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Protein cages and virus-like particles: from fundamental insight to biomimetic therapeutics

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Published On ::

Biomater. Sci., 2020, Advance Article
DOI: 10.1039/D0BM00159G, Minireview
Nicole F. Steinmetz, Sierin Lim, Frank Sainsbury
Protein cages found in nature have evolved for a variety of purposes and this review focuses on how they are being co-opted for use in immunotherapy and therapeutic delivery.
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Core–shell particles for drug-delivery, bioimaging, sensing, and tissue engineering

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Biomater. Sci., 2020, Advance Article
DOI: 10.1039/C9BM01872G, Review Article
Ratchapol Jenjob, Treethip Phakkeeree, Daniel Crespy
Core–shell particles offer significant advantages in their use for bioimaging and biosensors.
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ZBTB20-mediated titanium particle-induced peri-implant osteolysis by promoting macrophage inflammatory responses

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Biomater. Sci., 2020, Advance Article
DOI: 10.1039/D0BM00147C, Paper
Open Access
Junxiong Qiu, Peng Peng, Min Xin, Zhenkang Wen, Zhong Chen, Sipeng Lin, Manyuan Kuang, Yuan Fu, Guibin Fang, Shixun Li, Changchuan Li, Jiaji Mao, Ling Qin, Yue Ding
Aseptic loosening (AL) caused by wear particles released from implant surfaces is one of the main causes for the failure of artificial joints, which is initiated by macrophage inflammatory responses.
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In situ conversion of rose bengal microbubbles into nanoparticles for ultrasound imaging guided sonodynamic therapy with enhanced antitumor efficacy

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Biomater. Sci., 2020, 8,2526-2536
DOI: 10.1039/C9BM02046B, Paper
Rui Hou, Xiaolong Liang, Xiaoda Li, Xu Zhang, Xiaotu Ma, Fan Wang
Sonosensitizer microbubbles enhance drug accumulation and the antitumor efficacy of sonodynamic therapy by ultrasound mediated micro to nano conversion.
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Biomimic strategies for modulating the interaction between particle adjuvants and antigen-presenting cells

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Biomater. Sci., 2020, 8,2366-2375
DOI: 10.1039/C9BM02098E, Review Article
Jie Wu, Guanghui Ma
The design strategies of particle adjuvants by mimicking natural pathogens to strengthen their interaction with antigen-presenting cells.
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A nanosystem loaded with perfluorohexane and rose bengal coupled upconversion nanoparticles for multimodal imaging and synergetic chemo-photodynamic therapy of cancer

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Biomater. Sci., 2020, 8,2488-2506
DOI: 10.1039/C9BM02081K, Paper
Hai-yan Wang, Li Hou, Hai-liang Li, Xu Wang, Yang Cao, Bo-yu Zhang, Jing-tao Wang, Shi-jie Wei, Hong-wan Dang, Hai-tao Ran
A novel nanosystem (FURH-PFH-NPs) combined with LIFU and laser irradiation realized multimodal imaging, targeted release of HCPT, UCNPs-RB and synergetic chemo-photodynamic therapy of cancer.
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Bioinspired inorganic nanoparticles and vascular factor microenvironment directed neo-bone formation

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Biomater. Sci., 2020, 8,2627-2637
DOI: 10.1039/D0BM00041H, Paper
Hwan D. Kim, Jungha Park, Sivashanmugam Amirthalingam, R. Jayakumar, Nathaniel S. Hwang
VEGF-overexpressing human tonsil-derived stem cells (VEGF-hTMSCs) and a whitlockite microenvironment induce vascularized bone tissue formation in biodegradable polymeric scaffolds.
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NIR-emitting semiconducting polymer nanoparticles for in vivo two-photon vascular imaging

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Biomater. Sci., 2020, 8,2666-2672
DOI: 10.1039/C9BM02063B, Paper
Xiao-Ting Gong, Wenguang Xie, Jing-Jing Cao, Shengxiang Zhang, Kanyi Pu, Hao-Li Zhang
A NIR-emitting TPF probe (NESPN) was prepared using semiconducting polymers and used for continuously monitoring the whole process of ischemic stroke and subsequent reperfusion. This work provides a new and versatile tool for vascular research and diagnosis of vascular diseases.
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Highly responsive and rapid hydrogen peroxide-triggered degradation of polycaprolactone nanoparticles

