Lowrider magazine was once among the bestselling newsstand automotive periodicals in the country. After 42 years, it will cease to print this year.

On Tuesday, actor and comedian Maya Rudolph will host "Let's Go Crazy: The Grammy Salute to Prince," a primetime CBS TV special recorded in January.

In HBO documentary "Natalie Wood: What Remains Behind," the star's daughter Natasha Gregson Wagner offers a personal counterpoint to true crime gossip.

LIFE after death is real, according to a woman who astonishingly claims to have entered another dimension where she saw bright lights and her dead father.

HOW to live longer: If you are looking to lead a long life, eating a healthy, balanced diet is the hard and fast rule to live by. The best diet to follow is still debated vigorously but there is a broad consensus emerging.

ROCK legend Little Richard has died aged 87, but what was the cause of death?

MIRIAM MARGOLYES sparked outrage after the Harry Potter star admitted she wanted "Boris Johnson to die" of coronavirus after he was hospitalised during an on-air rant.

SPAIN'S 24-hour death toll from coronavirus has hit one of the lowest levels since March 18.

A coronavirus mortality model projects that nearly 135,000 Americans will die from COVID-19 by early August. The data has been revised and is now almost double previous projections, pushing the death toll in the US to over 200,000 by August.

Israel Ramirez Guardado was convicted Dec. 2 of first-degree murder for the 2018 attack on his 61-year-old mother, Francisca Ramirez.

News of Little Richard's death sent shockwaves across social media Saturday as tributes started pouring in from celebrities and musicians.

The claim that COVID-19 has a lower death toll than many other causes is partly false. There isn't yet a year's worth of data.

Hamilton County Sheriff's Office is investigating the death of a man who was found in a ditch Friday afternoon just northeast of Noblesville.

David Fouts had a good job at Salesforce and lived a standard middle-class life. That's why police in Hamilton County are baffled by his death.

Indiana has the highest death rate among states that are reopening. One widely cited model predicts big rise as Holcomb sends Hoosiers back to work

The president said that on taking office he had told the CIA that the al-Qaeda chief's death or capture was to be the agency's top priority. Senior administration officials say that he chaired five meetings in March working out the plans for this attack. It's really not clear to me if the political leadership makes much difference to operations like this, but it is certainly the impression Mr Obama wants to linger.

The raid took 40 minutes. The intelligence operation took years. It started with the search for a courier, perhaps something of a misnomer for a senior aide to Bin Laden, one of the few men he trusted, according to prisoners who had been interrogated. Four years ago they uncovered his identity. The very high level of precautions the man took made them all the more suspicious. Two years ago they discovered the areas in which he operated. Last summer they identified the compound, in an affluent suburb of Islamabad. Eight times the size of similar homes in the area, it had 18ft-high walls topped with barbed wire and inner walls 7ft high. A large place, worth a million dollars, but with no phone, no internet access. The CIA believes it was purpose-built to hide Bin Laden.

The US didn't tell the Pakistanis about the compound or about the raid until it had happened. That may create some diplomatic friction.

But the mood in America is exultant. As Twitter proclaimed the death of Bin Laden, before the president spoke, crowds gathered outside the White House, waving the stars and stripes and chanting "USA, USA". This is not a country that does quiet satisfaction. This is a cathartic moment for the nation, a moment when America's military might, know how and sheer will power seem to have come together to produce a result.

At a time when there are so many doubts about America's role in the world, and so much economic gloom, there is something clear and plain about celebrating the "rubbing out" of a bad guy, an enemy. The president has been congratulated by even his opponents, and this success allows him to appear grimly resolute in pursuit of America's core interests.

Senior administration officials say Bin Laden's death is not just a symbol, it removes a charismatic and respected leader whom al-Qaeda cannot replace. The official suggests the organisation is on a downward path that will be difficult to reverse. The domestic implications for Mr Obama are in the opposite direction, but may be just as important.

Indiana has the highest death rate among states that are reopening. One widely cited model predicts big rise as Holcomb sends Hoosiers back to work

The governor said state officials are trying to manage health risks, job risks and budget risks simultaneously.

Here are the Indiana coronavirus cases, tests and newly reported deaths from COVID-19 for Saturday, May 9.

A total of 430 Covid-19 related deaths have now been recorded in Northern Ireland

Despite the recent fatalities, the county's observed mortality rate associated with COVID-19 remained at about 2.1% — still significantly lower than the state's, which is roughly 4%.

Some are well known, some forgotten, but all played a key role in World War Two.

Italy has the third highest officially recorded coronavirus deaths, after the US and the UK.

The current best guess of a 1% death rate does not apply to everyone.

The Middlesex-London Health Unit is reporting that a man in his 40s has died from COVID-19.

Two men are in custody following a woman's death earlier this week in Simcoe.

The Middlesex-London Health Unit (MLHU) is reporting some good news regarding the status of COVID-19 in the region.

