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Design, synthesis, and biological evaluation of pyrazole–ciprofloxacin hybrids as antibacterial and antibiofilm agents against Staphylococcus aureus

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00623B, Research Article
Ojaswitha Ommi, Priyanka Sudhir Dhopat, Shashikanta Sau, Madhu Rekha Estharla, Srinivas Nanduri, Nitin Pal Kalia, Venkata Madhavi Yaddanapudi
A series of pyrazole–ciprofloxacin hybrids were designed, synthesized, and tested for antibacterial activity against Staphylococcus aureus, Pseudomonas aeruginosa, and Mycobacterium tuberculosis, aiming to combat antibiotic resistance.
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The content of this RSS Feed (c) The Royal Society of Chemistry




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Synthesis of cationic N-acylated thiazolidine for selective activity against Gram-positive bacteria and evaluation of N-acylation's role in membrane-disrupting activity

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00626G, Research Article
Aleena Pious, Vignesh Venkatasubramanian, Dharshini Karnan Singaravelu, Subburethinam Ramesh, Fuad Ameen, Anbazhagan Veerappan
Lipidation modulates the Gram-selective antibacterial activity of QPyNATh.
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The content of this RSS Feed (c) The Royal Society of Chemistry




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Technical, preclinical, and clinical developments of Fc-glycan-specific antibody–drug conjugates

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00637B, Review Article
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Qiang Yang, Yunpeng Liu
Fc-glycan-specific ADC is a significant advance in site-specific ADCs for cancer therapy. Notably, JSKN003 and IBI343 have demonstrated promising results in phase 1 clinical trials and are advancing into phase 3 studies.
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The content of this RSS Feed (c) The Royal Society of Chemistry




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Synthesis and antifungal evaluation of new azole derivatives containing 1,2,3-triazole

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00724G, Research Article
Zhengxiao Huang, Hongjie Chen, Xiao Zhang, Ruirui Wang, Chunyan Hu, Zewei Mao
A series of novel azole derivatives containing 1,2,3-triazole have been synthesized with good antifungal effects on sensitive and drug-resistant C. albicans.
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The content of this RSS Feed (c) The Royal Society of Chemistry




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Plea to include ‘panneer karumbu’ in Pongal gift hamper




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Case filed against actor Kasthuri over remarks on Telugu community




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NTK chief Seeman booked for alleged ‘derogatory remarks’ against Karunanidhi




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Uppiliyapuram, gateway to scenic Pachamalai, lacks bus stand with passengers left to fight the elements

Buses stop at a busy junction making it difficult for commuters as well as local businessmen; a site is yet to be identified for the bus stand




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Advanced baggage handling system introduced in Tiruchi airport




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Nagapattinam MP presses for new express trains, railway line extensions




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Association holds protest against delay in Anna University’s staff absorption, promotions




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Students cautioned against drug addiction




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583: Language Models, AI, and Digital Gardens with Maggie Appleton

Maggie Appleton talks with us about her work at Elicit, working with large and small language models, how humans vet the responses from AI, the discussion around the Soggoth meme in AI, using Discord as UI, what to do if your boss wants AI in your app, and why does she call her blog a digital garden?




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632: Adam Coster on Game Development and Crashlands 2

Adam Coster talks with us about working with his family in game development, how they get started making games, what all is involved with publishing games, deciding to go Steam and Netflix only for Crashlands 2, how web tech is involved in game development, and the fun of testing and doing Q&A for games.




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640: Navigating the Pros and Cons of Web Components

Riffing off a Dave Rupert blog post, Chris and Dave talk through the pros and cons of web components, when to use them, when it's a bad idea to use them, what would it take to make the Next.js of web components, and how long until we don't need anymore frameworks?




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Sunny days are here again

Despite the cost, a solar energy system is a great energy saver and a boon during power cuts, says Anamika Mukherjee




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It’s good ‘office times’ for Bengaluru

The buoyant office market of Bangalore quite makes up for the lukewarm residential segment, according to findings.




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Chennai’s mega carbon footprint

Chennai emerges as India’s No. 1 greenhouse gas emitter in a study done among seven major cities. Poor city and building design is the main culprit.




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The fight against encroachment

No one has the right to use precious road space as their private storage yard.




