dn

Doctor Johnson from Birdneck Animal Hospital Awarded the Certificate of Accredited Veterinarian

Dr. Wayne M Johnson, VMD at Birdneck Animal Hospital has achieved a new feat in his career with the Accreditation by United States Department of Agriculture.




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Doctor Johnson from Birdneck Animal Hospital Awarded the Certificate of Accredited Veterinarian

Dr. Wayne M Johnson, VMD at Birdneck Animal Hospital has achieved a new feat in his career with the Accreditation by United States Department of Agriculture.




dn

IPFS Collaboration With The NDN Team

Filecoin aims to build its network on top of the InterPlanetary File System (IPFS), a peer-to-peer data storage network and let users buy and sell unused storage on an open market.




dn

Baladna Announces Initial Public Offering

Baladna Food Industries, a subsidiary of Power International Holding, announced on October 17, 2019 to raise about QR1.42bn ($382m) in an initial public offering (IPO)




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Baladna Shares Begin Trading on Qatar Stock Exchange

Baladna, which recently concluded its initial public offer, made a debut on Qatar Stock Exchange (QSE), yesterday.




dn

E911 Enterprise Security Summit Comes to Grand Rapids Area Wednesday, August 7th

Effective January 1, 2020 all business and government locations in Michigan will be required to implement "Enhanced 911" service in their Multi Line Telephone Systems (MLTS).




dn

InfidelityDNATesting.com Prepares For Major Influx after Valentine's Day

Infidelity Historically Spikes on Valentine Day and Divorce The Day After.




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Perks of All-Inclusive Wedding Venues That Your Mom Didn't Tell You About

Hurst Convention Center Knows That Getting A 'Ring Before Spring' Also Means Securing A Venue That Won't Make You Scream.




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Dr M visits Qatar's dairy company Baladna

Prime Minister Tun Dr Mahathir Mohamad (centre) listens to a briefing by Qatar's Trade and Industry Minister Ali Ahmed Al-Kuwari (2nd-left) during the visit to Baladna farm in Doha. Also present is Foreign Minister Datuk Saifuddin Abdullah (left).




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epiAGE, Inc. Unveils an Advanced DNA Testing Service that Reveals True Facial Skin Age

Skin is the foundation of beauty. Intrinsic beauty is rooted in youthful skin. epiAGE, Inc. is launching a revolutionary direct-to-customer facial skin age service that can tell the intrinsic DNA age at specific spots on the facial skin.




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Baladna is Diamond Sponsor for 'Made in Qatar 2020' in Kuwait

Baladna Food Industries (BFI), Qatar's largest producer of fresh dairy & beverages, & a subsidiary of Baladna, will be the Diamond Sponsor of the upcoming 'Made in Qatar 2020' exhibition slated from February 19 to 22 at the Kuwait International Fair.




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Bravo's "Below Deck" Ashley Brinton aka Aye B release of newest Rap single "Wednesday Thought" Nov. 22nd

Ashley Brinton aka Aye B release of newest Rap single "Wednesday Thought"




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Baladna Diamond Sponsor of 'Made in Qatar' Expo Hosted by Kuwait

Baladna's stand received many exhibitors and visitors, who expressed their delight with the products the company exhibited, including milk, cheese, laban, labneh, and juices.




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Baladna Signed with Muntajat to Supply Locally Manufactured Plastic Raw Materials

Baladna announced the signing of an agreement with "Muntajat" to supply plastic raw materials used in the manufacture of milk




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How to Set Up an Emergency Preparedness Binder + Free Printable


The following is a guest post about how to set up an emergency preparedness binder from regular contributor, Kristin at The Gold Project.  Being prepared in case of an emergency is never a bad thing. When I think of an emergency, the first thing that pops into my head is losing my house to a […]

If you're seeing How to Set Up an Emergency Preparedness Binder + Free Printable anywhere other than on I'm an Organizing Junkie (or via my email list or a feed reader) it is being used by someone else without my permission. Please let me know, thank you!




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Portland Wins PRCA Award Following Successful Work on Baladna IPO

Strategic communications agency Portland has won the PRCA 2020 'Best IPO' campaign award for its support to Baladna's IPO on the Qatar Stock Exchange.