1. After death, special trains take 16 migrant workers to home districts  The Tribune India
2. Unable to Overcome Impact Of Tragedy: Aurangabad Train Accident Survivor  NDTV
3. NHRC issues notice to Maharashtra govt over deaths of migrant workers in Aurangabad train mishap, seeks det...  Zee News
4. Tragedy on tracks  The Indian Express
5. Coronavirus Essential podcast | Aurangabad train mows down 17 migrant workers; COVID-19 spreads in 8 Maharashtra jails  Moneycontrol.com
6. View Full coverage on Google News

1. Coronavirus LIVE Updates: Maharashtra's Tally of Infections Crosses 20,000 with 1,165 New Cases, 48 Deaths in Last 24 Hours  News18
2. Coronavirus India News LIVE | Tamil Nadu COVID-19 tally zooms to 6,535 with 526 new cases; 44 die  Moneycontrol
3. Retirement age hiked for all Tamil Nadu government staff  Deccan Chronicle
4. Andra Prasdesh to Reduce Retail Liquor Outlets to 2,934 by May End  News18
5. In Pictures | Day-45 of coronavirus lockdown leaves people in limbo  The Hindu
6. View Full coverage on Google News

“Death Stranding” is one of the oddest, and one of the best, games of 2019.

A Nigerian court sentenced a man to death in the country's first ever virtual ruling during a five-week coronavirus lockdown.

Another 346 people have died in the UK after testing positive for COVID-19, bringing the total to 31,587.

Amazon, the global e-commerce giant, will ask electronic scooter manufacturers to make clear in their online listings that their devices cannot be used on public roads.

The number of deaths from coronavirus in Italy now exceeds 30 000, officials have said.

A horror crash involving a truck and a tanker carrying a flammable substance has led to the closure of the N2, near the Mtunzini Toll Plaza on the KwaZulu-Natal north coast.

South Africa's net death rate has decreased amid the Covid-19 pandemic over the past five weeks, despite the 186 deaths thus far, Health Minister Zweli Mkhize says.

The Western Cape remains the epicentre of the Covid-19 pandemic in the country, with 4 809 cases, Health Minister Zweli Mkhize says.

Stay up to date with the latest news, views and analysis as the number of coronavirus cases in SA increases.

The mainstream media is still a powerful entity in America, even as its influence wanes in favor of social media. The evidence of this has come again in recent polls that show Republican Gov. Rob DeSantis’ slipping poll numbers in Florida versus Democratic Gov. Andrew Cuomo’s rising numbers in New York. And the curious part…

The post Media Lies at Work: As NY Deaths Go Up, So Do Cuomo’s Polls – As FL Deaths Go Down, So Do DeSantis’ Polls appeared first on The Western Journal.

By easing distancing measures, the Greater Montreal area could experience a substantial increase in the number of deaths per day due to the coronavirus, according to a new document published by the Institut national de santé publique du Québec (INSPQ) in collaboration with experts from Laval University.

Quebec public health officials announced Saturday that a total of 2,786 people have died from COVID-19 and there are now 36,986 confirmed cases.

The DML News App offers the best in news reporting.

The post REPORT: Governor criticized over highest nursing home death toll appeared first on Dennis Michael Lynch.

A woman in her 90s living at the Bradford Valley Care Community is the latest coronavirus victim in the region.

B.C. recorded 29 more cases of COVID-19 and one more death over the last 24 hours, provincial health officials announced Friday.

The following article, NY Shame: Workers Who Tested Positive For COVID-19 Were Allowed To Remain On The Job At Nursing Homes, As Death Toll For Nursing Home Patients Exceeds 3,000, was first published on 100PercentFedUp.com.

The coronavirus crisis at New York’s nursing homes is even worse than previously thought. Monday night, the state Department of Health issued new data, adding more than 1,600 people who were presumed to have died of the virus in nursing homes, but did not have a confirmed diagnosis, to the official toll. As of May […]

Continue reading: NY Shame: Workers Who Tested Positive For COVID-19 Were Allowed To Remain On The Job At Nursing Homes, As Death Toll For Nursing Home Patients Exceeds 3,000 ...

One more person has died from the coronavirus in the Windsor-Essex region on Saturday and nine new cases have been reported by the health unit.

The linear ubiquitin assembly complex (LUBAC) is an essential component of the innate and adaptive immune system. Modification of cellular substrates with linear polyubiquitin chains is a key regulatory step in signal transduction that impacts cell death and inflammatory signaling downstream of various innate immunity receptors. Loss-of-function mutations in the LUBAC components HOIP and HOIL-1 yield a systemic autoinflammatory disease in humans, whereas their genetic ablation is embryonically lethal in mice. Deficiency of the LUBAC adaptor protein Sharpin results in a multi-organ inflammatory disease in mice characterized by chronic proliferative dermatitis (cpdm), which is propagated by TNFR1-induced and RIPK1-mediated keratinocyte cell death. We have previously shown that caspase-1 and -11 promoted the dermatitis pathology of cpdm mice and mediated cell death in the skin. Here, we describe a reciprocal regulation of caspase-1 and LUBAC activities in keratinocytes. We show that LUBAC interacted with caspase-1 via HOIP and modified its CARD domain with linear polyubiquitin and that depletion of HOIP or Sharpin resulted in heightened caspase-1 activation and cell death in response to inflammasome activation, unlike what is observed in macrophages. Reciprocally, caspase-1, as well as caspase-8, regulated LUBAC activity by proteolytically processing HOIP at Asp-348 and Asp-387 during the execution of cell death. HOIP processing impeded substrate ubiquitination in the NF-κB pathway and resulted in enhanced apoptosis. These results highlight a regulatory mechanism underlying efficient apoptosis in keratinocytes and provide further evidence of a cross-talk between inflammatory and cell death pathways.

Nica M. Borradaile
Dec 1, 2006; 47:2726-2737
Research Articles