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Unlocking renewable energy from industrial waste: Biogas production from spent wash

It is a sustainable solution for industrial waste management and renewable energy generation




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Aggregated customer power

User-friendly financial services are a click away with account aggregators




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Flat organisation believers: Can you imagine a world without managers?

What does a manager do that we keep hiring new ones or keep promoting more of them? Which managerial layer is the most important?




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Sport against strokes

World Stroke Day — October 29




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Galathea Bay: New major port can be game changer

Transshipment port at Galathea Bay is strategically located on the East-West international trade and shipping route




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Bengaluru startup develops new tech for battery recycling, begins production

Li-ion battery recycler Metastable Materials launches commercial ops




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Spotlight on ways to end violence against children




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Navigating the flood of healthcare information, with a little help from AI

A global survey maps how willing, and equipped clinicians are in using artificial intelligence to support their work 




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Can we escape the gas chamber we have walked into?

All countries are falling short of their promise to do their mite for climate action




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GalaxEye: A multi-sensor peek at earth from outer space

Startup sets out to fill a crucial gap in satellite imagery for real-world applications




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Delhi riots case: HC dismisses plea by Khalid Saifi against attempt to murder charge

Mr. Saifi submitted that once the offences under the Arms Act were dropped against him and neither any weapon was recovered nor the alleged gunshot was attributed to him, the charge of attempt to murder could not be framed




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Delhi govt. to start drive against burning of waste in open today

Delhi, neighbouring States likely to experience ‘very poor’ quality air over next 10 days, have placed the depts. concerned on high alert: Gopal Rai




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Delhi HC dismisses plea by Khalid Saifi against attempt to murder charge




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Cannot change rules of the game once recruitment to public services commences: SC

The Constitution Bench says laws, rules and procedure governing recruitments to public services must be governed by the overarching principles of fundamental rights of equality and non-discrimination




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Lawyer sent to jail for 4 months from Delhi HC for ‘derogatory’ remarks against judges

The court directed the police to take Sanjeev Kumar into custody directly from the court and sent him to jail




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Leaves taken by doctors during RG Kar protest to be adjusted against their official quota: AIIMS Delhi




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Issue of infiltration in Santhal Pargana was raised, Hemant did not listen: Champai Soren

The longtime JMM-loyalist, who has now switched to the BJP, adds that decisions he had taken as CM — on tribal language education, PESA implementation, and jump-starting state recruitments — have been put on hold now




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Delhi | The DAG is hosting an exhibition that celebrates MF Husain and his enduring legacy 

An exhibition in New Delhi’s DAG covers pivotal moments of legendary artist and painter MF Husain’s artistic journey 




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Security upped outside Canadian High Commission due to protest against temple attack

The Hindu Sikh Global Forum members are marching towards the High Commission in the Chanakyapuri area




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Delhi Transport Minister Kailash Gahlot announces two new bus routes for outer Delhi




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1984 anti-Sikh riots case: Delhi HC says murder trial to continue against Congress leader Jagdish Tytler

Justice Manoj Kumar Ohri was hearing a plea filed by Mr. Tytler seeking a stay on the trial proceedings taking place against him in a Delhi court. The court would continue with the hearing on November 29




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Inter-State arms gang busted, Delhi police arrest 18 persons




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Delhi HC says murder trial to continue against Jagdish Tytler in 1984 riots case

Justice Manoj Kumar Ohri was hearing a plea filed by Mr. Tytler seeking a stay on the trial proceedings taking place against him in a Delhi court. The court will continue with the hearing on November 29




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BharatPe fraud case: Delhi HC quashes lookout circular against Ashneer Grover, wife




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Coming to grips with mega disasters

Rooted in research, the book reveals the existential threats we face and charts the roadmap ahead




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Strategies for an enduring legacy

How firms can thrive in an era of social tension, economic nationalism and tech revolution




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Why gas is not just hot air




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Navigating digital marketing space

This book provides a bird’s-eye view to marketing professionals of the ever evolving digital space




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DGCA approves Drone Academy at Telangana Agri University

It offers six-week training to ryots, agri-graduates, rural youth in drone piloting




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West Bengal farmers organise indigenous seed festival

Hundreds of farmers from different districts brought native varieties of paddy, pulses and vegetables and exchanged traditional knowledge




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Research paper warns against nationwide switch to natural farming without proper studies

It can hamper national food production, say authors, who cite contrasting results from two studies