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Teachers' Unions, Doctors Agree: Vaccines, Masks Crucial for Return-to-School

By www.medicinenet.com
Published On :: Mon, 29 Aug 2022 00:00:00 PDT

Title: Teachers' Unions, Doctors Agree: Vaccines, Masks Crucial for Return-to-School
Category: Health News
Created: 8/23/2021 12:00:00 AM
Last Editorial Review: 8/23/2021 12:00:00 AM


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No Change in Adolescent Drug, Alcohol Use During Pandemic

By www.medicinenet.com
Published On :: Mon, 29 Aug 2022 00:00:00 PDT

Title: No Change in Adolescent Drug, Alcohol Use During Pandemic
Category: Health News
Created: 8/24/2021 12:00:00 AM
Last Editorial Review: 8/24/2021 12:00:00 AM


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Just Starting Exercise in Your 60s? It'll Still Do a World of Good

By www.medicinenet.com
Published On :: Mon, 29 Aug 2022 00:00:00 PDT

Title: Just Starting Exercise in Your 60s? It'll Still Do a World of Good
Category: Health News
Created: 8/25/2021 12:00:00 AM
Last Editorial Review: 8/25/2021 12:00:00 AM


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Enlarged Prostate Doesn't Raise a Man's Odds for Cancer: Study

By www.medicinenet.com
Published On :: Mon, 29 Aug 2022 00:00:00 PDT

Title: Enlarged Prostate Doesn't Raise a Man's Odds for Cancer: Study
Category: Health News
Created: 8/25/2021 12:00:00 AM
Last Editorial Review: 8/25/2021 12:00:00 AM


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Don't Forget to Apply Sunscreen Before & After Water Fun

By www.medicinenet.com
Published On :: Mon, 29 Aug 2022 00:00:00 PDT

Title: Don't Forget to Apply Sunscreen Before & After Water Fun
Category: Health News
Created: 8/27/2021 12:00:00 AM
Last Editorial Review: 8/27/2021 12:00:00 AM


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Cooler Weather Could Mean More Diabetes in Dogs

By www.medicinenet.com
Published On :: Mon, 29 Aug 2022 00:00:00 PDT

Title: Cooler Weather Could Mean More Diabetes in Dogs
Category: Health News
Created: 8/22/2022 12:00:00 AM
Last Editorial Review: 8/22/2022 12:00:00 AM


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Dr. Anthony Fauci Will Step Down in December

By www.medicinenet.com
Published On :: Mon, 29 Aug 2022 00:00:00 PDT

Title: Dr. Anthony Fauci Will Step Down in December
Category: Health News
Created: 8/22/2022 12:00:00 AM
Last Editorial Review: 8/23/2022 12:00:00 AM


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Dogs Do Cry When Reunited With Owners

By www.medicinenet.com
Published On :: Mon, 29 Aug 2022 00:00:00 PDT

Title: Dogs Do Cry When Reunited With Owners
Category: Health News
Created: 8/23/2022 12:00:00 AM
Last Editorial Review: 8/23/2022 12:00:00 AM


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Michigan Officials Puzzled by Mysterious Deaths of 30 Dogs

By www.medicinenet.com
Published On :: Mon, 29 Aug 2022 00:00:00 PDT

Title: Michigan Officials Puzzled by Mysterious Deaths of 30 Dogs
Category: Health News
Created: 8/24/2022 12:00:00 AM
Last Editorial Review: 8/24/2022 12:00:00 AM


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Gabapentin vs. Tramadol

By www.medicinenet.com
Published On :: Fri, 22 Jul 2022 00:00:00 PDT

Title: Gabapentin vs. Tramadol
Category: Medications
Created: 3/22/2018 12:00:00 AM
Last Editorial Review: 7/22/2022 12:00:00 AM


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Alternative Medicine Popular Among Seniors, But Most Don't Tell Their Doctors About It

By www.medicinenet.com
Published On :: Wed, 27 Jul 2022 00:00:00 PDT

Title: Alternative Medicine Popular Among Seniors, But Most Don't Tell Their Doctors About It
Category: Health News
Created: 7/27/2022 12:00:00 AM
Last Editorial Review: 7/27/2022 12:00:00 AM


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How Do You Recover From a Retinal Migraine?

