DAILY BRIEFING: A fire that started north of Bothwell two days ago has been upgraded to emergency level, with firefighters pulling out because it is too dangerous.

Nine photographic panels, so large that they've never been displayed in public until now, depict the construction of Parliament House in Canberra 30 years ago.

Leaks from one of Adani's most significant contractors for its Carmichael coal mine, engineering firm GHD, show it has been rocked by internal dissent and management has been bombarded with complaints and questions about its work on the mine.

More payday lending practice stories are coming out of the woodwork as ASIC says it is "building a casebook" for a possible ban.

Calypso may be blind and deaf, but the gelding turns 50 today the day all horses in Australia have their birthday.

I can’t stop laughing at this.

Diskery.com Celebrates 20 Years On-line!

NIE Presents: The Hsu-nami, Fuck Your Birthday, NegativeHate, Stereobird @ Santos Party House

Diskery.com Celebrates 20 Years On-line!

Coronavirus has turned life upside-down, but Coloradans found alternative ways to celebrate in the here-and-now.

The rising basketball star was killed in a helicopter crash.

“Wish we were all together.”

She shared the sentimental letter on Instagram.

The Atlanta Track Club wants him to be remembered.

The gymnast turned 23 years old.

He did something really sweet for his late daughter.

The Atlanta Track Club wants him to be remembered.

All the stars' babies came out to play.

Russell Wilson, Beyoncé fall through dressed as superheroes.

(Yes, the one who phones home).

Компания Meizu вчера, кроме флагманских смартфонов, представила ещё свои обновлённые накладные Bluetooth-наушники Meizu HD60.

Facioscapulohumeral muscular dystrophy (FSHD) is caused by loss of repression of the DUX4 gene; however, the DUX4 protein is rare and difficult to detect in human muscle biopsies, and pathological mechanisms are obscure. FSHD is also a chronic disease that progresses slowly over decades. We used the sporadic, low-level, muscle-specific expression of DUX4 enabled by the iDUX4pA-HSA mouse to develop a chronic long-term muscle disease model. After 6 months of extremely low sporadic DUX4 expression, dystrophic muscle presented hallmarks of FSHD histopathology, including muscle degeneration, capillary loss, fibrosis, and atrophy. We investigated the transcriptional profile of whole muscle as well as endothelial cells and fibroadiopogenic progenitors (FAPs). Strikingly, differential gene expression profiles of both whole muscle and, to a lesser extent, FAPs, showed significant overlap with transcriptional profiles of MRI-guided human FSHD muscle biopsies. These results demonstrate a pathophysiological similarity between disease in muscles of iDUX4pA-HSA mice and humans with FSHD, solidifying the value of chronic rare DUX4 expression in mice for modeling pathological mechanisms in FSHD and highlighting the importance FAPs in this disease.

BACKGROUND Mirabegron is a β3-adrenergic receptor (β3-AR) agonist approved only for the treatment of overactive bladder. Encouraging preclinical results suggest that β3-AR agonists could also improve obesity-related metabolic disease by increasing brown adipose tissue (BAT) thermogenesis, white adipose tissue (WAT) lipolysis, and insulin sensitivity.METHODS We treated 14 healthy women of diverse ethnicities (27.5 ± 1.1 years of age, BMI of 25.4 ± 1.2 kg/m2) with 100 mg mirabegron (Myrbetriq extended-release tablet, Astellas Pharma) for 4 weeks in an open-label study. The primary endpoint was the change in BAT metabolic activity as measured by [18F]-2-fluoro-d-2-deoxy-d-glucose (18F-FDG) PET/CT. Secondary endpoints included resting energy expenditure (REE), plasma metabolites, and glucose and insulin metabolism as assessed by a frequently sampled intravenous glucose tolerance test.RESULTS Chronic mirabegron therapy increased BAT metabolic activity. Whole-body REE was higher, without changes in body weight or composition. Additionally, there were elevations in plasma levels of the beneficial lipoprotein biomarkers HDL and ApoA1, as well as total bile acids. Adiponectin, a WAT-derived hormone that has antidiabetic and antiinflammatory capabilities, increased with acute treatment and was 35% higher upon completion of the study. Finally, an intravenous glucose tolerance test revealed higher insulin sensitivity, glucose effectiveness, and insulin secretion.CONCLUSION These findings indicate that human BAT metabolic activity can be increased after chronic pharmacological stimulation with mirabegron and support the investigation of β3-AR agonists as a treatment for metabolic disease.TRIAL REGISTRATION Clinicaltrials.gov NCT03049462.FUNDING This work was supported by grants from the Intramural Research Program of the NIDDK, NIH (DK075112, DK075116, DK071013, and DK071014).

Criminal Minds newcomer Damon Gupton (Stephen Walker) celebrated his birthday yesterday, January 4. He was born on that day in 1973. Here...

