A ligand design allows compact nanoparticle materials, such as quantum dots (QDs), with excellent colloidal stability over a wide range of pH and under high salt concentrations. Self-assembled biomolecular conjugates with QDs can be obtained which are stable in biological environments. Energy transfer with these ligands is maximized by minimizing distances between QDs/nanoparticles and donors/acceptors directly attached to the ligands or assembled on their surfaces.

A verification and control method for at least one water purification system is described, which includes a step of supplying, by a server embedded with the water purification system, an editing interface comprising a zone for selecting items of exploitation information representing physical quantities associated with the water purification system, a step of selecting, via the first remote browser, at least one item of exploitation information to constitute at least one exploitation interface page, a step of sending a request to access the exploitation page, by a second remote browser, to the server, a step of collecting the value of each physical quantity represented by a selected item of information to constitute the page, and a step of supplying, by the server, the page comprising each collected value.

Activities, actions and events during user performance of physical activity may be detected using various algorithms and templates. Templates may include an arrangement of one or more states that may identify particular event types and timing between events. Templates may be specific to a particular type of activity (e.g., types of sports, drills, events, etc.), user, terrain, time of day and the like.

The invention relates to a bonding product suitable as a carrier for medicinal substances and to the compound derived therefrom that carries medicinal substances. The invention further relates to a process and device for preparing such bonding products and compounds. Further, the invention relates to a pharmaceutical composition containing such bonding products and compounds, and to the use thereof for preparing an infusible medicament for treating a disease.

Disclosed is a spectrofluorimetrically detectable luminescent composition consisting essentially of at least one energy transfer acceptor lanthanide(III) complex having an emission spectrum maximum in the range from 300 to 2000 nanometers and a luminescence-enhancing amount of at least one energy transfer donor selected from the group consisting of a fluorophore, a lumiphore, an organic compound, a salt of an organic ion, a metal ion, a metal ion complex, or a combination thereof. Such energy transfer donor enhances the luminescence of at least one energy transfer acceptor lanthanide(III) complex, with the conditions that the emission spectrum of any energy transfer donor differs from that of its energy transfer acceptor lanthanide(III) complex; and such energy transfer donor can be dissolved to form a unitary solution in a solvent having an evaporation rate at least as great as that of water.

A reagent for conjugation to a biomolecule, wherein the reagent is a single molecule with at least three functional parts and has schematic structure (I): a) wherein a trifunctional cross-linking moiety is coupled to b) an affinity ligand via a linker 1, said affinity ligand being capable of binding with another molecule having affinity for said ligand, to c) an effector agent, optionally via a linker 2, said effector agent exerting its effect on cells, tissues and/or humorous molecules in vivo or ex vivo, and to d) a biomolecule reactive moiety, optionally via a linker 3, said moiety being capable of forming a bond between the reagent and the biomolecule.

The present invention relates to a method of differentially diagnosing different types of dementia. In particular, the method relates to the use of specific SPECT tracers for differentially diagnosing Alzheimer's disease, Lewy-Body Dementia, and Frontotemporal Dementia.

The invention relates to antibody molecules having specificity for antigenic determinants of human OX40, therapeutic uses of the antibody molecules and methods for producing said antibody molecules.

The invention relates to melanocortin receptor-specific cyclic peptides of Formula (I) or a pharmaceutically acceptable salt thereof, where R1, R2, R3, R4a, R4b, R4c, R5, x and y are as defined in the specification. These compounds are particularly useful in the treatments of energy homeostasis and metabolism related (e.g. diabetes), food intake related and/or energy balance and body weight related diseases, disorders and/or conditions, including obesity, overweight and diseases, disorders and/or conditions associated with obesity and/or overweight, such as type 2 diabetes and metabolic syndrome.

