Olga Kopach, Noemi Esteras, Selina Wray, Dmitri A. Rusakov, and Andrey Y. Abramov

Frontotemporal dementia and parkinsonism (FTDP-17) caused by the 10+16 splice-site mutation in the MAPT provides an established platform to model tau-related dementia in vitro. Human iPSC-derived neurons have been shown to recapitulate the neurodevelopmental profile of tau pathology during in vitro corticogenesis as in the adult human brain. However, the neurophysiological phenotype of these cells has remained unknown, leaving unanswered questions over the functional relevance and the gnostic power of this disease model. Here we used electrophysiology to explore the membrane properties and intrinsic excitability of the generated neurons to find that human cells mature by ~150 days of neurogenesis to become compatible with matured cortical neurons. In earlier FTDP-17, neurons, however, exhibited a depolarized resting membrane potential associated with increased resistance and reduced voltage-gated Na⁺- and K⁺-channel-mediated conductance. The Na_v1.6 protein was reduced in FTDP-17. These led to a reduced cell capability of induced firing and changed action potential waveform in FTDP-17. The revealed neuropathology may thus contribute to the clinicopathological profile of the disease. This sheds new light on the significance of human models of dementia in vitro.

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Joint statements from the national science academies of the G7 nations were delivered today to the Italian government in advance of the G7 Summit to be held in Taormina, Italy, at the end of May.

The U.S. is losing ground in a second laser revolution of highly intense, ultrafast lasers that have broad applications in manufacturing, medicine, and national security, says a new report from the National Academies of Sciences, Engineering, and Medicine.

Today the National Academies of Sciences, Engineering, and Medicine released its review of the National Toxicology Program’s (NTP) draft monograph Systematic Review of Fluoride Exposure and Neurodevelopmental and Cognitive Health Effects.

Coronavirus deaths in the U.K. have passed those in Italy. Workers in the intensive care unit at the Royal Papworth Hospital in Cambridge are shown gearing up to care for COVID-19 patients.; Credit: Neil Hall/AP

Over 32,000 people have died from the new coronavirus in the United Kingdom, according to the Office for National Statistics, marking the first time in the pandemic that it has led Europe in the number of deaths.

The country has surpassed Italy in COVID-19 deaths. The U.S. still leads the world in the highest number of coronavirus deaths; over 70,270 had died from the disease as of Tuesday.

The number of total deaths recorded in the U.K. is "higher than we would wish, I think is all I can say," Angela McLean, chief scientific adviser of Ministry of Defence said during the country's press briefing Tuesday.

McLean also emphasized that deaths in U.K. care homes have been steadily rising and said the trend was something the country "need[s] to get to grips with."

"I don't think we'll get a real verdict on how well countries have done until the pandemic is over," British Foreign Secretary Dominic Raab said Tuesday. "And particularly until we have comprehensive international data on all causes of mortality."

Since different countries collect and report coronavirus data using different methods, the comparisons between regions are not perfect. As more time passes and more tests are conducted and more data comes in, coronavirus death rates will become more precise.

The peak in deaths comes as other European countries, including Italy and Spain, are easing shelter-in-place restrictions, while U.K. Prime Minister Boris Johnson is expected to modify Britain's orders in the next week.

This content is from Southern California Public Radio. View the original story at SCPR.org.

Tourism businesses operating in protected conservation areas in Europe engage in a high number of sustainable practices, a recent survey of over 900 small-to-medium enterprises (SMEs) reveals. Reasons for their sustainable behaviour include cutting costs, improving company image and lifestyle choices.

The global production, trade and use of goods and services has a significant impact on the environment — and rates of consumption are rising. A new study combines two assessment methods to quantify the impact of European trade on the environment. It finds that, overall, the EU was a net importer of environmental impact from 2000 to 2010, that machinery, equipment and vehicles contributed most to the EU’s export impacts and that the EU’s trade balance (import impact minus export impact) is increasing over time. The two assessment methods complement one another well and could form the basis for future country or region-wide studies, suggest the researchers, by enabling a detailed analysis of individual steps within a product’s trade flow, while also providing a larger picture of the overall process.

Increasing resource efficiency is a central aim of European environmental policy, and effective waste management must play a key role in this. A new report assesses waste management in 32 European countries, and identifies key lessons. Landfill taxes and mandatory separate collections of different waste types are highlighted as particularly successful policy instruments.

Higher public awareness of sustainable fishing practices, led by environmental NGOs, may have helped reduce the incidence of mislabelled fish in the UK, compared to Ireland, according to a recent study which assessed levels of fish fraudulently sold as ‘cod’ in these two countries.

Since the arrival of the European Soil Data Centre in 2006, assessing the state of soils at European level has never been easier, more efficient or more reliable, according to a new report by its designers. The database, which contains state-of-the-art scientific information for a range of key environmental concerns, was accessed 26,000 times in the first 11 months of operation.