By www.medicinenet.com
Published On :: Tue, 14 Jun 2022 00:00:00 PDT

Title: How Do You Recover From a Retinal Migraine?
Category: Diseases and Conditions
Created: 6/14/2022 12:00:00 AM
Last Editorial Review: 6/14/2022 12:00:00 AM


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How Do You Stop a Migraine Without Aura?

By www.medicinenet.com
Published On :: Thu, 16 Jun 2022 00:00:00 PDT

Title: How Do You Stop a Migraine Without Aura?
Category: Diseases and Conditions
Created: 6/16/2022 12:00:00 AM
Last Editorial Review: 6/16/2022 12:00:00 AM


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What Does a Neurologist Do for a Vestibular Migraine?

By www.medicinenet.com
Published On :: Wed, 22 Jun 2022 00:00:00 PDT

Title: What Does a Neurologist Do for a Vestibular Migraine?
Category: Diseases and Conditions
Created: 6/22/2022 12:00:00 AM
Last Editorial Review: 6/22/2022 12:00:00 AM


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How Do I Get Rid of a Stye Overnight?

By www.medicinenet.com
Published On :: Thu, 21 Jul 2022 00:00:00 PDT

Title: How Do I Get Rid of a Stye Overnight?
Category: Diseases and Conditions
Created: 8/18/2020 12:00:00 AM
Last Editorial Review: 7/21/2022 12:00:00 AM


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How Long Do Permanent Punctal Plugs Last?

By www.medicinenet.com
Published On :: Fri, 5 Aug 2022 00:00:00 PDT

Title: How Long Do Permanent Punctal Plugs Last?
Category: Diseases and Conditions
Created: 8/5/2022 12:00:00 AM
Last Editorial Review: 8/5/2022 12:00:00 AM


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How Do I Get My Baby to Sleep Longer at Night?

By www.medicinenet.com
Published On :: Tue, 23 Aug 2022 00:00:00 PDT

Title: How Do I Get My Baby to Sleep Longer at Night?
Category: Diseases and Conditions
Created: 8/18/2021 12:00:00 AM
Last Editorial Review: 8/23/2022 12:00:00 AM


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When Do Babies Start Teething?

By www.medicinenet.com
Published On :: Tue, 23 Aug 2022 00:00:00 PDT

Title: When Do Babies Start Teething?
Category: Diseases and Conditions
Created: 12/2/2021 12:00:00 AM
Last Editorial Review: 8/23/2022 12:00:00 AM


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How Long Do Potatoes Last? Raw, Cooked, and More

By www.medicinenet.com
Published On :: Fri, 26 Aug 2022 00:00:00 PDT

Title: How Long Do Potatoes Last? Raw, Cooked, and More
Category: Health and Living
Created: 8/26/2022 12:00:00 AM
Last Editorial Review: 8/26/2022 12:00:00 AM


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Does Hot Chocolate Have Caffeine? Hot Chocolate vs. Coffee & Tea

By www.medicinenet.com
Published On :: Fri, 26 Aug 2022 00:00:00 PDT

Title: Does Hot Chocolate Have Caffeine? Hot Chocolate vs. Coffee & Tea
Category: Health and Living
Created: 8/26/2022 12:00:00 AM
Last Editorial Review: 8/26/2022 12:00:00 AM


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Dogs Get Healthier When People Get Fitter

By www.medicinenet.com
Published On :: Sat, 27 Aug 2022 00:00:00 PDT

Title: Dogs Get Healthier When People Get Fitter
Category: Health News
Created: 8/25/2022 12:00:00 AM
Last Editorial Review: 8/26/2022 12:00:00 AM


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Does Coffee Raise Cholesterol?