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Partnership Agreement between "Baladna" and "Widam"

Partnership Agreement between "Baladna" and "Widam" To Supply the local Market with Veal Meat for the First Time




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X019 Recap: What We Liked and What We Didn't

On this blazin' episode of our Xbox show, we look back at Xbox's past this week as the original Xbox turns 18, sharing our favorite (not best, although they're often one and the same!) games from Microsoft's first console. And then we look ahead into the future, recapping X019's Inside Xbox livestream and discussing everything we liked and everything we didn't that Microsoft is cooking up now.




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KDnuggets™ News 20:n16, Apr 22: Scaling Pandas with Dask for Big Data; Dive Into Deep Learning: The Free eBook

4 Steps to ensure your AI/Machine Learning system survives COVID-19; State of the Machine Learning and AI Industry; A Key Missing Part of the Machine Learning Stack; 5 Papers on CNNs Every Data Scientist Should Read




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Top KDnuggets tweets, Apr 15-21: 21 Techniques to Write Better #Python Code with #PyCharm examples

Also: Math for Programmers!; If #Programming languages had honest slogans #humor; 5 Papers on CNNs Every Data Scientist Should Read; Why Understanding CVEs Is Critical for Data Scientists




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KDnuggets™ News 20:n17, Apr 29: The Super Duper NLP Repo; Free Machine Learning & Data Science Books & Courses for Quarantine

Also: Should Data Scientists Model COVID19 and other Biological Events; Learning during a crisis (Data Science 90-day learning challenge); Data Transformation: Standardization vs Normalization; DBSCAN Clustering Algorithm in Machine Learning; Find Your Perfect Fit: A Quick Guide for Job Roles in the Data World




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Top KDnuggets tweets, Apr 22-28: 24 Best (and Free) Books To Understand Machine Learning

Also: A Concise Course in Statistical Inference: The Free eBook; ML Ops: Machine Learning as an Engineering Discipline; Learning during a crisis (#DataScience 90-day learning challenge) ; Free High-Quality Machine Learning & Data Science Books & Courses: Quarantine Edition




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KDnuggets™ News 20:n18, May 6: Five Cool Python Libraries for Data Science; NLP Recipes: Best Practices

5 cool Python libraries for Data Science; NLP Recipes: Best Practices and Examples; Deep Learning: The Free eBook; Demystifying the AI Infrastructure Stack; and more.




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Top KDnuggets tweets, Apr 29 – May 5: 24 Best (and Free) Books To Understand Machine Learning

What are Some 'Advanced ' #AI and #MachineLearning Online Courses?; 24 Best (and Free) Books To Understand Machine Learning; Top 5 must-have #DataScience skills for 2020




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Free Market Madness?

Peter Ubel, physician and behavioral scientist at the University of Michigan and author of "Free Market Madness."




dn

The Fukushima Meltdown That Didn’t Happen

Charles Casto, recently retired from the Nuclear Regulatory Commission, on how smart leadership saved the second Fukushima power plant.





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SCCM Pod-404 Population-Based Epidemiology and Outcomes of Acute Kidney Injury in Critically Ill Children

Margaret M. Parker, MD, MCCM, speaks with Rashid Alobaidi, MD, on his article titled Population-Based Epidemiology and Outcomes of Acute Kidney Injury in Critically Ill Children published in the January 2020 issue of Pediatric Critical Care Medicine.




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YES moratorium: Credit firms can retain ratings of borrowers who couldn’t pay in March

The non-state lender on its part is not reporting such customers to these institutions.




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Physical education teachers shouldn’t be seen as second class citizens: Margaret Whitehead

During the webinar, titled ‘Physical Literacy: For Nation’s Development’, the panelists discussed a lot of topics related to physical literacy, including its meaning, the challenges it faces, its need of promotion, the lax attitude towards it and its importance in everybody’s life. The panel also discussed the lax attitude towards physical education in India.




dn

Man Sought In Rape, Carjacking, Kidnapping Cases Arrested In Virginia

Authorities say details on his capture are forthcoming,




dn

Snow Creates Traffic, School Closings On Wednesday

Snow continued into early Wednesday morning with a dusting to 1 inch around Baltimore, and higher amounts northwest of Baltimore City.




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Monmouth Features Pick 6 Carryover Of $80,000 For Holiday Wednesday Card

The Jersey Shore Pick 6 went unit once again on Sunday at Monmouth Park, resulting in a carryover of $80,081 heading into a special July 4 card on Wednesday. The 20-cent bet requires one winner for the jackpot payout. Picking all six winners on Sunday resulted in a payout of $4,625.30 for 20 cents. The sequence started with the potential of resulting in just […]

The post Monmouth Features Pick 6 Carryover Of $80,000 For Holiday Wednesday Card appeared first on Horse Racing News | Paulick Report.