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Biomater. Sci., 2020, 8,2394-2397
DOI: 10.1039/C9BM02019E, Communication
Peng-Hao Hsu, Carina Arboleda, Alexandra Stubelius, Ling-Wei Li, Jason Olejniczak, Adah Almutairi
Nanoparticles formulated from fast-degrading oxidation-responsive polycaprolactone are responsive to 50 μM of H2O2.
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Particle-mediated delivery of frataxin plasmid to a human sensory neuronal model of Friedreich's ataxia

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Biomater. Sci., 2020, 8,2398-2403
DOI: 10.1039/C9BM01757G, Communication
Ewa Czuba-Wojnilowicz, Serena Viventi, Sara E. Howden, Simon Maksour, Amy E. Hulme, Christina Cortez-Jugo, Mirella Dottori, Frank Caruso
Multilayered particles in gene therapy for Friedreich's ataxia induce a 27 000-fold increase in frataxin gene expression in a patient-derived cell model.
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Effective intracellular delivery of bevacizumab via PEGylated polymeric nanoparticles targeting CD44v6 receptor in colon cancer cells

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Published On ::

Biomater. Sci., 2020, Accepted Manuscript
DOI: 10.1039/D0BM00556H, Paper
Ana Baião, Flávia Sousa, Ana Oliveira, Carla Oliveira, Bruno Sarmento
Colorectal cancer (CRC) is one of the most incident and mortal cancers in the world, mainly due to its metastatic and metabolic ability. CD44 receptor isoform containing exon 6 (CD44v6)...
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Biogenic Aspergillus tubingensis silver nanoparticles’ in vitro effects on human umbilical vein endothelial cells, normal human fibroblasts, HEPG2, and Galleria mellonella

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Toxicol. Res., 2019, 8,789-801
DOI: 10.1039/C9TX00091G, Paper
Cristiane Angélica Ottoni, Durvanei Augusto Maria, Priscila Jane Romano de Oliveira Gonçalves, Welington Luiz de Araújo, Ana Olívia de Souza
Biogenic silver nanoparticles are ecofriendly and offers valuable possibilities of applications in several industrial areas.
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Synergistic antioxidant capacity of CsNPs and CurNPs against cytotoxicity, genotoxicity and pro-inflammatory mediators induced by hydroxyapatite nanoparticles in male rats

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Toxicol. Res., 2019, 8,939-952
DOI: 10.1039/C9TX00221A, Paper
Israa F. Mosa, Mokhtar Youssef, Maher Kamel, Osama F. Mosa, Yasser Helmy
Due to their dynamic characteristics, hydroxyapatite nanoparticles (HAP-NPs) have been employed numerous times in nanomedicine and in tissue engineering, particularly as diagnostic and therapeutic agents.
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Nanoparticle induced barrier function assessment at liquid–liquid and air–liquid interface in novel human lung epithelia cell lines

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Toxicol. Res., 2019, 8,1016-1027
DOI: 10.1039/C9TX00179D, Paper
Open Access
Lars Leibrock, Sandra Wagener, Ajay Vikram Singh, Peter Laux, Andreas Luch
To answer questions about nanoparticle toxicity, translocation and biokinetics following inhalation exposure, in vitro models should have functional barrier properties to mimic the in vivo situation as closely as possible.
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Cytotoxic effect of silica nanoparticles against hepatocellular carcinoma cells through necroptosis induction

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Toxicol. Res., 2019, 8,1042-1049
DOI: 10.1039/C9TX00240E, Paper
Yuexiang Niu, Engong Tang, Qingan Zhang
Hepatocellular carcinoma (HCC) is a common cancer that affects people worldwide with high morbidity and mortality, and its resistance to current chemotherapeutic drugs is a serious concern.
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RGD functionalized chitosan nanoparticle mediated targeted delivery of raloxifene selectively suppresses angiogenesis and tumor growth in breast cancer

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Nanoscale, 2020, Advance Article
DOI: 10.1039/C9NR10673A, Paper
Amit S. Yadav, N. Naga Venkata Radharani, Mahadeo Gorain, Anuradha Bulbule, Dattatrya Shetti, Gaurab Roy, Thejus Baby, Gopal C. Kundu
Peptide functionalized pH sensitive raloxifene-chitosan nanoparticles with high biocompatibility synergistically inhibit tumor growth and angiogenesis in breast cancer.
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Efficient sub-15 nm cubic-phase core/shell upconversion nanoparticles as reporters for ensemble and single particle studies