By www.medicinenet.com
Published On :: Thu, 12 May 2022 00:00:00 PDT

Title: Does Coffee Raise Cholesterol?
Category: Health News
Created: 5/11/2022 12:00:00 AM
Last Editorial Review: 5/12/2022 12:00:00 AM


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California Will Produce Its Own Insulin to Bring Down Prices

By www.medicinenet.com
Published On :: Fri, 8 Jul 2022 00:00:00 PDT

Title: California Will Produce Its Own Insulin to Bring Down Prices
Category: Health News
Created: 7/8/2022 12:00:00 AM
Last Editorial Review: 7/8/2022 12:00:00 AM


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Exercise, Puzzles, Games: How Do They Help Aging Brains?

By www.medicinenet.com
Published On :: Thu, 21 Jul 2022 00:00:00 PDT

Title: Exercise, Puzzles, Games: How Do They Help Aging Brains?
Category: Health News
Created: 7/21/2022 12:00:00 AM
Last Editorial Review: 7/21/2022 12:00:00 AM


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Many Who Need Opioid OD Antidote the Most Can't Afford It

By www.medicinenet.com
Published On :: Mon, 22 Aug 2022 00:00:00 PDT

Title: Many Who Need Opioid OD Antidote the Most Can't Afford It
Category: Health News
Created: 8/22/2022 12:00:00 AM
Last Editorial Review: 8/22/2022 12:00:00 AM


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People Underestimate Impact of Random Acts of Kindness

By www.medicinenet.com
Published On :: Thu, 25 Aug 2022 00:00:00 PDT

Title: People Underestimate Impact of Random Acts of Kindness
Category: Health News
Created: 8/24/2022 12:00:00 AM
Last Editorial Review: 8/25/2022 12:00:00 AM


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Banded Squats: Benefits and 11 Ways to Do Them

By www.medicinenet.com
Published On :: Mon, 8 Aug 2022 00:00:00 PDT

Title: Banded Squats: Benefits and 11 Ways to Do Them
Category: Health and Living
Created: 8/8/2022 12:00:00 AM
Last Editorial Review: 8/8/2022 12:00:00 AM


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FDA Warns Amazon, Other Vendors About Sale of Skin Tag Removal Products

By www.medicinenet.com
Published On :: Wed, 10 Aug 2022 00:00:00 PDT

Title: FDA Warns Amazon, Other Vendors About Sale of Skin Tag Removal Products
Category: Health News
Created: 8/10/2022 12:00:00 AM
Last Editorial Review: 8/10/2022 12:00:00 AM


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Nerve Block Plus Lidocaine Clears Psoriasis in Small Study

By www.medicinenet.com
Published On :: Tue, 16 Aug 2022 00:00:00 PDT

Title: Nerve Block Plus Lidocaine Clears Psoriasis in Small Study
Category: Health News
Created: 8/15/2022 12:00:00 AM
Last Editorial Review: 8/16/2022 12:00:00 AM


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What Causes Lower Abdominal Pain in Men?

By www.medicinenet.com
Published On :: Fri, 15 Jul 2022 00:00:00 PDT

Title: What Causes Lower Abdominal Pain in Men?
Category: Diseases and Conditions
Created: 7/15/2022 12:00:00 AM
Last Editorial Review: 7/15/2022 12:00:00 AM


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Why Do Men Often Die Before Women?

By www.medicinenet.com
Published On :: Fri, 15 Jul 2022 00:00:00 PDT

Title: Why Do Men Often Die Before Women?
Category: Health News
Created: 7/14/2022 12:00:00 AM
Last Editorial Review: 7/15/2022 12:00:00 AM


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How Do I Make My Ears Stop Ringing?