Antigen binding proteins with T cell receptor-like paratopes, that is, with an antigen binding region specific for an human leukocyte antigen-A2 restricted peptide are disclosed. The antigen binding proteins encompass antibodies in a variety of forms, including full-length antibodies, substantially intact antibodies, Fab fragments, F(ab')2 fragments, and single chain Fv fragments. Fusion proteins, such as scFv fusions with immunoglobulin or T-cell receptor domains, incorporating the specificity of the antigen binding region for each peptide are also contemplated by the invention. Furthermore, immunoconjugates may include antibodies to which is linked a radioisotope, fluorescent or other detectable marker, cytotoxin, or other molecule are also encompassed by the invention. Among other things, immunoconjugates can be used for delivery of an agent to elicit a therapeutic effect or to facilitate an immune effector function.

A remote time shift buffer system with shadow tuning. The remote time shift buffer system includes a client in communication with a remote video recorder. The client tunes to a channel from a television signal source and sends the channel content to a television. When a channel change occurs at the client, the remote video recorder tunes to the same channel as the client and buffers the content. When a pause live television (PLTV) function is initiated, the remote video recorder generates an independent RTSB content stream using the buffered content. Once the RTSB content stream is available, the client switches inputs and displays the RTSB content stream from the remote video recorder. Manipulating the position within the RTSB content stream does not affect buffering of the live content. The remote time shift buffer system provides pause live television functionality with minimal loss of content.

An exemplary method includes a media service provider system 1) providing an end user of an integrated media service with access to a media program by way of a plurality of different media distribution models, 2) maintaining a catalog that includes comprehensive information about the media program, the comprehensive information being an aggregate of non-redundant information about the media program obtained from a plurality of independent source catalogs corresponding to the plurality of different media distribution models, and 3) providing, based on the comprehensive information included in the catalog, a media service user interface that supports discovery of the comprehensive information about the media program regardless of a user interface context from which a user request for information about the media program is received. Corresponding systems and methods are also described.

A video-on-demand (VOD) content delivery system has a VOD Application Server which manages a database of templates ordered in a hierarchy for presentation of video content elements of different selected types categorized in hierarchical order. The templates include those for higher-order displays which have one or more links to lower-order displays of specific content. The VOD Application Server, in response to viewer request, displays a high-order templatized display, and in response to viewer selection of a link, displays the lower-order display of specific content. The hierarchical templatized displays enable viewers to navigate to an end subject of interest while having a unique visual experience of moving through a series of displays to the end subject of interest.

A method for controlling a vehicle equipped with a manual transmission and engine includes automatically engaging a brake, locking the transmission in neutral and starting the engine, in response to a signal whose origin is remote from the vehicle representing a desired engine start; and automatically engaging a brake and locking the transmission in neutral in response to a second signal indicating that the driver has exited the vehicle while the engine is running.

Methods and systems are provided for performing a multiple gear downshift of a transmission gear by transiently operating in an intermediate gear. In response to air mass flow not reaching a threshold for CAC self-cleansing for a set duration, the transmission gear may be downshifted from a higher gear to an intermediate gear, and then to a requested lower gear. Downshifting through an intermediate gear may also be controlled based on the gear shift request and maximum air mass flow levels for engine misfire.

A method and transmission control unit configured to improve shift event performance in a vehicle with an automatic transmission by determining a vent time for release of a clutch assembly in a transmission of a vehicle. The vehicle must be stopped and a gear selector in the vehicle must be set to a drive condition. If these conditions are met, the clutch assembly is vented. The vent time from when venting begins to when a turbine (or input shift) speed of the transmission rises is tracked. Once the turbine speed of the transmission rises, the clutch assembly is reapplied. The clutch assembly vent time is set based on the tracked vent time.

A method for controlling a transmission of a powertrain system includes executing a single source shortest path search to identify a preferred shift path originating with an initial powertrain state and terminating at a target powertrain state, wherein the single source shortest path search employs transition-specific costs and situational costs to identify the preferred shift path. The preferred shift path is executed to achieve the target powertrain state.

A method of controlling a multiple step downshift is disclosed. Two offgoing shift elements are released and two oncoming shift elements are engaged to complete the downshift. During a first phase of the downshift, one of the offgoing shift elements controls the rate of increase of input shaft speed. During a second phase of the downshift, one of the oncoming shift elements controls the rate of increase of the input shaft speed. The method computes target torque capacities such that output torque and input shaft acceleration are continuous during the transition between phases. Furthermore, the method computes target torque capacities such that both oncoming clutches reach zero relative speed simultaneously as the input shaft reaches the final speed ratio.