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Nanoscale, 2020, Advance Article
DOI: 10.1039/D0NR02172E, Paper
Meiling Tan, Melissa-Jane Monks, Dingxin Huang, Yongjun Meng, Xuewen Chen, Ying Zhou, Shuang-Fang Lim, Christian Würth, Ute Resch-Genger, Guanying Chen
A set of sub-15 nm ytterbium-enriched α-NaYbF4:Er3+@CaF2 core/shell upconversion nanoparticles have been developed for both ensemble- and single particle-level imaging studies, presenting a high quantum yield of 0.77% at a low saturation power density of 110 W cm−2.
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Strong plasmon–exciton coupling between lithographically defined single metal nanoparticles and monolayer WSe2

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Nanoscale, 2020, 12,9708-9716
DOI: 10.1039/D0NR01056A, Paper
Xiaohong Yan, Hong Wei
Strong coupling between monolayer WSe2 and lithographically defined single gold nanobowties is realized for the first time, and smaller nanobowties lead to larger coupling strength.
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The CpG molecular structure controls the mineralization of calcium phosphate nanoparticles and their immunostimulation efficacy as vaccine adjuvants

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Nanoscale, 2020, 12,9603-9615
DOI: 10.1039/C9NR09782A, Paper
Razieh Khalifehzadeh, Hamed Arami
Effects of the CpG molecular structure on the mineralization and immunostimulation efficacy of calcium phosphate nanoparticles are explored for vaccine delivery applications.
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Modulated podosome patterning in osteoclasts by fullerenol nanoparticles disturbs the bone resorption for osteoporosis treatment

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Nanoscale, 2020, 12,9359-9365
DOI: 10.1039/D0NR01625J, Communication
Kui Chen, Huan Geng, Wei Liang, Haojun Liang, Yujiao Wang, Jianglong Kong, Jiaxin Zhang, Yuelan Liang, Ziteng Chen, Jiacheng Li, Ya-nan Chang, Juan Li, Gengyan Xing, Gengmei Xing
Fullerenol hampers podosome patterning in osteoclasts, results in the failure of bone resorption.
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Effective atherosclerotic plaque inflammation inhibition with targeted drug delivery by hyaluronan conjugated atorvastatin nanoparticles

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Nanoscale, 2020, 12,9541-9556
DOI: 10.1039/D0NR00308E, Paper
Seyedmehdi Hossaini Nasr, Zahra Rashidijahanabad, Sherif Ramadan, Nate Kauffman, Narayanan Parameswaran, Kurt R. Zinn, Chunqi Qian, Ripla Arora, Dalen Agnew, Xuefei Huang
Atherosclerosis is associated with inflammation in the arteries. Hyaluronan atorvastatin nanoparticle conjugate could target CD44 overexpressed in atherosclerotic plaques and significantly reduce plaque associated inflammation.
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Exploring the direct synthesis of exchange-spring nanocomposites by reduction of CoFe2O4 spinel nanoparticles using in situ neutron diffraction

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Nanoscale, 2020, 12,9440-9451
DOI: 10.1039/D0NR00912A, Paper
Jakob Voldum Ahlburg, Cecilia Granados-Miralles, Frederik Holm Gjørup, Henrik Lyder Andersen, Mogens Christensen
In situ neutron powder diffraction (NPD) was employed for investigating gram-scale reduction of hard magnetic CoFe2O4 (spinel) nanoparticles into CoFe2O4/CoFe2 exchange-spring nanocomposites via H2 partial reduction.
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Clear observation of the formation of nanoparticles inside the ablation bubble through a laser-induced flat transparent window by laser scattering

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Nanoscale, 2020, 12,9640-9646
DOI: 10.1039/C9NR10560C, Paper
Kota Ando, Takashi Nakajima
We demonstrate the clear observation of laser-scattering signals from Ag nanoparticles (NPs) inside an ablation bubble.
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Size-dependent aggregation of hydrophobic nanoparticles in lipid membranes

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Nanoscale, 2020, 12,9452-9461
DOI: 10.1039/D0NR00868K, Paper
Open Access
Enrico Lavagna, Jonathan Barnoud, Giulia Rossi, Luca Monticelli
Aggregation of hydrophobic spherical nanoparticles in lipid membranes depends on nanoparticle size. Nanoparticles of ∼3 nm sense and induce membrane curvature.
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Fluorescent nanoparticle-based Internet of things