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My talk Wednesday at the Columbia coronavirus seminar

The talk will be sometime the morning of Wed 6 May in this seminar. Title: Some statistical issues in the fight against coronavirus. Abstract: To be a good citizen, you sometimes have to be a bit of a scientist. To be a good scientist, you sometimes have to be a bit of a statistician. And […]




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Prescribed Fire Update Wednesday, May 13, 2009

https://www.nps.gov/grca/learn/news/news-rx-update-2009-05-13.htm




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National Park Service Awards Concessions Contract to DNC Parks and Resorts at Grand Canyon, Inc.

The National Park Service has selected DNC Parks & Resorts at Grand Canyon, Inc., a subsidiary of Delaware North Companies, Inc., to provide a variety of visitor services at Grand Canyon National Park for the next 15 years. This is one of two concessions contracts that are expected to be awarded this year. https://www.nps.gov/grca/learn/news/nps-awards-concession-contract-to-dncpr.htm




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Tusayan Shuttle Bus Route at Grand Canyon National Park Begins Wednesday, March 1, 2017 to Help Ease Spring Break Congestion – Park and Ride; we’ll be Your Guide

The National Park Service will again offer shuttle bus service between Grand Canyon National Park and the neighboring town of Tusayan, Arizona in 2017. Service will begin March 1 to help ease spring break congestion on the South Rim. https://www.nps.gov/grca/learn/news/tusayan-route-starts-march-1-2017.htm




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RTDNA, Freedom Forum 'Local Broadcasters Town Hall' Seeks Presenters To Talk About Their Stations' Efforts To Address Pandemic

The RADIO TELEVISION DIGITAL NEWS ASSOCIATION and FREEDOM FORUM Power Shift Project are holding a "Local Broadcasters Town Hall" online on MAY 27th to highlight the work being done … more




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Daftar Judi Pulsa Idn Poker Online Terbaru

Daftar Judi Pulsa Idn Poker Online Daftar Judi Pulsa IDN – Mengetahui peluang sebenarnya dalam situasi bermain poker akan sering membuat Anda memikirkan kembali cara Anda bermain. Sebagian besar pemain menggunakan intuisi, dan seringkali cukup pandai melakukan hal ini, untuk menebak peluangnya dan bagaimana cara memainkannya. Namun ada cara yang lebih tepat (meskipun kurang praktis) […]

The post Daftar Judi Pulsa Idn Poker Online Terbaru appeared first on Themegalaxy.



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How to Change Your iPhone's DNS Servers

Just like in Mac OS X, you can change the DNS servers on your iPhone. This can significantly speed up Safari and other iPhone apps that use the Internet. For a general introduction to DNS, and to learn why you would want to change the DNS servers on your iPhone, see How to Change Your Mac's DNS Servers.

Before we start, you should know a couple things about how iOS handles DNS. First, these instructions only work for Wi-Fi connections - iOS does not allow you to change the DNS servers when connected to cellular networks. Also, the changes are network specific, so you'll need to change the DNS servers every time you connect to a new wireless network. The good news is that iOS remembers the settings, so you won't have to do anything the second time you connect to a network.

Here's how to change your iPhone's DNS servers:

  1. From the iPhone's home screen, tap Settings.

  2. Tap Wi-Fi. The screen shown below appears. The available wireless networks in range of your iPhone appear, as shown below.

  3. Find your wireless network in the list, and then click the arrow. The screen shown below appears.

  4. Tap the DNS field.

  5. Delete the current DNS servers, and enter the new DNS servers. (If you enter more than one DNS server, be sure sure to separate the servers with commas.)
    • To use OpenDNS, enter 208.67.222.222 and 208.67.220.220
    • To use Google DNS, enter 8.8.8.8 and 8.8.4.4
  6. Test your new DNS servers to make sure they're working.

That's it! You've updated your iPhone's DNS servers!

Related Articles


Meet Your Macinstructor

Matt Cone, the author of Master Your Mac, has been a Mac user for over 20 years. A former ghost writer for some of Apple's most notable instructors, Cone founded Macinstruct in 1999, a site with OS X tutorials that boasts hundreds of thousands of unique visitors per month. You can email him at: matt@macinstruct.com.