The present invention provides for a transmission shift assembly for a vehicle and methods of monitoring and controlling the same. The transmission shift assembly includes a transmission having a shift position member movable between a plurality of gear positions, an actuator configured to move the shift position between the gear positions, and a linkage coupled to the actuator and movable between a plurality of positions in response to movement of the actuator. The assembly further includes a controller to control the actuator, an ignition to receive a key, and at least one key sensor positioned within the ignition and configured to transmit a signal to the controller upon sensing removal of the key, the controller controlling the actuator to move the shift position member to a predetermined gear position upon receiving the signal from the key sensor that the key has been removed from the ignition.

The present invention provides variable mass labeling reagents, a set of the variable mass labeling reagents, and a multiplexed set of variable mass labeling reagents.

The present invention provides processes for the manufacturing of polypeptide conjugates. In particular, the invention provides methods for the purification of polypeptide conjugates, which include at least one polymeric modifying groups, such as a poly(alkylene oxide) moiety. Exemplary poly(alkylene oxide) moieties include poly(ethylene glycol) (PEG) and poly(propylene glycol). In an exemplary process, hydrophobic interaction chromatography (HIC) is used to resolve different glycoforms of glycoPEGylated polypeptides.

A data storage and retrieval system includes a head carriage unit adapted for rotational motion and having multiple heads disposed at a working surface. The system also includes a tape drive unit configured to move a tape media past the working surface of the head carriage unit, the tape media having a width approximately equal to a width of the working surface. As the head carriage unit rotates and the tape moves past the working surface, a first head is configured to write a data track to the tape and a second head is configured to thereafter read the data track, where data read by the second head is for use in verifying data integrity and performing error correction.

There is provided a disk drive apparatus including a first chassis unit that has a pickup base at which an optical pickup and a disk table have been disposed, and a first base chassis to which the pickup base has been attached, and a second chassis unit that has a second base chassis and at which a chucking pulley has been disposed. A first rectifying plate part is provided at the first base chassis. A second rectifying plate part is provided at the second base chassis.

A counter knife bank assembly of a chopper assembly for an agricultural combine is provided that can pass obstructions without damaging the knife blades of the knife blade assembly. The counter knife bank assembly includes a knife bank and a lever assembly connected to the knife bank. The knife bank is moveable between a first position and a second position relative to a stationary frame of the chopper assembly. The lever assembly includes an extension member having a first end connected to the knife bank, a biasing member connected to the extension member, and an abutment member. The abutment member is engaged with the biasing member and is biased against a stationary support member of the counter knife bank assembly for articulation therewith.

A knife includes a body that includes a handle section, a substantially circular blade housing section, and a blade including a cutting edge having substantially the same radius of curvature of the blade housing. The substantially circular blade housing section extends substantially perpendicular from the handle section. The blade extends longitudinally out of the blade housing at a position substantially 180° away from the position of the handle section along the circumference of the blade housing and terminates in a sharp point. The width of the blade at the portion immediately adjacent to the blade housing and opposite the blade point is substantially equal to the diameter of the blade housing.

A knife having a hook incorporated into the blade for skinning, wherein the hook is a belly hook that is positioned on the belly side or under side of the knife opposite a finger guard area. Methods of the using the knife include steps for using the cutting edge to cut and using the hook to cut by pressure applied away from the user's body.

A battery pack dehumidifier system for controlling the relative humidity within a battery pack enclosure is provided, the dehumidifier system including a desiccant that absorbs/adsorbs water vapor from the battery pack enclosure. The system heats and reactivates the desiccant at predetermined time intervals or when the humidity within the system reaches a preset level, thereby allowing the desiccant to regain its potential for absorbing/adsorbing water vapor.

The disclosed embodiments provide a battery pack for use with a portable electronic device. The battery pack includes a first set of cells with different capacities electrically coupled in a parallel configuration. Cells within the first set of cells may also have different thicknesses and/or dimensions. The first set of cells is arranged within the battery pack to facilitate efficient use of space within a portable electronic device. For example, the first set of cells may be arranged to accommodate components in the portable electronic device.

