of UP: Devotees celebrate 'Tulsi Vivah' at Balua Ghat in Prayagraj, marking sacred union of Lord Vishnu, Vrinda By www.newkerala.com Published On :: Wed, 13 Nov 2024 19:10:02 +0530 Full Article
of Rajnath Singh stresses on adaptive defence to cope with Age of Grey Zone, hybrid warfare By www.newkerala.com Published On :: Wed, 13 Nov 2024 19:20:02 +0530 Full Article
of Indian Coast Guard evacuates critically ill fisherman off Diu coast By www.newkerala.com Published On :: Wed, 13 Nov 2024 19:24:02 +0530 Full Article
of Union Jal Shakti Minister CR Paatil chairs 13th high-powered review meeting of Brahmaputra Board By www.newkerala.com Published On :: Wed, 13 Nov 2024 19:34:02 +0530 Full Article
of DRDO conducts maiden flight test of Long-Range Land Attack Cruise Missile (LRLACM) By www.newkerala.com Published On :: Wed, 13 Nov 2024 19:44:02 +0530 Full Article
of HC modifies the status quo order on maintaining constructions for Tent City in two islands of Lakshadweep By www.thehindu.com Published On :: Wed, 13 Nov 2024 19:14:08 +0530 Full Article Kochi
of No gaps in management of biodegradable waste, Kerala tells NGT By www.thehindu.com Published On :: Wed, 13 Nov 2024 19:23:47 +0530 Full Article Kerala
of HC quashes magistrate court’s directive to register FIR against police officers By www.thehindu.com Published On :: Wed, 13 Nov 2024 19:36:51 +0530 Magistrate court’s order to file FIR against police officers, including IPS officer and former Malappuram Superintendent of Police Sujith Das, in connection with an alleged sexual assault case quashed Full Article Kerala
of China's largest air show takes off with fighter jets, attack drones By www.thehindu.com Published On :: Wed, 13 Nov 2024 11:39:52 +0530 China has poured resources into modernising and expanding its aviation capabilities as it faces off against the United States and others around regional flashpoints like Taiwan. Full Article World
of 5.3 magnitude earthquake jolts parts of Pakistan By www.thehindu.com Published On :: Wed, 13 Nov 2024 13:40:21 +0530 No casualties have been reported so far for the earthquake that had its epicentre around the Hindukush mountain range Full Article World
of Iran executes in public a serial rapist convicted in dozens of cases By www.thehindu.com Published On :: Wed, 13 Nov 2024 14:43:02 +0530 Iran’s state media say authorities have executed in public a man convicted of raping dozens of women over two decades Full Article World
of Lebanon media claims Israeli strike hit apartment south of Beirut By www.thehindu.com Published On :: Wed, 13 Nov 2024 15:10:43 +0530 Israeli warplanes launched a strike at dawn targeting a residential apartment in a building in the Dawhet Full Article World
of Senior Russian naval officer killed in car bombing claimed by Kyiv By www.thehindu.com Published On :: Wed, 13 Nov 2024 21:28:48 +0530 Russia's state Investigative Committee said in a statement that an improvised explosive device had detonated in an act of terrorism, killing a serviceman whom it did not identify Full Article World
of In vitro identification of oridonin hybrids as potential anti-TNBC agents inducing cell cycle arrest and apoptosis by regulation of p21, γH2AX and cleaved PARP By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3674-3694DOI: 10.1039/D4MD00580E, Research ArticleJinhua Ning, Nini Zhan, Zhanpan Wu, Yuzhe Li, Die Zhang, Yadian Shi, Yingxun Zhou, Chuan-Huizi Chen, Wenbin JinOridonin analogue 11a showed significant antitumor efficacy in vitro via cell cycle arrest and apoptosis by regulation of p21, γH2AX and cleaved PARP accumulation, meanwhile, displayed much more stable than oridonin in human plasma.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
of New ATP-competitive inhibitors of E. coli GyrB obtained from the mapping of the hydrophobic floor at the binding site: synthesis and biological evaluation By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3759-3777DOI: 10.1039/D4MD00498A, Research ArticleLucas Gutierrez, Peter Peršolja, Rodrigo Tosso, Nace Zidar, Danijel Kikelj, Ricardo D. EnrizA diagram of the active site of E. coli gyrase B, highlighting the hydrophobic subsite, including key residues relevant to ligand binding.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
