me

PE/VC investments hit 24-month low of $1.7 bn, value falls by 39%

Uncertainty over the impact of Covid-19 is expected to act as a significant headwind to Indian PE/VC investments




me

PE and VC investments at $5.1 billion in 1Q2020; a 12-quarter low: IVCA-EY

At $2.2 billion, large deals declined by over 70 per cent on a year-on-year basis in the same period




me

[ASAP] Direct Identification of a-Bisabolol Enantiomers in an Essential Oil Using a Combined Ion Mobility–Mass Spectrometry/Quantum Chemistry Approach

Journal of Natural Products
DOI: 10.1021/acs.jnatprod.9b00982




me

[ASAP] PTP1B-Inhibiting Branched-Chain Fatty Acid Dimers from <italic toggle="yes">Eremophila oppositifolia</italic> subsp. <italic toggle="yes">angustifolia</italic> Identified by High-Resolution PTP1B Inhibiti

Journal of Natural Products
DOI: 10.1021/acs.jnatprod.0c00070




me

[ASAP] Genomics–Metabolomics Profiling Disclosed Marine <italic toggle="yes">Vibrio spartinae</italic> 3.6 as a Producer of a New Branched Side Chain Prodigiosin

Journal of Natural Products
DOI: 10.1021/acs.jnatprod.9b01159




me

[ASAP] 6-Deoxy- and 11-Hydroxytolypodiols: Meroterpenoids from the Cyanobacterium HT-58-2

Journal of Natural Products
DOI: 10.1021/acs.jnatprod.9b00844




me

[ASAP] Diisonitrile-Mediated Reactive Oxygen Species Accumulation Leads to Bacterial Growth Inhibition

Journal of Natural Products
DOI: 10.1021/acs.jnatprod.0c00125




me

[ASAP] Antineoplastic Agents. 607. Emetine Auristatins

Journal of Natural Products
DOI: 10.1021/acs.jnatprod.0c00031




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[ASAP] Isolation of Taste-Active Triterpenoids from <italic toggle="yes">Quercus robur</italic>: Sensory Assessment and Identification in Wines and Spirit

Journal of Natural Products
DOI: 10.1021/acs.jnatprod.0c00106




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[ASAP] Review of Biology and Ecology of Pharmaceutical Marine Sponges<source>Biology and Ecology of Pharmaceutical Marine Sponges</source>. Edited by Ramasamy Santhanam, Santhanam Ramesh, and Anbu Jeba Sunilson. <publisher-name>CRC Press

Journal of Natural Products
DOI: 10.1021/acs.jnatprod.0c00352




me

[ASAP] Review of Progress in the Chemistry of Organic Natural Products<source>Progress in the Chemistry of Organic Natural Products</source>, Volume 108. Edited by A. Douglas Kinghorn, Heinz Falk, Simon Gibbons, Jun’ichi Kobayashi, Yoshinori A

Journal of Natural Products
DOI: 10.1021/acs.jnatprod.0c00356




me

[ASAP] Inhibitory Effect of Cannabidiol on the Activation of NLRP3 Inflammasome Is Associated with Its Modulation of the P2X7 Receptor in Human Monocytes

Journal of Natural Products
DOI: 10.1021/acs.jnatprod.0c00138




me

[ASAP] A Grand Challenge. 3. Unbiased Phenotypic Function of Metabolites from Australia Plants <italic toggle="yes">Gloriosa superba</italic> and <italic toggle="yes">Alangium villosum</italic> against Parkinson

Journal of Natural Products
DOI: 10.1021/acs.jnatprod.9b00880




me

Fun and games with JavaScript

#484 — April 17, 2020

Unsubscribe  :  Read on the Web

???? If you're bored this weekend at all, consider joining the latest Ludum Dare — it's an online game jam that's been taking place for 18 years and more JavaScript entries are appreciated against all the Unity crowd ????

JavaScript Weekly

Writing an 'Emulator' in JavaScript (and Interfacing with Multiple UIs) — This is really neat. Tania built a Chip-8 interpreter in JavaScript and has gone into quite a bit of detail about what was involved here. Lots of neat bits and pieces to pick up from this.

Tania Rascia

jQuery 3.5.0 Released — I know many of you will groan, but I’m delighted when I see a new jQuery release. It’s still so heavily used. No headline features though, this is a security fix for a cross-site scripting vulnerability, plus some tweaks and fixes in preparation for jQuery 4.0 (yes!)