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Nanoscale, 2020, 12,9817-9823
DOI: 10.1039/D0NR01365J, Paper
Luca Fichera, Giovanni Li-Destri, Nunzio Tuccitto
The first working molecular-IoT prototype, based on a chemical communication network, was developed by employing three different carbon nanoparticles.
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DNA-directed arrangement of soft synthetic compartments and their behavior in vitro and in vivo

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Nanoscale, 2020, 12,9786-9799
DOI: 10.1039/D0NR00361A, Paper
Open Access
Juan Liu, Ioana Craciun, Andrea Belluati, Dalin Wu, Sandro Sieber, Tomaz Einfalt, Dominik Witzigmann, Mohamed Chami, Jörg Huwyler, Cornelia G. Palivan
Soft flexible DNA-linked polymersome clusters selectively interact with the cell membrane in vitro and in vivo.
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Quantitative encapsulation and retention of 227Th and decay daughters in core–shell lanthanum phosphate nanoparticles

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Nanoscale, 2020, 12,9744-9755
DOI: 10.1039/D0NR01172J, Paper
M. Toro-González, A. N. Dame, C. M. Foster, L. J. Millet, J. D. Woodward, J. V. Rojas, S. Mirzadeh, S. M. Davern
La(227Th)PO4 core +2 shells nanoparticles retained >99.75% of activity from 227Th and decay daughters (223Ra, 211Pb) for targeted alpha therapy.
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Elucidating the relationship between nanoparticle morphology, nuclear/magnetic texture and magnetic performance of sintered SrFe12O19 magnets

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Nanoscale, 2020, 12,9481-9494
DOI: 10.1039/D0NR01728K, Paper
Matilde Saura-Múzquiz, Anna Zink Eikeland, Marian Stingaciu, Henrik Lyder Andersen, Cecilia Granados-Miralles, Maxim Avdeev, Vladimir Luzin, Mogens Christensen
The relationship between nanoparticle morphology, self-induced atomic/magnetic texture and magnetic properties of high-performance hexaferrite magnets is elucidated using neutron/X-ray pole figure analysis and neutron/synchrotron powder diffraction.
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A unique synthesis of rare-earth-Co-based single crystal particles by “self-aligned” Co nano-arrays

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Nanoscale, 2020, Accepted Manuscript
DOI: 10.1039/D0NR00490A, Paper
Qiong Wu, Liying Cong, Yue Ming, Chenglin Li, Zhenhui Ma, Xiangyu Ma, Yatao Wang
In this study, anisotropic SmCo5 magnets were prepared by a distinctive method, which is the high-temperature reductive annealing of Co@Sm2O3 with specially designed nanostructure. High resolution transmission electron microscope and...
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Bad Neighbour, Good Neighbour: How Magnetic Dipole Interactions Between Soft and Hard Ferrimagnetic Nanoparticles Affect Macroscopic Magnetic Properties in Ferrofluids

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Published On ::

Nanoscale, 2020, Accepted Manuscript
DOI: 10.1039/D0NR02023K, Paper
Niéli Daffé, Jovana Zecevic, Kalliopi Trohidou, Marcin Sikora, Mauro Rovezzi, Claire Carvallo, Marianna Vasilakaki, Sophie Neveu, Johannes D. Meeldijk, Nadejda Bouldi, Veronica Gavrilov, Yohan Guyodo, Fadi Choueikani, Vincent Dupuis, Dario Taverna, Philippe Sainctavit, Amélie JUHIN
Fluids responding to magnetic fields (ferrofluids) offer a scene with no equivalent in nature to explore long-range magnetic dipole interactions. Here, we studied the very original class of binary ferrofluids,...
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Unexpectedly high stability and surface reconstruction of PdAuAg nanoparticles for formate oxidation electrocatalysis

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Nanoscale, 2020, Accepted Manuscript
DOI: 10.1039/D0NR01358G, Paper
Bowei Pan, Fuyi Chen, Kou Bo, Junpeng Wang, Quan Tang, Longfei Guo, Qiao Wang, Zhen Li, Weiqi Bian, Jiali Wang
High-performance Pd-based nanocatalysts for alkaline methanol and formate fuel cells have aroused wide attention. Hence, a series of ternary Pd-Au-Ag nanoalloys are synthesized on the carbon nanotubes and demonstrate a...
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The influence of surface roughness on the adhesive interactions and phase behavior of suspensions of calcite nanoparticles

