CORONATION STREET has confirmed Oliver Battersby's seizure diagnosis and has revealed there is currently no cure. So what does this mean for his future and childhood?

INFINITY pools can offer a dreamy escape from the current situation with seamless views over dazzling skylines, land and sea.

Manchester United are confident of landing one of their key transfer targets.

SPFL fixtures have been released for the 2019/20 season as Neil Lennon’s Celtic target a ninth-consecutive league title.

A MYSTERIOUS NASA experiment has finally been resolved following a decade of conspiracy theories and wild speculation, after the US Space Force revealed the top-secret mission of its unmanned X-37B spacecraft.

CORONATION STREET fans will have to wait until the end of the year to find out whether Yasmeen will get justice for being coercively controlled, but it seems she will head down a darker path before then.

CORONATION STREET has confirmed Oliver Battersby's seizure diagnosis and has revealed there is currently no cure. So what does this mean for his future and childhood?

FA Cup ball numbers for the fourth round draw have been confirmed as Manchester United and Liverpool sweat on their spot after being held to draws.

Find out when the Carabao Cup draw for the third round takes place and how to watch it on TV.

FA Cup first round draw takes place on Monday evening and Express Sport is on hand to bring you everything you need to know.

Newcastle's £300m takeover is set to complete within a week.

ROYAL CARIBBEAN has made further changes to their policy in a bid to instil confidence in customers and reduce the risk of financial losses for customers.

WE DON'T usually think of the Queen as the "mother of the nation".

Within an eight hour period, IMPD officers have been involved the fatal shooting of two suspects and the death of a pregnant pedestrian.

Through his personal streaming platform, IndyCar veteran Conor Daly's Twitch offers fans a front-row seat to a driver's race-day mind.

Plainfield Correctional Facility inmates grow produce in a garden to give to needy.

Plainfield Correctional Facility inmates donate fruits and vegetables from their garden to community organizations.

Plainfield's volleyball team won nine matches in 2015. This year, they've won 11 matches already. Here's what changed.

Brownsburg upended Plainfield on Dec. 7 but the Bulldogs will be missing a key player when the two teams meet in the Hendricks County finals.

Brownsburg defeats Plainfield, 55-43

An off-duty Plainfield police officer was arrested Friday night on suspicion of driving while intoxicated.

Daryn Wright has a résumé, and a routine, unlike any other girl in this weekend's state swimming and diving championships.

Plainfield picked up a 59-42 win over Greenwoon on Friday night, and still has eyes on Mid-State title.

Within an eight hour period, IMPD officers have been involved the fatal shooting of two suspects and the death of a pregnant pedestrian.

A member of Mike Pence's staff has tested positive for coronavirus, the White House confirms.

Key graphics explaining how coronavirus has spread in the UK and the government's response.

Lesotho's Prime Minister Thomas Thabane has reiterated his intention to retire by the end of July "or earlier", despite risk of prosecution for his alleged involvement in the 2017 murder of his estranged wife.

velocityconf: New #velocityconf speaker interview w/ @sascha_d http://t.co/zg4tzDzIlH Config Management: It's Not About the Tool

Conservatives had this Common Core thing all wrong, it was said. We’d be proven wrong by history. Common Core, pushed by President Barack Obama, was going to work. It wasn’t like all the other liberal education plans. A new study by the Pioneer Institute reveals that, no, we were right all along. The study, released…

The post New Study Confirms We Were Right: Reading, Math Scores Have Collapsed Thanks to Obama, Common Core appeared first on The Western Journal.

Quebec public health officials announced Saturday that a total of 2,786 people have died from COVID-19 and there are now 36,986 confirmed cases.

Canada Post's main plant in Calgary has six confirmed cases of COVID-19. That news was confirmed Friday by Dr. Deena Hinshaw at her daily update.

Human remains located in Mulmur Township in March have been confirmed to be those of an 88-year-old Caledon man who was reported missing seven months ago.

S. A. Nazarov
Trans. Moscow Math. Soc. 80 (2020), 1-51.
Abstract, references and article information

Five alleged members of hacking group InfinityBlack got some unexpected visitors last week when Polish law enforcement arrested them.

The confidence level of Hong Kong’s exporters has fallen to its lowest-ever level in the face of a triple challenge – the COVID-19 outbreak, softening global demand and lingering trade tension between the United States and Mainland...

The UK-based digital identity specialist managed to raise a bumper round during the peak of the COVID-19 pandemic, and is looking at ways to apply its technology to help combat the global crisis

The action mechanisms revealed by the biochemical and structural analyses of replicative and translesion synthesis (TLS) DNA polymerases (Pols) are retained in their cellular roles. In this regard, DNA polymerase θ differs from other Pols in that whereas purified Polθ misincorporates an A opposite 1,N6-ethenodeoxyadenosine (ϵdA) using an abasic-like mode, Polθ performs predominantly error-free TLS in human cells. To test the hypothesis that Polθ adopts a different mechanism for replicating through ϵdA in human cells than in the purified Pol, here we analyze the effects of mutations in the two highly conserved tyrosine residues, Tyr-2387 and Tyr-2391, in the Polθ active site. Our findings that these residues are indispensable for TLS by the purified Pol but are not required in human cells, as well as other findings, provide strong evidence that the Polθ active site is reconfigured in human cells to stabilize ϵdA in the syn conformation for Hoogsteen base pairing with the correct nucleotide. The evidence that a DNA polymerase can configure its active site entirely differently in human cells than in the purified Pol establishes a new paradigm for DNA polymerase function.