By www.medicinenet.com
Published On :: Tue, 10 May 2022 00:00:00 PDT

Title: How Do I Make My Ears Stop Ringing?
Category: Diseases and Conditions
Created: 5/10/2022 12:00:00 AM
Last Editorial Review: 5/10/2022 12:00:00 AM


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Does Tinnitus Ever Go Away?

By www.medicinenet.com
Published On :: Fri, 3 Jun 2022 00:00:00 PDT

Title: Does Tinnitus Ever Go Away?
Category: Diseases and Conditions
Created: 6/3/2022 12:00:00 AM
Last Editorial Review: 6/3/2022 12:00:00 AM


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How Does a Man Deal With Menopause?

By www.medicinenet.com
Published On :: Wed, 27 Apr 2022 00:00:00 PDT

Title: How Does a Man Deal With Menopause?
Category: Diseases and Conditions
Created: 4/27/2022 12:00:00 AM
Last Editorial Review: 4/27/2022 12:00:00 AM


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Does Menopause Make You More Sensitive to Pain?

By www.medicinenet.com
Published On :: Wed, 11 May 2022 00:00:00 PDT

Title: Does Menopause Make You More Sensitive to Pain?
Category: Diseases and Conditions
Created: 5/11/2022 12:00:00 AM
Last Editorial Review: 5/11/2022 12:00:00 AM


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High Blood Pressure Doubles Odds That COVID Will Be Severe

By www.medicinenet.com
Published On :: Mon, 25 Jul 2022 00:00:00 PDT

Title: High Blood Pressure Doubles Odds That COVID Will Be Severe
Category: Health News
Created: 7/25/2022 12:00:00 AM
Last Editorial Review: 7/25/2022 12:00:00 AM


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Wisdom Teeth

By www.medicinenet.com
Published On :: Thu, 4 Aug 2022 00:00:00 PDT

Title: Wisdom Teeth
Category: Diseases and Conditions
Created: 1/31/2005 12:00:00 AM
Last Editorial Review: 8/4/2022 12:00:00 AM


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Do You Use Mouthwash Before or After Brushing?

By www.medicinenet.com
Published On :: Fri, 5 Aug 2022 00:00:00 PDT

Title: Do You Use Mouthwash Before or After Brushing?
Category: Health and Living
Created: 8/5/2022 12:00:00 AM
Last Editorial Review: 8/5/2022 12:00:00 AM


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Health Conditions a Dentist Might Find That Have Nothing to Do With Your Teeth

By www.medicinenet.com
Published On :: Fri, 12 Aug 2022 00:00:00 PDT

Title: Health Conditions a Dentist Might Find That Have Nothing to Do With Your Teeth
Category: Health News
Created: 8/11/2022 12:00:00 AM
Last Editorial Review: 8/12/2022 12:00:00 AM


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How Do I Know if I Have an Ovarian Cyst or Tumor?

By www.medicinenet.com
Published On :: Thu, 7 Jul 2022 00:00:00 PDT

Title: How Do I Know if I Have an Ovarian Cyst or Tumor?
Category: Diseases and Conditions
Created: 7/7/2022 12:00:00 AM
Last Editorial Review: 7/7/2022 12:00:00 AM


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tramadol

By www.medicinenet.com
Published On :: Tue, 2 Aug 2022 00:00:00 PDT

Title: tramadol
Category: Medications
Created: 12/31/1997 12:00:00 AM
Last Editorial Review: 8/2/2022 12:00:00 AM


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Tramadol vs. Hydrocodone

By www.medicinenet.com
Published On :: Fri, 5 Aug 2022 00:00:00 PDT

Title: Tramadol vs. Hydrocodone
Category: Medications
Created: 4/24/2017 12:00:00 AM
Last Editorial Review: 8/5/2022 12:00:00 AM


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When Hospital Patient & Doctor Speak Same Language, Outcomes Improve