Standardised methods of categorising environmental data are needed at European and international levels for effective international policies. A recent study has concluded that a European framework that harmonises environmental data at the continental scale corresponds well with national classification systems, although some modifications may be needed to capture small-scale regional variations.

The impact of air quality on public welfare is important to policy development. However, it is difficult to make a clear link between the two when air pollution tends to be reported at a country level and wellbeing is an individual measure. A new study takes a step further towards linking the two by analysing regional level air quality across the EU and relating it to levels of life satisfaction.

A Bosnian pine (Pinus heldreichii) growing in the highlands of northern Greece has been dendrocronologically dated to be more than 1075 years old. This makes it currently the oldest known living tree in Europe. The millenium old pine was discovered by scientists from Stockholm University (Sweden), the University of Mainz (Germany) and the University of Arizona (USA).

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A new Pan-European landscape map (LANMAP) has been developed that allows a common classification of landscapes across Europe.

The development of Green Infrastructure (GI) in a UK case study has been researched in a recent study. Some issues caused by an imbalance in stakeholder power and conflicting roles played by major stakeholders were identified with the project. Stakeholder participation is central to the concept of GI and the research reiterates the importance for those implementing GI to ensure that participation is effective and balanced.

Over 8% of land in Europe could be at moderate-to-high risk of wind-driven soil erosion, a new study has estimated. In the first assessment of its kind, the researchers produced maps which show wind erosion risk across 36 countries. This information could help guide actions to tackle land degradation.

An analysis of flash flood forecasting in Europe has produced recommendations for emergency planners and others to improve flood risk management in vulnerable regions. In particular, the researchers recommend improved data collection and sharing, a common European policy for flash flood forecasting, and that local risk management recognises the specific challenges presented by flash floods.

Researchers have created a simple tool to analyse the risk of river flooding across almost all of Europe, and to estimate the associated economic losses. They found that Eastern Europe, Scandinavia, Austria and the UK are the regions and countries most at threat.

Cultural and institutional barriers, coupled with a lack of confidence about whether and how to use it, mean that the European Flood Awareness System (EFAS) has yet to be fully integrated into national flood warning systems, according to a recent study.

The reduction in summer storms in the western Mediterranean could be partly caused by land use change on coasts and mountain slopes, a new study reports. This lack of storms causes water vapour to build up above the region and may lead to heavy rainfall and flooding in central Europe.

Extreme and catastrophic floods in Europe, such as those seen in 2013, currently occur approximately once every 16 years, but this may increase to once every 10 years by 2050, according to new research. The study also suggests that annual average economic losses caused by extreme floods could reach almost five times higher than 2013 values.

Agriculture plays a large role in the management of water in the EU. However, there is little consistent information on water use in irrigation. New EU supported research has estimated how much water is used for irrigation in European countries, providing a framework to analyse agricultural pressures on water quantity.

A new study suggests that abandoned farmland is widespread in Europe and that not all land that has been abandoned is unsuitable for farming. Understanding how abandoned farmland is distributed may be important for making land management decisions – for instance, recultivation versus reversion to forest.

Soil erosion is an important issue in Europe, with consequences for water quality, ecosystem services supply and crop production. In this study, researchers enhanced an existing model to estimate soil loss and create an updated map of soil erosion across the EU. The authors say the tool can simulate the effects of land use changes and management practices and will support effective policy decisions.

Pollen allergy is a common cause of allergic respiratory diseases such as hay fever and asthma. A recent continent-wide study suggests that rising carbon dioxide (CO2) emissions over the last 30 years may be increasing pollen counts especially in European cities, which could have serious consequences for public health.

The impact of air quality on public welfare is important to policy development. However, it is difficult to make a clear link between the two when air pollution tends to be reported at a country level and wellbeing is an individual measure. A new study takes a step further towards linking the two by analysing regional level air quality across the EU and relating it to levels of life satisfaction.

Forests can play a critical role in the mitigation of climate change, but at the same time, climate change is threatening the health and condition of forests. Therefore their protection and adaptation is essential. The EU has adopted a green paper on 'Forest protection and information in the EU: preparing forests for climate change'. This special thematic issue provides current information on the dynamics and relationships between forests and climate change and insight into the role of forest management and ecosystem services in protecting EU forests.

The noise generated by commercial shipping can impair the ability of the critically endangered European eel to avoid predators, new research has found. The results show that marine noise can have serious effects on these animals with potentially fatal consequences.

The factors enabling eco-innovation have been analysed across 19 European countries in a new study. Regulations and environmental subsidies were found to be more important factors in Eastern Europe than in wealthier Western European countries. External research and development (R&D) was also more relevant in Eastern Europe, demonstrating the need for specific technology transfers from other countries and competitors.