Timmy Willison (jQuery Foundation)

Build a Game of Battleship with TypeScript & Java. Free Course — Join over 2000 developers creating a game of Battleship with TypeScript, Spring Cloud Stream (Java), and PubSub+. This free 30-minute course is a great way to learn the basics of messaging and event-driven architecture with the Aurelia framework.

Solace sponsor

Profiling React.js Performance — Goes into detail on aspects of the React Profiler API, React’s new experimental Interaction Tracing API, and measuring custom metrics using the User Timing API.

Addy Osmani

Userscripts are Fun and Still Very Much Relevant — ‘Userscripts’ are basically JavaScript programs that run in the context of other Web pages so you can add your own features. They were really popular for a while but still exist and are still a neat use case for using JavaScript to improve your Web experience.

Eldad Bercovici

Another Look at What's New in ECMAScript 2020 — We linked to Dr Axel’s roundup recently, but here’s another take, looking at dynamic imports, nullish coalescing, optional chaining, BigInt, and more.

Ianis T.

⚡️ Quick Releases

???? Jobs

JavaScript Developer at X-Team (Remote) — Join the most energizing community for developers. Work from anywhere with the world's leading brands.

X-Team

Senior JavaScript Developer (Warsaw, Relocation Package) — Open source rich text editor used by millions of users around the world. Strong focus on code quality. Join us.

CKEditor

Find a Job Through Vettery — Vettery specializes in tech roles and is completely free for job seekers. Create a profile to get started.

Vettery

???? Tutorials

How To Create a Particle Trail Animation in JavaScript — Particle animations are particularly (sorry) striking.. and in this article, Anna Prenzel shows how to easily create your own such effects with Anime.js.

Smashing Magazine

Strategies for Migrating to TypeScript — A quick overview of some strategies for migrating code bases from JavaScript over to TypeScript.

Dr. Axel Rauschmayer

Developing in a Monorepo While Still Using Webpack — Second part in a series discussing things the team at Etsy learned during the migration of a home-grown, Require.js-based build system to webpack, which took over a year.

Salem Hilal

A More Productive Way to Build Your JavaScript Apps — Write better code, debug it, and test it – all in one place. Try WebStorm. No configuration required.

WebStorm sponsor

▶  Let's Build a Digital Circuit Simulator in JavaScript — A special episode of the Low Level JavaScript series takes us on a brief journey into the world of digital logic.

Low Level JavaScript

How To Set Up an Express API Backend Project with PostgreSQL — A pretty extensive walkthrough of creating an HTTP API using Express with Node.js and Postgres on the backend, then deploying it all on Heroku.

Chidi Orji

Speed Up Your Angular App: 14 Optimization Tips — Tips on how to make your Angular app smaller, faster, and more responsive.

Marcelo Ricardo de Oliveira

Class-Related Types in TypeScript

Dr. Axel Rauschmayer

????▶ A Fireside Chat on the State of Microservices on April 21 — We recently helped The Software House with a developer survey (thanks to those who took it!) and now they’re doing a live chat on the state of microservices next Tuesday featuring Yan Cui, Alessando Vozza, and others.

The Software House

???? Code & Tools

Puppeteer 3.0: It Now Supports Firefox — Best known for as a way to headlessly control Chrome from Node, Puppeteer has recently seen some competition in the form of the cross-browser Playwright recently. But, no fear, Puppeteer is stepping up and can now work cross-browser too. We also learn Puppeteer is migrating to TypeScript.

Mathias Bynens

Open-Source Serverless CMS Powered by React, Node.js and GraphQL API — Build dynamic websites and apps with Webiny. 100% powered by JavaScript. Deploy your sites to AWS Lambda.

Webiny Serverless CMS sponsor

Rome: An Experimental JavaScript Toolchain — A compiler, linter, formatter, bundler, testing framework and more. Started by Sebastian McKenzie (of Babel and Yarn fame), Rome is now a project from the React Native team at Facebook. Related repo.

Facebook

Vime: A New, Modern Media / Video Player for the Web — Aims to be a ‘modern alternative to Video.js and Plyr’: “The idea behind Vime is we want you to control the player, not the other way around.” Modular, tree-shakable, and with potential for a plugin ecosystem. GitHub repo.

Rahim Alwer

Vuln Cost: An Open Source Security Scanner for VS Code — Free Snyk-powered VS Code extension that finds security vulnerabilities in npm packages, providing feedback in-line with your code, such as how many vulnerabilities a package has.

snyk

ip-num: A Library to Work with ASN, IPv4, and IPv6 Numbers — Happy in both Node and the browser.

dadepo

Flip: Animated Flip Counter Plugin to Add a Countdown to a Website — Adds an animated dynamic countdown timer to a page. No dependencies, responsive and mobile friendly, and fits any language, locale, or time zone.