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The New Loudness Target War

In the classic loudness war, music and radio producers have been trying to create their recordings as loud as possible and loudness normalization was introduced to stop that. Now one can see the start of a new loudness target war, where podcasters set their loudness targets higher and higher, mainly triggered by high target recommendations of platforms like Spotify or Amazon Alexa.
In this article, we will show how to resist the loudness target war and still be compliant with major platforms.

Resist the loudness target war! (Photo by Nayani Teixeira)

What's the problem?

“Two or three years ago it seemed that many stations were finally realizing that better radio could improve ratings. And the major myth brought over from AM radio – that a louder signal, regardless of quality, attracts more listeners – appeared to be losing its strength,” writes Robert Orban. The times of excessively compressed audio, putting loudness over sound quality, were coming to an end. We were hoping the same when we wrote about the CALM Act and EBU R128 in 2012. Those measures were meant to make programs sound more evened out and set a standard for a reasonable loudness level.

Except, Orban's article was published in 1979 (PDF, p. 60 ff.), and he concludes: "The loudness war has escalated, and quality is once again being sacrificed." 40 years later, a new loudness target war is emerging. While, yes, radio and TV stations have widely adopted the new standards, prominent competitors in the audio market are pushing for higher loudness targets once again.

Loudness war: the trend of increasing audio levels in recorded music over time. (Screenshot delamar.de)

Why LOUDER is not better

Historically, the loudness war has escalated with the advent of digital technology. Peak level normalization and quasi peak program meters (QPPM) encouraged producers to push audio signals to the limit. Just shy of clipping, signals could now be compressed to the highest possible levels, using multiband compressors and limiters. While this lifted quieter signals up, transforming a waveform into a brick, marketers thought that the louder songs on CDs and almost yelling voices on FM radio would attract listeners. On the other hand, reduced dynamics makes audio less interesting and can lead to listener fatigue, as Rip Rowan pointedly illustrated in his 2002 article "Over the Limit":

WHY IS THE LOUDER IS BETTER APPROACH THE WRONG APPROACH? BECAUSE WHEN ALL OF THE SIGNAL IS AT THE MAXIMUM LEVEL, THEN THERE IS NO WAY FOR THE SIGNAL TO HAVE ANY PUNCH. THE WHOLE THING COMES SCREAMING AT YOU LIKE A MESSAGE IN ALL CAPITAL LETTERS. AS WE ALL KNOW, WHEN YOU TYPE IN ALL CAPITAL LETTERS THERE ARE NO CUES TO HELP THE BRAIN MAKE SENSE OF THE SIGNAL, AND THE MIND TIRES QUICKLY OF TRYING TO PROCESS WHAT IS, BASICALLY, WHITE NOISE. LIKEWISE, A SIGNAL THAT JUST PEGS THE METERS CAUSES THE BRAIN TO REACT AS THOUGH IT IS BEING FED WHITE NOISE. WE SIMPLY FILTER IT OUT AND QUIT TRYING TO PROCESS IT.

Hence, many spoken word producers and broadcasters luckily wisened up and committed to new standards, based on loudness normalization instead of peak normalization. LUFS, Loudness Units relative to Full Scale, is a unit that measures an audio track's average loudness. All segments of a program can then be normalized to a certain LUFS value. As we have discussed before, -23 LUFS is standard now for broadcasters of the EBU, which for example has led to advertising segments no longer being much louder than the rest of any particular program. For a short while, it seemed like a peace agreement, or at least a truce had been achieved in the loudness war.

Human loudness perception is based on average levels instead of peak levels. (Screenshot theproaudiofiles.com)

Loudness Targets and Dynamic Range

However, while LUFS adoption is increasing across the industry, this doesn't mean that people have stopped trying to be louder than everybody else. And indeed -23 LUFS is not the one-size-fits-all value. We have recommended -16 LUFS for podcasts ourselves. The loudness of a production played in a cinema should be different from one made for earphones and noisy listening environments. Some headphones expect a louder signal and don't have enough gain to work with -23 LUFS under all circumstances.

The closer a production gets to 0 LUFS though, the less dynamic range can be reproduced. However, the dynamic range also depends on the dBTP, the maximum True Peak level, which indicates the level of the highest possible peak value. For instance, the aforementioned EBU R128 standard of -23 LUFS also defines a -1 dBTP. The difference between the LUFS and dBTP levels is called Peak to Loudness Range, PLR. For EBU R128 the PLR would be 22 LU (Loudness Units), a podcast with -16 LUFS and -1 dBTP has a PLR of 15 LU. Thus, the PLR is a measure of the maximum possible dynamic range of an audio production.