An envelope has a top face, a bottom face and an open lower edge. A plurality of gift items are in a generally rectangular configuration. The gift items have a top surface, a bottom surface, a first end, and a second end. The gift items have a length and a width each less that the length and the width of the envelope. A plurality of adhesive stripes are adapted to attach the plurality of gift items end to end. In this manner the gift items are held end to end when the gift items are folded in a corrugated fashion and placed within the envelope. The gift items may be removed by pulling them out from the open lower edge of the envelope.

Methods and system for encoded information processing are described. In one embodiment, an encoded pattern may be optically detected from source media. The encoded pattern may be associated with programming content of a content source. The encoded pattern may be decoded to reproduce encoded data. The programming content may be identified based on reproduction of the encoded data. A scheduled start time of the programming content may be obtained. When a current device time is within a notification time qualification of the scheduled start time, a programming content start alert may be generated. An interactive opportunity notification associated with the programming content may be provided based on generation of the programming content start alert. Additional methods and systems are disclosed.

A multiple-segment transmission line in a hard disk drive enables a wider optimization range of the slope, duration and amplitude of the transmission line overshoot (TLO) wave shape. There is a first segment with two traces for connection to the write driver circuitry, an end segment with two traces for connection to the write head and at least two intermediate segments. The number of traces in a segment is different from the number of traces in the segments to which the segment is immediately connected. There is an even number of traces in each segment and the traces in each segment are interleaved. The number of segments and the number of traces in each segment can be selected to achieve the desired impedance levels for the different segments to achieve the desired wave shape for the TLO. All of the traces on the transmission line are preferably coplanar.

An axle assembly having a carrier housing, a pair of axle tubes, a differential case, a pair of differential bearings and a pair of bearing adjusters. The carrier housing includes a cavity, which is configured to receive the differential case, and a pair of axle tubes that are mounted to the carrier housing. The differential case includes bearing bores into which the outer races of the differential bearings are received. The bearing adjusters are threaded to the carrier housing and support the differential bearings on a side opposite the differential case.

An information output device includes a first processor configured to execute a process to determine a type of notification information which is outputted from a computer and which notifies a state of the computer; and a second processor configured to execute a process to create a chart, in which a first coordinate axis represents time when the notification information is outputted from the computer, a second coordinate axis represents the type of the notification information, and the notification information is drawn at a corresponding position, and output the chart.

Methods and apparatus for correlating event notifications between agents in a management network are provided. An agent constructs a network notification in response to receiving an event notification. If the received event notification is associated with a prior notification already received and stored by the agent, a correlation attribute is added to the constructed network notification. If the received notification matches a peer agent notification category that another agent in the management network is interested in receiving, the constructed network notification is sent to the other agent.

Through an asynchronous callback enhancement, a thread makes a non-blocking request (e.g., send, receive, I/O) to a message passing interface library, and a callback routine is associated with the request as an asynchronous callback to the thread. The callback is queued for execution in the requesting thread and so has a deterministic execution context. Callback queuing may occur in response to another thread detecting that the request is complete. Further control over callback execution is provided by state transitions which determine whether the thread is open to processing (e.g., executing) an asynchronous callback. Callback association is done by a broad or by narrow association routines. An application which has processes organized in ranks, each including a communication thread with associated callback(s), and multiple worker threads. Interruptible wait enhancements may also be present.

The invention provides intermediates of the formula: as well as a method of their preparation by reacting a thiol having at least two hydroxyl groups with a mono-unsaturated organic compound in the presence of a base catalyst. A polymerizable urethane acrylate oligomer or urethane methacrylate oligomer is formed by reacting a polyisocyanate with the intermediate. The polymerizable urethane acrylate oligomer or urethane methacrylate is blended with a polymerization initiator to form a composition which is useful in such applications as adhesives.