Rik Schennink

The Perfect Partner to MongoDB Atlas. Try It for Free

Studio 3T sponsor

A JavaScript API for Controlling 'Simpsons: Hit & Run' — Including this as a bit of fun if you fancy noodling on something odd. Remote controlling games from JS seems neat, although I suspect just getting this running would take a while..

Tavis Ormandy




me

Medical inbound tourism poised to get a push: FAITH chairman Nakul Anand

Medical inbound tourism, already on the rise, will get a boost with addition of Tier-II and -III hospitals




me

Govt has put out a progressive Budget aimed at boosting infra: Sujeet Kumar

It has restored confidence of businesses as well as provided on-ground support that MSMEs need and farmers deserve, Co-founder of Udaan said




me

Budget: No tax relief for home buyers stuck in stalled projects, says FPCE

Real estate developers' apex bodies CREDAI and Naredco have also expressed disappointment over the Budget as their demand of one-time restructuring of builders' loan was not met




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Budget's much-needed leg-up for small units: CRISIL SME Tracker

An evaluation of 13,000 MSMEs using the CRISIL Quantix database shows that working capital comprises over half of their need for debt




me

Power industry hails proposal for smart prepaid metering across the country

Power ministry has been planning it for two years, but with limited success




me

Govt not included AGR dues payment in Budget 2020-21: DEA Secretary

15 entities owe the government about Rs 1.47 trillion in past dues -- Rs 92,642 crore in unpaid licence fee and another Rs 55,054 crore in outstanding spectrum usage charges




me

RBI MPC starts meeting to decide new rates amid slowdown, rising inflation

The retail inflation that for several months remained in the comfort zone of the central bank has started inching up and crossed the 7 per cent mark during December 2019




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LIC disinvestment: 100,000 employees stage walk-out across country

There are 13 unions in LIC, and employees and officers affiliated to 11 unions were on protest




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Economy fundamentals strong; markets show faith in Budget 2020: Sitharaman

FM says country's macroeconomic parameters are sound




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Budget disappointing; but fiscal, taxation measures welcome: EAC member

India's GDP growth is expected to slip to a decadal low of 5 per cent this fiscal, pressured by domestic factors like drop in consumption, as well as global issues




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No timeline to remove income tax exemptions, says Nirmala Sitharaman

"We have not made up our minds as yet (on the removal of all exemptions)... We are trying step by step, move forward and no particular timeline given," she said




me

Understanding Depression and Distress Among Medical Students

Interview with Laura Weiss Roberts, MD, MA, author of Understanding Depression and Distress Among Medical Students




me

What If Physicians Actually Had to Control Medical Costs?

Interview with Robert H. Brook, MD, ScD, author of What If Physicians Actually Had to Control Medical Costs?




me

Substituted Interests and Best Judgments: An Integrated Model of Surrogate Decision Making

Interview with Daniel P. Sulmasy, MD, PhD, author of Substituted Interests and Best Judgments: An Integrated Model of Surrogate Decision Making




me

he United States' Engagement in Global Tobacco Control

Interview with Lawrence O. Gostin, JD, author of The United States' Engagement in Global Tobacco Control




me

Re"evolutionary" Regenerative Medicine

Interview with Helen M. Blau, PhD, author of Re"evolutionary" Regenerative Medicine




me

A Physician Management Infrastructure

Interview with Peter J. Pronovost, MD, PhD, author of A Physician Management Infrastructure




me

Curtailing Diversion and Abuse of Opioid Analgesics Without Jeopardizing Pain Treatment

Interview with Nora D. Volkow, MD, author of Curtailing Diversion and Abuse of Opioid Analgesics Without Jeopardizing Pain Treatment




me

Patient-Physican Communication: It's About Time

Interview with Wendy Levinson, MD, author of Patient-Physican Communication: It's About Time




me

Improving Postdischarge Outcomes in Patients Hospitalized for Acute Heart Failure Syndromes

Interview with Mihai Gheorghiade, MD, author of Improving Postdischarge Outcomes in Patients Hospitalized for Acute Heart Failure Syndromes




me

Prevention of Melanoma With Regular Sunscreen Use

Interview with June K. Robinson, MD, author of Prevention of Melanoma With Regular Sunscreen Use




me

Interventions for War-Related Posttraumatic Stress Disorder: Meeting Veterans Where They Are