Platforms: Apple, Google, Amazon, and Spotify

Our already pretty high recommendation of -16 LUFS, -1 dBTP for mobile listening was also adopted by Apple's best practices for podcasts and recommendations for Google Assistant. Some are pushing it too far, though. A daily updated analysis by podnews shows that many podcasts are much louder than -16 LUFS.

Distribution of loudness across a selection of podcasts. (Screenshot podnews.net)

This might in part be due to specs published by other competitors in the audio space:

Amazon, for instance, recommends -14 LUFS at -2 dBTP for Alexa skills, meaning a PLR of only 12 LU. While this might work for Alexa's synthesized voice, which doesn't have much variability, it produces a dynamic range too low for spoken word content.
However, Amazon also says that a skill may be rejected if the program loudness is lower -19 LUFS or higher -9 LUFS, therefore a target of -16 LUFS is perfectly fine, which means that Alexa's robot voice leads by 2 LU compared to the audio content.

Spotify normalizes audio to the equivalent of about -14 LUFS, -1 dbTP, but they still use ReplayGain, which is not exactly the same as LUFS but gives similar results. Spotify mainly decreases the volume of overly loud productions, but can also increase the volume on some playback devices if the audio is much too soft.
For pop music, -14 LUFS is acceptable, but for podcasts or classical music, it is too high. However, (pop) music can always be played a bit louder compared to speech, therefore a loudness target of -16 LUFS for podcasts is fine on Spotify as well.

Make LUFS, not war

If producers just use the highest recommended target and therefore the loudness (target) war goes into another battle, we will hear more compressed, distorted voices once again, lacking emotion and many subtleties that are reflected in the dynamic range of how we speak.

Setting a loudness target higher than -16 LUFS does not improve the listening experience in any way. However, many productions would benefit from sensitively adjusting differences in dynamics throughout the production, lifting up quieter segments, lowering loud segments, and treating speech and music differently. As pointed out in a presentation recently (video, in German), you can do that directly in your DAW or use a leveler to automate dynamics processing.

Instead of just raising the loudness target, adjusting differences in levels can help to make the listening experience much more enjoyable.

Recent album releases suggest that the music industry is still in the middle of the loudness war, often limiting the peak to loudness range to single digit LU values. (By the way, your vinyl-buying friend is right, vinyl records do sound better because they don't work with the highest compression rates.) Hopefully, podcasters, radio producers and other spoken word artists, as well as the platforms that host and publish their productions, can resist the temptation of louder and louder audio.
Make (no more than -16) LUFS, not war!

Conclusion

With some podcasts, smart speakers and streaming platforms trying to be louder than the competition, the listening experience deteriorates. However, podcasts can sound great and loud enough even in noisy environments, when well produced:

  • Never set a loudness target higher than -16 LUFS for spoken word audio.
  • If your audio is too quiet, try lifting up quieter sections and reducing the volume of louder sections, directly in your DAW or by using a leveler.
  • These settings will work fine on all current platforms, including Amazon Alexa and Spotify.

Resist the loudness target war!







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Solitary wave solutions and global well-posedness for a coupled system of gKdV equations. (arXiv:2002.09531v2 [math.AP] UPDATED)

In this work we consider the initial-value problem associated with a coupled system of generalized Korteweg-de Vries equations. We present a relationship between the best constant for a Gagliardo-Nirenberg type inequality and a criterion for the existence of global solutions in the energy space. We prove that such a constant is directly related to the existence problem of solitary-wave solutions with minimal mass, the so called ground state solutions. To guarantee the existence of ground states we use a variational method.




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On boundedness, gradient estimate, blow-up and convergence in a two-species and two-stimuli chemotaxis system with/without loop. (arXiv:1909.04587v4 [math.AP] UPDATED)

In this work, we study dynamic properties of classical solutions to a homogenous Neumann initial-boundary value problem (IBVP) for a two-species and two-stimuli chemotaxis model with/without chemical signalling loop in a 2D bounded and smooth domain. We successfully detect the product of two species masses as a feature to determine boundedness, gradient estimates, blow-up and $W^{j,infty}(1leq jleq 3)$-exponential convergence of classical solutions for the corresponding IBVP. More specifically, we first show generally a smallness on the product of both species masses, thus allowing one species mass to be suitably large, is sufficient to guarantee global boundedness, higher order gradient estimates and $W^{j,infty}$-convergence with rates of convergence to constant equilibria; and then, in a special case, we detect a straight line of masses on which blow-up occurs for large product of masses. Our findings provide new understandings about the underlying model, and thus, improve and extend greatly the existing knowledge relevant to this model.