Process for the preparation of etherified melamine/formaldehyde condensates, in which first a methylolation of melamine with a formaldehyde component in the molar ratio of from 1:6 to 1:15, preferably at a pH of >7, is carried out. This is followed by an etherification of the resulting hydroxymethylation intermediate in the presence of a C1-C20-alkyl, preferably of a C1-C6-alcohol, particularly preferably of a C1-C4-alcohol, at a pH of 9.5 being established before, during and/or after the distillation. According to the invention, a plurality of hydroxymethylation, etherification and distillation steps follow in order to achieve an etherified melamine/formaldehyde condensate which is distinguished by a high degree of hydroxymethylation, a high solids content and a low viscosity.

Disclosed is an automotive road construction machine, particularly a recycler or a cold stripping machine, comprising an engine frame that is supported by a chassis, a working roller which is stationarily or pivotally mounted on the engine frame and is used for machining a ground surface or road surface. The chassis is provided with wheels or tracked running gears which are connected to the engine frame via lifting column and are vertically adjustable relative to the engine frame. Each individually vertically adjustable lifting column is equipped with a device for measuring the actual vertical state of the lifting column.

A vibratory compactor having a first compacting element having a variable vibratory mechanism that sets a modifiable compaction effort, a second compacting element, a first sensor configured to measure a first surface compactability associated with the first compacting element, a second sensor configured to measure a second surface compactability associated with the second compacting element and a control system. The control system is configured to receive the first surface compactability, receive the second surface compactability, determine a target compaction effort for the first compacting element based on the first surface compactability and the second surface compactability, and modify the variable vibratory mechanism to set the compaction effort at the target compaction effort.

A lipstick case lipstick body lift seat anti-slipped structure includes a lipstick case, an outer tube, a lift seat with an opening facing upward, and a lipstick body. A plurality of anti-slipped blocking grooves is formed on an upwardly inclined side of each of the two inclined guiding grooves. The outer tube is sleeved on an outer side of the small diameter guiding tube, and a spiral guiding groove is disposed on an inner wall of the outer tube concavely. The lipstick body is sleeved in the lift seat. Two lift guiding columns are disposed on an outer wall of the lift seat protrudingly for engaging with the inclined guiding grooves correspondingly and pressing into the spiral guiding groove. An anti-slipped blocking portion is protrudingly disposed on an outer diameter of each of the lift guiding columns corresponding to the anti-slipped blocking grooves.

A mounting flange for attaching an HVAC air diffuser terminal in an opening in a floor or other mounting surface. The mounting flange includes a trim ring and a flange clip. The flange clip is adjustably and movably received in a slot defined a side of the trim ring. A pawl on the flange clip engages with ratchets defined in a surface of the trim ring adjacent to the slot to maintain the flange clip in selected position relative the underside of a floor. The air diffuser terminal is secured in the floor opening between gripping surfaces on the flange clip and the trim ring. An optional screw operably connects the flange clip with the trim ring so that the diffuser may be securely tightened in the floor opening.

Certain example implementations of the disclosed technology include a light emitting device. The light emitting device may include an enclosure with four sides and a top edge surface associated with each of the four sides. The enclosure may be capable of mounting on a grid frame of a suspended ceiling such that a portion of the top edge surfaces contacts a portion of the grid frame. The light emitting device may further include a light modifying element characterized by a substrate with four or more edges, a back surface disposed on the top edge surface of each of the four sides of the enclosure, and a front surface. In certain example embodiments the substrate may further comprise two or more edge trusses. A periphery of the light-emitting front surface may be capable of contacting the grid frame after the light emitting device is mounted to the grid frame.

An illumination device (1) comprises: input terminals (2) for coupling to AC mains;a LED string (10) connected in series with the input terminals;a rectifier (30), having input terminals connected in series with the LED string;a controllable voltage source (40), having input terminals coupled to the rectifier output terminals;a series arrangement of at least one auxiliary LED (51) and a second ballast resistor (52) connected to the output terminals of the controllable voltage source. The voltage source comprises: a series arrangement of an adjustable first resistor (46) and a second resistor (47) connected in parallel to the input terminals;a tuneable Zener diode (49) connected in parallel to the output terminals, having a control input terminal (48) connected to the node between the two resistors; wherein positive output terminal is connected to positive input terminal and negative output terminal is connected to negative input terminal.