Interview with Charles Hoge, MD, author of Interventions for War-Related Posttraumatic Stress Disorder: Meeting Veterans Where They Are




me

Implementation of Medicare Part D and Nondrug Medical Spending for Elderly Adults With Limited Prior Drug Coverage

Interview with J. Michael McWilliams, MD, Phd, author of Implementation of Medicare Part D and Nondrug Medical Spending for Elderly Adults With Limited Prior Drug Coverage




me

Adjunctive Risperidone Treatment for Antidepressant-Resistant Symptoms of Chronic Military Service-Related PTSD

Interview with John H. Krystal, MD, author of Adjunctive Risperidone Treatment for Antidepressant-Resistant Symptoms of Chronic Military Service-Related PTSD




me

Sleep-Disordered Breathing, Hypoxia, and Risk of Mild Cognitive Impairment and Dementia in Older Women

Interview with Katie L. Stone, PhD, author of Sleep-Disordered Breathing, Hypoxia, and Risk of Mild Cognitive Impairment and Dementia in Older Women




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Implementing Accountable Care Organizations: Ten Potential Mistakes and How to Learn From Them

Interview with Stephen M. Shortell, PhD, MPH, MBA, author of Implementing Accountable Care Organizations: Ten Potential Mistakes and How to Learn From Them




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Quality of Life, Burnout, Educational Debt, and Medical Knowledge Among Internal Medicine Residents

Interview with Colin P. West, MD, PhD, author of Quality of Life, Burnout, Educational Debt, and Medical Knowledge Among Internal Medicine Residents




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Association of Unconscious Race and Social Class Bias With Vignette-Based Clinical Assessments by Medical Students

Interview with Julie A. Freischlag, MD, author of Association of Unconscious Race and Social Class Bias With Vignette-Based Clinical Assessments by Medical Students




me

Cognitive Behavior Therapy Augmentation of Pharmacotherapy in Pediatric Obsessive-Compulsive Disorder: The Pediatric OCD Treatment Study II (POTS II) Randomized Controlled Trial

Interview with Martin E. Franklin, PhD, author of Cognitive Behavior Therapy Augmentation of Pharmacotherapy in Pediatric Obsessive-Compulsive Disorder: The Pediatric OCD Treatment Study II (POTS II) Randomized Controlled Trial




me

Prediction of Erectile Function Following Treatment for Prostate Cancer

Interview with Martin G. Sanda, MD, author of Prediction of Erectile Function Following Treatment for Prostate Cancer




me

Effect of Increasing Doses of Saw Palmetto Extract on Lower Urinary Tract Symptoms: A Randomized Trial

Interview with Kevin T. McVary, MD, author of Effect of Increasing Doses of Saw Palmetto Extract on Lower Urinary Tract Symptoms: A Randomized Trial




me

Prevalence and Outcomes of Same-Day Discharge After Elective Percutaneous Coronary Intervention Among Older Patients

Interview with Sunil V. Rao, MD, author of Prevalence and Outcomes of Same-Day Discharge After Elective Percutaneous Coronary Intervention Among Older Patients




me

Regional Variation in the Association Between Advance Directives and End-of-Life Medicare Expenditures

Interview with Lauren Hersch Nicholas, PhD, MPP, author of Regional Variation in the Association Between Advance Directives and End-of-Life Medicare Expenditures




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Use of Electron-Beam Sterilized Hemodialysis Membranes and Risk of Thrombocytopenia

Interview with Mercedeh Kiaii, MD, author of Use of Electron-Beam Sterilized Hemodialysis Membranes and Risk of Thrombocytopenia




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National and Regional Trends in Heart Failure Hospitalization and Mortality Rates for Medicare Beneficiaries, 1998-2008

Interview with Jersey Chen, MD, MPH, author of National and Regional Trends in Heart Failure Hospitalization and Mortality Rates for Medicare Beneficiaries, 1998-2008




me

Effect of Intracoronary Delivery of Autologous Bone Marrow Mononuclear Cells 2 to 3 Weeks Following Acute Myocardial Infarction on Left Ventricular Function: The LateTIME Randomized Trial

Interview with Jay H. Traverse, MD, author of Effect of Intracoronary Delivery of Autologous Bone Marrow Mononuclear Cells 2 to 3 Weeks Following Acute Myocardial Infarction on Left Ventricular Function: The LateTIME Randomized Trial