of Discovery of hybrid Glypromate conjugates with neuroprotective activity against paraquat-induced toxicity By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3711-3727DOI: 10.1039/D4MD00584H, Research ArticleSara C. Silva-Reis, Vera M. Costa, Daniela Correia da Silva, David M. Pereira, Xavier Cruz Correia, Xerardo García-Mera, José E. Rodríguez-Borges, Ivo E. Sampaio-DiasA series of bicyclic-based Glypromate conjugates with reduction of protein aggregation elicited by Aβ25–35 and neuroprotective activity against paraquat-induced toxicity is reported, paving the way for the discovery of novel neurotherapeutics.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
of Fexinidazole optimization: enhancing anti-leishmanial profile, metabolic stability and hERG safety By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3837-3852DOI: 10.1039/D4MD00426D, Research ArticleAbdrrahman Shemsu Surur, Chin Fung Chan, Frieda-Marie Bartz, Iris L. K. Wong, Van T. D. Nguyen, Lukas Schulig, Andreas Link, Tak Hang Chan, Larry M. C. Chow, Patrick J. BednarskiStructure-guided optimization of fexinidazole led to analog (S)-51, a promising lead compound with superior activity, improved metabolic stability, and enhanced hERG safetyThe content of this RSS Feed (c) The Royal Society of Chemistry Full Article
of Design and synthesis of novel multi-target tetrabromophthalimides as CBS and Topo-II inhibitors and DNA intercalators By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3800-3816DOI: 10.1039/D4MD00585F, Research ArticleMarwa Abdel-Motaal, Dalal Ali Aldakhili, Ayman B. Farag, Ayman Abo Elmaaty, Marwa Sharaky, Nadia A. Mohamed, Saad Shaaban, Abdullah Yahya Abdullah Alzahrani, Ahmed A. Al-KarmalawyNovel multi-target tetrabromophthalimides as CBS and Topo-II inhibitors and DNA intercalators.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
of Prediction of synergistic gemcitabine-based combination treatment through a novel tumor stemness biomarker NANOG in pancreatic cancer By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3853-3861DOI: 10.1039/D4MD00165F, Research ArticleJiongjia Cheng, Ting Zhu, Shaoxian Liu, Jiayu Zhou, Xiaofeng Wang, Guangxiang LiuThe synergistic effect observed in gemcitabine-based combination therapies targeting pancreatic cancer stem cells was correlated with the inhibiting effect on the expression of stemness-related gene NANOG.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
of Novel PROTAC probes targeting KDM3 degradation to eliminate colorectal cancer stem cells through inhibition of Wnt/β-catenin signaling By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3746-3758DOI: 10.1039/D4MD00122B, Research Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Shadid U. Zaman, Piyusha P. Pagare, Hongguang Ma, Rosalie G. Hoyle, Yan Zhang, Jiong LiWe designed and synthesized novel IOX1-based PROTACs, which can selectively degrade KDM3A and KDM3B to eliminate colorectal cancer stem cells through inhibition of Wnt signaling.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
of Evaluating the therapeutic potential of genetically engineered probiotic Zbiotics (ZB183) for non-alcoholic steatohepatitis (NASH) management via modulation of the cGAS-STING pathway By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3817-3836DOI: 10.1039/D4MD00477A, Research ArticleMaha Saad, Walaa Ibrahim, Amany Helmy Hasanin, Aya Magdy Elyamany, Marwa MatboliZBiotics administration in the NASH model downregulated the RNA panel (MAPK3, EDN1, TNF, miR-6888-5p, lncRNA RABGAP1L-DT-206), restored intestinal barrier integrity, reduced hepatic inflammation, and improved lipid profiles and liver enzymes.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
of Design and synthesis of novel 8-(azaindolyl)-benzoazepinones as potent and selective ROCK inhibitors By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3862-3879DOI: 10.1039/D4MD00313F, Research ArticleDaniele Pala, David Clark, Christine Edwards, Elisa Pasqua, Laura Tigli, Barbara Pioselli, Piotr Malysa, Fabrizio Facchinetti, Fabio Rancati, Alessandro AccettaThis study reports a novel, potent and selective series of ROCK inhibitors based on 8-(azaindolyl)-benzoazepinones identified through a core-hopping strategy.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
of Correction: computational design, synthesis, and assessment of 3-(4-(4-(1,3,4-oxadiazol-2-yl)-1H-imidazol-2-yl)phenyl)-1,2,4-oxadiazole derivatives as effective epidermal growth factor receptor inhibitors: a prospective strategy for anticancer therapy By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3912-3912DOI: 10.1039/D4MD90040E, Correction Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Nilesh Raghunath Khedkar, Milind Sindkhedkar, Alex JosephThe content of this RSS Feed (c) The Royal Society of Chemistry Full Article