Systems and methods for updating status of digital certificate subkeys. A request is made to a key server to verify if a given key is revoked. If it is not, then the key with its subkeys is acquired from the key server. If one or more subkeys or signatures of the subkeys are different in the acquired key, then the key is replaced.

The present invention generally pertains to multilayer film including four or more discrete layers. The films contain two external layers, an internal stiffening layer and an internal shrink layer. The external layers include linear low density polyethylene resin, the stiffening layer includes polypropylene or a high density polyethylene and the shrink layer includes low density polyethylene. The multilayer films of the present invention have a gloss of at least 62% at 45 degrees, together with a 2% secant tensile modulus greater than 400 MPa.

An interesting section identifying device for identifying an interesting section of a video file based on an audio signal included in the video file, the interesting section being a section in which a user is estimated to express interest, includes an interesting section candidate extracting unit that extracts an interesting section candidate from the video file, the interesting section candidate being a candidate for the interesting section, a detailed structure determining unit that determines whether the interesting section candidate includes a specific detailed structure, and an interesting section identifying unit that identifies the interesting section by analyzing a specific section when the detailed structure determining unit determines that the interesting section candidate includes the detailed structure, the specific section including the detailed structure and being shorter than the interesting section candidate.

Embodiments of the disclosed invention include a system and method for recording media content. For example, in one embodiment, a method for recording media content is disclosed that includes communicating with a home gateway to determine whether a device connected to the home gateway has enough free storage space to store a media content in response to a determination that an internal data storage unit of a set top box does not have sufficient free storage space to store the media content. In one embodiment, the method routes the storage of the media content to the device via the home gateway in response to a determination that the device connected to the home gateway has sufficient free storage space to store the media content.

A processing system decodes packetized program information including ancillary program specific information comprising a plurality of hierarchically ordered information tables. The ancillary information is used in acquiring and decoding packetized program information to provide a video program for display. The processing system employs a method involving detection of a mismatch between a version number of a first table of the program specific information (e.g. a virtual channel table (VCT), or channel information table (CIT)) and a corresponding version number of the first table conveyed in a second table (e.g. a master guide table (MGT)). If a mismatch is detected, the first and second tables are forced to contain a compatible first table version number. The packetized program information is decoded to provide a video program for display using the program specific information including the first and second tables including the forced compatible version number. A detected mismatch may also be disregarded to enable the decoding of the packetized program information and a User's channel line-up may be edited to remove channels associated with a detected mismatch or other program specific information error condition.

A television receiver including a tuner and one or more processors may be presented. The television receiver may be configured to tune the tuner to a television channel. The television receiver may be configured to create and store an omnibus channel file containing a plurality of television programs broadcast consecutively on the television channel over a period of time. The television receiver may be configured to, after a predefined period of time, select the omnibus channel file for deletion. The television receiver may be configured to determine a television program to receive extended storage. The television receiver may be configured to store a portion of the omnibus channel file as an individual program file, wherein the portion of the omnibus channel file corresponds to the television program. The television receiver may be configured to, after storing the portion of the omnibus channel file, delete the omnibus channel file.

An aspect of the present invention is drawn to a device for use with an electrostatic chuck having a top surface and a bottom surface, the top surface being separated from the bottom surface by a width, the electrostatic chuck additionally having a hole therein, the hole having a first width at the top surface and having a second width at the bottom surface, the first width being less than the second width, the top surface being capable of having wafer disposed thereon. The device includes a pin, a shaft, a neck portion and an outer housing portion. The pin has a pin width less than the first width. The shaft has a pin-holding portion, an end portion and a central portion disposed between the pin-holding portion and the end portion. The central portion has a first bearing portion. The outer housing portion has a first end and a second end and includes a second bearing portion. The shaft is disposed within the outer housing portion and is moveable relative to the outer housing portion. The neck portion is disposed at the first end. The second bearing portion is stationary relative to the neck portion. The first bearing portion is movable relative to the second bearing portion.