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Nanoscale, 2020, Accepted Manuscript
DOI: 10.1039/D0NR00834F, Paper
Open Access
Juan D. Olarte-Plata, Goran Svaland, Fernando Bresme
We investigate the impact of nanoparticle roughness on the phase behaviour of suspensions lue{in models} of calcium carbonate nanoparticles. We use a Derjaguin approach that incorporates roughness effects and interactions...
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Near-infrared nanosecond-pulsed laser-activated high efficient intracellular delivery mediated by nano-corrugated mushroom-shaped gold-coated polystyrene nanoparticles

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Nanoscale, 2020, Accepted Manuscript
DOI: 10.1039/D0NR01792B, Paper
Tuhin Subhra Santra, Srabani Kar, Chih-Wei Chen, Jayant Borana, Te-Chang Chen, Ming-Chang Lee, Fan-Gang Tseng
Here, efficient intracellular delivery of molecules with high cell viability is reported using nanosecond-pulsed laser-activated plasmonic photoporation mediated by high-aspect-ratio nano-corrugated mushroom-shaped gold-coated polystyrene nanoparticles (nm-AuPNPs) at near-infrared wavelength. Upon...
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Lake Alfred Public Library, part of the Polk County Library Consortium

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Published On :: Mon, 20 Jan 2014 11:55:09 -0400


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Webster College Library - Part 1

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Published On :: Mon, 20 Jan 2014 11:55:13 -0400


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Webster College Library - Part 2

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Published On :: Mon, 20 Jan 2014 11:55:15 -0400


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Cooper Memorial Library, part of the Lake County Library System

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Published On :: Mon, 20 Jan 2014 11:55:24 -0400


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Palm Beach County Library System - Part 1

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Published On :: Mon, 20 Jan 2014 11:55:25 -0400


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Palm Beach County Library System - Part 2

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Published On :: Mon, 20 Jan 2014 11:55:26 -0400


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Fort Meade Public Library, part of the Polk County Library Cooperative

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Published On :: Mon, 20 Jan 2014 11:55:28 -0400


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Old court house now an apartment building

By digital.lib.usf.edu
Published On :: Mon, 20 Jan 2014 12:42:47 -0400


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Crooked River Light part of network

By digital.lib.usf.edu
Published On :: Mon, 20 Jan 2014 12:43:08 -0400


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Del Ingeniero Germán Matamoros Blanco, Area Aguas Subterráneas SENARA para el Ingeniero José Miguel Zeledón, Jefe Departamento de Aguas, MINAE

By digital.lib.usf.edu
Published On :: Sun, 26 Jan 2014 15:14:10 -0400


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Ing. José Joaqin Chacon Solano, Jefe Departamento de Aguas Instituto Meteorológico Nacional. Certificado de inscripcion de Guzmith

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Published On :: Sun, 26 Jan 2014 15:14:15 -0400


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Del Ing. Edgar Mairena Navarro, encargado de proyectos, Región Pacífico Central, para Departamento de Aguas, MINAE. Asunto: Resolución de la SETENA

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Published On :: Sun, 26 Jan 2014 15:14:17 -0400


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Del Ing. José M. Zeledon C., jefe, Departamento de Aguas, para Heibel Rodriguez Araya, gerente general, Instituto Costarricense de Acueductos y Alcantarillados (Aya). Concesión de prorroga

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Published On :: Sun, 26 Jan 2014 15:14:20 -0400


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De Vera Zeledón Pinto para sres. Ministerio de Energía y Ambiente, Departamento de Aguas

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Published On :: Sun, 26 Jan 2014 15:14:25 -0400


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Del Ing. José J. Chacón S., subjefe de Departamento, Ministerio del Ambiente y Energía, Instituto Meteorológico Nacional, para el Ing. José Miguel Zeledón Calderón, jefe, Departamento de Aguas

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Published On :: Sun, 26 Jan 2014 15:14:32 -0400


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Informe sobre denuncia de toma de agua por parte de Hotel Belmar

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Published On :: Sun, 26 Jan 2014 15:14:34 -0400


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Del Ing. Germán Matamoros Blanco, SENARA, para el Ing. José Miguel Zeledón, jefe, Departamento de Aguas, MINAE

By digital.lib.usf.edu
Published On :: Sun, 26 Jan 2014 15:14:39 -0400


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