of Anticancer potential of copper(I) complexes based on isopropyl ester derivatives of bis(pyrazol-1-yl)acetate ligands By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Accepted ManuscriptDOI: 10.1039/D4MD00610K, Research Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Maura Pellei, Carlo Santini, Miriam Caviglia, Jo' Del Gobbo, Chiara Battocchio, Carlo Meneghini, Simone Amatori, Chiara Donati, Eleonora Zampieri, Valentina Gandin, Cristina MarzanoIn this paper, the isopropyl ester derivatives LOiPr and L2OiPr of bis(pyrazol-1-yl)acetic acid and bis(3,5-dimethyl-pyrazol-1-yl)acetic acid were used as chelators for the preparation of the new Cu(I) phosphane complexes 1-4....The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
of Supreme Court stays order for CBI probe into sexual assault of minor in Chennai By www.thehindu.com Published On :: Wed, 13 Nov 2024 13:07:47 +0530 Calls for a list of five to seven direct recruit IPS officers, including three women, who hail from other States but are now serving in Tamil Nadu cadre Full Article Tamil Nadu
of Tamil Nadu CM Stalin to launch Phase II of nutritional intervention programme for malnourished children, mothers By www.thehindu.com Published On :: Wed, 13 Nov 2024 17:23:48 +0530 Mothers of over 76,700 babies in the age group of zero to six months, identified as malnourished, would be covered under Phase II of the programme Full Article Tamil Nadu
of Leaders of various parties condemn attack on govt. doctor By www.thehindu.com Published On :: Wed, 13 Nov 2024 20:08:06 +0530 Full Article Tamil Nadu
of Southern Railway refuses to share inquiry report of Perumon train tragedy By www.thehindu.com Published On :: Wed, 13 Nov 2024 20:15:33 +0530 105 people had died in after several coaches of the Island Express fell into the Ashtamudi Lake in 1988 Full Article Tamil Nadu
of SBI, HDFC Bank, ICICI Bank figure in RBI’s 2024 list of Domestic Systemically Important Banks (D-SIBs) By www.thehindu.com Published On :: Wed, 13 Nov 2024 12:00:14 +0530 Higher D-SIB surcharge fixed for SBI and HDFC Bank, will be applicable from April 01, 2025 Full Article Business
of Arvinder Singh Sahney is new chairman of Indian Oil By www.thehindu.com Published On :: Wed, 13 Nov 2024 19:43:29 +0530 Full Article Business
of Godrej Industries Q2 net profit surges over three fold to ₹288 crore By www.thehindu.com Published On :: Wed, 13 Nov 2024 21:47:28 +0530 Full Article Business
of SKDRDP provides desks and benches worth ₹2.75 crore to 507 government primary schools in four districts of Karnataka By www.thehindu.com Published On :: Wed, 13 Nov 2024 12:49:14 +0530 Rajya Sabha MP Veerendra Heggade urges parents to get their wards admitted to government schools as they now have better facilities Full Article Mangaluru
of Free and fair inquiry sought into death of snakebite victim in Srikakulam district By www.thehindu.com Published On :: Wed, 13 Nov 2024 18:10:47 +0530 Son of the victim alleges that local medical and health officials misleading higher-ups regarding the incident Full Article Andhra Pradesh
of Target is to to make 30,000 MT of sand available every day in East Godavari district, says Collector By www.thehindu.com Published On :: Wed, 13 Nov 2024 19:25:35 +0530 P. Prasanthi warns boatmen associations of stringent action if they attempt to prevent vehicles transporting sand from the sand reaches Full Article Andhra Pradesh
of Andhra Pradesh Budget reflects aspirations of all sections of people, say legislators By www.thehindu.com Published On :: Wed, 13 Nov 2024 20:10:11 +0530 It has given impetus to the developmental goals outlined in the NDA’s election manifesto, say MLAs on the first day of discussion Full Article Andhra Pradesh
of PAG report points out Andhra Pradesh govt.’s failure to disclose quantum of off-budget borrowings in Budget By www.thehindu.com Published On :: Wed, 13 Nov 2024 20:19:16 +0530 Principal amount outstanding in 2019-20 was ₹67,171 crore, and it touched ₹1,54,797 crore in 2023-24, says the PAG report released by the I&PR Department Full Article Andhra Pradesh
of Devotees offer special prayers at Sri Kalyana Venkateswara Swamy temple in Srikakulam By www.thehindu.com Published On :: Wed, 13 Nov 2024 20:19:39 +0530 Full Article Andhra Pradesh