Once again the calendar rolls to December 16, also known as Jane Austen Day. We celebrate every year with our fellow Janeites, remembering the author who has given us so much joy. We have a few links to share with our Gentle Readers. Firstly, an article in the TLS from Devoney Looser about how we…

It's Starfighter's Birthday! I thought I'd celebrate by announcing the big news..

Polish your vinyl sweethearts, I'll be making the big trip from NYC to SF to attend Yaoi-con this October! I'll have a little love table and everything!

I am really excited to go! It'll be my first time there.. and just thinking about the vast treasures ...of erotica to behold is making me eager! Plus, I will get to meet some sweet west coast honies. So if you're in the area or heading over, be sure to stop by! I'll be so happy to meet you guys!

Here's some more about the con:

Yaoi-Con Info

It's a date! -HamletMachine

1. Happy birthday Sai Pallavi: 4 times the actress redefined female superstar tag  Onmanorama
2. Birthday Special! Sai Pallavi is the epitome of elegance and grace in sarees. PHOTOS  Times of India
3. Happy Birthday Sai Pallavi: 5 Instagram Pictures Of The Actress You Can’t Miss  News18
4. Happy birthday Sai Pallavi: A powerhouse performer  Deccan Herald
5. Sai Pallavi birthday: Rana Daggubati, Naga Chaitanya and others send wishes  The Indian Express
6. View Full coverage on Google News

1. Early superannuation withdrawals frozen as hacking fallout revealed  Daily Telegraph
2. Calls for better superannuation protection  Busselton Dunsborough Mail
3. AFP investigating 'sophisticated' theft of $120,000 from 150 super accounts  Sydney Morning Herald
4. Is your super payout at risk? Thousands drained by fraudsters in COVID scam  7NEWS.com.au
5. Police confirm up to 150 victims of early super access fraud  The New Daily
6. View Full coverage on Google News

Closet Cooking celebrates 13 years of sharing tasty food and recipes! The 13th year was one of the tastiest yet! I continued to explore new foods and flavours with a focus on trying to keep things quick and easy! I explored plenty of new recipes while also taking the time to update some good old...

Read On →

The post Happy 13th Birthday Closet Cooking appeared first on Closet Cooking.

Recently a flurry of articles about academic overachievers appeared in scientific journals. Specifically, the research found that people with a diagnosis of Autism were more frequently high achievers in school. And people diagnosed with ADHD were more frequently low achievers in school. A paper published last week in the Journal of Autism and Developmental Disorders […]

The post Aspergers or ADHD? The answer will surprise you. appeared first on Penelope Trunk Careers.

Supporters for Ahmaud Arbery, the unarmed black jogger who was fatally shot by two white men on a Georgia road in broad daylight, are planning to run 2.23 miles Friday to celebrate what would be his 26th birthday and call for justice in the case. Organizers of the virtual run are asking people to go for a walk, jog or run and post a photo, video or written message on social media with the hashtag #IRunwithAhmaud.

On the occasion of Jack Charlton's 85th birthday, we have dug out a special message to the legendary manager, recorded by Ardal O'Hanlon and the late Dermot Morgan for a special tribute edition of Kenny Live

Supporters for Ahmaud Arbery, the unarmed black jogger who was fatally shot by two white men on a Georgia road in broad daylight, are planning to run 2.23 miles Friday to celebrate what would be his 26th birthday and call for justice in the case. Organizers of the virtual run are asking people to go for a walk, jog or run and post a photo, video or written message on social media with the hashtag #IRunwithAhmaud.

Move over, Polar Bear. Mr. December is heading for Queens.

Earth Day's 50th anniversary reminds us of how far we've come, and how far we need to go in protecting the environment from its biggest threat: us.

Lin-Manuel Miranda, Neil Patrick Harris, Josh Groban and Meryl Streep are just a few of the artists featured in Take Me to the World, a tribute to the iconic Broadway composer and lyricist.

Lin-Manuel Miranda, Neil Patrick Harris, Josh Groban and Meryl Streep are just a few of the artists featured in Take Me to the World, a tribute to the iconic Broadway composer and lyricist.

Move over, Polar Bear. Mr. December is heading for Queens.

Supporters for Ahmaud Arbery, the unarmed black jogger who was fatally shot by two white men on a Georgia road in broad daylight, are planning to run 2.23 miles Friday to celebrate what would be his 26th birthday and call for justice in the case. Organizers of the virtual run are asking people to go for a walk, jog or run and post a photo, video or written message on social media with the hashtag #IRunwithAhmaud.

Move over, Polar Bear. Mr. December is heading for Queens.

UCLA tight end Greg Dulcich played it cool when he was on the phone with coach Chip Kelly. But when he got off the phone, it got loud in his house.