A recent study has analysed risks to European renewable industries from the Chinese supply of critical raw materials. The offshore wind sector was found to be the most vulnerable of the renewable industries to supply risks. EU and industry strategies should be able to deal with these supply risks in the short term, but there are potential long-term risks to solar and wind sectors. The development of alternative technologies less reliant on these raw materials, and methods to recycle these materials is, therefore, a priority.

Heatwaves in Europe are likely to become more frequent and devastating, according to recent research. Climate change will lead to extended periods of high day and night-time temperatures, coupled with high humidity, and will particularly affect the Mediterranean coast and southern European river basins, where there are many densely populated urban areas.

A review of the European Climate Change Programme has concluded that the initiative has successfully identified cost-efficient policy measures to reduce greenhouse gas (GHG) emissions, allowed consensus-building among key stakeholders, and positioned the European Union as a leader in climate change actions.

The impact of climate change on electricity consumption is important to both adaptation and mitigation policies. New research has estimated that over the next 100 years climate change could cause up to a 20 per cent decrease in demand for electricity for heating in Northern Europe and up to a 20 per cent increase in demand for electricity for cooling in Southern Europe.

Scientists have calculated carbon budgets for croplands in Europe, based on field measurements from nine sites across Europe. They found that significant soil carbon losses occurred from cropping even though some farmers used measures to enhance carbon-sequestration. These results may challenge findings from some other modelling studies if they turn out to be typical for all EU croplands.

Connecting Europe and North Africa with a single, long-distance electricity ‘supergrid’ is technically possible and the cheapest option available to meet Europe’s renewable energy targets, according to new research. However, significant political challenges, such as minimising the perception of risk and attracting sufficient investment, need to be overcome.

A recent study has highlighted the potential of one form of solar power, Concentrating Solar Power (CSP), to make a significant contribution to meeting future electricity demands from renewable sources in Europe.

A new study provides an approach for estimating the risk of antibiotic contamination associated with different soils and different antimicrobial products. The researchers estimated and mapped soil contamination risk across Europe and suggest that their methods could be used to inform antibiotic resistance monitoring or policies designed to reduce contamination.

Climate change will affect the spread and risk of many infectious diseases in Europe, according to a recent survey of leading health experts. The results suggest that more needs to be done to prepare for the expected changes in infectious disease levels, such as improved monitoring of disease.

The impact of climate change on the distribution of tree species is likely to have economic implications for the timber industry. A new study has estimated that climate-induced shifts in range could reduce the value of European forest land for the timber industry by between 14 and 50% by 2100. At the higher end of this estimate, this could equate to a potential loss of several hundred billions of euros.

Harmful algal blooms may become more common in north western European waters as a result of climate change, according to a new study. The researchers predicted that by the end of this century blooms of two groups of algal species will occur over larger areas and for longer periods every year.

Higher temperatures being brought about by global warming are increasing methane emissions from the extensive northern European peatlands, a recent study has found. The researchers also say that future estimations of greenhouse gas emissions can be improved via better land-cover classification — i.e. determining how much peatland is fenland or bogland.

Waves hitting Europe’s Atlantic coast during the winter of 2013–2014 were the most powerful in nearly 70 years, reports a new study. They caused significant coastal erosion and the study found examples of beaches which are now several metres lower. The study’s authors say that coastal planners should consider increasingly stormy conditions in the north-east Atlantic, as predicted by some climate change models.

Researchers have modelled the exposure to multiple hazards across different regions of Europe in relation to heat, cold, drought, wildfire, flooding and wind. The study indicated that, over the next century, environmental hazards are likely to increase, particularly along coastlines and on floodplains, and that south-western Europe is likely to be the worst-hit region.

A new study has assessed the vulnerability of 571 European cities to heatwaves, droughts and flooding caused by climate change. The causes of vulnerability differ across Europe and the researchers say the results could be used to design policies to mitigate the impacts.

Increasing resource efficiency is a central aim of European environmental policy, and effective waste management must play a key role in this. A new report assesses waste management in 32 European countries, and identifies key lessons. Landfill taxes and mandatory separate collections of different waste types are highlighted as particularly successful policy instruments.

Recycled waste material could play a major role in the construction of roads in Europe, bringing both environmental and economic benefits. A new study proposes a scenario where 50% of the asphalt for Europe’s roads consists of recycled materials, leading to significant reductions in costs, energy use and greenhouse gas emissions.

Satellite observations are valuable aids to detect and monitor fire activity. A recent study has investigated how satellite images of fire activity, together with information on vegetation cover and fire risk associated with long and short-term atmospheric conditions could be used to help authorities better manage the risk of wildfires in Mediterranean Europe.