of Andhra Pradesh govt. reaffirms commitment to ‘irrigating every acre of farmland’ in State through river-interlinking projects By www.thehindu.com Published On :: Wed, 13 Nov 2024 20:43:13 +0530 Full Article Andhra Pradesh
of India’s office leasing soars 41% in 2024 amid rent hikes, supply crunch, and GCC growth: Cushman & Wakefield By www.thehindubusinessline.com Published On :: Wed, 13 Nov 2024 09:20:06 +0530 In an interview to businessline, Cushman & Wakefield’s Veera talks about commercial space leasing outlook, trends, and rental and supply trends for the coming months Full Article Real Estate
of IMD forecasts onset of winter in Telangana by November-end By www.thehindu.com Published On :: Wed, 13 Nov 2024 11:22:39 +0530 Full Article Telangana
of Over 2,300 kilograms of drugs incinerated by Cyberabad police By www.thehindu.com Published On :: Wed, 13 Nov 2024 16:02:00 +0530 The wide range of drugs were seized from 155 cases registered under the NDPS Act Full Article Hyderabad
of Hyderabad to get regional centre of Indian Institute of Creative Technology By www.thehindu.com Published On :: Wed, 13 Nov 2024 17:34:11 +0530 All activities are going to start quickly. The facility in Hyderabad will be set up in the IMAGE Tower, said Secretary, Union Ministry of Information and Broadcasting Full Article Hyderabad
of Metro Rail services to be extended to Medchal and other parts of northern Hyderabad under Phase-III: Telangana CM By www.thehindu.com Published On :: Wed, 13 Nov 2024 19:18:36 +0530 Full Article Hyderabad
of Millions of Nigerians go hungry as floods compound hardship By www.thehindu.com Published On :: Wed, 13 Nov 2024 15:07:00 +0530 Torrential rains and floods in 29 of Nigeria's 36 states this year have destroyed more than 1.5 million hectares of cropland, affecting more than nine million people Full Article Environment
of Uncontrolled diabetes increases risk of hearing loss; doctors call for more awareness, screening By www.thehindu.com Published On :: Wed, 13 Nov 2024 19:04:48 +0530 Hearing loss occurs twice as frequently in patients with uncontrolled diabetes as compared to the non-diabetic population, doctors say, calling for screening to be included in routine diabetes care Full Article Health
of Synthesis and evaluation of photoaffinity labeling reagents for identifying binding sites of sulfated neurosteroids on NMDA and GABAA receptors By pubs.rsc.org Published On :: RSC Adv., 2024, 14,36352-36369DOI: 10.1039/D4RA07074G, Paper Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Mingxing Qian, Yuanjian Xu, Hong-Jin Shu, Zi-Wei Chen, Lei Wang, Charles F. Zorumski, Alex S. Evers, Steven Mennerick, Douglas F. CoveyPhotoaffinity labels (PALs) for sulfated steroid binding sites on GABAA and NMDA receptors. The PALs have varying profiles of positive and negative modulatory (PAM and NAM) actions.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
of Synthesis of MOF-supported Pt catalyst with high electrochemical oxidation activity for methanol oxidation By pubs.rsc.org Published On :: RSC Adv., 2024, 14,36370-36377DOI: 10.1039/D4RA06393G, Paper Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Merve Akin, Hatice Kars, Muhammed Bekmezci, Aysenur Aygun, Mert Gul, Guray Kaya, Fatih SenIn this study, Pt and Pt@Ti-MOF NPs catalysts were synthesized by chemical reduction method. Ti-MOF structure was synthesized using the solvothermal method, and the effect of Ti-MOF on methanol oxidation was investigated.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
of Karnataka bypolls: Channapatna, Shiggaon and Sandur constituencies witness overall turnout of 76.9% till 5 p.m. By www.thehindu.com Published On :: Wed, 13 Nov 2024 10:37:35 +0530 A total of 45 candidates are in the fray in these byelections Full Article Karnataka
of Karnataka High Court dismisses Union Bank of India’s petition seeking transfer of Valmiki corporation case to CBI By www.thehindu.com Published On :: Wed, 13 Nov 2024 15:28:26 +0530 ‘Banking Regulations Act does not empower banks to seek transfer of probe into criminal cases registered by States to agency of its choice’ Full Article Karnataka
of Karnataka bypolls: A few residents of Savanur boycott polling in Shiggaon Assembly constituency By www.thehindu.com Published On :: Wed, 13 Nov 2024 16:31:09 +0530 Some families at Dandinpet in Savanur boycotted the bypolls over not being given record of occupancy rights to them. Full Article Karnataka