The Ministry of Health and Wellness has reported ten new positive COVID-19 test results, pushing the tally of confirmed cases to 488. Among the ten new cases, eight are females, and two are males. Their ages range from four years to 39-years-...

Rationale: To conduct a retrospective study comparing three ¹²³I-FP-CIT-SPECT quantitative methods in patients with neurodegenerative syndromes as referenced to neuropathological findings. Methods: ¹²³I-FP-CIT-SPECT and neuropathological findings among patients with neurodegenerative syndromes from the Mayo Alzheimer's Disease Research Center and Mayo Clinic Study of Aging were examined. Three ¹²³I-FP-CIT-SPECT quantitative assessment Methods: MIMneuro (MIM Software Inc.), DaTQUANT (GE Healthcare), and manual region of interest (ROI) creation on an Advantage Workstation (GE Healthcare) were compared to neuropathological findings describing the presence or absence of Lewy body disease (LBD). Striatum to background ratios (SBRs) generated by DaTQUANT were compared to the calculated SBRs of the manual method and MIMneuro. The left and right SBRs for caudate, putamen and striatum were evaluated with the manual method. For DaTQUANT and MIMneuro the left, right, total and average SBRs and z-scores for whole striatum, caudate, putamen, anterior putamen, and posterior putamen were calculated. Results: The cohort included 24 patients [20 (83%) male, aged 75.4 +/- 10.0 at death]. The antemortem clinical diagnoses were Alzheimer’s disease dementia (ADem, N = 6), probable dementia with Lewy bodies (pDLB, N = 12), mixed ADem/pDLB (N = 1), Parkinson’s disease with mild cognitive impairment (N = 2), corticobasal syndrome (N = 1), idiopathic rapid eye movement sleep behavior disorder (iRBD) (N = 1) and behavioral variant frontotemporal dementia (N = 1). Seventeen (71%) had LBD pathology. All three ¹²³I-FP-CIT-SPECT quantitative methods had area under the receiver operating characteristics (AUROC) values above 0.93 and up to 1.000 (p<0.001) and showed excellent discrimination between LBD and non-LBD patients in each region assessed, p<.001. There was no significant difference between the accuracy of the regions in discriminating the two groups, with good discrimination for both caudate and putamen. Conclusion: All three ¹²³I-FP-CIT-SPECT quantitative methods showed excellent discrimination between LBD and non-LBD patients in each region assessed, using both SBRs and z-scores.

Tumor cells can spread to distant sites through their ability to switch between mesenchymal and amoeboid (bleb-based) migration. Because of this difference, inhibitors of metastasis must account for each migration mode. However, the role of vimentin in amoeboid migration has not been determined. Because amoeboid leader bleb–based migration (LBBM) occurs in confined spaces and vimentin is known to strongly influence cell-mechanical properties, we hypothesized that a flexible vimentin network is required for fast amoeboid migration. To this end, here we determined the precise role of the vimentin intermediate filament system in regulating the migration of amoeboid human cancer cells. Vimentin is a classic marker of epithelial-to-mesenchymal transition and is therefore an ideal target for a metastasis inhibitor. Using a previously developed polydimethylsiloxane slab–based approach to confine cells, RNAi-based vimentin silencing, vimentin overexpression, pharmacological treatments, and measurements of cell stiffness, we found that RNAi-mediated depletion of vimentin increases LBBM by ∼50% compared with control cells and that vimentin overexpression and simvastatin-induced vimentin bundling inhibit fast amoeboid migration and proliferation. Importantly, these effects were independent of changes in actomyosin contractility. Our results indicate that a flexible vimentin intermediate filament network promotes LBBM of amoeboid cancer cells in confined environments and that vimentin bundling perturbs cell-mechanical properties and inhibits the invasive properties of cancer cells.

Seeking to bring another versatile infielder into the fold, the Giants on Friday agreed to terms with Yangervis Solarte on a Minor League contract with an invitation to Major League Spring Training.

The Astros logo outside the Ballpark of the Palm Beaches really is something to see, all the way from Haverhill Rd. The closer you get the bigger it gets, the white "H" right there in front of the huge orange star. Underneath the "H" is the following message, white against orange: "2017 World Champions." It would have been a simple matter to put "2018" down there, too. There was room.

HARRISBURG, Pennsylvania (AP) — A Pennsylvania inmate whose dreadlocks violated a jail’s haircut policy has been released from solitary confinement after more than a year, although his federal lawsuit is still pending. A federal...

Days after The Gleaner reported a clarion call from Port Maria Mayor Richard Creary for the quarantine of St Mary communities owing to growing concerns about the spread of COVID-19 in the parish, the Government responded with the lockdown of three...

Ketel Marte does not lack for confidence when it comes to switching from second base/shortstop to center field, which is where he's expected to see a lot of time this season.