selected studies, these pathways were manipulated in LFs with miR-98 inhibitor (anti-miR-98), miR-98 overexpression (miR-98 mimic), or the PPARγ agonist rosiglitazone. Compared with unexposed controls, nicotine increased NGF, FN1, ET-1, COL1A1, and COL3A1 expression in human and mouse LFs and mouse lung homogenates. In contrast, nicotine reduced miR-98 levels in LFs in vitro and in lung homogenates in vivo. Treatment with anti-miR-98 alone was sufficient to recapitulate increases in NGF, FN1, and ET-1, whereas treatment with a miR-98 mimic significantly suppressed luciferase expression in cells transfected with a luciferase reporter linked to the putative seed sequence in the NGF 3'UTR and also abrogated nicotine-induced increases in NGF, FN1, and ET-1 in LFs. Similarly, rosiglitazone increased miR-98 and reversed nicotine-induced increases in NGF, FN1, and ET-1. Taken together, these findings demonstrate that nicotine-induced increases in NGF and other markers of airway remodeling are negatively regulated by miR-98.

Peter Lasch
Dec 1, 2020; 19:2125-2138
Technological Innovation and Resources

Adult progenitor cell populations typically exist in a quiescent state within a controlled niche environment. However, various stresses or forms of damage can disrupt this state, which often leads to dysfunction and aging. We built a glucocorticoid (GC)-induced liver damage model of mice, found that GC stress induced liver damage, leading to consequences for progenitor cells expansion. However, the mechanisms by which niche factors cause progenitor cells proliferation are largely unknown. We demonstrate that, within the liver progenitor cells niche, Galectin-3 (Gal-3) is responsible for driving a subset of progenitor cells to break quiescence. We show that GC stress causes aging of the niche, which induces the up-regulation of Gal-3. The increased Gal-3 population increasingly interacts with the progenitor cell marker CD133, which triggers focal adhesion kinase (FAK)/AMP-activated kinase (AMPK) signaling. This results in the loss of quiescence and leads to the eventual stemness exhaustion of progenitor cells. Conversely, blocking Gal-3 with the inhibitor TD139 prevents the loss of stemness and improves liver function. These experiments identify a stress-dependent change in progenitor cell niche that directly influence liver progenitor cell quiescence and function.

Over the past decade, modern methods of MS (MS) have emerged that allow reliable, fast and cost-effective identification of pathogenic microorganisms. Although MALDI-TOF MS has already revolutionized the way microorganisms are identified, recent years have witnessed also substantial progress in the development of liquid chromatography (LC)-MS based proteomics for microbiological applications. For example, LC-tandem MS (LC-MS²) has been proposed for microbial characterization by means of multiple discriminative peptides that enable identification at the species, or sometimes at the strain level. However, such investigations can be laborious and time-consuming, especially if the experimental LC-MS² data are tested against sequence databases covering a broad panel of different microbiological taxa. In this proof of concept study, we present an alternative bottom-up proteomics method for microbial identification. The proposed approach involves efficient extraction of proteins from cultivated microbial cells, digestion by trypsin and LC–MS measurements. Peptide masses are then extracted from MS¹ data and systematically tested against an in silico library of all possible peptide mass data compiled in-house. The library has been computed from the UniProt Knowledgebase covering Swiss-Prot and TrEMBL databases and comprises more than 12,000 strain-specific in silico profiles, each containing tens of thousands of peptide mass entries. Identification analysis involves computation of score values derived from correlation coefficients between experimental and strain-specific in silico peptide mass profiles and compilation of score ranking lists. The taxonomic positions of the microbial samples are then determined by using the best-matching database entries. The suggested method is computationally efficient – less than 2 mins per sample - and has been successfully tested by a test set of 39 LC-MS¹ peak lists obtained from 19 different microbial pathogens. The proposed method is rapid, simple and automatable and we foresee wide application potential for future microbiological applications.

Paramphistomosis, caused by the rumen fluke, Calicophoron daubneyi, is a parasitic infection of ruminant livestock which has seen a rapid rise in prevalence throughout Western Europe in recent years. Following ingestion of metacercariae (parasite cysts) by the mammalian host, newly-excysted juveniles (NEJs) emerge and invade the duodenal submucosa which causes significant pathology in heavy infections. The immature larvae then migrate upwards, along the gastrointestinal tract, and enter the rumen where they mature and begin to produce eggs. Despite their emergence, and sporadic outbreaks of acute disease, we know little about the molecular mechanisms used by C. daubneyi to establish infection, acquire nutrients and to avoid the host immune response. Here, transcriptome analysis of four intra-mammalian life-cycle stages, integrated with secretome analysis of the NEJ and adult parasites (responsible for acute and chronic disease respectively), revealed how the expression and secretion of selected families of virulence factors and immunomodulators are regulated in accordance with fluke development and migration. Our data show that whilst a family of cathepsins B with varying S2 sub-site residues (indicating distinct substrate specificities) are differentially secreted by NEJs and adult flukes, cathepsins L and F are secreted in low abundance by NEJs only. We found that C. daubneyi has an expanded family of aspartic peptidases, which is up-regulated in adult worms, although they are underrepresented in the secretome. The most abundant proteins in adult fluke secretions were helminth defence molecules (HDMs) that likely establish an immune environment permissive to fluke survival and/or neutralise pathogen-associated molecular patterns (PAMPs) such as bacterial lipopolysaccharide in the microbiome-rich rumen. The distinct collection of molecules secreted by C. daubneyi allowed the development of the first coproantigen-based ELISA for paramphistomosis which, importantly, did not recognise antigens from other helminths commonly found as co-infections with rumen fluke.