By www.medicinenet.com
Published On :: Mon, 11 Jul 2022 00:00:00 PDT

Title: When Hospital Patient & Doctor Speak Same Language, Outcomes Improve
Category: Health News
Created: 7/11/2022 12:00:00 AM
Last Editorial Review: 7/11/2022 12:00:00 AM


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pseudoephedrine

By www.medicinenet.com
Published On :: Tue, 9 Aug 2022 00:00:00 PDT

Title: pseudoephedrine
Category: Medications
Created: 8/9/2022 12:00:00 AM
Last Editorial Review: 8/9/2022 12:00:00 AM


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Organ From Live Donor Best When Child Needs New Kidney

By www.medicinenet.com
Published On :: Thu, 18 Aug 2022 00:00:00 PDT

Title: Organ From Live Donor Best When Child Needs New Kidney
Category: Health News
Created: 8/17/2022 12:00:00 AM
Last Editorial Review: 8/18/2022 12:00:00 AM


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What Is the Main Cause of Leaky Gut, and How Do You Fix It?

By www.medicinenet.com
Published On :: Tue, 23 Aug 2022 00:00:00 PDT

Title: What Is the Main Cause of Leaky Gut, and How Do You Fix It?
Category: Diseases and Conditions
Created: 8/23/2022 12:00:00 AM
Last Editorial Review: 8/23/2022 12:00:00 AM


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How Do I Get Rid of Winter Depression?

By www.medicinenet.com
Published On :: Wed, 27 Apr 2022 00:00:00 PDT

Title: How Do I Get Rid of Winter Depression?
Category: Diseases and Conditions
Created: 4/27/2022 12:00:00 AM
Last Editorial Review: 4/27/2022 12:00:00 AM


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How Do I Increase Serotonin?

By www.medicinenet.com
Published On :: Tue, 5 Jul 2022 00:00:00 PDT

Title: How Do I Increase Serotonin?
Category: Diseases and Conditions
Created: 5/24/2021 12:00:00 AM
Last Editorial Review: 7/5/2022 12:00:00 AM


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Study Casts Doubt on 'Chemical Imbalance' Theory of Depression

By www.medicinenet.com
Published On :: Tue, 9 Aug 2022 00:00:00 PDT

Title: Study Casts Doubt on 'Chemical Imbalance' Theory of Depression
Category: Health News
Created: 8/9/2022 12:00:00 AM
Last Editorial Review: 8/9/2022 12:00:00 AM


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Mutational scanning of CRX classifies clinical variants and reveals biochemical properties of the transcriptional effector domain [RESEARCH]

By genome.cshlp.org
Published On :: 2024-10-29T06:46:07-07:00

The transcription factor (TF) cone-rod homeobox (CRX) is essential for the differentiation and maintenance of photoreceptor cell identity. Several human CRX variants cause degenerative retinopathies, but most are variants of uncertain significance. We performed a deep mutational scan (DMS) of nearly all possible single amino acid substitutions in CRX using a cell-based transcriptional reporter assay, curating a high-confidence list of nearly 2000 variants with altered transcriptional activity. In the structured homeodomain, activity scores closely aligned to a predicted structure and demonstrated position-specific constraints on amino acid substitution. In contrast, the intrinsically disordered transcriptional effector domain displayed a qualitatively different pattern of substitution effects, following compositional constraints without specific residue position requirements in the peptide chain. These compositional constraints were consistent with the acidic exposure model of transcriptional activation. We evaluated the performance of the DMS assay as a clinical variant classification tool using gold-standard classified human variants from ClinVar, identifying pathogenic variants with high specificity and moderate sensitivity. That this performance could be achieved using a synthetic reporter assay in a foreign cell type, even for a highly cell type-specific TF like CRX, suggests that this approach shows promise for DMS of other TFs that function in cell types that are not easily accessible. Together, the results of the CRX DMS identify molecular features of the CRX effector domain and demonstrate utility for integration into the clinical variant classification pipeline.


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