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Connectedness of square-free Groebner Deformations. (arXiv:2005.03569v1 [math.AC])

Let $Isubseteq S=K[x_1,ldots,x_n]$ be a homogeneous ideal equipped with a monomial order $<$. We show that if $operatorname{in}_<(I)$ is a square-free monomial ideal, then $S/I$ and $S/operatorname{in}_<(I)$ have the same connectedness dimension. We also show that graphs related to connectedness of these quotient rings have the same number of components. We also provide consequences regarding Lyubeznik numbers. We obtain these results by furthering the study of connectedness modulo a parameter in a local ring.




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ExpDNN: Explainable Deep Neural Network. (arXiv:2005.03461v1 [cs.LG])

In recent years, deep neural networks have been applied to obtain high performance of prediction, classification, and pattern recognition. However, the weights in these deep neural networks are difficult to be explained. Although a linear regression method can provide explainable results, the method is not suitable in the case of input interaction. Therefore, an explainable deep neural network (ExpDNN) with explainable layers is proposed to obtain explainable results in the case of input interaction. Three cases were given to evaluate the proposed ExpDNN, and the results showed that the absolute value of weight in an explainable layer can be used to explain the weight of corresponding input for feature extraction.




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Coding for Optimized Writing Rate in DNA Storage. (arXiv:2005.03248v1 [cs.IT])

A method for encoding information in DNA sequences is described. The method is based on the precision-resolution framework, and is aimed to work in conjunction with a recently suggested terminator-free template independent DNA synthesis method. The suggested method optimizes the amount of information bits per synthesis time unit, namely, the writing rate. Additionally, the encoding scheme studied here takes into account the existence of multiple copies of the DNA sequence, which are independently distorted. Finally, quantizers for various run-length distributions are designed.




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A Beautiful Day in the Neighborhood is a gentle, deeply moving ode to the power of kindness

[IMAGE-1] I started sobbing from the opening moments of A Beautiful Day in the Neighborhood, and I didn't stop crying for two hours. And then after I left the cinema and ran into a fellow film critic who had also just seen it, I literally could not manage a word of discussion without bursting into tears again.…



  • Film/Film News

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Optical element for correcting color blindness

Described herein are devices, compositions, and methods for improving color discernment.




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Cytosine analogue, a method of preparation of a cytosine analogue, a DNA methyltransferase 1 inhibitor, a method for DNA methylation inhibition, the use of the analogue in the treatment of diseases associated with deviations from normal DNA methylation

A cytosine analog, a method of preparation of a cytosine analog, a DNA methyltransferase 1 inhibitor, and a method for DNA methylation inhibition, is provided for the treatment of diseases associated with deviations from normal DNA methylation. The analog of cytosine may be comprised of 1, N4, 5 and 6-substituted derivatives of cytosine or 5,6-dihydrocytosine, wherein the analog can be described by the chemical formula where R1 is H, R3, R4, 2'-deoxyribosyl, R4 is alkyl or aryl, X is N or C, wherein if X in the analog of formula I is N, then R5 is no substituent and if X in the analog of formula I and/or II is C or if X in the analog of formula II is N, then R5 and R6 are independently alkyl, aryl, hydroxyalkyl, aminoalkyl, hydroxyl, carboxyl, amino group, alkoxyl, aryloxyl, aminoalkyl, aminoaryl, thio group, sulfonyl, sulfinyl or halogen.




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Nonhuman mammal whose mtDNA is from a nonhuman mammal resistant to a selected disease or disorder and whose nDNA is from a nonhuman donor mammal more susceptible to the selected disease or disorder

Provided herein are mitochondrial-nuclear exchanged cells and animals comprising mitochondrial DNA (mtDNA) from one subject and nuclear DNA (nDNA) from a different subject. Methods for producing a mitochondrial-nuclear exchanged animal and animals made by the methods are provided. Also provided are methods of screening for agents useful for treating a disease or disorder using mitochondrial-nuclear exchanged animals or cells, tissues or organs thereof.